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Postoperative encapsulated hemoperitoneum in a patient with gastric stromal tumor treated by exposed endoscopic full-thickness resection: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 601-608页

作者： Hui-Fei lu Jing-Jing Li De-Bin Zhu Li-Qi Mao Li-Fen Xu Jing Yu Lin-Hua yao Department of Gastroenterology the First People’s Hospital of HuzhouHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Gastric stromal tumors,originating from mesenchymal tissues,are one of the most common tumors of the digestive *** stromal tumors originating from the muscularis propria,compared with conventional endoscopic submucosal dissection(ESD),endoscopic full-thickness resection(EFTR)can remove deep lesions and digestive tract wall tumors ***,this technique has major limitations such as perforation,postoperative bleeding,and post-polypectomy ***,we report a case of postoperative serous surface bleeding which formed an encapsulated hemoperitoneum in a patient with gastric stromal tumor that was treated with exposed *** treatment options to address this complication are *** SUMMARY A 47-year-old male patient had a hemispherical protrusion found during gastric endoscopic ultrasonography,located at the upper gastric curvature adjacent to the stomach fundus,with a smooth surface mucosa and poor *** lesion was 19.3 mm×16.1 mm in size and originated from the fourth ultrasound *** tomography(CT)revealed no significant evidence of lymph node enlargement or distant *** conventional ESD technology for mucosal pre-resection,exposed EFTR was performed to resect the intact tumor in order to achieve a definitive histopathological *** on its morphology and immunohistochemical expression of CD117 and DOG-1,the lesion was proven to be consistent with a gastric stromal *** days after exposed EFTR,CT showed a large amount of encapsulated fluid and gas accumulation around the *** addition,gastroscopy suggested intracavitary bleeding and abdominal puncture drainage indicated serosal *** on these findings,the patient was diagnosed with serosal bleeding resulting in encapsulated abdominal hemorrhage after exposed EFTR for a gastric stromal *** patient received combined treatments,such as hemostasis under gastroscopy,gastrointestinal decompression,and abdominal

关键词： Exposed endoscopic full-thickness resection Gastric stromal tumors Hemoperitoneum Abdominal infection Complication Postoperative bleeding Case report

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Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

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Journal of Integrative Medicine 2024年第4期22卷 493-502页

作者： Qian-zhuo Liu Hui Han Xin-ru Fang lu-yao Wang Dan Zhao Miao-zhu Yin Nian Zhang Peng-yu Jiang Zhi-hui Ji Li-min Wu Department of Neurology the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Center for Reproduction and Genetics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031Anhui ProvinceChina

Objective:Hepatolenticular degeneration (HLD) is an autosomal recessive disorder that manifests as multiorgan damage due to impaired copper (Cu) metabolism. Female patients with HLD often experience reproductive impairments. This study investigated the protective effect of berberine against ovarian damage in toxic-milk (TX) mice, a murine model for ***:Mice were categorized into control group, HLD TX group (HLD group), penicillamine (Cu chelator)-treated TX group and berberine-treated TX group. Body weight, ovary weight and the number of ovulated eggs were recorded. Follicular morphology and cellular ultrastructure were examined. Total iron, ferrous iron (Fe2+) and trivalent iron (Fe3+) levels, as well as malondialdehyde (MDA), glutathione(GSH) and oxidized glutathione (GSSG), were measured in the ovaries. Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum (ER) ***:Ovarian tissue damage was evident in the HLD group, with a significant increase in ferroptosis and ER stress compared to the control group. This damage was inhibited by treatment with penicillamine,a Cu chelator. Compared with the HLD group, berberine increased the number of ovulations, and improved ovarian morphology and ultrastructure. Further, we found that berberine reduced total iron,Fe2+, MDA and GSSG levels, elevated GSH levels, decreased the expression of the ferroptosis marker protein prostaglandin-endoperoxide synthase 2 (PTGS2), and increased glutathione peroxidase 4 (GPX4)expression. Furthermore, berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase (PERK) ***:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice. Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.

关键词： Berberine Hepatolenticular degeneration Copper deposition Ferroptosis Endoplasmic reticulum stress

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Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpoxvaccinated healthy population:A case report

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iLABMED 2024年第1期2卷 60-66页

作者： Chuming Chen Weiming yao Siran Huang Ling Peng Shiyan Feng Weibo Wu Yunlan Yi Zhiqiang Cheng yang yang Yan yang Liuqing yang Hongzhou lu Fuxiang Wang Department of Infectious Diseases National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina Department of Pathology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina Department of Blood Transfusion National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina

Since the first reported case of monkeypox in the UK in May 2022,there has been an upward trend in monkeypox cases and a global ***,reports of severe cases are relatively *** this study,we report a case of severe monkeypox in a patient with *** patient presented with skin lesions that started on his face and around the penis and persisted for several *** the course of the disease,he received systematic symp-tomatic supportive treatment,topical remedies,and special care for the *** also underwent cidofovir antiviral therapy and smallpox‐vaccinated healthy population‐derived plasma therapy in succession,with the condition ultimately showing improvement after plasma *** more than 3 months of hospitalization,he fully *** the best of our knowledge,this is the first reported use of smallpox‐vaccinated healthy population‐derived plasma in the treatment of severe monkeypox cases.

关键词： antiviral therapy co‐infection HIV monkeypox plasma therapy severe infection

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Association between plasma growth differentiation factor 15 levels and pre-eclampsia in China

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Chronic Diseases and Translational Medicine 2024年第2期10卷 140-145页

作者： Shuhong Xu Yicheng lu Mengxin yao Zhuoqiao yang Yan Chen Yaling Ding Yue Xiao Fei Liang Jiani Qian Jinchun Ma Songliang Liu Shilan Yan Jieyun Yin Qiuping Ma Taicang Affiliated Hospital of Soochow University The First People's Hospital of TaiCangSoochow UniversitySuzhouJiangsuChina Department of Epidemiology and Health Statistic Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable DiseasesSuzhou Medical College of Soochow UniversitySuzhouJiangsuChina Changshu Hospital Affiliated to Nanjing University of Chinese Medicine SuzhouJiangsuChina Department of Chronic Disease Gusu Center for Disease Control and PreventionSuzhouJiangsuChina Huzhou First People's Hospital HuzhouZhejiangChina

Background Growth differentiation factor-15(GDF-15)is a stress response protein and is related to cardiovascular diseases(CVD).This study aimed to investigate the association between GDF-15 and pre-eclampsia(PE).Method The study involved 299 pregnant women,out of which 236 had normal pregnancies,while 63 participants had *** serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits and then translated into multiple of median(MOM)to avoid the influence of gestational week at blood *** models were performed to estimate the association between GDF-15 MOM and PE,presenting as odd ratios(ORs)and 95%confidence intervals(CIs).Results MOM of GDF-15 in PE participants was higher compared with controls(1.588 vs.1.000,p1)had a 4.74-fold(95%CI=2.23–10.08,p<0.001)increased risk of PE,adjusted by age,preconceptional body mass index,gravidity,and *** These results demonstrated that higher levels of serum GDF-15 were associated with ***-15 may serve as a biomarker for diagnosing PE.

关键词： growth differentiation factor 15 macrophage inhibiting cytokine 1 pre-eclampsia

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A comparison of the effect of alendronate and You-Gui-Wan on osteoporosis in female rats with kidney-yang deficiency

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Traditional Medicine Research 2024年第6期9卷 31-41页

作者： Mei-Mei Wu Xing-Peng He Wan-Ting Wu Wen-Jie lu Yan-yang Mai Kun-Cai Xu yao-Feng Zhi Hai-Xin Mo Jia-Di He Xin Zhang Peng-Fei Li Clinical Experimental Center Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational ResearchJiangmen Central HospitalJiangmen 529030China Traumatic Orthopedics Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510470China Department of Intelligent Engineering Guiyang Institute of Information Science and TechnologyGuiyang 550025China

Background:In traditional Chinese medicine,You-Gui-Wan(YGW)is typically used to treat osteoporosis associated with kidney-yang ***,there have been few mechanistic studies on the effectiveness of kidney-yang deficiency-type osteoporosis with *** further clarify the role of YGW in the effect of osteoporosis with kidney-yang deficiency,the study analyzed the therapeutic advantages of YGW by comparing the therapeutic effects of YGW and alendronate(ALN)on osteoporosis with kidney-yang ***:SPF female SD rats were randomly divided into control,osteoporosis,osteoporosis with kidney-yang deficiency,osteoporosis with kidney-yang deficiency+YGW and osteoporosis with kidney-yang deficiency+ALN *** for the control group,osteoporosis was induced by the removal of bilateral *** 12 weeks,rats with osteoporosis in the kidney-yang deficiency group had kidney-yang deficiency syndrome triggered by hydrocortisone for 14 *** were treated with YGW or ALN for 12 *** weights of rats were ***-eosin staining staining was used to observe pathological changes in bone trabeculae,liver,spleen,and kidneys of *** of the growth plate cartilage of rats in different groups was observed by safranine-O *** expression of osteoclast key indices(ACP)and osteoblast key indices(ALP)in the bone tissue of rats in the different groups was observed by immunohistochemical *** expression of bone resorption-related indicators(TRAP and NXT-1),bone formation-related indicators(BALP,BGP,and P1NP),and major indicators of kidney-yang deficiency(ACTH,T3,T4,cAMP,and cGMP)were observed using an ELISA detection *** expression levels of the main indices of liver function(ALT and AST)were detected in different ***:The differences between the osteoporosis with kidney-yang deficiency group and osteoporosis group were that the weight of rats and the expression of ACTH,T3,T4,and cAMP decreased significantl

关键词： osteoporosis kidney-yang deficiency You-Gui-Wan alendronate

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平茬高度对中国沙棘伐桩萌枝能力及营养元素积累与分配的影响

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Journal of Plant Ecology 2024年第3期17卷 49-62页

作者： Shenghong Liu Zhongmu Li Kaihong Nie Sai lu Zengyu yao Genqian Li College of Forestry Southwest Forestry UniversityKunming 650224China Zhaohua Forestry Bureau of Guangyuan City Guangyuan 628060China

伐桩萌枝作为森林萌蘖更新的主要途径,在森林群落演替和植被恢复过程中起到关键作用。为了解伐桩萌枝能力对平茬高度的响应规律及其养分积累与分配策略,确定最有利于伐桩萌枝潜力发挥的平茬高度,本研究以具有早衰特征的15 a中国沙棘(Hip... 详细信息

伐桩萌枝作为森林萌蘖更新的主要途径,在森林群落演替和植被恢复过程中起到关键作用。为了解伐桩萌枝能力对平茬高度的响应规律及其养分积累与分配策略,确定最有利于伐桩萌枝潜力发挥的平茬高度,本研究以具有早衰特征的15 a中国沙棘(Hippophae rhamnoides ***)为研究对象,设置3个平茬高度处理(0、10、20 cm),以不平茬为对照进行比较分析。结果表明:(i)随平茬高度的增大,伐桩萌枝数量呈直线上升,存活率呈直线下降,生长量(伐桩萌枝高、伐桩萌枝地径、伐桩萌枝丛幅)先升后降,平茬10 cm最有利于萌枝的发生、存活与生长。(ii)营养元素(N、P、K、Ca、Mg)含量和储量随平茬高度的增大先升后降,平茬10 cm时最高。同时,平茬使种群加大了叶片、垂直根和水平根的营养元素分配。(iii)伐桩萌枝生长量与营养元素含量、储量呈正相关,伐桩萌枝数量和存活率与营养元素含量、储量呈正相关趋势,其中Mg在伐桩萌枝能力发挥过程中起到重要作用。上述研究结果表明,平茬改变了中国沙棘营养元素的积累能力及其分配格局进而影响伐桩萌枝能力。通过回归方程估计,最有利于伐桩萌枝能力和营养元素积累能力发挥的平茬高度为11.0–14.0 cm。

关键词：平茬高度伐桩萌枝森林萌蘖更新营养元素积累和分配中国沙棘(Hippophae rhamnoides ssp.sinensis)

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Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard

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Zoological Research 2024年第3期45卷 464-467页

作者： Hai-Meng Li Bo-yang Liu Min-Hui Shi Le Zhang Shang-Chen yang Sunil Kumar Sahu Liang-Yu Cui Shan-Lin Liu Nicolas Dussex Yue Ma Dan Liu Wei-yao Kong Hao-Rong lu Yue Zhao Love Dalén Huan Liu Tian-Ming Lan Guang-Shun Jiang Yan-Chun Xu College of Wildlife and Protected Area Northeast Forestry UniversityHarbinHeilongjiang 150040China State Key Laboratory of Agricultural Genomics BGI ResearchShenzhenGuangdong 518083China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China BGI Research WuhanHubei 430074China Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China Centre for Palaeogenetics Svante Arrhenius väg 20CStockholm 10691Sweden Department of Zoology Stockholm UniversityStockholm 10691Sweden Department of Bioinformatics and Genetics Swedish Museum of Natural HistoryStockholm 10691Sweden Heilongjiang Siberian Tiger Park HarbinHeilongjiang 150000China Jinlin Provincial Academy of Forestry Science ChangchunJilin 130033China China National GeneBank BGI ResearchShenzhenGuangdong 518120China Guangdong Provincial Key Laboratory of Genome Read and Write BGI ResearchShenzhenGuangdong 518083China BGI Life Science Joint Research Center Northeast Forestry UniversityHarbinHeilongjiang 150040China Feline Research Center of National Forestry and Grassland Administration College of Wildlife and Protected AreaNortheast Forestry UniversityHarbinHeilongjiang 150040China National Forestry and Grassland Administration Research Center of Engineering Technology for Wildlife Conservation and Utilization HarbinHeilongjiang 150040China

DEAR EDITOR,Big cats,such as Amur tigers(Panthera tigris altaica)and Amur leopards(*** orientalis),are apex predator and have evolved specialized traits for hunting and carnivory(Moya et al.,2022),thus playing a crucial role in maintaining biodiversity and ecosystem integrity by regulating prey-predator ***,human-induced pressures,habitat fragmentation,and environmental alterations have restricted these species in small and isolated ***,all extant big cats are categorized as endangered or threatened according to their conservation *** tigers and Amur leopards share overlapping geographic ranges,habitats,and certain prey species in the forests of Northeast Asia(Jiang et al.,2015).To reduce interspecies conflict,these carnivores exhibit differentiated dietary and temporal *** tigers predominantly prey on large ungulates,while Amur leopards hunt small to medium-sized animals(Sugimoto et al.,2016).Additionally,they occupy different temporal niches,with tigers being active at night and leopards more active during the *** spatial and temporal niche partitioning,interspecific competition between these two species is ***,benefiting from their greater size,have a competitive advantage over leopards,which can manifest in occasional leopard predation by tigers and declines in leopard populations with increasing tiger density(Jiang et al.,2015).Tigers also displace leopards from marginal habitats in nature reserves where they coexist.

关键词： habitat Panthera resolved

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Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca^(2+) Handling After Myocardial Infarction

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Research 2024年第1期2023卷 583-594页

作者： Sheng-an Su Yuhao Zhang Wudi Li Yutao Xi Yunrui lu Jian Shen Yuankun Ma Yaping Wang Yimin Shen Lan Xie Hong Ma yao Xie Meixiang Xiang Department of Cardiology Cardiovascular Key Laboratory of Zhejiang ProvinceThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Texas Heart Institute HoustonTX 77030USA

Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial infarction(MI).Accumulating data show that ischemia,sympathetic activation,and inflammation contribute to ***,the role and mechanisms of abnormal mechanical stress in ventricular arrhythmia following MI remain *** aimed to examine the impact of increased mechanical stress and identify the role of the key sensor Piezo1 in ventricular arrhythmogenesis in *** with increased ventricular pressure,Piezo1,as a newly recognized mechano-sensitive cation channel,was the most up-regulated mechanosensor in the myocardium of patients with advanced heart ***1 was mainly located at the intercalated discs and T-tubules of cardiomyocytes,which are responsible for intracellular calcium homeostasis and intercellular communication.

关键词： ventricular homeostasis Ventricular

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柴田是真纸本漆绘《宝贝尽图漆绘》的复原实践与运用

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南京艺术学院学报（美术与设计） 2024年第1期 74-78,I0011页

作者：路瑶南京艺术学院设计学院江苏南京210013

柴田是真是活跃在江户幕府末期到明治时期的绘师兼漆工,他的绘画与漆工作品具有独特的艺术表现形式。本文以柴田是真明治年间创作的纸本漆绘《宝贝尽图漆绘》为研究样本,试图从现状研究、审美创新、复原实践及运用等四个方面展开探讨,... 详细信息

柴田是真是活跃在江户幕府末期到明治时期的绘师兼漆工,他的绘画与漆工作品具有独特的艺术表现形式。本文以柴田是真明治年间创作的纸本漆绘《宝贝尽图漆绘》为研究样本,试图从现状研究、审美创新、复原实践及运用等四个方面展开探讨,在复原的过程中寻找合适的路径,明确材料及技法的选择和运用,为当今纸本漆绘的创作做好基础性研究。

关键词：柴田是真纸本漆绘复原实践与运用

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基于创新性内侧壁成型工艺的多光学通道微型碱金属原子气室

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Engineering 2024年第4期35卷 46-55页

作者： Mingzhi Yu yao Chen Yongliang Wang Xiangguang Han Guoxi luo Libo Zhao Yanbin Wang Yintao Ma Shun lu Ping yang Qijing Lin Kaifei Wang Zhuangde Jiang International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 265503China Moon Environment Technology Co. Ltd.Yantai 264000China Emergency Department The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China

Existing microfabricated atomic vapor cells have only one optical channel,which is insufficient for supporting the multiple orthogonal beams required by atomic *** this study,we present a novel wafer-level manufacturing process for fabricating multi-optical-channel atomic vapor cells and an innovative method for batch processing the inner sidewalls of millimeter glass holes to meet optical channel *** characterization and transmittance tests demonstrate that the processed inner sidewalls satisfy the criteria for an optical *** addition,the construction of an integrated processing platform enables multilayer non-isothermal anode bonding,the filling of inert gases,and the recovery and recycling of noble *** of the absorption spectra and free-induction decay signals of xenon-129(^(129)Xe)and xenon-131(^(131)Xe)under different pump-probe schemes demonstrate the suitability of our vapor cell for use in atomic devices including atomic gyroscopes,dual-beam atomic magnetometers,and other optical/atomic *** proposed micromolding technology has broad application prospects in the field of optical-device processing.

关键词： Microfabricated atomic vapor cells Inner-sidewall molding Multiple optical channels Quantum sensing

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