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Bottom-up construction of low-dimensional perovskite thick films for high-performance X-ray detection and imaging

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Light(Science & Applications) 2024年第9期13卷 1809-1819页

作者： Siyin Dong Zhenghui Fan wei wei Shujie Tie Ruihan Yuan Bin Zhou Ning Yang Xiaojia Zheng Liang shen Sichuan Research Center of New Materials Institute of Chemical MaterialsChina Academy of Engineering PhysicsShuangliuChengduChina State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringInternational Center of Future ScienceJilin UniversityChangchunChina

Quasi-two-dimensional(Q-2D)perovskite exhibits exceptional photoelectric properties and demonstrates reduced ion migration compared to 3D perovskite,making it a promising material for the fabrication of highly sensitive and stable X-ray ***,achieving high-quality perovskite films with sufficient thickness for efficient X-ray absorption remains ***,we present a novel approach to regulate the growth of Q-2D perovskite crystals in a mixed atmosphere comprising methylamine(CH3NH2,MA)and ammonia(NH3),resulting in the successful fabrication of high-quality films with a thickness of hundreds of ***,we build a heterojunction X-ray detector by incorporating the perovskite layer with titanium dioxide(TiO2).The precise regulation of perovskite crystal growth and the meticulous design of the device structure synergistically enhance the resistivity and carrier transport properties of the X-ray detector,resulting in an ultrahigh sensitivity(29721.4μC Gyair−1 cm−2)for low-dimensional perovskite X-ray detectors and a low detection limit of 20.9 nGyair s−*** have further demonstrated a flat panel X-ray imager(FPXI)showing a high spatial resolution of 3.6 lpmm−1 and outstanding X-ray imaging capability under low X-ray *** work presents an effective methodology for achieving high-performance Q-2D perovskite FPXIs that holds great promise for various applications in imaging technology.

关键词： perovskite dimensional performance

Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids

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Protein & Cell 2024年第4期15卷 285-304页

作者： Yunuo Mao wei Wang Jingwei Yang Xin Zhou Yongqu lu Junpeng Gao Xiao Wang lu Wen wei Fu Fuchou Tang School of Life Sciences Biomedical Pioneering Innovation CenterDepartment of General SurgeryThird HospitalPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics(ICG) Ministry of Education Key Laboratory of Cell Proliferation and DifferentiationBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Peking University Third Hospital Cancer Center Beijing 100871China The Research Center of Stem Cell and Regenerative Medicine School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Colorectal cancer(CRC)is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be ***,we established human CRC tumor-derived organoids that well represent both morphological and molecular heterogeneities of original *** efficiently identify repurposed drugs for CRC,we developed a robust organoid-based drug screening *** combining the repurposed drug library and computation-based drug prediction,335 drugs were tested and 34 drugs with anti-CRC effects were *** importantly,we conducted a detailed transcriptome analysis of drug responses and divided the drug response signatures into five representative patterns:differentiation induction,growth inhibition,metabolism inhibition,immune response promotion,and cell cycle *** anticancer activities of drug candidates were further validated in the established patient-derived organoids-based xenograft(PDOX)system in *** found that fedratinib,trametinib,and bortezomib exhibited effective anticancer ***,the concordance and discordance of drug response signatures between organoids in vitro and pairwise PDOX in vivo were *** study offers an innovative approach for drug discovery,and the representative transcriptome features of drug responses provide valuable resources for developing novel clinical treatments for CRC.

关键词： colorectal cancer organoids drug repurposing patient-derived organoids-based xenograft mechanism of action

An in-situ polymerized interphase engineering for high-voltage allsolid- state lithium-metal batteries

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Nano Research 2024年第4期17卷 2687-2692页

作者： lu Nie Shaojie Chen Mengtian Zhang Tianyi Gao Yuyao Zhang Ran wei Yining Zhang wei Liu School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Tsinghua-Berkeley shenzhen Institute&Tsinghua shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

All-solid-state lithium batteries(ASSLBs)have attracted great interest due to their promising energy density and strong ***,the interface issues,including large interfacial resistance between electrode and electrolyte and low electrochemical stability of solid-state electrolytes against high-voltage cathodes,have restricted the development of high-voltage ***,we report an ASSLB with stable cycling by adopting a conformal polymer interlayer in-situ formed at the Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)–cathode *** polymer can perfectlyﬁll the voids and create a stable interface contact between LLZTO and *** addition,the electric field across the polymer interlayer is reduced compared with pure solid polymer electrolyte(SPE),which facilitates the electrochemical stability with high-voltage *** all-solid-state Li|LLZTO-SPE|LiFe_(0.4)Mn_(0.6)PO_(4)(LMFP)cells achieve a low interface impedance,high specific capacity,and excellent cycling *** work presents an effective and practical strategy to rationally design the electrode–electrolyte interface for the application of high-voltage ASSLBs.

关键词： all-solid-state lithium batteries interface contact electric field electrochemical stability

A Deep Neural Collaborative Filtering Based Service Recommendation Method with Multi-Source Data for Smart Cloud-Edge Collaboration Applications

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Tsinghua Science and Technology 2024年第3期29卷 897-910页

作者： Wenmin Lin Min Zhu Xinyi Zhou Ruowei Zhang Xiaoran Zhao Shigen shen lu Sun Alibaba Business School Hangzhou Normal UniversityHangzhou 311121China Blockchain Laboratory of Agricultural Vegetables Weifang University of Science and TechnologyShouguang 262700China School of Computer Science Qufu Normal UniversityRizhao 276827China School of Information Engineering Huzhou UniversityHuzhou 313000China

Service recommendation provides an effective solution to extract valuable information from the huge and ever-increasing volume of big data generated by the large cardinality of user ***,the distributed and rich multi-source big data resources raise challenges to the centralized cloud-based data storage and value mining approaches in terms of economic cost and effective service recommendation *** view of these challenges,we propose a deep neural collaborative filtering based service recommendation method with multi-source data(i.e.,NCF-MS)in this paper,which adopts the cloud-edge collaboration computing paradigm to build recommendation *** specifically,the Stacked Denoising Auto Encoder(SDAE)module is adopted to extract user/service features from auxiliary user profiles and service *** Multiple Layer Perceptron(MLP)module is adopted to integrate the auxiliary user/service features to train the recommendation ***,we evaluate the effectiveness of the NCF-MS method on three public *** experimental results show that our proposed method achieves better performance than existing methods.

关键词： deep neural collaborative filtering multi-source data cloud-edge collaboration application stackeddenoising auto encoder multiple layer perceptron

Enhancing Deep Learning Soil Moisture Forecasting Models by Integrating Physics-based Models

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Advances in Atmospheric Sciences 2024年第7期41卷 1326-1341页

作者： lu LI Yongjiu DAI Zhongwang wei wei SHANGGUAN Nan wei Yonggen ZHANG Qingliang LI Xian-Xiang LI School of Atmospheric Sciences Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangzhou 510275China Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Guangzhou 510275China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China College of Computer Science and Technology Changchun Normal UniversityChangchun 130123China

Accurate soil moisture(SM)prediction is critical for understanding hydrological ***-based(PB)models exhibit large uncertainties in SM predictions arising from uncertain parameterizations and insufficient representation of land-surface *** addition to PB models,deep learning(DL)models have been widely used in SM predictions ***,few pure DL models have notably high success rates due to lacking physical ***,we developed hybrid models to effectively integrate the outputs of PB models into DL models to improve SM *** this end,we first developed a hybrid model based on the attention mechanism to take advantage of PB models at each forecast time scale(attention model).We further built an ensemble model that combined the advantages of different hybrid schemes(ensemble model).We utilized SM forecasts from the Global Forecast System to enhance the convolutional long short-term memory(ConvLSTM)model for 1–16 days of SM *** performances of the proposed hybrid models were investigated and compared with two existing hybrid *** results showed that the attention model could leverage benefits of PB models and achieved the best predictability of drought events among the different hybrid ***,the ensemble model performed best among all hybrid models at all forecast time scales and different soil *** is highlighted that the ensemble model outperformed the pure DL model over 79.5%of in situ stations for 16-day *** findings suggest that our proposed hybrid models can adequately exploit the benefits of PB model outputs to aid DL models in making SM predictions.

关键词： soil moisture forecasting hybrid model deep learning ConvLSTM attention mechanism

Combination of iron flocculation and qPCR for quantitative evaluation of virus-shedding intensity of goldfish Carassius auratus infected with cyprinid herpesvirus 2 in the water and the effect of sodium chlorite powder in blocking waterborne horizontal viral transmission

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Aquaculture and Fisheries 2024年第4期9卷 617-625页

作者： Yufei Zhai Fei shen Hao Wang Liqun lu National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China Key Laboratory for Freshwater Aquatic Genetic Resources at Shanghai Ocean University Ministry of Agriculture and Rural AffairsShanghai201306China College of Fisheries and Life Science Shanghai Ocean UniversityShanghai201306China

Cyprinid herpesvirus 2(CyHV-2),a member of the Alloherpesviridae family belonging to the genus Cyprinivirus,was initially isolated from goldfish(Carassius auratus)and has been recently emerging as a virulent pathogen for cultured prussian carp(Carassius auratus gibelio)*** this study,a novel and effective method for concentration and quantification of live CyHV-2 virions from water was successfully established through coupling the iron flocculation with real time qPCR ***,the shedding intensity of CyHV-2 in fish-tank water from artificially-challenged goldfish(25 fish/20 L)was monitored continuously for 7 days on a daily basis through quantitating viral genomic copy numbers by qPCR,and the maximum shedding level was determined to be 105 copies/*** transmission research system was established by inoculating healthy goldfish in water spiked with serial dilution of CyHV-2 virions ranging from 107 to 103 copies/*** results indicated that water-borne CyHV-2 efficiently caused the infection of tested goldfish even in a concentration of 103 copies/L,and the overall transmission efficacy was not linearly correlated with the level of input virus in the fish *** disinfectant Composite Sodium Chlorite Powder(CSCP)has been widely applied in aquaculture to control microbial infection through direct spill in the water,and its effect in inactivating the CyHV-2 infectivity remains *** further determined that the EC50 of CSCP against 3.89 TCID50/mL CyHV-2 was close to 15.625μg/mL in vitro,and application of CSCP in a level as high as 60μg/mL(the safety concentration of CSCP for goldfish)couldn’t protect goldfish from CyHV-2 challenge through ***,the disinfectant CSCP was regarded as none-effective for blocking CyHV-2 transmission in water during ***,our data provided quantitative data to demonstrate the shedding intensity of CyHV-2 in water,and CSCP was shown to be not effective in blocking water-borne horizontal

关键词： Cyprinid herpesvirus 2 Iron flocculation Virus shedding Water-borne horizontal transmission Composite sodium chlorite powder

Enhancing the electrocatalytic performance of nitrate reduction to ammonia by in-situ nitrogen leaching

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Chinese Chemical Letters 2024年第2期35卷 564-569页

作者： Mimi Fu Yini Mao Hua Wang wei luo Yimin Jiang wei shen Ming Li Rongxing He College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Electrochemical nitrate reduction reaction (NITRR) is regarded as a “two birds-one stone” method for the treatment of nitrate contaminant in polluted water and the synthesis of valuable ammonia, which is retarded by the lack of highly reactive and selective electrocatalysts .Herein, for the first time, nickel foam supported Co_(4) N was designed as a high-performance NITRR catalyst by an in-situ nonmetal leaching-induced *** the optimal potential, the Co_(4) N/NF catalyst achieves ultra-high Faraday efficiency and NH_(3) selectivity of 95.4% and 99.4%, *** situ X-ray absorption spectroscopy (XAS), together with other experiments powerfully reveal that the nitrogen vacancies produced by nitrogen leaching are stable and play a key role in boosting nitrate reduction to *** calculations confirm that Co_(4) N with abundant nitrogen vacancies can optimize the adsorption energies of NO_(3)^(-) and intermediates, lower the free energy (Δ G ) of the potential-determining step (*NH_(3) to NH_(3) ) and inhibit the formation of N-containing *** addition, we also conclude that the nitrogen vacancies can stabilize the adsorbed hydrogen, making H_(2) quite difficult to produce, and lowering ΔG from *NO to *NOH, which facilitates the selective reduction of *** study reveals significant insights about the in-situ nonmetal leaching to enhance the NITRR activity.

关键词： Co4N Nitrate reduction In-situ nonmetal leaching Nitrogen vacancy Mechanism

A justice and innovative way ahead of consumption-based emission accounting approach

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Science China Earth Sciences 2024年第10期67卷 2999-3010页

作者： Qun shen Hongbo DUAN Yun TANG Linbing TANG Li SHANG Xinyu DOU wei wei weiqiang CHEN Zhu LIU State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization CAS Key Laboratory of Low-Carbon Conversion Science&EngineeringShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China School of Economics&Management University of Chinese Academy of SciencesBeijing 100190China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Earth System Science Tsinghua UnivesityBeijing 100084China

Carbon emission accounting is an important basis for global climate *** on the consumption-based accounting(CBA)method,the characteristics of carbon flow between national,regional,and product processes could be more clearly ***,CBA is more conducive to clarifying the attribution of responsibilities between producers and consumers,with the principles of fairness and *** accounting for carbon emissions in typical countries from 1990 to 2019,we found that the CBA emissions are higher than the production-based accounting(PBA)emissions in major developed countries,while the results are reversed for developing *** the past 30 years,the CBA emissions in targeted developed countries generally have shown a downward trend,while in developing countries,they have shown an upward *** emissions in China have shown a continuous growth trend from 1990 to 2019,but the pace has slowed down significantly over the last ***,the embodied carbon intensity of China’s exports continues to decline,indicating that China is providing more green and low-carbon products to the *** the PV industry as an example,this study further reveals the contribution of specific product industries to the country’s carbon transfer through product carbon footprint *** order to provide a scientific basis for global mitigation and climate governance,it is urgent to innovate a scientific,practical,and standardized CBA technology system.

关键词： Consumption-based accounting Production-based accounting Carbon transfer Carbon footprint

Unveiling non-radiative center control in CsPbBr_(3) nanocrystals:A comprehensive comparative analysis of hot injection and ligandassisted reprecipitation approaches

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Nano Research 2024年第5期17卷 4525-4534页

作者： Daocheng Hong Yuchen Zhang Shuhan Pan Hanyu Liu wei Mao Wanli Zhang Yuhui Ye Zhihong wei Xuxing lu Xiaoyong Wang Zhenda lu Yuxi Tian Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China

Metal-halide perovskite nanocrystals(NCs)have gained significant attention in the field of optoelectronic and photonic devices due to their promising *** their exceptional optical properties,the impact of different synthetic strategies on the fundamental nature of NCs,such as nonradiative recombination centers,remains poorly *** this study,we investigated the photophysical properties of CsPbBr_(3) NCs synthesized using two distinct methods,hot injection and ligand-assisted reprecipitation,at the individual particle *** observed different blinking behaviors under specific photoexcitation power densities and proposed,through intensity-lifetime analysis and Monte-Carlo simulations,that these different synthetic strategies can fabricate NCs with similar crystal structures but distinct surface quenchers with varying energy levels,which significantly affected the photo-induced blinking-down and blinking-up behaviors in individual *** findings indicate a practical and feasible approach for controlling defect engineering in perovskite NCs,with significant implications for their use in optoelectronic and other technological applications.

关键词： metal-halide perovskite nanocrystals photophysical properties nonradiative recombination centers hot injection method ligand-assisted reprecipitation