检索结果-南通市图书馆

Deep learning for automatically predicting early haematoma expansion in Chinese patients

Stroke & Vascular Neurology 2021年第4期6卷 610-614,I0067-I0072页

作者： Jia-wei Zhong Yu-jia Jin Zai-jun Song Bo Lin Xiao-hui lu Fang Chen lu-sha tong Department of Neurology Zhejiang University School of Medicine Second Affiliated HospitalHangzhouChina College of Computer Science and Technology Zhejiang UniversityHangzhouChina State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University School of Mechanical EngineeringHangzhouChina Department of Computer Science and Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina

Background and purpose Early haematoma expansion is determinative in predicting outcome of intracerebral haemorrhage(ICH)*** aims of this study are to develop a novel prediction model for haematoma expansion by applying deep learning model and validate its prediction *** Data of this study were obtained from a prospectively enrolled cohort of patients with primary supratentorial ICH from our *** developed a deep learning model to predict haematoma expansion and compared its performance with conventional non-contrast CT(NCCT)*** evaluate the predictability of this model,it was also compared with a logistic regression model based on haematoma volume or the BAT *** A total of 266 patients were finally included for analysis,and 74(27.8%)of them experienced early haematoma *** deep learning model exhibited highest C statistic as 0.80,compared with 0.64,0.65,0.51,0.58 and 0.55 for hypodensities,black hole sign,blend sign,fluid level and irregular shape,*** the C statistics for swirl sign(0.70;p=0.211)and heterogenous density(0.70;p=0.141)were not significantly higher than that of the deep learning ***,the predictive value for the deep learning model was significantly superior to that of the logistic model of haematoma volume(0.62;p=0.042)and the BAT score(0.65;p=0.042).Conclusions Compared with the conventional NCCT markers and BAT predictive model,the deep learning algorithm showed superiority for predicting early haematoma expansion in ICH patients.

关键词： patients expansion predicting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

引用

Stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： Yujia Jin Yu-hui Huang Yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye lu-hang Jin Jian Wu Chang-zheng Yuan Feng Gao lu-sha tong Neurology Department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina Department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(cSS)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of cSS and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(cSS-CMB−,cSS-CMB+,cSS+CMB−,cSS+CMB+)according to cSS and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin Scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had cSS and 468(69.5%)had *** with cSS+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** cSS−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of cSS+.Conclusions Patients with different combinations of cSS and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours(HOPE):protocol for a randomised,controlled,multicentre study

引用

Stroke & Vascular Neurology 2024年第3期9卷 318-323,I0274-I0282页

作者： Zhongyu luo Ying Zhou Yaode He Shenqiang Yan Zhicai Chen Xuting Zhang Yi Chen lu-sha tong Wansi Zhong Haitao Hu Kemeng Zhang Jiansheng Yang Bruce C V Campbell Min Lou Department of Neurology Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina Department of Medicine and Neurology Melbourne Brain Centre at Royal Melbourne HospitalParkvilleVictoriaAustralia

Background While intravenous thrombolysis is recommended for patients who had an acute ischaemic stroke(AIS)within 4.5hours of symptom onset,there are few randomised trials investigating the benefits of thrombolysis beyond this therapeutic *** To determine whether patients who had an AIS selected with the presence of potentially salvageable tissue on CT perfusion at 4.5–24hours after stroke onset(for stroke with unknown onset time,the midpoint of the time last known to be well and symptom recognition time;for wake-up stroke,the midpoint of the time last known to be well or sleep onset and wake up time)will benefit from intravenous *** HOPE is a prospective,multicentre,randomised,open-label blinded endpoint trial with the stage of phase *** treatment allocation employs 1:1 *** treatment arm under investigation is alteplase with standard therapy,the control arm is standard *** imaging criteria include ischaemic core volume≤70mL,penumbra≥10mL and mismatch≥20%.Study outcomes The primary outcome is non-disabled functional outcome(assessed as modified Rankin Scale score of 0–1 at 90 days).Discussion HOPE is the first trial to investigate whether intravenous thrombolysis with alteplase offers benefits in patients who had an AIS presenting within 4.5–24hours,which has the potential to extend time window and expand eligible population for thrombolysis therapy.

关键词： patients intravenous centre

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pyrrolic nitrogen coordinated Ni^(2+) dual-atom catalyst for boosting CO_(2) electroreduction

引用

Science China Chemistry 2025年第2期68卷 570-579页

作者： Zhi-Wei Chen Hong-Juan Wang Chang Liu Xiu-Li lu tong-Bu lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Nitrogen-doped carbon materials have been widely used for the constructions of single-atom catalysts,while the effect of different species of doped nitrogen on the catalytic activity of CO_(2) electroreduction has rarely been *** we found that pyrrolic-N coordinated Ni2+catalysts display much higher electrocatalytic CO_(2)-to-CO activity and selectivity than the corresponding pyridinic-N coordinated low valent Ni^((0–+2))catalysts,and pyrrolic-N coordinated Ni2 dual-atoms catalyst of Ni2/N-CNTs exhibits the best electrocatalytic performance,with over 90%Faradaic efficiencies in a broad potentials from−0.6 to−1.2 V *** hydrogen electrode,as well as an outstanding CO specific current of 56.2 A/mgNi and high turnover frequency of 6.2×10^(4) h^(−1),over 7-times higher than those of pyridinic-N coordinated Ni *** results indicate the weak electron-donor nature of pyrrolic-N facilitates the generation of a reduced active site at low overpotential for boosting CO_(2) *** functional theory calculations reveal that the reaction free energy for the*COOH formation on pyrrolic-N coordinated Ni catalysts are lower than those on pyridinic-N coordinated Ni catalysts,and a H_(2)Oadsorbed Ni_(2)/N-CNTs displays the optimized reaction free energy for both*COOH formation and CO desorption,which derive the best catalytic performance.

关键词： dual-atom catalyst CO_(2) electroreduction synergistic catalysis pyrrolic-N pyridinic-N

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prioritization Hindsight Experience Based on Spatial Position Attention for Robots

引用

Machine Intelligence Research 2025年第1期22卷 160-175页

作者： Ye Yuan Yu sha Feixiang Sun Haofan lu Shuiping Gou Jie luo China Nuclear Power Technology Research Institute Co. Ltd.Shenzhen518028China School of Artificial Intelligence Xidian UniversityXi’an710071China Suzhou Tianhe China Power International Engineering Technology Co. Ltd.Suzhou215000China

Sparse rewards pose significant challenges in deep reinforcement learning as agents struggle to learn from experiences with limited reward *** experience replay(HER)addresses this problem by creating“small goals”within a hierarchical decision ***,HER does not consider the value of different episodes for agent *** this paper,we propose SPAHER,a framework for prioritizing hindsight experiences based on spatial position *** allows the agent to prioritize more valuable experiences in a manipulation *** achieves this by calculating transition and trajectory spatial position functions to determine the value of each episode for experience *** evaluate SPAHER on eight robot manipulation tasks in the Fetch and Hand environments provided by OpenAI *** results show that our method improves the final mean success rate by an average of 3.63%compared to HER,especially in challenging Hand ***,these improvements are achieved without any increase in computation time.

关键词： Hindsight experience replay spatial position attention sparse reward deep reinforcement learning prioritization hindsight experience

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO_(2) photoreduction

引用

Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia Dong tong-Bu lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Dinuclear metal synergistic catalysis(DMSC)has been proved powerful in boosting CO_(2)reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework(MOF),obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center(M-In),three MOFs with dinuclear homometallic catalytic centers(MM-In),and three MOFs with dinuclear heterometallic catalytic centers(MM’-In,M/M’=Co(II),Ni(II),Zn(II)).It was found that all these MOFs can serve as catalysts for photochemical CO_(2)reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g^(-1)h^(-1),which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO_(2)reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO_(2)reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO_(2)reduction photocatalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

引用

Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang lu-Yu Liu sha-sha Cui Ting-Ting Li Xiao-Meng Yang Zhijuan Liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of insomnia on anxiety and depression:Mediation of cognitive failures and moderated mediation of neuroticism

引用

World Journal of Psychiatry 2025年第2期15卷 161-172页

作者： Yue Li Jia-Long Yu Shu-Yi Wang lu-Xin Xie Jia-Long Hong sha Liu Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Humanities and Social Science Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Medical Sciences Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term *** the relationship between mental health indicators would aid in identifying solutions to improve public mental *** To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental *** A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult *** neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity ***'s correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health *** A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)*** rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were *** the mental health indicators,there were significant differences by age and between those with siblings and those who were only *** and cognitive failures were significantly positively correlated with mental health *** moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism *** Cognitive failures and neuroticism play important roles in mental ***,enhancing subjective cognitive function and regulating emotio

关键词： Insomnia Anxiety Depression Neuroticism Cognitive failures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune indicators and depression in adolescents:Associations with monocytes,lymphocytes,and direct bilirubin

引用

World Journal of Psychiatry 2025年第2期15卷 23-32页

作者： Jian Dai Xiao-tong Lin lu-lu Shen Xi-Wen Zhang Zi-Wen Ding Jing Wang Xi-Wang Fan Wei-Dong Ning Department of Clinical Psychology Jiangbin HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Clinical Research Center for Mental Disorders Shanghai Pudong New Area Mental Health CenterSchool of MedicineTongji UniversityShanghai 200124China

BACKGROUND Depression is a significant psychiatric disorder with particularly high prevalence among *** mental health condition can have severe consequences,including academic failure,social withdrawal,and suicidal *** the increasing rate of depression in this age group,understanding the underlying biological mechanisms is essential for early detection and *** studies have suggested that immune markers play a role in the pathophysiology of depression,prompting further investigation of their potential association with depressive symptoms in *** To investigate the relationship between immune markers(monocytes,lymphocytes,and direct bilirubin)and the incidence and severity of depression among *** This cross-sectional study recruited 145 adolescent patients with depression[male(M)/female(F)=38/107]from Jiangbin Hospital in Guangxi,Zhuang and 163 healthy controls(M/F=77/86)from routine health *** samples were collected after an overnight *** severity was measured using the Zung Self-Rating Depression *** inclusion criteria were age 12-24 years,diagnosis of depressive disorder(ICD-10),and no recent antidepressant *** exclusion criteria included psychiatric comorbidities and serious somatic *** statistical methods included group comparisons and correlation *** There was a higher prevalence of females in the depression group(P<0.001).Significant age differences were observed between the groups(Z=9.43,P<0.001).The depression group had higher monocyte(Z=3.43,P<0.001)and lymphocyte(t=2.29,P<0.05)counts,and higher serum direct bilirubin levels(Z=4.72,P<0.001).Monocyte count varied significantly according to depression severity,with lower counts in the mild group(Z=-2.90,P<0.05).A negative correlation between age and lymphocyte counts was observed(ρ=-0.22,P<0.01).Logistic regression analysis showed that serum direct bilirubin levels significantly predicted

关键词： Depression Adolescents Immune markers Monocyte Lymphocyte Direct bilirubin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy:tackling herpesvirus drug resistance

引用

Science China(Life Sciences) 2025年第2期68卷 515-526页

作者： Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping Lan Hao Zhang lu shang Bo Zheng Mi Wang Yingchun Liu Lifang Zhang Chenzhong Fei Wu tong Changlong Liu Ersheng Kuang Guangzhi tong Feng Gu shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesShanghai 200241China Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural AffairsShanghai 200241China State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Institute of Human Virology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China School of Medicine Tsinghua UniversityBeijing 100084China

The emergence of drug resistance to virus(i.e.,acyclovir(ACV)to herpesviruses)has been termed one of the common clinical issues,emphasizing the discovery of new antiviral *** address it,a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV),anα-herpesvirus causing human and pig *** results demonstrated that type 2 voltage-gated chloride channels(CLC-2)encoded by one of the identified genes,CLCN2,is a potential drug target for anti-herpesvirus ***-2 inhibitors,omeprazole(OME)and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid(DIDS),can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e.,PRV,HSV and EBV),and effectively treat murine herpes simplex encephalitis(HSE).Additionally,DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly,both DIDS and OME were able to inhibit ACV-resistant HSV-1 strain *** study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug *** discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

关键词： herpesviruses CRISPR host-directed therapy CLC-2 DIDS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：