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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Multi-Stage-Based Siamese Neural Network for Seal Image Recognition

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 405-423页

作者： Jianfeng lu Xiangye Huang Caijin Li Renlin Xin Shanqing zhang Mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and *** seal inspection is commonly audited manually to ensure document ***,manual assessment of seal images is tedious and laborintensive due to human errors,inconsistent placement,and completeness of the *** image recognition systems are inadequate enough to identify seal types accurately,necessitating a neural network-based method for seal image ***,neural network-based classification algorithms,such as Residual Networks(ResNet)andVisualGeometryGroup with 16 layers(VGG16)yield suboptimal recognition rates on stamp ***,the fixed training data categories make handling new categories to be a challenging *** paper proposes amulti-stage seal recognition algorithmbased on Siamese network to overcome these ***,the seal image is pre-processed by applying an image rotation correction module based on Histogram of Oriented Gradients(HOG).Secondly,the similarity between input seal image pairs is measured by utilizing a similarity comparison module based on the Siamese ***,we compare the results with the pre-stored standard seal template images in the database to obtain the seal *** evaluate the performance of the proposed method,we further create a new seal image dataset that contains two subsets with 210,000 valid labeled pairs in *** proposed work has a practical significance in industries where automatic seal authentication is essential as in legal,financial,and governmental sectors,where automatic seal recognition can enhance document security and streamline validation ***,the experimental results show that the proposed multi-stage method for seal image recognition outperforms state-of-the-art methods on the two established datasets.

关键词： Seal recognition seal authentication document tampering siamese network spatial transformer network similarity comparison network

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Covalent Organic Frameworks Based Single-site Electrocatalysts for Oxygen Reduction Reaction

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Chemical Research in Chinese Universities 2022年第5期38卷 1151-1162页

作者： BU ran lu Yingying zhang Bing State Key Laboratory of Chemical Engineering Institute of Pharmaceutical EngineeringCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027P.R.China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200P.R.China

Single site catalysts(SSCs)are a new type of heterogeneous catalysts formed by isolated metal atoms supported on kinds of *** have shown great potential for energy conversion and storage in recent years,especially for oxygen reduction reactions(ORR).Typically,SSCs are confined on the substrate by strong chemical interactions,such as coordination ***,the surface chemical environment and porous properties of the supports are crucial to the performance of *** recent years,COFs have become excellent candidates for preparing SSCs as they can precisely assemble monomers into highly ordered crystalline porous materials with a fine structure and definite *** this review,we not only summarize the characteristics and advantages of COFs based SSCs,but also highlight the applications of COFs constructed from different single active sites for ORR in recent ***,challenges in practical application,feasible strategies and perspectives are proposed for the of COFs based SSCs.

关键词： Covalent organic framework Oxygen reduction reaction Single site catalyst Energy conversion Carbon-based catalyst

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Fabrication of corrosion inhibiting microcapsules functional coating and their high-efficiency corrosion resistance

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Rare Metals 2024年第2期43卷 842-848页

作者： Hao-ran Yun lu lu Xue-Long Hao Xing-Xiang zhang School of Material Science and Engineering Tiangong UniversityTianjin300387China National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials General Research Institute for Nonferrous MetalsBeijing100088China Guobiao(Beijing)Testing&Certification Co. Ltd.Beijing101407China

Benzotriazole(BTA)was loaded into calcium carbonate microsphere shell by self-assembly method and a new type of high-efficiency corrosion inhibiting microcapsules(CIMs)were fabricated,which were added and dispersed into epoxy resin coating to obtain a new corrosion resistance functional *** corrosion inhibition effect of benzotriazole on aluminum alloy matrix was verified by polarization curve *** effectiveness of the CIMs and their loading capacity on inhibitor were evaluated by scanning electron microscope,laser confocal Raman spectroscopy together with thermogravimetric analysis.

关键词： corrosion coating resistance

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Amorphization of Ni_(61)Nb_(39) Alloy by Laser Surface Treatment

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Journal of Iron and Steel Research International 2016年第1期23卷 37-41页

作者： Zhong-xiang lu ran LI Yan LI Tao zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang University China Aerospace Components Engineering Center China Academy of Space Technology

The surface of Ni_（61）Nb_（39） crystalline ingot was treated by laser surface melting with different processing parameters.A fully amorphous layer with a thickness of approximately 10μm could be produced on the top surface under optimal *** amorphous-crystalline composite layer with the depth from 10 to 50μm,consisting of amorphous matrix and intermetallic phases of Ni_3 Nb and Ni_6Nb_7,could be *** micro-hardness（about 831HV）of the treated surface was remarkably improved by nearly 100% compared with the value of the crystalline substrate caused by the formation of the fully amorphous structure.A finite volume simulation was adopted to evaluate the temperature distribution in the laser-affected zone of Ni_（61）Nb_（39） alloys and to reveal the mechanism of glass formation in the laser-affected zone.

关键词： laser processing metallic glass glass formation composite structure finite volume simulation

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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社区老年人照护需求现状及影响因素研究:基于三省的基线调查

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中国全科医学 2025年第1期28卷 59-64页

作者：安然唐昕齐士格王志会崔露张晗郭浩岩中国疾病预防控制中心慢性非传染性疾病预防控制中心老年健康室北京市100050 首都医科大学公共卫生学院北京市100069 中国疾病预防控制中心营养与健康所北京市100050

背景人口老龄化背景下对老年人照护的研究逐渐成为热点。以往对老年人照护需求率的调查存在较大差异(8.54%~53.15%),缺乏大样本的研究证据。目的了解我国社区老年人照护需求现状及其影响因素。方法调查对象来自国家重大公共卫生专项“... 详细信息

背景人口老龄化背景下对老年人照护的研究逐渐成为热点。以往对老年人照护需求率的调查存在较大差异(8.54%~53.15%),缺乏大样本的研究证据。目的了解我国社区老年人照护需求现状及其影响因素。方法调查对象来自国家重大公共卫生专项“老年期重点疾病预防和干预”项目2019年的基线调查,该调查采用多阶段分层整群随机抽样方法,在辽宁省、河南省和广东省的16个区(县)共抽取16199名60岁及以上老年人开展问卷调查,问卷内容主要包括基本人口学特征(性别、年龄、城乡、婚姻状况、文化程度、职业、体质量、居住情况)、照护需求现状、患慢性病情况、病人健康问卷抑郁自评量表(PHQ-9)、简易智能精神状态检查(MMSE)量表、老年人日常生活活动能力调查(ADL)量表、自评健康状况、每天锻炼身体和跌倒情况(过去1年)等。采用PHQ-9评定老年人的心理状况、MMSE量表评估老年人的认知功能,老年人照护需求评估采用ADL量表(存在BADL或IADL失能)或自报需要照护。采用Logistic回归分析探讨老年人照护需求的影响因素。结果收集有效样本数据16193份,社区老年人照护需求率为14.57%(95%CI=14.02%~15.11%),随着年龄增加照护需求率逐步上升,女性的照护需求率高于男性(P<0.05)。多因素Logistic分析结果显示,年龄每增加一岁照护需求风险增加7%(OR=1.07,95%CI=1.06~1.08);与文盲相比,文化程度在小学、初中、高中及以上老年人照护需求OR(95%CI)分别为0.33(0.29~0.37)、0.24(0.20~0.28)、0.17(0.12~0.22);与每日锻炼身体相比,每日不锻炼老年人照护需求OR(95%CI)为1.17(1.05~1.30);与不患慢性病人群相比,患1~2种和患3种及以上慢性病老年人照护需求OR(95%CI)分别为1.29(1.10~1.51)、1.57(1.35~1.82);与认知功能正常相比,认知功能异常老年人照护需求OR(95%CI)为2.02(1.79~2.27);与自评健康状态好相比,自评健康状况一般和自评健康状况差老年人照护需求OR(95%CI)分别为1.29(1.14~1.46)、2.68(2.27~3.16);与没有摔倒过相比,摔倒1~2次和3次及以上老年人照护需求OR(95%CI)分别为1.23(1.06~1.43)、2.00(1.59~2.52);与心理状况良好相比,轻度和中重度抑郁老年人照护需求OR(95%CI)分别为1.14(1.21~1.65)、2.05(1.69~2.48)。结论我国三省社区老年人照护需求率较高,且高龄、身体及心理健康状况差、跌倒次数多的老年人照护需求率更高。

关键词：病人医疗护理老年照护居住特征照护需求老年人影响因素分析

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河南农村5岁以下儿童秋冬季急性胃肠炎疾病负担研究

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中国微生态学杂志 2017年第6期29卷 643-646页

作者：杨振冉陆张平赵嘉咏徐强郭秋生张荣中国疾病预防控制中心农村改水技术指导中心北京102200 中国疾病预防控制中心传染病预防控制处北京102200 河南省疾病预防控制中心传染病所河南郑州450000 睢县疾病预防控制中心河南商丘476000

目的了解河南农村秋冬季节5岁以下儿童急性胃肠炎流行现状和疾病负担。方法采用单纯随机整群抽样方法,抽取7个行政村的所有5岁以下儿童共513名。结果 5岁以下儿童秋冬季急性胃肠炎2周发病率为9.4%,疾病负担平均为2.7151DALYs/千人,年龄... 详细信息

目的了解河南农村秋冬季节5岁以下儿童急性胃肠炎流行现状和疾病负担。方法采用单纯随机整群抽样方法,抽取7个行政村的所有5岁以下儿童共513名。结果 5岁以下儿童秋冬季急性胃肠炎2周发病率为9.4%,疾病负担平均为2.7151DALYs/千人,年龄越小疾病负担越高;0岁组最高,为6.5839DALYs/千人。患儿例均经济负担为284.84元,其中直接经济负担为211.83元,间接经济负担为72.98元。结论 5岁以下儿童秋冬季急性胃肠炎发病率随年龄增长呈下降趋势,疾病负担主要集中于3岁以下儿童(尤其0~1岁婴幼儿);秋冬季应积极预防病毒性急性胃肠炎,防控重点应在2岁以下儿童;早就诊早治疗,以减少住院病例,降低疾病负担。

关键词：急性胃肠炎秋冬季疾病负担儿童腹泻

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An in-situ polymerized interphase engineering for high-voltage allsolid- state lithium-metal batteries

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Nano Research 2024年第4期17卷 2687-2692页

作者： lu Nie Shaojie Chen Mengtian zhang Tianyi Gao Yuyao zhang ran Wei Yining zhang Wei Liu School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

All-solid-state lithium batteries(ASSLBs)have attracted great interest due to their promising energy density and strong ***,the interface issues,including large interfacial resistance between electrode and electrolyte and low electrochemical stability of solid-state electrolytes against high-voltage cathodes,have restricted the development of high-voltage ***,we report an ASSLB with stable cycling by adopting a conformal polymer interlayer in-situ formed at the Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)–cathode *** polymer can perfectlyﬁll the voids and create a stable interface contact between LLZTO and *** addition,the electric field across the polymer interlayer is reduced compared with pure solid polymer electrolyte(SPE),which facilitates the electrochemical stability with high-voltage *** all-solid-state Li|LLZTO-SPE|LiFe_(0.4)Mn_(0.6)PO_(4)(LMFP)cells achieve a low interface impedance,high specific capacity,and excellent cycling *** work presents an effective and practical strategy to rationally design the electrode–electrolyte interface for the application of high-voltage ASSLBs.

关键词： all-solid-state lithium batteries interface contact electric field electrochemical stability

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui zhang Zhi-Lai Zhan Guang-lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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