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Co-doped BaFe_(2)As_(2) Josephson junction fabricated with a focused helium ion beam

Chinese Physics B 2024年第4期33卷 181-186页

作者：陈紫雯张焱马平徐中堂李宇龙王越路建明马衍伟甘子钊 Applied Superconductivity Research Center Peking UniversityBeijing 100871China State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Peking UniversityBeijing 100871China Institute of Condensed Matter Physics School of PhysicsPeking UniversityBeijing 100871China Yangtze Delta Institute of Optoelectronics Peking UniversityBeijing 100871China Key Laboratory of Applied Superconductivity Institute of Electrical EngineeringChinese Academy of SciencesBeijing 100190China

Josephson junction plays a key role not only in studying the basic physics of unconventional iron-based superconductors but also in realizing practical application of thin-film based devices,therefore the preparation of high-quality iron pnictide Josephson junctions is of great *** this work,we have successfully fabricated Josephson junctions from Co-doped BaFe_(2)As_(2)thin films using a direct junction fabrication technique which utilizes high energy focused helium ion beam(FHIB).The electrical transport properties were investigated for junctions fabricated with various He^(+)irradiation *** junctions show sharp superconducting transition around 24 K with a narrow transition width of 2.5 K,and a dose correlated foot-structure resistance which corresponds to the effective tuning of junction properties by He^(+)*** J_c suppression by more than two orders of magnitude can be achieved by increasing the He^(+)irradiation dose,which is advantageous for the realization of low noise ion pnictide thin film *** Shapiro steps are observed under 10 GHz microwave *** above results demonstrate the successful fabrication of high quality and controllable Co-doped BaFe_(2)As_(2)Josephson junction with high reproducibility using the FHIB technique,laying the foundation for future investigating the mechanism of iron-based superconductors,and also the further implementation in various superconducting electronic devices.

关键词： focused helium ion beam Co doped BaFe_(2)As_(2) Josephson junction

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Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β-catenin signaling pathways

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Animal Models and Experimental Medicine 2024年第3期7卷 208-221页

作者： Da-zhuang lu Li-jun Zeng Yang Li Ran-li Gu Meng-long Hu ping Zhang Peng Yu Xiao Zhang Zheng-wei Xie Hao Liu Yong-sheng Zhou Department of Prosthodontics Peking University School and Hospital of StomatologyBeijingChina National Center of Stomatology BeijingChina National Clinical Research Center for Oral Diseases BeijingChina Beijing Key Laboratory of Digital Stomatology BeijingChina Department of Cariology and Endodontology Peking University School and Hospital of StomatologyBeijingChina Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices BeijingChina

Background:Osteoporosis is a chronic bone disease characterized by bone loss and decreased bone ***,current anti-resorptive drugs carry a risk of various *** deep learning-based efficacy prediction system(DLEPS)is a forecasting tool that can effectively compete in drug screening and prediction based on gene expression *** study aimed to explore the protective effect and potential mechanisms of cinobufotalin(CB),a traditional Chinese medicine(TCM),on bone ***:DLEPS was employed for screening anti-osteoporotic agents according to gene profile changes in primary ***-CT,histological and morphological analysis were applied for the bone protective detection of CB,and the osteogenic differentiation/function in human bone marrow mesenchymal stem cells(hBMMSCs)were also *** underlying mechanism was verified using qRT-PCR,Western blot(WB),immunofluorescence(IF),***:A safe concentration(0.25mg/kg in vivo,0.05μM in vitro)of CB could effectively preserve bone mass in estrogen deficiency-induced bone loss and promote osteogenic differentiation/function of *** BMPs/SMAD and Wnt/β-catenin signaling pathways participated in CB-induced osteogenic differentiation,further regulating the expression of osteogenesis-associated factors,and ultimately promoting ***:Our study demonstrated that CB could significantly reverse estrogen deficiency-induced bone loss,further promoting osteogenic differentiation/function of hBMMSCs,with BMPs/SMAD and Wnt/β-catenin signaling pathways involved.

关键词： BMPs/SMAD bone loss cinobufotalin hBMMSCs osteogenesis osteoporosis Wnt/β-catenin signaling pathways

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MBE脱氧条件与InGaAs/InP APD性能的相关性

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红外与毫米波学报 2024年第1期43卷 63-69页

作者：郭子路王文娟曲会丹范柳燕诸毅诚王亚杰郑长林王兴军陈平平陆卫中国科学院上海技术物理研究所红外物理国家重点实验室上海200083 中国科学院大学北京100049 上海科技大学物质科学与技术学院上海201210 上海量子科学研究中心上海201315 复旦大学应用表面物理国家重点实验室和物理学系上海200438

InP基InGaAs/InP雪崩光电二极管(APD)对近红外光具有高敏感度,使其成为微弱信号和单光子探测的理想光电器件。然而随着先进器件结构越来越复杂,厚度尺寸从量子点到几微米不等,性能越来越受材料中晶格缺陷的影响和工艺条件的制约。采用... 详细信息

InP基InGaAs/InP雪崩光电二极管(APD)对近红外光具有高敏感度,使其成为微弱信号和单光子探测的理想光电器件。然而随着先进器件结构越来越复杂,厚度尺寸从量子点到几微米不等,性能越来越受材料中晶格缺陷的影响和工艺条件的制约。采用固态源分子束外延(MBE)技术分别在As和P气氛保护下对InP衬底进行脱氧处理并外延生长晶格匹配的In_(0.53)Ga_(0.47)As薄膜和APD结构材料。实验结果表明,As脱氧在MBE材料质量方面比P脱氧具有明显的优势,可获得陡直明锐的异质结界面,降低载流子浓度,提高霍尔迁移率,延长少子寿命,并抑制器件中点缺陷或杂质缺陷引起的暗电流。因此,As脱氧可以有效提高MBE材料的质量,这项工作优化了InP衬底InGaAs/InP外延生长参数和器件制造条件。

关键词：分子束外延 P/As切换异质界面扩散 InGaAs/InP雪崩光电二极管

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城市扩张、要素流动与乡村振兴

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数理统计与管理 2024年第3期43卷 481-492页

作者：霍露萍西安外国语大学经济金融学院陕西西安710128

文章基于2011至2020年中国30个省(市、自治区)面板数据,采用空间计量模型,实证检验城市扩张对乡村振兴的影响及其作用机制,研究发现:(1)不论是0-1空间权重矩阵、地理距离权重矩阵还是经济距离权重矩阵,中国乡村振兴水平均存在一定的空... 详细信息

文章基于2011至2020年中国30个省(市、自治区)面板数据,采用空间计量模型,实证检验城市扩张对乡村振兴的影响及其作用机制,研究发现:(1)不论是0-1空间权重矩阵、地理距离权重矩阵还是经济距离权重矩阵,中国乡村振兴水平均存在一定的空间关联效应,表明乡村振兴具有空间集聚性;(2)乡村振兴受到城市扩张的显著正面影响,但不同地区的影响程度存在差异,稳健性检验强化了这一结论;(3)进一步分析内在机制发现,要素流动是城市扩张促进乡村振兴的重要途径。

关键词：城市扩张乡村振兴要素流动空间面板模型

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基于Transformer紧凑编码的局部近重复视频检测算法

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计算机科学 2024年第5期51卷 108-116页

作者：王萍余圳煌鲁磊西安交通大学信息与通信工程学院西安710049

针对现有局部近重复视频检测算法特征存储消耗大、整体查询效率低、提取特征时并未考虑近重复帧之间细微的语义差异等问题,文中提出了一种基于Transformer紧凑编码的局部近重复视频检测算法。首先,提出了一个基于Transformer的特征编码... 详细信息

针对现有局部近重复视频检测算法特征存储消耗大、整体查询效率低、提取特征时并未考虑近重复帧之间细微的语义差异等问题,文中提出了一种基于Transformer紧凑编码的局部近重复视频检测算法。首先,提出了一个基于Transformer的特征编码器,其学习了大量近重复帧之间细微的语义差异,可以在编码帧特征时对各个区域特征图引入自注意力机制,在有效降低帧特征维度的同时也提高了编码后特征的表示性。该特征编码器通过孪生网络训练得到,该网络不需要负样本就可以有效学习近重复帧之间的相似语义信息,因此无需沉重和困难的难负样本标注工作,使得训练过程更加简易和高效。其次,提出了一个基于视频自相似度矩阵的关键帧提取方法,可以从视频中提取丰富但不冗余的关键帧,从而使关键帧特征序列能够更全面地描述原视频内容,提升算法的性能,同时也大幅减少了存储和计算冗余关键帧带来的开销。最后,基于关键帧的低维紧凑编码特征,采用基于图网络的时间对齐算法,实现局部近重复视频片段的检测和定位。该算法在公开的局部近重复视频检测数据集VCDB上取得了优于现有算法的实验性能。

关键词：局部近重复视频检测 Transformer 视频自相似度矩阵关键帧提取

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乳腺穿刺非原发实体恶性肿瘤23例临床病理学分析

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中华病理学杂志 2024年第4期53卷 331-336页

作者：谷文巧王璐徐静纯平国强韩雪王聪南京医科大学第一附属医院江苏省人民医院病理科南京210029

目的探讨乳腺穿刺病理中对非原发实体恶性肿瘤的精准诊断及鉴别诊断。方法收集南京医科大学第一附属医院2013年1月至2023年3月行乳腺、腋窝或颈部淋巴结空心针穿刺标本,病理诊断为乳腺非原发实体恶性肿瘤的病例23例,结合其临床资料、形... 详细信息

目的探讨乳腺穿刺病理中对非原发实体恶性肿瘤的精准诊断及鉴别诊断。方法收集南京医科大学第一附属医院2013年1月至2023年3月行乳腺、腋窝或颈部淋巴结空心针穿刺标本,病理诊断为乳腺非原发实体恶性肿瘤的病例23例,结合其临床资料、形态学及免疫标志物表达特征分析鉴别思路和诊断线索。结果23例患者均为女性,平均年龄56岁(29~75岁),原发与转移间隔平均时间为21个月(0~204个月)。原发部位包括卵巢(9例)、肺(5例)、胃肠道(4例)、胰腺(1例)、肝内胆管(1例)、甲状腺(1例)、鼻腔(1例)和前臂皮肤(1例)。转移性肿瘤镜下均未见原位癌成分,形态学差异大,与原发肿瘤具有相似性,但神经内分泌肿瘤、女性生殖系统来源的肿瘤与乳腺癌具有极大形态学和免疫表型的重叠。转移性肺癌细胞异型性明显,常见瘤巨细胞;女性生殖系统来源浆液性癌形态学与免疫表型可酷似乳腺浸润性微乳头状癌;消化道转移性腺癌常具有黏液分泌特征;转移性神经内分泌肿瘤形态温和貌似实性乳头状癌,但雌激素受体阴性。TRPS1通常呈阴性表达(18/23),其中卵巢(4/9)及肝内胆管(1/1)来源肿瘤呈强弱不等的阳性表达。结论乳腺穿刺标本诊断时需结合临床病史及影像学,认真体会病理形态学特征:如有无原位癌成分,肿瘤分化是否与免疫表型匹配,并结合恰当的免疫组织化学抗体鉴别组合,才能精准识别肿瘤的来源为非乳腺原发。

关键词：乳腺肿瘤肿瘤转移免疫组织化学

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Prevalence,patterns,risk factors and outcomes of peritoneal metastases after laparoscopic hepatectomy for hepatocellular carcinoma:a multicenter study from China

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 3-15,I0001-I0004页

作者： Yuan-Xiang lu Jian-ping Zhao Guan-Dou Yuan Ming-Gen Hu Chuan-Dong Sun Kun-lun Chen Yao Chen Yong-Yi Zeng Zhi-Ying Yang Wan-Guang Zhang Hepatic Surgery Center Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanningChina Faculty of Hepato-Pancreato-Biliary Surgery Chinese PLA General HospitalBeijingChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Radiology Intervention The Affiliated Tumor Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouChina Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Department of General Surgery China-Japan Friendship HospitalBeijingChina

Background:We aim to investigate the prevalence,patterns,risk factors,and outcomes of peritoneal metastases(PM)after curative laparoscopic hepatectomy(LH)for hepatocellular carcinoma(HCC).Methods:A multicenter cohort of 2,138 HCC patients who underwent curative LH from August 2010 to December 2016 from seven hospitals in China was retrospectively *** incidence of PM following LH was evaluated and compared with that in open hepatectomy(OH)after 1:1 propensity score matching(PSM).Results:PM prevalence was 5.1%(15/295)in the early period[2010-2013],2.6%(47/1,843)in the later period[2014-2016],and 2.9%(62/2,138)in all LH patients,which was similar to 4.0%(59/1,490)in the OH *** recurrence patterns,timing,and treatment did not significantly vary between the LH and OH patients(P>0.05).Multivariate logistic regression revealed that tumor diameter>5 cm,non-anatomical resection,presence of microvascular invasion,and lesionslusions:The prevalence,patterns and independent risk factors of PM were identified for HCC patients after *** was not associated with increased incidence of PM in HCC patients for experienced *** re-excision of PM was associated with prolonged survival.

关键词： Prevalence hepatocellular carcinoma(HCC) peritoneal metastases(PM) laparoscopic hepatectomy(LH) open hepatectomy(OH)

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Pulse rate estimation based on facial videos:an evaluation and optimization of the classical methods using both self-constructed and public datasets

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Traditional Medicine Research 2024年第1期9卷 14-22页

作者： Chao-Yong Wu Jian-Xin Chen Yu Chen Ai-ping Chen lu Zhou Xu wang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Cardiology Department Shenzhen Hospital of Beijing University of Chinese MedicineShenzhen 518172China Traditional Chinese Medicine(Zhong Jing)School Henan University of Chinese MedicineHenan 450046China

Pulse rate is one of the important characteristics of traditional Chinese medicine pulse diagnosis,and it is of great significance for determining the nature of cold and heat in *** prediction of pulse rate based on facial video is an exciting research field for getting palpation information by observation ***,most studies focus on optimizing the algorithm based on a small sample of participants without systematically investigating multiple influencing factors.A total of 209 participants and 2,435 facial videos,based on our self-constructed Multi-Scene Sign Dataset and the public datasets,were used to perform a multi-level and multi-factor comprehensive *** effects of different datasets,blood volume pulse signal extraction algorithms,region of interests,time windows,color spaces,pulse rate calculation methods,and video recording scenes were ***,we proposed a blood volume pulse signal quality optimization strategy based on the inverse Fourier transform and an improvement strategy for pulse rate estimation based on signal-to-noise ratio threshold *** found that the effects of video estimation of pulse rate in the Multi-Scene Sign Dataset and Pulse Rate Detection Dataset were better than in other *** with Fast independent component analysis and Single Channel algorithms,chrominance-based method and plane-orthogonal-to-skin algorithms have a more vital anti-interference ability and higher *** performances of the five-organs fusion area and the full-face area were better than that of single sub-regions,and the fewer motion artifacts and better lighting can improve the precision of pulse rate estimation.

关键词： pulse rate heart rate photoplethysmography observation and pulse diagnosis facial videos

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Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua lu Yan Yang Xi-Wen Liu ping Wei Shu-Cai Wan Hao-Qing Xie Xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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注重从基础研究中汲取胰腺神经内分泌肿瘤诊疗的新思路

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协和医学杂志 2024年第4期15卷 734-739页

作者：王先泽平陆吴文铭中国医学科学院北京协和医院基本外科北京100730 中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室北京100730

胰腺神经内分泌肿瘤(pancreatic neuroendocrine neoplasm,pNEN)是最常见的消化系统神经内分泌肿瘤,具有复杂的临床表现和高度异质性,仅从临床角度对其诊疗策略进行归纳总结具有一定难度。近20年来,pNEN的基础研究得到了深入发展,进而... 详细信息

胰腺神经内分泌肿瘤(pancreatic neuroendocrine neoplasm,pNEN)是最常见的消化系统神经内分泌肿瘤,具有复杂的临床表现和高度异质性,仅从临床角度对其诊疗策略进行归纳总结具有一定难度。近20年来,pNEN的基础研究得到了深入发展,进而推动其理论体系和诊疗策略不断进步,显著提高了pNEN的治疗效果。本文通过回顾近年来pNEN相关基础研究进展,深入探讨基础研究对pNEN临床诊疗的推动作用:一方面,基础研究的发展可进一步揭示pNEN差异性生物学行为的本质,为临床提供参考;另一方面,参考其他肿瘤领域可迁移性的基础研究成果,也是辅助提升pNEN临床诊疗水平的捷径。

关键词：胰腺神经内分泌肿瘤精准诊疗肿瘤类器官液体活检影像组学免疫治疗

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