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Effectiveness of magnetic resonance imaging and spiral computed tomography in the staging and treatment prognosis of colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2135-2144页

作者： lu-na bai lu-Xian Zhang Department of Radiology Zhongshan Hospital Xiamen UniversityXiamen 361004Fujian ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a prevalent cancer type in clinical settings;its early signs can be difficult to detect,which often results in late-stage diagnoses in many *** early detection and diagnosis of CRC are crucial for improving treatment success and patient survival ***,imaging techniques have been hypothesized to be essential in managing CRC,with magnetic resonance imaging(MRI)and spiral computed tomography(SCT)playing a significant role in enhancing diagnostic and treatment *** To explore the effectiveness of MRI and SCT in the preoperative staging of CRC and the prognosis of laparoscopic *** Ninety-five individuals admitted to Zhongshan Hospital Xiamen University underwent MRI and SCT and were diagnosed with *** precision of MRI and SCT for the presurgical classification of CRC was assessed,and pathological staging was used as a *** operating characteristic curves were used to evaluate the diagnostic efficacy of blood volume,blood flow,time to peak,permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction on the prognosis of patients with *** Pathological biopsies confirmed the following CRC stages:23,23,32,and 17 at T1,T2,T3,and T4,*** were 39 cases at the N0 stage,22 at N1,34 at N2,44 at M0 stage,and 51 at *** pathological findings as the benchmark,the combined use of MRI and SCT for preoperative TNM staging in patients with CRC demonstrated superior sensitivity,specificity,and accuracy compared with either modality alone,with a statistically significant difference in accuracy(Pnalysis revealed the predictive values for laparoscopic treatment prognosis,as indicated by the areas under the curve for blood volume,blood flow,time to peak,and permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volu

关键词： Magnetic resonance imaging Spiral computed tomography Colorectal cancer Prognosis Receiver operating characteristic curve Retrospective study

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Microphysical Insights into a Tornadic Supercell from Dual-Polarization Radar Observations in Jiangsu, China on 14 May 2021

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Journal of Meteorological Research 2024年第2期38卷 303-320页

作者： Chao YUAN Yang bai Pengfei SUN Hua bai lu XIA China Meteorological Administration Tornado Key Laboratory Foshan 528315 Institute of Atmospheric Environment China Meteorological AdministrationShenyang 110166 Panjin national Climate Observatory Panjin 124010 Yangzhou Meteorological Bureau of Jiangsu Province Yangzhou 225100 Yichun Meteorological Bureau of Heilongjiang Province Yichun 153000

Tornadoes are incredibly powerful and destructive natural events,yet the microphysical characteristics of the parent storm and its effects on tornadogenesis remain *** study analyzed polarization radar data of a tornadic supercell that occurred in Jiangsu Province of China on 14 May 2021,in comparison with another tornadic supercell and two non-tornadic supercells that occurred in the same region in *** two tornadic supercells exhibited lower differential reflectivity(ZDR)in the hook echo region compared with the non-tornadic supercells,indicating smaller median drop sizes.A distinct increase in ZDR from the melting of frozen hydrometeors,observed between2.5-and 4.0-km altitude in the non-tornadic storms,was absent in the tornadic *** non-tornadic supercells also displayed substantially higher specific differential phase(KDP)below the melting level,likely aroused from enhanced melting and *** findings suggest fundamental microphysical contrasts between tornadic and nontornadic ***,tornadic supercells have smaller droplets and may reduce melting in hook ***,greater separation between the ZDR arc and the KDP foot was observed during *** vertical gradient of KDP related to the cooling pool strength of the hook echo,regulating rear-flank downdraft *** the limited number of cases investigated,the findings of this study indicate that monitoring ZDR,KDP,and drop size distribution trends could assist with tornado prediction and warnings.

关键词： tornado polarimetric radar supercell hook echo drop size distribution

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Evaluating CMIP6 models in simulating the North Pacific decadal variability in sea surface salinity

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Science China Earth Sciences 2024年第8期67卷 2661-2680页

作者： Jian CHEN Hailong LIU Pengfei LIN Wenrong bai Chengzu bai lu WANG Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China State Key Laboratory of Geo-Information Engineering Xi’an 710054China Beijing Municipal Climate Center Beijing Meteorological BureauBeijing 100089China Space System Department Equipment Department Beijing 100096China

The North Pacific sea surface salinity(SSS)decadal variability(NPSDV)and its potential forcing were evaluated from 25 coupled models of the Coupled Model Intercomparison Project phase 6(CMIP6)considering the prospects for decadal climate *** results indicated that the CMIP6 models generally reproduced the spatial patterns of *** large standard deviation of the SSS anomaly over the strong current regions,such as the Kuroshio-Oyashio Extension(KOE),North Pacific Current(NPC),California Current System(CCS),and Alaskan Coastal Current(ACC),is reflected in the two leading modes of NPSDV:a dipole with out-of-phase loadings in the KOE-NPC versus CCS-ACC and a monopole with positive loading over the *** order of modes is sensitive to individual models that exhibit discrepancies,especially in temporal phases and power *** autoregressive model of order-1 was used to reconstruct the NPSDV with several forcing *** generally weaker influence of forcings in an autoregressive model of order-1 is partly related to the overestimated response time of NPSDV relative to *** NPSDV variances originate from the persistence of SSS anomalies,but the dominant forcing factors are diverse among *** model diversity for the NPSDV simulation mainly arises from the influence of the tropical El Ni?o-Southern Oscillation through teleconnection on the North Pacific Oscillation or Aleutian Low with timescale ***,models that can reproduce the NPSDV well are not dependent on those with larger impacts from the North Pacific oceanic processes.

关键词： North Pacific Sea surface salinity Decadal variability CMIP6 Leading mode

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Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1677-1692页

作者： Dongsheng bai Jiawei Zhao Runde Wang Jiaying Du Chen Zhou Chunyang Gu Yuxiang Wang lulu Zhang Yue Zhao na lu State Key Laboratory of natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal *** identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is *** our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus *** enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory ***,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy ***,*** up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRna and an increase in mucin synthesis in goblet *** espe-cially significant finding is that *** activates the AhR pathway,thereby promoting the expression of *** summary,our results strongly indicate that *** enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRna stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

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A unified fractional flow framework for predicting the liquid holdup in two-phase pipe flows

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Petroleum Science 2024年第4期21卷 2614-2624页

作者： Fuqiao bai Yingda lu Mukul M.Sharma Hildebrand Department of Petroleum and Geosystems Engineering The University of Texas at Austin

Two-phase pipe flow occurs frequently in oil & gas industry, nuclear power plants, and CCUS. Reliable calculations of gas void fraction(or liquid holdup) play a central role in two-phase pipe flow models. In this paper we apply the fractional flow theory to multiphase flow in pipes and present a unified modeling framework for predicting the fluid phase volume fractions over a broad range of pipe flow conditions. Compared to existing methods and correlations, this new framework provides a simple,approximate, and efficient way to estimate the phase volume fraction in two-phase pipe flow without invoking flow patterns. Notably, existing correlations for estimating phase volume fraction can be transformed and expressed under this modeling framework. Different fractional flow models are applicable to different flow conditions, and they demonstrate good agreement against experimental data within 5% errors when compared with an experimental database comprising of 2754 data groups from 14literature sources, covering various pipe geometries, flow patterns, fluid properties and flow *** gas void fraction predicted by the framework developed in this work can be used as inputs to reliably model the hydraulic and thermal behaviors of two-phase pipe flows.

关键词： Pipe fractional flow Liquid holdup Multiphase pipe flow Gas void fraction

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Study of the pressure transient behavior of directional wells considering the effect of non-uniform flux distribution

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Petroleum Science 2024年第3期21卷 1765-1779页

作者： Yan-Zhong Liang bai-lu Teng Wan-Jing luo School of Energy Resources China University of Geosciences(Beijing)Beijing100083China

During the production,the fluid in the vicinity of the directional well enters the wellbore with different rates,leading to non-uniform flux distribution along the directional ***,in all existing studies,it is oversimplified to a uniform flux distribution,which can result in inaccurate results for field ***,this paper proposes a semi-analytical model of a directional well based on the assumption of non-uniform flux ***,the direction well is discretized into a carefully chosen series of linear sources,such that the complex well trajectory can be captured and the nonuniform flux distribution along the wellbore can be considered to model the three-dimensional flow *** using the finite difference method,we can obtain the numerical solutions of the transient flow within the *** the aid of Green's function method,we can obtain the analytical solutions of the transient flow from the matrix to the *** complete flow behavior of a directional well is perfectly represented by coupling the above two types of transient ***,on the basis of the proposed model,we conduct a comprehensive analysis of the pressure transient behavior of a directional *** computation results show that the flux variation along the direction well has a significant effect on pressure *** addition,the directional well in an infinite reservoir may exhibit the following flow regimes:wellbore afterflow,transition flow,inclined radial flow,elliptical flow,horizontal linear flow,and horizontal radial *** horizontal linear flow can be observed only if the formation thickness is much smaller than the well ***,a dip region that appears on the pressure derivative curve indicates the three-dimensional flow behavior near the wellbore.

关键词： Directional well Pressure transient behavior Semi-analytical model Non-uniform flux

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Carbon-based interface engineering and architecture design for high-performance lithium metal anodes

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Carbon Energy 2024年第1期6卷 207-235页

作者： na Zhu Yuxiang Yang Yu Li Ying bai Junfeng Rong Chuan Wu SINOPEC Research Institute of Petroleum Processing Co. Ltd.BeijingChina Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Yangtze Delta Region Academy of Beijing Institute of Technology JiaxingChina

Metallic lithium(Li)is considered the“Holy Grail”anode material for the nextgeneration of Li batteries with high energy density owing to the extraordinary theoretical specific capacity and the lowest negative electrochemical ***,owing to inhomogeneous Li-ion flux,Li anodes undergo uncontrollable Li deposition,leading to limited power output and practical *** materials and their composites with controllable structures and properties have received extensive attention to guide the homogeneous growth of Li to achieve high-performance Li *** this review,the correlation between the behavior of Li anode and the properties of carbon materials is ***,we review emerging strategies for rationally designing high-performance Li anodes with carbon materials,including interface engineering(stabilizing solid electrolyte interphase layer and other functionalized interfacial layer)and architecture design of host carbon(constructing three-dimension structure,preparing hollow structure,introducing lithiophilic sites,optimizing geometric effects,and compositing with Li).Based on the insights,some prospects on critical challenges and possible future research directions in this field are *** is anticipated that further innovative works on the fundamental chemistry and theoretical research of Li anodes are needed.

关键词： carbon materials dendrites hosts interfacial layers Li metal anodes

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Deformation characteristics of ultra-deep circular shaft in soft soil:A case study

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Underground Space 2024年第3期16卷 239-260页

作者： Yafei Qiao Feng Xie Zhanwei bai Jiafeng lu Wenqi Ding Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Engineering Project Management Company Shanghai Chengtou Water GroupShanghai 200002China SGIDI Engineering Consulting(Group)Co. Ltd.Shanghai 200093China

A circular shaft is often used to access a working well for deep underground space *** the depth of underground space increases,the excavation depth of the shaft *** this study,the deformation characteristics of a circular shaft with a depth of 56.3 m were presented and *** main monitoring contents included:(1)wall deflection;(2)vertical wall movement;(3)horizontal soil movement;(4)vertical surface movement;and(5)basal ***,the maximum wall deflection was only 7.7 *** with the wall deflection data collected for another 29 circular excavations,the ratio of maximum wall deflection to excavation depth of this shaft was smaller due to a smaller ratio of diameter to excavation *** wall deflection underwent two stages of deformation:the first stage was mainly circumferential compression caused by the mutual extrusion of joints between walls,and the second stage was typical vertical deflection *** horizontal soil movement outside the shaft was greater than the wall deflection and the deep soil caused great horizontal movement because of dewatering at confined water ***,a basal heave of 203.8 mm occurred in the pit centre near the ***,the shaft was uplifted over time and showed 3 stages of vertical *** surface outside the shaft exhibited settlement and uplift deformation at different locations due to different *** basal heave caused by excavation was the dominant factor,driving the vertical movement of the shaft as well as the surrounding *** correlation between the wall deflection and the surface settlement outside the shaft was weak.

关键词： Circular shaft Site monitoring Deflection Vertical deformation Soft soil

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Two diversities meet in the rhizosphere:root specialized metabolites and microbiome

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Journal of Genetics and Genomics 2024年第5期51卷 467-478页

作者： Xiaochen Wang Jingying Zhang Xinjun lu Yang bai Guodong Wang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China College of Advanced Agricultural Sciences Chinese Academy of SciencesBeijing 100049China

Plants serve as rich repositories of diverse chemical compounds collectively referred to as specialized *** compounds are of importance for adaptive processes,including interactions with various microbes both beneficial and *** microbes as bioreactors,the chemical diversity undergoes dynamic changes when root-derived specialized metabolites(RSMs)and microbes encounter each other in the *** advancements in sequencing techniques and molecular biology tools have not only accelerated the elucidation of biosynthetic pathways of RSMs but also unveiled the significance of RSMs in plant-microbe *** this review,we provide a comprehensive description of the effects of RSMs on microbe assembly in the rhizosphere and the influence of corresponding microbial changes on plant health,incorporating the most up-to-date information ***,we highlight open questions that remain for a deeper understanding of and harnessing the potential of RSM-microbe interactions to enhance plant adaptation to the ***,we propose a pipeline for investigating the intricate associations between root exometabolites and the rhizomicrobiome.

关键词： Root specialized metabolites Microbiome Plant-microbe interactions Rhizosphere Diversity

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A New Method for the Aging Evaluation of Oil-Paper Insulation Using η-Butanol and Methanol

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 717-726页

作者： Jianyi Wang Yuanxiang Zhou Jun Liu Zhaowei Wang Song bai Jiayu lu Department of High Voltage China Electric Power Research InstituteBeijing 100192China State Key Laboratory of Power Grid Environmental Protection Beijing 100192China Electrical Engineering Department Tsinghua UniversityBeijing 100084China Solar Storage Division of State Key Lab of Power System and Generation Equipment School of Electrical EngineeringXinjiang UniversityUrumqi 830047China State Grid Wuwei Electric Power Supply Company Wuwei 733000China

To improve the accuracy and efficiency of the aging life prediction and assessment of transformer oil-paper insulation,and to make up for the deficiencies of traditional characterizers,such as 2-furfural,carbon monoxide,and carbon dioxide,a method for the simultaneous determination of methanol,ethanol,n−propanol,and η-butanol in oil with a single injection is established by headspace-gas chromatography-mass *** measured results show that the determination limits of the four alcohol characterizers can be controlled to 10μg/kg *** on this method,the change patterns of the above four alcohols with thermal aging time and degree of polymerization are obtained through thermal aging experimental ***,η-propanol,and η-butanol in oil indicate nearly linear correlations with thermal aging time and degree of polymerization,similar to that of *** analyzing 52 sets of measured data of 500 kV EHV transformers in operation,η-butanol is found to have excellent performance,and a new method to evaluate the aging state of oil-paper insulation employing η-butanol and methanol is proposed along with the aging attention value *** measured data of 500 kV EHV transformers in operation indicate that the combination of η-butanol and methanol as the preferred characterizers can effectively compensate for the shortcoming of traditional characterizers in the early stages of aging,and the feasibility of the method is *** possible pathways for the generation of η-butanol by cellulose cleavage during the aging of oil-paper are proposed from the chemical structure of cellulose.

关键词： Aging characterization determination method methanol η-butanol oil-paper insulation 500 kV transformers

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