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The enhanced mechanical properties of SiC nanowires/Ba0.75Sr0.25Al2Si2O8 ceramics with embedded SiO2 interface

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Journal of Advanced Ceramics 2024年第7期13卷 933-941页

作者： Xin Li Xiaomeng Fan Haojie luo Xiaoke lu Jimei Xue Fang Ye Yongsheng liu Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical UniversityXi’an 710072China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

In this work,low-softening-temperature and low-modulus SiO2 was introduced as an embedded interface between SiC nanowires(SiCnws)and a BaxSr1−xAl2Si2O8 ceramic matrix to enhance strength and toughness of the *** the sintering process,molten SiO2 enhances the flowability of the ceramic powders and modifies the dispersion of *** strengthening effect of SiCnws was fully realized,and the flexural strength of the optimized ceramics reached 193±16 MPa,which represents an increase of 52.6%.After the formation of the embedded SiO2 interface with a low modulus,cracks can deflect along the SiCnws surface,which is consistent with the criterion of He and *** can effectively extend the crack propagation path,and the fracture toughness(K_(IC))is thus improved by 94.0%,reaching 3.1±0.5 MPa·m^(1/2).

关键词： multiphase ceramics SiO2 interface densification mechanical properties

Ordovician reservoirs in Fuxian area:Gas accumulation patterns and their implications for the exploration of lower Paleozoic carbonates in the southern Ordos Basin

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Energy Geoscience 2024年第1期5卷 63-71页

作者： Ning Gu Juntao Zhang Xiaohui Jin Fei Yang lu liu Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Huabei Oil&Gas Branch SINOPECZhengzhouHenan450000China

In recent years,the Fuxian area in the southeastern Ordos Basin has undergone significant exploration,with industrial gas flow tested in wells drilled into the Ordovician marine *** this,the gas accumulation patterns of this area are not fully understood,posing challenges for further *** analysis of geological conditions indicates that the Ordovician Majiagou Formation in this area hosts two gas plays:one found in weathering crusts and the other found in interior of the *** investigated various typical gas reservoirs in the area,focusing on differentiating the geological conditions and factors controlling gas accumulation in the weathering-crust and interior gas *** results suggest three primary gas accumulation patterns in the Majiagou Formation in the Fuxian area:(1)upper gas accumulation in weathering crusts,present in the high parts of landforms such as residual paleo-hills or buried paleo-platform(Pattern I);(2)the stereoscopic pattern with gas accumulation in both weathering crusts and strata interior,arising in high parts of landforms such as residual paleo-hills or buried paleo-platforms(Pattern II);(3)lower gas accumulation in strata interior,occurring in the upper reaches and on both sides of paleo-trenches(Pattern III).This study will serve as a geological basis for future exploration deployment in the Fuxian area.

关键词： Gas accumulation Ordovician Weathering crust play Interior play Fuxian area The ordos basin

Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome

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Neuroscience Bulletin 2024年第4期40卷 439-450页

作者： Xiaotong Wu Yali liu Xiaomeng Wang lu Zheng Libiao Pan Hao Wang Department of Neurosurgery of Second Affiliated Hospital and School of Brain Science and Brain Medicine Key Laboratory for Biomedical Engineering of Education MinistryZhejiang University School of MedicineHangzhou310058China Nanhu Brain-computer Interface Institute Hangzhou311100China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain Machine IntegrationKey Laboratory of Precise Treatment and Clinical Translational Research of Neurological DiseasesSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310058China Lingang Laboratory Shanghai200031China

While somatosensory over-reactivity is a common feature of autism spectrum disorders such as fragile X syndrome(FXS),the thalamic mechanisms underlying this remain ***,we found that the developmental elimination of synapses formed between the principal nucleus of V(PrV)and the ventral posterior medial nucleus(VPm)of the somatosensory system was delayed in fragile X mental retardation 1 gene knockout(Fmr1 KO)mice,while the developmental strengthening of these synapses was *** showed excessive VGluT2 puncta in mutants at P12–13,but not at P7–8 or P15–16,confirming a delay in somatic pruning of PrV-VPm *** synaptic function was associated with a reduction in the frequency of quantal AMPA events,as well as developmental deficits in presynaptic vesicle size and *** results uncovered the developmental impairment of thalamic relay synapses in Fmr1 KO mice and suggest that a thalamic contribution to the somatosensory over-reactivity in FXS should be considered.

关键词： Fragile X syndrome Synaptic refinement VPm Sensory over-reactivity

Strategic regulation of nitrogen-containing intermediates for enhanced nitrate reduction over Co_(3)O_(4)/SiC catalyst having multiple active centers

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Journal of Energy Chemistry 2024年第9期96卷 291-299页

作者： Ming-Hao Guan Hao-Nan Xu Jin liu Tao Wu An-Hui lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Regulating the intermediates involved in the electrocatalytic nitrate reduction reaction(NO_(3)RR)is crucial for the enhancement of reaction ***,it remains a great challenge to regulate the reaction intermediates through active site manipulation on the surface of the ***,a family of n%-Co_(3)O_(4)/SiC(n=5,8,12,20)catalysts with a delicate percentage of Co^(2+)and Co^(3+)were prepared for NO_(3)*** found that Co^(3+)primarily acts as the active site for NO_(3)^(−)reduction to NO_(2)^(−),while Co^(2+)is responsible for the conversion of NO_(2)^(−)to NH_(3).Moreover,the conversion of these intermediates over the active sites is autonomous and separately *** processes synergistically accomplish the reduction of nitrate ions to synthesize *** the experimental studies and density functional theory(DFT)calculations,it is discovered the pathway(^(*)NHO→^(*)NHOH→^(*)NH_(2)OH→^(*)NH_(2)→^(*)NH_(3))is more favorable due to the lowerΔG value(0.25 eV)for the rate-limiting step(^(*)NO→^(*)NHO).The NH_(3)yield rate of 8%-Co_(3)O_(4)/SiC reached 1.08 mmol/(cm^(2)h)with a Faradaic efficiency of 96.4%at−0.89 V versus the reversible hydrogen electrode(RHE),surpassing those of most reported non-noble NO_(3)RR *** strategy not only provides an efficient catalyst for NO_(3)RR but also serves as an illustrative model for the regulation of multi-step reaction intermediates through the design of distinct active sites,thereby presenting a new approach to enhance the efficiency of intricate reactions.

关键词： Electrocatalysis Nitratereduction Co_(3)O_(4)/SiC catalysts Intermediates control

Chemical simulation teaching system based on virtual reality and gesture interaction

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 148-168页

作者： Dengzhen lu Hengyi LI Boyu QIU Siyuan liu Shuhan QI School of Computer Science and Technology Harbin Institute of TechnologyShenzhen 518055China Pengcheng Laboratory Shenzhen 518052China

Background Most existing chemical experiment teaching systems lack solid immersive experiences,making it difficult to engage *** address these challenges,we propose a chemical simulation teaching system based on virtual reality and gesture *** The parameters of the models were obtained through actual investigation,whereby Blender and 3DS MAX were used to model and import these parameters into a physics *** establishing an interface for the physics engine,gesture interaction hardware,and virtual reality(VR)helmet,a highly realistic chemical experiment environment was *** code script logic,particle systems,as well as other systems,chemical phenomena were ***,we created an online teaching platform using streaming media and databases to address the problems of distance *** The proposed system was evaluated against two mainstream products in the *** the experiments,the proposed system outperformed the other products in terms of fidelity and *** The proposed system which offers realistic simulations and practicability,can help improve the high school chemistry experimental education.

关键词： Chemical experiment simulation Gesture interaction Virtual reality Model establishment Process control Streaming media Database

Advanced Machine Learning Methods for Prediction of Blast-Induced Flyrock Using Hybrid SVR Methods

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1595-1617页

作者： Ji Zhou Yijun lu Qiong Tian Haichuan liu Mahdi Hasanipanah Jiandong Huang College of Civil and Environmental Engineering Hunan University of Science and EngineeringYongzhou425006China Hunan Provincial Key Laboratory of Intelligent Protection and Utilization Technology in Masonry Artifacts Hunan University of Science and EngineeringYongzhou425006China School of Civil Engineering Guangzhou UniversityGuangzhou510006China Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam School of Engineering&Technology Duy Tan UniversityDa Nang550000Vietnam

Blasting in surface mines aims to fragment rock masses to a proper ***,flyrock is an undesirable effect of blasting that can result in human *** this study,support vector regression(SVR)is combined with four algorithms:gravitational search algorithm(GSA),biogeography-based optimization(BBO),ant colony optimization(ACO),and whale optimization algorithm(WOA)for predicting flyrock in two surface mines in ***,three other methods,including artificial neural network(ANN),kernel extreme learning machine(KELM),and general regression neural network(GRNN),are employed,and their performances are compared to those of four hybrid SVR *** modeling,the measured and predicted flyrock values are validated with some performance indices,such as root mean squared error(RMSE).The results revealed that the SVR-WOA model has the most optimal accuracy,with an RMSE of 7.218,while the RMSEs of the KELM,GRNN,SVR-GSA,ANN,SVR-BBO,and SVR-ACO models are 10.668,10.867,15.305,15.661,16.239,and 18.228,***,combining WOA and SVR can be a valuable tool for accurately predicting flyrock distance in surface mines.

关键词： Flyrock induced by blasting optimization algorithms SVR GRNN

Evaluating CMIP6 models in simulating the North Pacific decadal variability in sea surface salinity

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Science China Earth Sciences 2024年第8期67卷 2661-2680页

作者： Jian CHEN Hailong liu Pengfei LIN Wenrong BAI Chengzu BAI lu WANG Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China State Key Laboratory of Geo-Information Engineering Xi’an 710054China Beijing Municipal Climate Center Beijing Meteorological BureauBeijing 100089China Space System Department Equipment Department Beijing 100096China

The North Pacific sea surface salinity(SSS)decadal variability(NPSDV)and its potential forcing were evaluated from 25 coupled models of the Coupled Model Intercomparison Project phase 6(CMIP6)considering the prospects for decadal climate *** results indicated that the CMIP6 models generally reproduced the spatial patterns of *** large standard deviation of the SSS anomaly over the strong current regions,such as the Kuroshio-Oyashio Extension(KOE),North Pacific Current(NPC),California Current System(CCS),and Alaskan Coastal Current(ACC),is reflected in the two leading modes of NPSDV:a dipole with out-of-phase loadings in the KOE-NPC versus CCS-ACC and a monopole with positive loading over the *** order of modes is sensitive to individual models that exhibit discrepancies,especially in temporal phases and power *** autoregressive model of order-1 was used to reconstruct the NPSDV with several forcing *** generally weaker influence of forcings in an autoregressive model of order-1 is partly related to the overestimated response time of NPSDV relative to *** NPSDV variances originate from the persistence of SSS anomalies,but the dominant forcing factors are diverse among *** model diversity for the NPSDV simulation mainly arises from the influence of the tropical El Ni?o-Southern Oscillation through teleconnection on the North Pacific Oscillation or Aleutian Low with timescale ***,models that can reproduce the NPSDV well are not dependent on those with larger impacts from the North Pacific oceanic processes.

关键词： North Pacific Sea surface salinity Decadal variability CMIP6 Leading mode

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Bioactivities,Mechanisms,Production,and Potential Application of Bile Acids in Preventing and Treating Infectious Diseases

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Engineering 2024年第7期38卷 13-26页

作者： Shuang liu Shuo Yang Biljan Blazekovic lu Li Jidan Zhang Yi Wang Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia

Infectious diseases are a global public health problem,with emerging and re-emerging infectious diseases on the rise ***,their prevention and treatment are still major *** acids are common metabolites in both hosts and microorganisms that play a significant role in controlling the metabolism of lipids,glucose,and *** acids have historically been utilized as first-line,valuable therapeutic agents for related metabolic and hepatobiliary ***,bile acids are the major active ingredients of cow bezoar and bear bile,which are commonly used traditional Chinese medicines(TCMs)with the therapeutic effects of clearing heat,detoxification,and relieving wind and *** recent years,the promising performance of bile acids against infectious diseases has attracted attention from the scientific *** paper reviews for the first time the biological activities,possible mechanisms,production routes,and potential applications of bile acids in the treatment and prevention of infectious *** with previous reviews,we comprehensively summarize existing studies on the use of bile acids against infectious diseases caused by pathogenic microorganisms that are leading causes of global morbidity and *** addition,to ensure a stable supply of bile acids at affordable prices,it is necessary to clarify the biosynthesis of bile acids in vivo,which will assist scientists in elucidating the accumulation of bile acids and discovering how to engineer various bile acids by means of chemosynthesis,biosynthesis,and chemoenzymatic ***,we explore the current challenges in the field and recommend a development strategy for bile-acid-based drugs and the sustainable production of bile *** presented studies suggest that bile acids are potential novel therapeutic agents for managing infectious diseases and can be artificially synthesized in a sustainable way.

关键词： Bile acids Infectious diseases Bioactivities Mechanisms Anti-infective agents

Role of mitochondrial dysfunction in kidney disease:Insights from the cGAS-STING signaling pathway

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Chinese Medical Journal 2024年第9期137卷 1044-1053页

作者： lu Li Fei liu Chunyue Feng Zhenjie Chen Nan Zhang Jianhua Mao Department of Nephrology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of Pediatric Intensive Care Unit Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China

Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney ***,the precise molecular mechanisms linking mitochondrial damage to kidney disease remain *** recent insights into the cyclic guanosine monophosphate-adenosine monophosphate(GMP-AMP)synthetase(cGAS)-stimulator of interferon gene(STING)signaling pathway have revealed its involvement in many renal *** of these findings is that mitochondrial DNA(mtDNA)induces inflammatory responses via the cGAS-STING ***,we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage,focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney ***,we summarize the latest findings of cGAS-STING signaling pathway in cell,with a particular emphasis on its downstream signaling related to kidney *** review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway,kidney diseases,and mitochondrial dysfunction.

关键词： Mitochondrial dysfunction Mitochondrial DNA cGAS-STING pathway Kidney diseases Chronic kidney disease