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Statistical Approach for Classification of Dinosaur Eggs from the Heyuan Basin at the Northeast of Guangdong Province

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Acta Geologica Sinica(English Edition) 2012年第2期86卷 294-303页

作者： Kohei TANAKA lu Junchang LIU yi huang Zhiqing Yoshitsugu KOBAYASHI huang Dong Darla K. ZELENITSKY Department of Geoscience University of Calgary Calgary T2N1N4 Canada Institute of Geology Chinese Academy of Geological Sciences Beijing 10037 China Heyuan Museum Heyuan 517000 China Hokkaido University Museum Hokkaido University Sapporo 060-0810 Japan

The Zhutian and Dafeng formations （Upper Cretaceous） of the Heyuan Basin in northeastern Guangdong Province, China, have produced thousands of dinosaur eggs. Macromorphological features （egg diameter, egg shape, outer surface texture, and shell thickness） of 461 eggs were analyzed using non-destructive techniques and subjected to statistical analyses in order to assess their diversity and taxonomic affinities. Three types （1, 2 and 3） of eggs were discerned based on shape and outer surface morphology. Type 1 eggs are spherical to ellipsoidal in shape and have a rough surface. Three subtypes （Type 1-A-l, l-A-2, and l-B） are apparent from scatter plots and cluster analyses of egg diameters and shell thickness. Type 2 eggs are elongate with linear ornamentation on the surface, and are comparable to eggs that belong to the oofamily Elongatoolithidae. Type 3 eggs are elongate with a smooth surface, and are assigned to the oofamily Prismatoolithidae. Macromorphological features of the various egg types suggest that Type 1 could have been laid by ornithischian, sauropod or therizinosaur dinosaurs, Type 2 by oviraptorids, and Type 3 by troodontids. This study represents the first comprehensive statistical analysis of macrofeatures of dinosaur eggs, and reveals taxonomic diversity in the dinosaurs that were laying eggs in the Upper Cretaceous Heyuan area heretofore unrecognized in skeletal remains.

关键词： dinosaur egg Nanxiong Group Late Cretaceous Heyuan Basin Guangdong China

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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利伐沙班在犬和猫临床应用的研究进展

动物医学进展 2025年第1期46卷 97-102页

作者：王炜江蓝路心怡付诗懿刘亦婷韦力煣俞峰刘波中国农业大学动物医学院北京100193 中国农业大学教学动物医院北京100193

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够... 详细信息

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够特异性抑制活性凝血因子X从而抑制血栓形成。近年来人医领域对利伐沙班的相关临床研究逐渐丰富,涉及单用利伐沙班或使用双通路抑制疗法防治不同类型的动、静脉血栓栓塞,可为其应用于兽医临床提供据。犬、猫临床使用利伐沙班的研究正相继开展,论文就犬、猫血栓栓塞疾病发病情况、防治现状,利伐沙班的药理学特性及其在人医、兽医领域的临床试验研究进展进行综述,以期为兽医临床上利伐沙班的进一步研究提供参考。

关键词：新型口服抗凝药利伐沙班血栓栓塞犬猫

Observability Analysis and Navigation Algorithm for Distributed Satellites System Using Relative Range Measurements

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Journal of Systems Science & Complexity 2018年第5期31卷 1206-1226页

作者： SU Qiya huang yi Beijing Institute of Remote Sensing Equipment Beijing 100854 China Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049 China

The problem of navigation for the distributed satellites system using relative range mea- surements is investigated. Firstly, observability for every participating satellites is analyzed based on the nonlinear Keplerian model containing J2 perturbation and the nonlinear measurements. It is proven that the minimum number of tracking satellites to assure the observability of the distributed satellites system is three. Additionally, the analysis shows that the J2 perturbation and the nonlinearity make little contribution to improve the observability for the navigation. Then, a quasi-consistent extended Kalman filter based navigation algorithm is proposed, which is quasi-consistent and can provide an on- line evaluation of the navigation precision. The simulation illustrates the feasibility and effectiveness of the proposed navigation algorithm for the distributed satellites system.

关键词： Distributed satellites system (DSS) navigation observability quasi-consistent extendedKalman filter (QCEKF) relative range.

ADRC BASED INPUT DISTURBANCE REJECTION FOR MINIMUM-PHASE PLANTS WITH UNKNOWN ORDERS AND/OR UNCERTAIN RELATIVE DEGREES

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Journal of Systems Science & Complexity 2012年第4期25卷 625-640页

作者： Chunzhe ZHAO yi huang School of Computer Science and Engineering Chongqing Three Gorges University Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of Sciences

The capability of ADRC is studied for linear time-invariant SISO minimum-phase systems with unknown orders, uncertain relative degrees, and unknown input disturbances. It is proved that ADRC can reject the unknown input disturbance and guarantee the close-loop stability for the plants with unknown but bounded relative degrees. Meanwhile, some close-loop performances can be achieved. The influence of the sensor noise is also discussed. And it is demonstrated by numerical examples that one ADRC with fixed parameters can be applied to a group of plants of different orders, relative degrees, and parameters.

关键词： ADRC frequency performance sensor noise uncertain relative degree unknown input disturbance unknown order.

Tuning of Sampled-Data ADRC for Nonlinear Uncertain Systems

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Journal of Systems Science & Complexity 2016年第5期29卷 1187-1211页

作者： XUE Wenchao huang yi Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences

This paper concerns with the parameters tuning of active disturbance rejection control(ADRC) for a class of nonlinear systems with sampling rate not fast enough. The theoretical results show the quantitative relationship between the sampling rate, the parameters of ADRC, the size of uncertainties in system and the properties of the closed-loop system. Furthermore, the capability of the sampled-data ADRC under given sampling rate is quantitatively discussed.

关键词： Active disturbance rejection control (ADRC) extended state observer nonlinear uncertain systems parameters tuning sampled-data control.

有氧运动调节转化生长因子β/Smad通路缓解db/db糖尿病小鼠的肝脏纤维化

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中国组织工程研究 2025年第14期29卷 2951-2957页

作者：黄朝露黄毅吴昌燕李芳菲李海燕黔东南民族职业技术学院临床医学系贵州省凯里市556000 贵州医科大学基础医学院贵州省贵阳市550000 贵州中医药大学基础医学院贵州省贵阳市550000 温州医科大学附属第一医院康复科浙江省温州市325000

背景:有氧运动可抑制糖尿病小鼠肝纤维化,但具体作用机制尚未阐明。目的:基于转化生长因子β/Smad信号通路探讨有氧运动改善db/db小鼠肝纤维化的作用机制。方法:将8周龄雄性db/db小鼠和年龄匹配的m/m小鼠随机分为m/m对照组、m/m+运动组... 详细信息

背景:有氧运动可抑制糖尿病小鼠肝纤维化,但具体作用机制尚未阐明。目的:基于转化生长因子β/Smad信号通路探讨有氧运动改善db/db小鼠肝纤维化的作用机制。方法:将8周龄雄性db/db小鼠和年龄匹配的m/m小鼠随机分为m/m对照组、m/m+运动组、db/db对照组、db/db+运动组,每组10只,运动组小鼠接受12周有氧运动。运动结束后检测各组小鼠空腹血糖,进行葡萄糖耐量测试和胰岛素耐量测试;摘取肝脏计算肝脏指数,摘眼球取血检测生化指标;苏木精-伊红染色、油红O染色和Masson染色观察小鼠肝组织的病理变化,免疫组化检测肝组织中转化生长因子β1、p-Smad3的表达;Western blot检测肝组织中转化生长因子β1、Smad3、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达水平。结果与结论:①与m/m组和m/m+运动组小鼠相比,db/db组小鼠体质量、肝质量、肝脏指数、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白和肌酶水平均显著升高(P<0.01);高密度脂蛋白水平显著降低(P<0.01);转化生长因子β1、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达水平显著升高(P<0.01);葡萄糖、胰岛素耐量测试的曲线下面积显著增加(P<0.01);肝组织病理染色显示大量炎症细胞浸润,脂滴增多,明显纤维化;②与db/db组相比,db/db+运动组小鼠体质量、肝质量、肝脏指数、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白和肌酶水平显著降低(P<0.05或P<0.01);高密度脂蛋白水平显著升高(P<0.05);转化生长因子β1、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达显著降低(P<0.05或P<0.01);此外,糖耐量、胰岛素耐量测试的曲线下面积明显减少(P<0.01,P<0.05),肝脏病理损伤得到明显改善;③结果表明,有氧运动有效减轻了糖尿病小鼠肝纤维化,其机制可能与调控转化生长因子β/Smad信号通路有关。

关键词：有氧运动转化生长因子β Smad 信号通路 db/db 肝纤维化

SPLITTING EXTRAPOLATIONS FOR SOLVING BOUNDARY INTEGRAL EQUATIONS OF LINEAR ELASTICITY DIRICHLET PROBLEMS ON POLYGONS BY MECHANICAL QUADRATURE METHODS

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Journal of Computational Mathematics 2006年第1期24卷 9-18页

作者： Jin huang Tao lu University of electronic & science technology of China Chengdu 610055 Mathematical College Sichuan University Chengdu 610065 China

Taking hm as the mesh width of a curved edge Гm （m = 1, ..., d ） of polygons and using quadrature rules for weakly singular integrals, this paper presents mechanical quadrature methods for solving BIES of the first kind of plane elasticity Dirichlet problems on curved polygons, which possess high accuracy O（h0^3） and low computing complexities. Since multivariate asymptotic expansions of approximate errors with power hi^3 （i = 1, 2, ..., d） are shown, by means of the splitting extrapolations high precision approximations and a posteriori estimate are obtained.

关键词： Splitting extrapolation Linear elasticity Dirichlet problem Boundary integral equation of the first kind Mechanical quadrature method

The characterization of the time-dependent nonlinear viscoelastic of an LDPE melt using a simple thixotropy model

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Acta Mechanica Sinica 2005年第4期21卷 330-335页

作者： Shuxin huang Chuanjing lu Department of Engineering Mechanics Shanghai Jiao Tong UniversityShanghai 200030 China

A new simple thixotropy model was proposed in the present paper to characterize the thixotropy-loop experiments and the start-up experiment of an LDPE （PE-FSB23D0221Q200） melt. The thixotropy model is a combination of a viscoelastic-component and a postulated kinetics process of structure change, which is constituted in terms of the indirect microstructural approach usually adopted in the characterization of thixotropy. The descriptions of the thixotropy model on both the thixotropy-loop tests and the startup test show good agreement with the experimental values, indicating the good capability of the model in characterizing the time-dependent nonlinear viscoelastic. The stress overshoot phenomenon and the stress relaxation after cessation of the thixotropy loop test can be described well by the model, whereas both of the typical viscoelastic phenomena could not be described in our previous work with a variant huang model.

关键词： Time-dependent viscoelastic Stressovershoot Stress relaxation ,A simple thixotropy model