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Current Medical Science 2022年第2期42卷 462-466页

作者： lu-yao li De-qing WU li-lan yao Feng li Chao liU Fu-quan JIA Department of Pathology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Forensic DNA laboratory of Jinjiang Public Security Bureau Jinjiang362200China Center of Forensic Expertise Affiliated Hospital of Zunyi Medical UniversityZunyi563099China Hohhot Public Security Bureau Hohhot010000China Department of Forensic Medicine Inner Mongolia Medical UniversityHohhot010059China

Objective Population genetic analysis based on genetic markers harbors valuable forensic *** this regard,it is informative and imperative to explore Han groups as they are the largest population of *** particular,there is a largely underrepresented amount of information from recent decades regarding the southeast costal Han ***,the aim of this study is to investigate the available genetic characteristics of the Han population living in the Jinjiang,Fujian Province,Southeastern *** We sampled 858 saliva samples and used the commercially available Microreader^(TM) Y Prime Plus ID System to identify population data of Y-short tandem repeat(STR)loci of this *** A total of 822 different haplotypes were *** overall haplotype diversity,discriminatory power and haplotype match probability were 0.9999,0.9999 and 0.0012,*** Our results showed that the Jinjiang Han population was closely genetically related to Han groups of ***,we identified a set of 37 Y-STRs that are highly polymorphic,and that can provide meaningful information in forensic practice and human genetic research.

关键词： forensic genetics Y-short tandem repeat Jinjiang Han haplotype diversity Microreader^(TM)Y Prime Plus ID System

Psychiatrists’occupational stigma conceptualization,measurement,and intervention:A literature review

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World Journal of Psychiatry 2023年第6期13卷 298-318页

作者： Xiao-li Shi lu-yao li Zhi-Guang Fan School of Education Jilin International Studies UniversityChangchun 130000Jilin ProvinceChina

Psychiatrists require frequent contact with and treatment of patients with mental *** to the influence of associative stigma,psychiatrists may also be targets of *** stigma warrants special consideration because it significantly affects psychiatrists'career advancement,well-being,and their patients’*** that there is no complete summary of this issue,this study reviewed the existing literature on psychiatrists'occupational stigma to clearly synthesize its concepts,measurement tools,and intervention ***,we emphasize that psychiatrists’occupational stigma is a multifaceted concept that simultaneously encompasses physically,socially,and morally tainted ***,standardized methods to specifically measure psychiatrists’occupational stigma are *** for psychiatrists’occupational stigma may consider the use of protest,contact,education,comprehensive and systematic methods,as well as the use of psychotherapeutic *** review provides a theoretical basis for the development of relevant measurement tools and intervention ***,this review seeks to raise public awareness of psychiatrists'occupational stigma,thereby promoting psychiatric professionalism and reducing its stigma.

关键词： Psychiatrists Occupational stigma Conceptualization Measurement Intervention Associative stigma

Ultrasonic vibration-assisted multi-scale plastic forming of high-entropy alloys in milliseconds

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Rare Metals 2023年第4期42卷 1146-1153页

作者： Wen-Xin Wen lu-yao li Zhen li Wen-Qing Ruan Shuai Ren Zhen-Xuan Zhang Xiong liang Huan liu Jiang Ma Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen518060China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055China College of Mechanics and Materials Hohai UniversityNanjing210000China

Due to their excellent properties of specific strength,fracture resistance,corrosion and oxidation resistance,the high-entropy alloys have attracted widespread attention as engineering *** the sake of industrial applications,one of the essential stages would be the forming of them,especially the construction of multi-sc ale structures from macroscale to nanoscale.

关键词： alloys materials. resistance

Haplotype and Genetic Analysis of 41 Y-STR Loci in the Wuwei Han Population from Gansu Province,China

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Current Medical Science 2023年第1期43卷 184-190页

作者： lu-yao li Sheng-gui FAN Hui GONG Xing FAN De-chun WANG Neng-xiu li Fu-quan JIA Department of Pathology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China The Judicial Authentication Center Wuwei Public Security BureauWuwei733000China Department of Forensic Medicine Inner Mongolia Medical UniversityHohhot010059China

Objective Y-Chromosomal short tandem repeat polymorphism(Y-STR)analysis plays an indispensable role in the identification of male individuals,population genetics,and biogeographic *** profiles of many populations based on Y-STR markers in human genomes are ample,haplotype data for the Wuwei Han are still *** In this study,2180 unrelated Wuwei Han male individuals residing in Gansu Province,China were collected and genotyped using the novel Microreader™40Y Plus ID *** relationship reconstructions,multidimensional scaling(MDS),and heatmap analysis were performed based on the genetic distance(Rst)values between our studied population and other populations of the Ymax module in the Y-STR Haplotype Reference Database(YHRD).Results A total of 2129 unique haplotypes were obtained,and the haplotype diversity(HD)and discrimination capacity(DC)for the Wuwei Han were 0.9999 and 0.9931,*** Our results demonstrate that the Wuwei Han population had intimate genetic relationships with East Asians,especially the geographically close Han ***,this Y-Chromosomal assay gives valuable information about paternal lineages in male individual tracking and genealogical database construction.

关键词： MicroreaderTM 40Y Plus ID system Y-STR haplotype Y-InDel Wuwei Han population genetics

Trust Degree of Web Services and Its Evaluation with Neural Network

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Wuhan University Journal of Natural Sciences 2006年第5期11卷 1302-1305页

作者： HUANG Baohua HU Heping lu Zhengding yao Hanbing li Ruixuan College of Computer Science and Technology HuazhongUniversity of Science and Technology Wuhan 430074Hubei China

The concept and definition of trust degree of Web service is given. Evaluating trust degree of Web services with the method of neural network from the aspect of trust history sequence is proposed. The principle of the method, applicable neural network structure, neural network construc ting, input standardization, training sample constructing, and the procedure of evaluating trust degree of Web services with trained neural network are described. Experiments show that it is feasible and effective to evaluate trust degree of Web Service with neural network.

关键词： Web services trust degree neural network

Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice

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Neural Regeneration Research 2023年第3期18卷 568-576页

作者： lu-yao li Qi Wang lu Deng Zhen lin Jing-Jing lin Xin-Ye Wang Tian-Yang Shen Yi-Hui Zheng Wei lin Pei-Jun li Xiao-Qin Fu Zhen-Lang lin Department of Pharmacy The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Neonatology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Geriatrics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Orthopedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Neurology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Recent studies have shown that chlorogenic acid(CGA),which is present in coffee,has protective effects on the nervous ***,its role in neonatal hypoxic-ischemic brain injury remains *** this study,we established a newborn mouse model of hypoxic-ischemic brain injury using a modified Rice-Vannucci method and performed intraperitoneal injection of *** found that CGA intervention effectively reduced the volume of cerebral infarct,alleviated cerebral edema,restored brain tissue structure after injury,and promoted axon growth in injured brain ***,CGA pretreatment alleviated oxygen-glucose deprivation damage of primary neurons and promoted neuron *** addition,changes in ferroptosis-related proteins caused by hypoxic-ischemic brain injury were partially reversed by ***,CGA intervention upregulated the expression of the key ferroptosis factor glutathione peroxidase 4 and its upstream glutamate/cystine antiporter related factors SLC7A11 and *** summary,our findings reveal that CGA alleviates hypoxic-ischemic brain injury in neonatal mice by reducing ferroptosis,providing new ideas for the treatment of neonatal hypoxic-ischemic brain injury.

关键词： chlorogenic acid ferroptosis glutathione peroxidase 4 lipid peroxidation neonatal hypoxic-ischemic brain injury neurons neuroprotection oxidative stress oxygen-glucose deprivation system Xc^(-)

Epidemiological trends of urinary tract infections,urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019

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Military Medical Research 2022年第4期9卷 432-443页

作者： Cong Zhu Dan-Qi Wang Hao Zi Qiao Huang Jia-Min Gu lu-yao li Xing-Pei Guo Fei li Cheng Fang Xiao-Dong li Xian-Tao Zeng Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Evidence-Based Medicine and Clinical Epidemiology Second School of Clinical MedicineWuhan UniversityWuhan 430071China Institutes of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Urology Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina

Background:Urinary tract infections(UTI),urolithiasis,and benign prostatic hyperplasia(BPH)are three of the most common nonmalignant conditions in ***,there is still a lack of comprehensive and updated epidemiological *** study aimed to investigate the disease burden of UTI,urolithiasis,and BPH in 203 countries and territories from 1990 to ***:Data were extracted from the Global Burden of Disease 2019,including incident cases,deaths,disabilityadjusted life-years(DALYs)and corresponding age-standardized rate(ASR)from 1990 to *** annual percentage changes(EAPC)were calculated to evaluate the trends of *** associations between disease burden and social development degrees were analyzed using a sociodemographic index(SDI).Results:Compared with 1990,the incident cases of UTI,urolithiasis,and BPH increased by 60.40%,48.57%,and 105.70%in 2019,*** age-standardized incidence rate(ASIR)of UTI increased(EAPC=0.08),while urolithiasis(EAPC=–0.83)and BPH(EAPC=–0.03)decreased from 1990 to *** 2019,the age-standardized mortality rate(ASMR)of UTI and urolithiasis were 3.13/100,000 and 0.17/100,000,*** had the largest increase(110.56%)in DALYs in the past three decades,followed by UTI(68.89%)and urolithiasis(16.95%).The burden of UTI was mainly concentrated in South Asia and Tropical Latin America,while the burden of urolithiasis and BPH was recorded in Asia and Eastern ***,the ASIR and SDI of urolithiasis in high-SDI regions from 1990to 2019 were negatively correlated,while the opposite trend was seen in low-SDI *** 2019,the ASIR of UTI in females was 3.59 times that of males,while the ASIR of urolithiasis in males was 1.96 times higher than that in *** incidence was highest in the 30–34,55–59,and 65–69 age groups among the UTI,urolithiasis,and BPH groups,***:Over the past three decades,the disease burden has increased for UTI but decreased for urolithiasis and BPH

关键词： Urinary tract infections Urolithiasis Benign prostatic hyperplasia Disease burden Incidence Mortality Disability-adjusted life-years

Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats

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Military Medical Research 2023年第1期10卷 1-16页

作者： lu-yao li Jie Han Lan Wu Cheng Fang Wei-Guang li Jia-Min Gu Tong Deng Chang-Jiang Qin Jia-Yan Nie Xian-Tao Zeng Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Gastrointestinal Surgery Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Stomatology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Urology Zhong‑nan Hospital of Wuhan UniversityWuhan 430071China

Background: Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia(BPH) has not been well understood. Hence, this study aimed to investigate the regulation of BPH on gut microbiota composition and ***: We analyzed gut samples from rats with BPH and healthy control rats, the gut microbiota composition and metabonomics were detected by 16S rDNA sequencing and liquid chromatography tandem mass spectrometry(LC–MS/MS).Results: High-throughput sequencing results showed that gut microbiota beta-diversity increased(Plicutes(Plity, the levels of several predominant genera were different. In addition, there were no statistically significant differences in several bacteria. BPH group vs. control group: Firmicutes(52.30% vs. 57.29%, P>0.05), Bacteroidetes(46.54% vs. 41.64%,P>0.05), Clostridia(50.89% vs. 54.66%, P>0.05), Ruminococcaceae(25.67% vs. 20.56%, P>0.05). LC–MS/MS of intestinal contents revealed that differential metabolites were mainly involved in cellular processes, environmental information processing, metabolism and organismal systems. The most important pathways were global and overview maps, lipid metabolism, amino acid metabolism, digestive system and endocrine system. Through enrichment analysis, we found that the differential metabolites were significantly enriched in metabolic pathways, steroid hormone biosynthesis,ovarian steroidogenesis, biosynthesis of unsaturated fatty acids and bile secretion. Pearson correlation analysis(R=0.94) showed that there was a strong correlation between Prevotellaceae, Corynebacteriaceae, Turicibacteraceae,Bifid

关键词： Benign prostatic hyperplasia Gut microbiota Intestinal metabolites Microbial diversity

Global,regional,and national burden of kidney,bladder,and prostate cancers and their attributable risk factors,1990–2019

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Military Medical Research 2022年第3期9卷 303-318页

作者： Hao Zi Shao-Hua He Xie-Yuan Leng Xiao-Feng Xu Qiao Huang Hong Weng Cong Zhu lu-yao li Jia-Min Gu Xu-Hui li Dao-Jing Ming Xiao-Dong li Shuai Yuan Xing-Huan Wang Da-lin He Xian-Tao Zeng Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Precision Medicine Centre The Second People’s Hospital of HuaihuaHuaihua418000China The First School of Clinical Medicine Anhui Medical UniversityHefei230000China Department of Urology Xianyang Central HospitalXianyang712000China Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Institutes of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng475000China Department of Urology Huaihe Hospital of Henan UniversityKaifeng475000China Institute of Urology Wuhan UniversityWuhan430071China

Background:The burden of kidney,bladder,and prostate cancers has changed in recent *** study aims to investigate the global and regional burden of,and attributable risk factors for genitourinary cancers during the past 30 ***:We extracted data of kidney,bladder,and prostate cancers from the Global Burden of Disease 2019 database,including incidence,mortality,disability-adjusted life-years(DALYs),and attributable risk factors from 1990 to *** annual percentage changes(EAPC)were calculated to assess the changes in age-standardized incidence rate,age-standardized mortality rate(ASMR),and age-standardized DALYs rate(ASDR).The associations between cancers burden and socio-demographic index(SDI)were also ***:Compared with 1990,the global incident cases in 2019 were higher by 154.78%,123.34%,and 169.11%for kidney,bladder,and prostate cancers,*** the 30-year study period,there was a downward trend in ASMR and ASDR for bladder cancer(EAPC=–0.68 and–0.83,respectively)and prostate cancer(EAPC=–0.75 and–0.71,respectively),but an upward trend for kidney cancer(EAPC=0.35 and 0.12,respectively).Regions and countries with higher SDI had higher incidence,mortality,and DALYs for all three types of *** burden of bladder and prostate cancers was mainly distributed among older men,whereas the burden of kidney cancer increased among middle-aged *** related mortality and DALYs decreased,but high body mass index(BMI)and high fasting plasma glucose(FPG)related mortality and DALYs increased among kidney,bladder,and prostate cancers during the study ***:Kidney,bladder,and prostate cancers remain major global public health challenges,but with distinct trend for different disease entity across different regions and socioeconomic *** proactive intervention strategies,at both the administrative and academic levels,based on the dynamic changes,are needed.

关键词： Genitourinary cancer Kidney cancer Bladder cancer Prostate cancer Incidence Mortality Disability-adjusted life-years Global Burden of Disease

Salvage radical prostatectomy for radiorecurrent prostate cancer： the Chinese experience

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Chinese Medical Journal 2013年第23期126卷 4592-4593页

作者： GAO Xu WANG Hai-feng FANG Zi-yu lu Xin li yao-ming WANG Yan SUN Ying-hao Department of Urology Changhai Hospital Second Military University Shanghai 200433 China

For localized prostate cancer, radiation therapy （RT） is commonly used. However, in the first five years of RT, 10%-20% of localized prostate cancer patients, ano 30%-50% of the locally advanced prostate cancer patients will progress to biochemical recurrence. In the past, only few these patients considered salvage radical prostatectomy （SRP） as their primary selection due to the significant morbidity.

关键词： radiorecurrent prostate cancer salvage radical prostatectomy biochemical recurrence