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Influence of Intestinal Lymphatic Ligation on Pulmonary Injury in Rats with Severe Acute Pancreatitis

Current Medical Science 2022年第4期42卷 711-719页

作者： Yuan-qi LIU lu-lu wang Li CHEN Yu-xia XIONG Department of Pharmacology School of PharmacySouthwest Medical UniversityLuzhou 646000China Chengdu Vocational and Technical College Chengdu610000China Department of Pharmacy the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000China

Objective:The present study explored the mechanisms involved in intestinal lymphatic ligation in rats with severe acute pancreatitis(SAP).Methods:Male Sprague Dawley rats were randomly divided into 4 groups:saline group,saline+ligation group,SAP group,and SAP+ligation group.Rats in the SAP group were administered sodium taurocholate solution.Isolated mesenteric lymph duct ligation was administered to the saline+ligation and SAP+ligation groups.Endotoxin(ET),nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),myeloperoxidase(MPO),and superoxide dismutase(SOD)were detected.Nuclear factor-KB(NF-κB)and intercellular cell adhesion molecule-1(ICAM-1)proteins were observed.The mRNA of inducible nitric oxide synthase(iNOS)and Toll-like receptor 4(TLR4)was detected by PCR.Results:Pathomorphological analysis showed that necrosis was present in the lung of rats in the SAP group,but only mild lesions in the SAP+ligation group.ET,NO,TNF-α,and IL-1 in the serum and lung tissue were significantly decreased and MPO was increased in the SAP+ligation group as compared with the SAP group.However,MPO was increased.The expression of NF-κB and ICAM-1,either iNOS or TLR4,was upregulated in the SAP group,but downregulated in the SAP+ligation group.Intestinal lymph duct ligation prevented ET translocation,the release of inflammation factors,and inflammation injury.Conclusion:The intestinal lymph duct ligation could alleviate SAP-induced pulmonary injury by suppressing NF-κB activation in rats.

关键词： intestinal lymphatic ligation severe acute pancreatitis lung injury intestinal bacterial translocation

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Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第1期7卷 228-242页

作者： Jin-Lan Zhang Yu-Huan Li lu-lu wang Hong-Qi Liu Shuai-Yao lu Yong Liu Ke Li Bin Liu Su-Yun Li Feng-Min Shao Kun wang Ning Sheng Rui Li Jin-Jin Cui Pei-Chun Sun Chun-Xia Ma Bo Zhu Zhe wang Yuan-Hao Wan Shi-Shan Yu Yongsheng Che Chao-Yang wang Chen wang Qiangqian Zhang Li-Min Zhao Xiao-Zhong Peng Zhenshun Cheng Jun-Biao Chang Jian-Dong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Institute of Medical Biology Chinese Academy of Medical Science and Peking Union Medical CollegeKunming 650031 YunnanChina Genuine Biotech.Inc. Pingdingshan 467000 HenanChina Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan Research Center for Infectious Diseases and CancerWuhan 430071 HubeiChina The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000 HenanChina Department of Internal Medicine Henan Provincial Peoples HospitalZhengzhou 450003 HenanChina Henan Key Laboratory of Organic Functional Molecule and Drug Innovation School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007 HenanChina National Clinical Research Center for Respiratory Diseases Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China School of Chemistry Zhengzhou UniversityZhengzhou 450001 HenanChina

Azvudine(FNC)is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase(RdRp).Recently,we discovered FNC an agent against SARS-CoV-2,and have taken it into Phase III trial for COVID-19 patients.FNC monophosphate analog inhibited SARS-CoV-2 and HCoV-OC43 coronavirus with an EC_(50) between 1.2 and 4.3 μM,depending on viruses or cells,and selective index(SI)in 15-83 range.Oral administration of FNC in rats revealed a substantial thymus-homing feature,with FNC triphosphate(the active form)concentrated in the thymus and peripheral blood mononuclear cells(PBMC).Treating SARS-CoV-2 infected rhesus macaques with FNC(0.07 mg/kg, qd,orally)reduced viral load,recuperated the thymus,improved lymphocyte profiles,alleviated in flammation and orga n damage,and lessened grou nd・glass opacities in chest X-ray.Sin gle-cell seque ncing suggested the promotion of thymus function by FNC.A randomized,single-arm clinical trial of FNC on compassionate use(n=31)showed that oral FNC(5 mg,qd)cured all COVID-19 patients,with 100%viral ribonucleic acid negative conversion in 3.29±2.22 days(range:1-9 days)and 100%hospital discharge rate in 9.00±4.93 days(range:2-25 days).The side-effect of FNC is minor and transient dizziness and nausea in 16.12%(5/31)patients.Thus,FNC might cure COVID-19 through its anti-SARS-CoV-2 activity concentrated in the thymus,followed by promoted immunity.

关键词： patients inhibited concentrated

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Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis

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Current Medical Science 2020年第3期40卷 570-573页

作者： lu-lu wang Maria GSHWANDTNER Leopold ECKHART Erwin TSCHACHLER Department of Dermatology Research Division of Biology and Pathobiology of the SkinMedical University of ViennaViennaA-1090Austria Department of Pediatrics The University of Hong Kong-Shenzhen HospitalShenzhen518053China

Cerebellar degeneration-related antigen 1(CDR1)was described to be expressed in the nervous system and in different types of cancer tissues.In the present study,we demonstrate that CDR1 is in addition ubiquitously expressed in human epidermis,dermis and isolated skin cells.Both CDR1 mRNA and protein were detected in human skin-derived mast cells,melanocytes,fibroblasts and keratinocytes,suggesting that CDR1 does not have a neuron-specific function.

关键词： cerebellar degeneration-related antigen 1 skin keratinocyte mast cell

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Tri-functionalized polypropylene separator by rGO/MoO_(2) composite for high-performance lithium–sulfur batteries

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Rare Metals 2021年第10期40卷 2810-2818页

作者： Kun Xu Xin Liang lu-lu wang Yong wang Ju-Feng Yun Yi Sun Hong-Fa Xiang School of Materials Science and Engineering Engineering Research Center of High Performance Copper Alloy Materials and ProcessingMinistry of EducationHefei University of TechnologyHefei 230009China

The popularity of lithium–sulfur batteries has been increasing gradually due to their ultrahigh theoretical specific capacity and energy density. Nevertheless, they also have lots of drawbacks to be overcome, such as poor conductivity, severe volume expansion, and serious“shuttle effect”. In this work, reduced graphene oxide/molybdenum dioxide(rGO/MoO_(2)) composite is synthesized and applied to modify polypropylene separator. The modified polypropylene separator introduces synergistic tri-functions of physical adsorption, chemical interaction and catalytic effects, which can inhibit the“shuttle effect” and enhance the electrochemical performances of lithium-sulfur batteries. In the prepared r GO/MoO_(2) composite, the polar MoO_(2) chemically adsorbs the intermediate lithium polysulfide, while the rGO with good electrical conductivity not only acts as a physical barrier to prevent diffusion of polysulfide ions, but also improves the conversion efficiency of active material intercepted on the separator. As a consequence, the battery assembled with rGO/MoO_(2) modified polypropylene separator exhibits a reversible capacity of 757.5 mAh·g^(-1) after 200 cycles at0.2 C with a negligible capacity decay of 0.207% per cycle,which indicates a good long-period cycling stability. Furthermore, the rate performance and self-discharge suppression are also improved by introducing modified polypropylene separator. It shows that rGO/MoO_(2) composite is a promising material for separator modification in lithium-sulfur batteries.

关键词： rGO/MoO_(2)composite Li–S batteries Separator modification Shuttle effect

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Visualization of nasal powder distribution using biomimetic human nasal cavity model

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Acta Pharmaceutica Sinica B 2024年第1期14卷 392-404页

作者： Jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen wang Zeru Li Jianhua lu lulu wang Xiaofeng wang Jie Wu Lixin Sun Jiwen Zhang Zhigang wang Rui Yang Li Wu Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Key Laboratory of Molecular Pharmacology and Drug Evaluation School of PharmacyMinistry of EducationYantai UniversityYantai 264005China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201210China Nantong Haimen People’s Hospital Nantong 226199China Yangtze Delta Drug Advanced Research Institute Nantong 226126China Shenyang Pharmaceutical University Shenyang 110016China National Institutes for Food and Drug Control Beijing 100000China Nanjing University of Chinese Medicine Nanjing 210023China

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity.However,no reliable method is currently available to assess its impact on delivery performance.In this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal cavity.The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females.The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test.The experimental device produced the most satisfactory results with five spray times.Furthermore,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,respectively.Additionally,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo correlation.In conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

关键词： Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing Nasal drug distribution

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The health principle of TaiChi pile under fascia static pull

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TMR Non-Drug Therapy 2023年第3期6卷 16-17页

作者： Zi-Li Zhang Ye Zhao Xi Xu Zhen wang lu-lu wang Tai Chi Culture College Handan UniversityHandan 056005China Department of Public Health International CollegeKrirk UniversityBangkok 10220Thailand Tianlong TaiChi Institute Suzhou 215200China

TaiChi pile function originated from the ancient health guidance method in China.Practice has proved that it plays a good role in removing diseases and fitness,prolonging life.Fascia is an anatomical structure formed by connective tissue,one of the four tissues.It is an independent sensory organ and a tension network system running through the whole body[1].

关键词： removing originated Tai

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Synchronous diagnosis and treatment of acute myeloid leukemia and chronic lymphocytic leukemia:Two case reports

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World Journal of Clinical Cases 2021年第30期9卷 9144-9150页

作者： Rong-Rong Chen Li-Xia Zhu lu-lu wang Xue-Ying Li Jia-Nai Sun Mi-Xue Xie Jing-Jing Zhu De Zhou Jian-Hu Li Xin Huang Wan-Zhuo Xie Xiu-Jin Ye Department of Hematology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The concurrence of acute myeloid leukemia(AML)and chronic lymphocytic leukemia(CLL)is rare.Previous reports of such cases have focused mainly on clinical diagnosis and characteristics,so the mechanism remains unclear,and therapy options have been poorly explored.CASE SUMMARY Here,we report two cases of synchronous AML and CLL.Flow cytometry revealed two distinct abnormal cell populations(myeloblasts and lymphoid cells)according to scatter characteristics.CD5-positive B cell lymphoma with myeloid leukemia invasion was observed on lymph node biopsy.Chemotherapy regimens indicated for both AML and CLL were used in our patients,and our patients achieved complete response after chemotherapy.Next-generation sequencing of 88 genes was performed.CONCluSION We conclude that early mutation and dysregulation at the hematopoietic stem cell stage and the accumulation of multiple rearrangements may cause the concurrence of CLL and AML.The treatment of infection and combination therapy aimed at the CLL component are significant in the management of patients with concurrent CLL and AML.

关键词： Acute myeloid leukemia Chronic lymphocytic leukemia B-cell lymphoma-2 inhibitors Therapy Ten-eleven translocation-2 Case report

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Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin wang Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense research.Effective progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and informatics.However,individual molecular machines are only capable of producing nanometer work and generally have only a single functionality.In order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new paradigm.In this review,we comprehensively discuss recent developments in the collective behaviors of molecular machines.In particular,collective behavior is divided into two paradigms.One is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional materials.The other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale operations.We discuss design strategies for both modes and focus on the modulation of features and properties.Subsequently,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： Ying lu Se wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic environment.In this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(Flu)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond cleavage.In addition,the indirect photodegradation of Flu in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water environment.Our results provide a theoretical basis for understanding the phototransformation process of Flu in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

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Adaptive Robust Waveform Selection for Unknown Target Detection in Clutter

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Journal of Electronic Science and Technology 2014年第2期12卷 229-234页

作者： lu-lu wang Hong-Qiang wang Yu-Liang Qin Yong-Qiang Cheng the School of Electronic Science and Engineering National University of Defense Technology

A basic assumption of most recently proposed waveform design algorithms is that the target impulse response is a known deterministic function or a stochastic process with a known power spectral density （PSD）. However, it is well-known that a target impulse response is neither easily nor accurately obtained; besides it changes sharply with attitude angles. Both of the aforementioned cases complicate the waveform design process. In this paper, an adaptive robust waveform selection method for unknown target detection in clutter is proposed. The target impulse response is considered to be unknown but belongs to a known uncertainty set. An adaptive waveform library is devised by using a signal-to-clutter-plus-noise ratio （SCNR）- based optimal waveform design method. By applying the minimax robust waveform selection method, the optimal robust waveform is selected to ensure the lowest performance bound of the unknown target detection in clutter. Results show that the adaptive waveform library outperforms the predefined linear frequency modulation （LFM） waveform library on the SCNR bound.

关键词： Adaptive waveform library,clutter,minimax robust selection,target detection

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