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Mechanism of low molecular weight GTP binding protein RAC1 in injury of neural function of rats with cerebral ischemia reperfusion

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 460-464页

作者： Ya-Hong Li lu-jun qiao Xiao-Ying Lin Department of Critical Care Medicine Dongying Shengli Oil Field Central Hospital Department of Neurology Affiliated Ji'nan Central Hospital of School of Medicine Shandong University

Objective: To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion. Methods: Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group(I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766(NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde. Results: Number of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference(Plusions: The inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function.

关键词： RAC1 Cerebral ischemia reperfusion Neural function

Endoscopic intratympanic methylprednisolone injection for treatment of refractory sudden sensorineural hearing loss and one case in pregnancy

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Endoscopic intratympanic methylprednisolone injection for tr...

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

2010全国耳鼻咽喉头颈外科中青年学术会议

作者： Chen Yang Wen Li-Ting Xu Zhan Hu Peng-Gang lu Lian-jun qiao Li Qiu Jian-Hua Department of Otolaryngology Head & Neck Surgery,Xijing Hospital,Fourth Military Medical University 710032

Objective To evaluate the effectiveness of transtympanic methylprednisolone injection in patients with refractory sudden sensorineural hearing loss via endoscopic diode laser myringotomy.

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua lu jun Shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： jun Jiang Zhenjie lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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超细粉煤灰提取氧化铁的研究

砖瓦 2018年第6期 30-33页

作者：李贺军卢俏刘晓庆贵州省建材产品质量监督检验院贵州贵阳550000

采用酸溶法提取粉煤灰中Fe_2O_3。实验研究了盐酸浓度、酸溶温度、酸溶时间及料液比对粉煤灰中Fe_2O_3回收率的影响。结果表明:酸溶法可以提取粉煤灰中的Fe_2O_3,在盐酸浓度1.5mol/L、酸溶温度85℃、酸溶时间2h、料液比1:20条件下,粉煤... 详细信息

采用酸溶法提取粉煤灰中Fe_2O_3。实验研究了盐酸浓度、酸溶温度、酸溶时间及料液比对粉煤灰中Fe_2O_3回收率的影响。结果表明:酸溶法可以提取粉煤灰中的Fe_2O_3,在盐酸浓度1.5mol/L、酸溶温度85℃、酸溶时间2h、料液比1:20条件下,粉煤灰中Fe_2O_3最大回收率可达92.0%。提取的Fe_2O_3晶型为α-Fe_2O_3,平均粒径为2.790μm,晶体形貌类似于球状。

关键词：超细粉煤灰 Fe2O3

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可信环境下数据交易协同机制研究及应用

现代计算机（中旬刊） 2017年第11期 45-51页

作者：陆雯珺徐巧云李超上海计算机软件技术开发中心上海201112

大数据时代数据交易流通成为价值变现的重要手段,传统的数据交易模式存在数据造假、数据截留等弊端,而区块链技术的出现解决这些问题,打造了可信的数据交易环境。基于区块链的数据交易平台在性能、效率上与实际要求存在一定差距,因此从... 详细信息

大数据时代数据交易流通成为价值变现的重要手段,传统的数据交易模式存在数据造假、数据截留等弊端,而区块链技术的出现解决这些问题,打造了可信的数据交易环境。基于区块链的数据交易平台在性能、效率上与实际要求存在一定差距,因此从协同角度出发,提出可信环境下数据交易的协同机制,优化数据交易流程和共识过程,并在此基础上设计协同机制下可信数据交易平台架构,为可信环境下数据交易平台的设计研发提供一种参考思路和方法。

关键词：区块链可信数据交易协同机制平台架构

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka lu Ju-Song Yang Fu-Min Zhang Ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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5-脂氧合酶及其相关产物与心脑血管损伤的研究进展

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中国药理学通报 2025年第1期41卷 13-18页

作者：黄林露彭军中南大学湘雅药学院药理学系湖南长沙410013

5-脂氧合酶(5-lipoxygenase,5-LOX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LOX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密... 详细信息

5-脂氧合酶(5-lipoxygenase,5-LOX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LOX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密切相关。靶向抑制5-LOX及其相关产物级联反应中的酶和受体能够对心脑血管损伤起到保护作用,表明5-LOX及其相关产物可能是治疗心脑血管疾病潜在的靶点。已有的相关抑制剂包括5-LOX/5-LOX激活蛋白抑制剂、白三烯A4水解酶/白三烯C4合成酶抑制剂、白三烯受体拮抗剂,这些抑制剂通过不同的机制减轻炎症,抑制促炎介质白三烯的产生,促进抗炎脂质介质的形成,在心肌缺血/再灌注损伤和动脉粥样硬化的治疗中显示出了潜在的价值。该文综述了5-LOX及其相关产物在心脑血管疾病中的作用,同时总结了相关抑制剂在心脑血管应用中的研究进展。

关键词： 5-脂氧合酶心肌缺血/再灌注心肌梗死缺血性脑损伤动脉粥样硬化 5-脂氧合酶抑制剂

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手机屏蔽膜对电磁辐射的影响

电光系统 2017年第2期 47-51页

作者：吴禄军李乔姚卓民张苏南中国电子科技集团公司第二十七研究所郑州450047

基于手机等效模型，给出了手机电磁波辐射原理。通过改变屏蔽膜在手机内部的不同放置位置对电磁辐射的影响试验，得出了手机屏蔽膜对手机电磁辐射影响的一些结论：在不影响正常通话的前提下，手机屏蔽膜能较大程度地降低手机对人体的电... 详细信息

基于手机等效模型，给出了手机电磁波辐射原理。通过改变屏蔽膜在手机内部的不同放置位置对电磁辐射的影响试验，得出了手机屏蔽膜对手机电磁辐射影响的一些结论：在不影响正常通话的前提下，手机屏蔽膜能较大程度地降低手机对人体的电磁辐射。

关键词：手机等效模型电磁辐射屏蔽膜