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Primary Research of Immunological Mechanism of Combined Hepatitis A-Measles-Varicella Vaccine

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Chemical Research in Chinese Universities 2011年第1期27卷 83-86页

作者： LI Ying-hua GUAN Feng ZHANG Xi-zhen zhao Hong-guang LIU Jing-ye LINT Cheng-he WANG Peng-fu The First Hospital of Jilin University Changchun 130021 P R. China College of Life Science Jilin University Changchun 130012 P R. China Changchun Institute of Biological Products Changchun 130062 P. R. China

To explore the primary humoral and cellular immunological mechanism of the combined hepatitis A-measles-varicella vaccine, the mice were inoculated with hepatitis A-measles-varicella vaccine by intraperitoneally and two weeks later, blood was collected to observe the mice＇s immunological status. Antibody level was measured to appraise the humoral immunity. At the same time, T lymphocyte surface marker, NK cell activity, LAK cell activity, delayed type hypersensitivity of skin, Mφ phagocytic function, mRNA level of cytokine IL-2 and IFN-γ plus lymphocyte transformation test were used to analyze the cellular immunity. The humoral immunity results show that the combined hepatitis A-measles-varicella vaccine produce the same antibody level as their corresponding univalent vaccine, and maintained fine immunogenicity and security. The result of cellular immunity shows that the combined vaccine could activate physical immunocyte, increase the regulative ability of cytokine, enhance the physical immune function and immune defense ability. The present research proved the security and better humoral and cellular immunity of combined hepatitis A-measles-varicella vaccine from the immunological point of view, which laid good foundation for further study and development.

关键词： Combined hepatitis A-measles-varicella vaccine Humoral immunity Cellular immunity

A New Chromone Glycoside from Cassia siamea Lam.

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Chinese Chemical Letters 2001年第8期12卷 703-704页

作者： Tai Sheng lu Yang hua YI Shi Long MAO Da Zheng ZHOU Qiang Zhi XU Hai Feng TANG Shu Yu ZHANG Center of Marine Drug Research School of PharmacySecond Military Medical UniversityShanghai 200433

2-methyl-5-propyl-7, 12-dihydroxy chromone-12-O-β-D-glucopyranoside was isolated from the stem of Cassia siamea. The structure was elucidated by chemical and spectral evidences.

关键词： Cassia siamea 2-methyl-5-propyl-7 12-dihydroxy-chromone-12-O-β-D-glucopyrano-side

Layer-by-layer epitaxy of multi-layer MoS2 wafers

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National Science Review 2022年第6期9卷 153-162页

作者： Qinqin Wang Jian Tang Xiaomei Li Jinpeng Tian Jing Liang Na Li Depeng Ji Lede Xian Yutuo Guo lu Li Qinghua Zhang Yanbang Chu Zheng Wei Yanchong zhao luojun Du hua Yu Xuedong Bai Lin Gu Kaihui Liu Wei Yang Rong Yang Dongxia Shi Guangyu Zhang Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Collaborative Innovation Center of Quantum Matter and School of Physics Peking University Songshan Lake Materials Laboratory

The 2D semiconductor of MoS2has great potential for advanced electronics technologies beyond *** far, high-quality monolayer MoS2wafers have been available and various demonstrations from individual transistors to integrated circuits have also been shown. In addition to the monolayer, multilayers have narrower band gaps but improved carrier mobilities and current capacities over the ***, achieving high-quality multi-layer MoS2wafers remains a challenge. Here we report the growth of high-quality multi-layer Mo S2 4-inch wafers via the layer-by-layer epitaxy process. The epitaxy leads to well-defined stacking orders between adjacent epitaxial layers and offers a delicate control of layer numbers up to six. Systematic evaluations on the atomic structures and electronic properties were carried out for achieved wafers with different layer numbers. Significant improvements in device performances were found in thicker-layer field-effect transistors(FETs), as expected. For example, the average field-effect mobility(μFE) at room temperature(RT) can increase from ～80 cm~2·V-1·s-1for monolayers to ～110/145 cm~2·V-1·-1for bilayer/trilayer devices. The highest RT μFEof 234.7 cm~2·V-1·s-1and record-high on-current densities of 1.70 m A·μm-1at Vds= 2V were also achieved in trilayer MoS2FETs with a high on/off ratio of >107. Our work hence moves a step closer to practical applications of 2D MoS2in electronics.

关键词： 2D semiconductor multilayer MoS_2 wafer layer-by-layer epitaxy high performance transistors thin film transistors

DIP-MOEA:a double-grid interactive preference based multi-ob jective evolutionary algorithm for formalizing preferences of decision makers

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Frontiers of Information Technology & Electronic Engineering 2022年第11期23卷 1714-1732页

作者： luda zhao Bin WANG Xiaoping JIANG Yicheng lu Yihua HU College of Electronic Engineering National University of Defense TechnologyHefei 230037China Third Interdisciplinary Center National University of Defense TechnologyHefei 230037China Unit 78092 of People's Liberation Army of China Chengdu 610000China

The final solution set given by almost all existing preference-based multi-objective evolutionary algorithms(MOEAs)lies a certain distance away from the decision makers’preference information ***,we propose a multi-ob jective optimization algorithm,referred to as the double-grid interactive preference based MOEA(DIPMOEA),which explicitly takes the preferences of decision makers(DMs)into ***,according to the optimization ob jective of the practical multi-ob jective optimization problems and the preferences of DMs,the membership functions are mapped to generate a decision preference grid and a preference error ***,we put forward two dominant modes of population,preference degree dominance and preference error dominance,and use this advantageous scheme to update the population in these two ***,the populations in these two grids are combined with the DMs’preference interaction information,and the preference multi-ob jective optimization interaction is *** verify the performance of DIP-MOEA,we test it on two kinds of problems,i.e.,the basic DTLZ series functions and the multi-ob jective knapsack problems,and compare it with several different popular preference-based *** results show that DIP-MOEA expresses the preference information of DMs well and provides a solution set that meets the preferences of DMs,quickly provides the test results,and has better performance in the distribution of the Pareto front solution set.

关键词： Multi-objective evolutionary algorithm(MOEA) Formalizing preference of decision makers Population renewal strategy Preference interaction

A Molecularly Imprinted Polymer Sensor Based on the Electropolymerization of p-Aminothiophenol-Functionalized Au Nanoparticles Electrode for the Detection of Nonylphenol

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Biomedical and Environmental Sciences 2020年第11期33卷 887-891页

作者： KOU Jing lu Li Li FAN zhao Yu HAN Yi Qun ZHOU Run Zhe XIA Ying zhao LYU Fang Zhi ZHANG Xiu Jaffrezic-Renault NICOLE GUO Zhen Zhong Hubei Province Key Laboratory of Occupational Hazard Identification and Control Medical CollegeWuhan University of Science and TechnologyWuhan 430065P.R.China New Medicine Innovation and Development Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlMedical CollegeWuhan University of Science and TechnologyWuhan430065PR China School of Public Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuahn430030PR China University of Lyon Institute of Analytical SciencesUMR-CNRS 52805La Doua StreetVilleurbanne 69100Frane

Endocrine disruptors(EDCs),also known as Environmental Hormones(EHs),refer to substances in the environment that interfere with the endocrine systems of humans and *** substances can lead to genital disorders in humans and animals[1].Nonylphenol(Nph)is a kind of relatively distributed substance of *** is the metabolite of nonylphenol polyethoxy and an important fine chemical,raw material,and intermedium[2]。

关键词： phenol Molecular polymerization

Smoking, smoking cessation, and survival after cancer diagnosis in 128,423 patients across cancer types

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Cancer Communications 2022年第12期42卷 1421-1424页

作者： huakang Tu Yuanqing Ye Maosheng huang Kunlin Xie Wong-Ho Chow hua zhao Xifeng Wu Department of Big Data in Health Science School of Public Health Center of Clinical Big Data and Analytics of The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058P.R.China Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province HangzhouZhejiang 310058P.R.China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan UniversityChengduSichuan 610041P.R.China Department of Family Medicine and Population Health Virginia Commonwealth UniversityRichmondVA 23284USA Cancer Center Zhejiang UniversityHangzhouZhejiang 310058P.R.China

Dear Editor,Given the systemic and substantial health consequences of smoking and the significant cancer risk from smoking[1,2],it is expected that cancer patients would quit smoking after cancer ***,the smoking rate among cancer survivors is only slightly lower than that among the general population[3,4],and 64%of smokers diagnosed with cancer continued to smoke even after they learned they had cancer[5].In addition,some former smokers may resume smoking after surviving cancer[6].A number of previous studies have investigated the association between smoking and clinical outcomes in cancer patients[1,7–10].Nevertheless,most studies were conducted in smoking-related cancers,and evidence for non-smoking-related cancers is *** is an urgent need for more convincing evidence showing the harms of smoking and the benefits of smoking cessation to promote smoking cessation in cancer patients and *** systematically studied the associations of smoking status,smoking intensity,age at initiation,and smoking cessation at cancer diagnosis with all-cause mortality in a prospective cohort of 128,423 cancer patients across 23 cancer types from the MD Anderson Cancer Patients and Survivors Cohort.

关键词： diagnosis patients smoke

Effect of the distance between focusing lens and target surface on quantitative analysis of Mn element in aluminum alloys by using filament-induced breakdown spectroscopy

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Chinese Physics B 2020年第12期29卷 276-280页

作者： Xue-Tong lu Shang-Yong zhao Xun Gao Kai-Min Guo Jing-Quan Lin School of Science Changchun University of Science and TechnologyChangchun 130012China School of Physical Science and Technology Baotou Teachers'CollegeBaotou 014030China

Ultrafast laser filament-induced breakdown spectroscopy(FIBS)is a potential technique for quantitative analysis of trace *** this work,we investigate the effect of the distance between focusing lens and target surface on the FIBS quantitative analysis of Mn element in aluminum alloys,and several major parameters are calculated such as the linear correlation coefficient(R^2),limits of detection(LOD),relative standard deviation(RSD),and root-mean-square error of cross-validations(RMSECV).The results show that the quantitative analysis parameter values before and after filament position are *** optimal value can be obtained at the filament region,the average values of total 23 positions of R^2,LOD,RSD,and RMAECV were 99.45%,1.41 mg/kg,7.12%,and 0.56%,***,the spatial distributions of quantitative analysis parameter values in filament region are noticeable,and this is essentially due to intensity clamping effect in a filament.

关键词： filament-induced breakdown spectroscopy limits of detection relative standard deviation root-mean-square error of cross-validations

面向新时代地方高校师范生培养的“遥感概论”教学内容与方法创新

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南阳师范学院学报 2025年第1期24卷 78-82页

作者：戚鹏程赵菲菲鲁丰先张淼张杰云崔艳南阳师范学院地理科学与旅游学院河南南阳473061 南阳师范学院生命科学学院河南南阳473061

面向新时代背景下高素质专业化中学地理教师的培养需求,探讨了地理科学专业“遥感概论”课程的教学内容与方法创新。抽样调查了当前国内地理科学专业“遥感概论”课程的开设情况。从对中学地理教学的支持、师范生的学习困难和课程思政... 详细信息

面向新时代背景下高素质专业化中学地理教师的培养需求,探讨了地理科学专业“遥感概论”课程的教学内容与方法创新。抽样调查了当前国内地理科学专业“遥感概论”课程的开设情况。从对中学地理教学的支持、师范生的学习困难和课程思政三个方面分析了开展教学创新的必要性。针对课程存在的问题,提出了一系列创新策略,包括重构课程目标和内容以加强对中学地理教学的支撑,采用直观教学法以提升教学效率以及课程思政的科学建设与合理融入等。

关键词：地理科学专业师范生培养 “遥感概论”

Band structures of TiO_2 doped with N, C and B

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第4期7卷 299-303页

作者： XU Tian-hua SONG Chen-lu LIU Yong HAN Gao-rong Department of Materials Science and Engineering Zhejiang University Hangzhou 310027 China

This study on the band structures and charge densities of nitrogen (N)-, carbon (C)- and boron (B)-doped titanium dioxide (TiO2) by first-principles simulation with the CASTEP code (Segall et al., 2002) showed that the three 2p bands of im-purity atom are located above the valence-band maximum and below the Ti 3d bands, and that along with the decreasing of im-purity atomic number, the fluctuations become more intensive. We cannot observe obvious band-gap narrowing in our result. Therefore, the cause of absorption in visible light might be the isolated impurity atom 2p states in band-gap rather than the band-gap narrowing.

关键词： CASTEP code Titanium dioxide Band structure Charge density