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Chinese Herbal Medicines 2025年第1期17卷 156-165页

作者： Lina Sun Cuiling zuo Baonan Ma Xinxin Liu Yifei Guo Xiangtao Wang Meihua Han Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Research Center of Pharmaceutical Engineering Technology Harbin University of Commerce

Objective:In order to enhance the efficacy of anti-breast cancer,paclitaxel nanoparticles（PTX NPs） and polypyrrole nanoparticles（PPy NPs） were combined with photothermal therapy and *** the same time,the two dosage forms of PTX NPs and PTX NPs gel were ***:PTX NPs were prepared by self-assembly method,and then the cytotoxicity in vitro was investigated by Methyl thiazolyl tetrazolium（MTT） and other methods,and the efficacy and side effects in vivo were further ***:The average hydrated diameter,PDI and electric potential of PTX NPs were（210.20±1.57） nm,（0.081±0.003） mV and（15.80±0.35） mV,*** results showed that the IC50value of PTX NPs on 4 T1 cells was 0.490 μg/mL,while that of PTX injection was 1.737 μg/*** cell inhibitory effect of PTX NPs was about 3.5 times higher than that of PTX *** tumor inhibition rates of PTX NPs and gel were 48.64% and 56.79%,*** with local photothermal stimulation,the tumor inhibition rate of the PTX NPs reached 91.05%,surpassing that of the gel under the same conditions（48.98%）,moreover,the organ index and H&E staining results of PTX NPs showed a decrease in ***:This combination therapy can significantly enhance the effect of anti-breast cancer,and the synergistic effect of chemotherapy and light and heat provides a feasible and effective strategy for the treatment of tumor.

关键词： breast cancer combination therapy paclitaxel photothermal therapy polypyrrole

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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身处江湖而心系台阁——杨维桢复杂心态新探

华南师范大学学报(社会科学版) 2025年第1期 5-19,205页

作者：左东岭首都师范大学中国诗歌研究中心北京100048

杨维桢一生尽管居官之时少而隐居之时多,但其人生理想却始终是渴望进入朝廷台阁而名垂不朽。在隐居杭州与平江之时,尽管在与江南文人的诗酒唱和中养成风流潇洒的才子风度与追求享乐自适的人生观念,但屡次求人举荐复官的行为与《三史正... 详细信息

杨维桢一生尽管居官之时少而隐居之时多,但其人生理想却始终是渴望进入朝廷台阁而名垂不朽。在隐居杭州与平江之时,尽管在与江南文人的诗酒唱和中养成风流潇洒的才子风度与追求享乐自适的人生观念,但屡次求人举荐复官的行为与《三史正统辩》的撰写,显示出他稳定而强烈的台阁情结;在隐居松江时期,尽管多与隐逸之士来往并自称“风月福人”,但通过与张士诚政权中诸多官员的密切交际及鼓励弟子出仕张吴的行为,说明他更愿意乐在廊庙台阁,其乐在山林江湖则是进取无望之后的无奈选择;在入明之后,他表面上依然表示坚守自我的隐逸之志,但通过对其《送检校王君盖昌还京序》《赠术士曹仲修序》等重要文献的考察,可以看到他渴望进入新朝台阁以完成制礼作乐、修史补经的强烈愿望。杨维桢的一生,无论在山水漫游、诗酒雅集的人生享乐中沦陷有多深,也无论具有多么怪异出格的行为与神出鬼没的笔调,他心中始终都没有放弃儒者的责任与进入台阁以承担传道修史的理想,心系台阁是其最为稳固的心理情结。

关键词：漫游江湖享乐意识台阁情结传道修史

Nd_(2)Fe_(14)B/PrCo_(5)纳米双相快淬带的磁性能与相互作用

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金属热处理 2025年第1期50卷 42-46页

作者：薄宇左建华王浩鲁伟内蒙古科技大学理学院内蒙古包头014010 内蒙古自治区高性能稀土永磁材料重点实验室内蒙古包头014010

采用感应熔炼和熔体快淬法制备Nd_(2)Fe_(14)B/PrCo_(5)纳米双相快淬带,研究了PrCo_(5)含量对快淬带相结构、磁性能和交换耦合作用的影响。XRD测试结果表明,快淬带具有Nd_(2)Fe_(14)B和PrCo_(5)双硬磁相,并且在制备过程中并未氧化和产... 详细信息

采用感应熔炼和熔体快淬法制备Nd_(2)Fe_(14)B/PrCo_(5)纳米双相快淬带,研究了PrCo_(5)含量对快淬带相结构、磁性能和交换耦合作用的影响。XRD测试结果表明,快淬带具有Nd_(2)Fe_(14)B和PrCo_(5)双硬磁相,并且在制备过程中并未氧化和产生新相。PrCo_(5)含量对磁性能影响明显,适量添加PrCo_(5)有助于提升矫顽力,但剩磁、最大磁能积随PrCo_(5)含量的增加而降低。回复曲线研究表明,回复曲线的“开口”现象与PrCo_(5)含量有关;δ_(M)曲线测试表明Nd_(2)Fe_(14)B/PrCo_(5)快淬带存在强烈的交换耦合作用。综合分析,PrCo_(5)含量为12%时Nd_(2)Fe_(14)B/PrCo_(5)纳米双相快淬带获得最优磁性能,剩磁M_(r)=8.73 kGs,矫顽力H_(cj)=11.03 kOe,最大磁能积(BH)_(Max)=15.83 MGOe。

关键词：纳米双相 Nd_(2)Fe_(14)B/PrCo_(5)快淬带磁性能交换耦合

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吸引资产权的属性、结构与实践路径

旅游学刊 2025年第1期40卷 14-29页

作者：左冰中山大学旅游学院广东珠海519082

文章突破西方主流理论关于财产属性的公/私二元分野,基于吸引资产的集合性、协同性和价值弱可分割性的特征,论证了吸引资产的“俱乐部”产品性质,阐明了吸引资产权作为用益物权的共有产权属性。文章进而结合乡村旅游发展背景,在区分吸... 详细信息

文章突破西方主流理论关于财产属性的公/私二元分野,基于吸引资产的集合性、协同性和价值弱可分割性的特征,论证了吸引资产的“俱乐部”产品性质,阐明了吸引资产权作为用益物权的共有产权属性。文章进而结合乡村旅游发展背景,在区分吸引资产系统和吸引资产单元的基础上,刻画出公权性与私权性吸引资产的结构性嵌套关系,并提出了管理跨边界、跨尺度吸引资产系统的原则性方法。文章建议基于中央深化农村土地改革的“三权分置”精神,构建“吸引资产权(集体地权)+(成员)不动产股权+(个体)不动产经营收益”的权利结构体系,推进农村“三变”改革。这一方案不仅能够最大程度地坚持集体土地所有制本质,妥善平衡公私关系,实现维护人民福祉与保障财产权利的有效结合,亦可为国家在文化和旅游相关的商业和经济领域创造出新的资本形式。文章丰富了公共资源管理理论,从发展旅游的角度提供了对土地以及地上物的价值的新认识和对其权益属性的新理解,为基于中国独特的土地所有权制度创新吸引资产权的实践形式提供了思路。

关键词：吸引资产权用益物权俱乐部产品集体土地所有制嵌套产权三权分置

Topological states constructed by two different trivial quantum wires

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Chinese Physics B 2025年第1期34卷 246-255页

作者： Jing-Run Lin Linxi Lv Zheng-Wei zuo School of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023China

The topological states of the two-leg and three-leg ladders formed by two trivial quantum wires with different lattice constants are theoretically investigated. Firstly, we take two trivial quantum wires with a lattice constant ratio of 1:2 as an example. For the symmetric nearest-neighbor intra-chain hopping two-leg ladder, the inversion symmetry protected topological insulator phase with two degenerate topological edge states appears. When the inversion symmetry is broken, the topological insulators with one or two topological edge states of different energies and topological metals with edge states embedded in the bulk states could emerge depending on the filling factor. The topological origin of these topological states in the two-leg ladders is the topological properties of the Chern insulators and Chern metals. According to the arrangement of two trivial quantum wires, we construct two types of three-leg ladders. Each type of the three-leg ladder could be divided into one trivial subspace and one topological nontrivial subspace by unitary transformation. The topological nontrivial subspace corresponds to the effective two-leg ladder model. As the filling factor changes, the system could be in topological insulators or topological metals phases. When the two-leg ladder is constructed by two trivial quantum wires with a lattice constant ratio of 1:3 and 2:3, the system could also realize rich topological states such as the topological insulators and topological metals with the topological edge states. These rich topological states in the two-leg and three-leg ladders could be confirmed by current experimental techniques.

关键词： trivial quantum wire topological invariant inversion symmetric topological insulator Chern metal

Achieving ultralow leakage current in Schottky-MIS cascode anode lateral field-effect diode based on AlGaN/GaN HEMT

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Science China(Information Sciences) 2025年第1期68卷 379-385页

作者： Fangzhou WANG Changhong GAO Guojian DING Cheng YU Zhuocheng WANG Xiaohui WANG Qi FENG Ping YU Peng zuo Wanjun CHEN Yang WANG Haiqiang JIA Hong CHEN Bo ZHANG Zeheng WANG Songshan Lake Materials Laboratory School of Microelectronics Southern University of Science and Technology State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Manufacturing Commonwealth Scientific and Industrial Research Organisation

In this paper,we design and fabricate a Schottky-metal-insulator-semiconductor（MIS） cascode anode GaN lateral field-effect diode（CA-LFED） to achieve ultralow reverse leakage current(ILEAK).The device based on AlGaN/GaN highelectron-mobility-transistor（HEMT） includes a normally-off MIS-controlled channel that is cascoded with a high barrier height Schottky *** reverse bias,the high electric-field is effectively prevented by the normally-off MIS-controlled channel *** with the high barrier height Schottky contact,this feature significantly suppresses the *** by the device fabrication,the CA-LFED with high breakdown voltage（BV）>600 V shows an ultralow ILEAKof 3.6×10-9A/mm as well as a low forward voltage drop（VF） of 2.2 *** performance suggests that the CA-LFED can be a promising candidate for ultralow ILEAKand better VF-ILEAKtrade-off GaN power diode applications.

关键词： Schottky-MIS cascode anode lateral field-effect diode (LFED) ultralow reverse leakage current ($I_{\rm{LEAK}}$) forward drop and reverse leakage trade-off AlGaN/GaN HEMTs

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3D打印反刍仿生结构对餐厨垃圾厌氧发酵产甲烷性能的影响

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太原理工大学学报 2025年第1期56卷 54-61页

作者：左欢孙辰浙江理工大学化学与化工学院浙江杭州嘉兴大学生物与化学工程学院浙江嘉兴

【目的】随着社会经济发展,城市固体废弃物中餐厨垃圾占比增加。通过厌氧发酵制取生物甲烷是餐厨垃圾能源化利用的关键技术之一。针对厌氧发酵反应器长期运行不稳定、抗外界扰动能力较弱的问题,利用3D打印技术和柔性硅胶材料制作反刍仿... 详细信息

【目的】随着社会经济发展,城市固体废弃物中餐厨垃圾占比增加。通过厌氧发酵制取生物甲烷是餐厨垃圾能源化利用的关键技术之一。针对厌氧发酵反应器长期运行不稳定、抗外界扰动能力较弱的问题,利用3D打印技术和柔性硅胶材料制作反刍仿生部件,并将其应用于连续搅拌罐式反应器中,以期改善反应器的运行性能。【方法】根据反应器中是否添加仿生部件设置实验组(Ruminant)和对照组(Control),通过调节有机负荷和试验温度等参数,探究仿生部件增强厌氧发酵产甲烷量及稳定性的影响作用。【结果】实验结果表明,在45℃的温度扰动中,仿生部件有效稳定了微生物群落结构,从而保证了反应器运行的稳定性。Ruminant组没有积累丁酸,pH维持在6.7~7.6,Ruminant组比CH4产量最高为217 mL·g^(-1)·L^(-1)·d^(-1),比Control组高39%。

关键词：仿生部件厌氧发酵温度扰动甲烷生成 3D打印

Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

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Science China Earth Sciences 2025年第1期68卷 11-26页

作者： Man-Hei NG Xiaoping ZHANG Jianwu CHEN Yongqiang SHI Fuchang zuo Wenxi PENG Weichun FU Liansheng LI Pengwei luO Chi-Long TANG Guozheng ZHANG Zhiwu MEI Li WANG Cunhui LI Jiaming OU Yanyan Xu State Key Laboratory of lunar and Planetary Sciences Macao University of Science and TechnologyMacao999078China Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control EngineeringBeijing100190China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of PhysicsLanzhou730000China China National Space Administration(CNSA) Macao Center for Space Exploration and ScienceMacao999078China

The Solar X-ray Detector(SXD)on-board the Macao Science Satellite-1B(MSS-1B)was successfully launched via the Chinese Long March-2C rocket on 21 May 2023,and commenced operations in early June of the same *** MSS-1B/Soft X-ray Detection Units(SXDUs)employ two silicon drift detectors(SDDs),providing a wide range of energy spectra spanning from 0.7 to 24 ***,the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 ***,we perform thorough calibrations of the MSS-1B/SXDUs,employing a combination of ground experiments and *** addition,quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES),provides compelling evidence of their ***,the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs,unlocking their potential for facilitating the study of dynamic evolution of solar ***,the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays,thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B(MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

Impact of 1064nm continuous laser irradiation on the image quality of CCD image sensors

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Optoelectronics Letters 2025年

作者： ZHANG Cuiheng zuo Minghui NIE Pin ZHU Xiaoyong WANG Di Jilin Key Laboratory of Solid-State Laser Technology and Application， School of Physics， Changchun University of Science and Technology

Charge-coupled device (CCD) is widely used in various fields due to its high sensitivity， low power consumption， and high quantum efficiency. However， strong laser irradiation can cause permanent damage to CCD image sensors， thereby affecting the quality of the images. In order to thoroughly investigate the impact of lasers on the image quality of CCD image sensors， this paper employs objective image quality assessment methods to study the damage effects of 1064 nm continuous lasers on CCD image sensors at different power densities. Through a comprehensive analysis of grayscale distribution histograms， PSNR (peak signal-to-noise ratio)， and SSIM (structural similarity index measure)， the variations in image quality with increasing power density are revealed. The research results indicate that at low power density levels， the image quality decreases slowly; however， once the power density reaches a threshold， the image quality rapidly declines. When the image quality is severely damaged， the frequency of the main grayscale value drops to 0， and the degree of image damage saturates. Additionally， with the increase in power density， the dynamic range of the image first expands and then shrinks， eventually shifting towards the low grayscale value range.

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