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Combination strategies for first-line treatment of patients with unresectable hepatocellular carcinoma:prospect of natural products

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Chinese Journal of Natural Medicines 2024年第1期22卷 1-3页

作者： zhang Lele lu Jinjian School of Basic Medical Sciences Chengdu UniversityChengdu 610106China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao 999078China

Liver cancer stands as a significant global health concern,contributing substantially to cancer incidence and mortality,particularly in Asian countries[1].Hepatocellular carcinoma(HCC)accounts for approximately 90%of all liver cancer cases and is characterized by a high-risk profile and a generally poor prognosis[2].To address advanced HCC,systemic therapy has been recommended,leading to the approval of a range of treatment regimens in clinical ***,first-line therapy involved the use of multitargeted tyrosine kinase inhibitors(TKIs)such as sorafenib or lenvatinib,while cabozantinib,ramucirumab.

关键词： Unresectable hepatocellular carcinoma Combination strategies Immunotherapy PD-1/PD-L1 Natural products

A novel graph oversampling framework for node classification in class-imbalanced graphs

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Science China(Information Sciences) 2024年第6期67卷 214-229页

作者： Riting XIA Chunxu zhang yan zhang Xueyan LIU Bo yanG Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University College of Artificial Intelligence Jilin University College of Computer Science and Technology Jilin University College of Communication Engineering Jilin University

Graph neural network(GNN) is a promising method to analyze graphs. Most existing GNNs adopt the class-balanced assumption, which cannot deal with class-imbalanced graphs well. The oversampling technique is effective in alleviating class-imbalanced problems. However, most graph oversampling methods generate synthetic minority nodes and their edges after applying GNNs. They ignore the problem that the representations of the original and synthetic minority nodes are dominated by majority nodes caused by aggregating neighbor information through GNN before oversampling. In this paper, we propose a novel graph oversampling framework, termed distribution alignment-based oversampling for node classification in classimbalanced graphs(named Graph-DAO). Our framework generates synthetic minority nodes before GNN to avoid the dominance of majority nodes caused by message passing in GNNs. Additionally, we introduce a distribution alignment method based on the sum-product network to learn more information about minority nodes. To our best knowledge, it is the first to use the sum-product network to solve the class-imbalanced problem in node classification. A large number of experiments on four real datasets show that our method achieves the optimal results on the node classification task for class-imbalanced graphs.

关键词： graph neural network class-imbalanced graphs sum-product network oversampling node classification

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The structure-directing role of heterologous seeds in the synthesis of zeolite

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Green Energy & Environment 2024年第5期9卷 792-801页

作者： Haoyang zhang Binyu Wang Wenfu yan State Key Laboratory of Inorganic Synthesis&Preparative Chemistry College of ChemistryJilin UniversityChangchun130012China

Zeolites have been widely used as catalysts,ion-exchangers,and adsorbents in chemical industries,detergent industry,steel industry,glass industry,ceramic industry,medical and healthﬁeld,and environmentalﬁeld,and recently applied in energy ***-assisted synthesis is a very effective approach in promoting the crystallization of *** some cases,the target zeolite cannot be formed in the absence of seed *** homologous seed-assisted synthesis,the structure of the seed zeolite is the same to that of the target zeolite,while the structure of the seed zeolite is different to that of the target zeolite in the heterologous seed-assisted *** this review,we brieﬂy summarized the heterologous seed-assisted syntheses of zeolites and analyzed the structure-directing effect of heterologous seeds and surveyed the“common composite building units(CBUs)hypothesis”and the“common secondary building units(SBUs)hypothesis”.However,both hypotheses cannot explain all observations on the heterologous seed-assisted ***,we proposed that the formation of the target zeolite does need nuclei with the structure of target zeolite and the formation of the nuclei of the target zeolite can be promoted by either the undissolved seed crystals with the same CBUs or SBUs to the target zeolite or by the facilitated appropriate distribution of the speciﬁc building units due to the presence of the heterologous seed that does not have any common CBUs and SBUs with the target zeolite.

关键词： Zeolite Heterologous seed Synthesis Structure-directing effect

Impact of climate and human activity on NDVI of various vegetation types in the Three-River Source Region, China

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Journal of Arid Land 2024年第8期16卷 1080-1097页

作者： lu Qing KANG Haili zhang Fuqing XIA Yuanping yan Bing Research Center of Resource and Environment Economics East China University of TechnologyNanchang 330013China Jiangxi Key Laboratory of Watershed Ecological Process and Information East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China Nanchang Key Laboratory of Landscape Process and Territorial Spatial Ecological Restoration East China University of TechnologyNanchang 330013China Institute of Energy Research Jiangxi Academy of SciencesNanchang 330096China

The Three-River Source Region(TRSR)in China holds a vital position and exhibits an irreplaceable strategic importance in ecological preservation at the national *** the basis of an in-depth study of the vegetation evolution in the TRSR from 2000 to 2022,we conducted a detailed analysis of the feedback mechanism of vegetation growth to climate change and human activity for different vegetation *** the growing season,the spatiotemporal variations of normalized difference vegetation index(NDVI)for different vegetation types in the TRSR were analyzed using the Moderate Resolution Imaging Spectroradiometer(MODIS)-NDVI data and meteorological data from 2000 to *** addition,the response characteristics of vegetation to temperature,precipitation,and human activity were assessed using trend analysis,partial correlation analysis,and residual *** indicated that,after in-depth research,from 2000 to 2022,the TRSR's average NDVI during the growing season was *** preliminary ranking of the average NDVI for different vegetation types was as follows:shrubland(0.5762)>forest(0.5443)>meadow(0.4219)>highland vegetation(0.2223)>steppe(0.2159).The NDVI during the growing season exhibited a fluctuating growth trend,with an average growth rate of 0.0018/10a(Pluctuations.A further detailed analysis revealed that climate change had a significant positive impact on the TRSR from 2000 to 2022,particularly in its

关键词： growing season normalized difference vegetation index(NDVI) highland vegetation trend analysis partial correlation analysis residual analysis contribution rate

Glacial-interglacial cycles recorded in clay minerals from the eastern Tibetan Plateau over the last 800 ka and their indications

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Science China Earth Sciences 2024年第7期67卷 2162-2177页

作者： Xiaoyan zhang Chunxia zhang yan ZHAO Bin HU Zhengtang GUO Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Clay mineral proxies have been widely used to reconstruct changes in provenance and the ***,high-altitude clay mineral indications and long-term and orbital variations have not been fully ***,we present an800-ka clay-mineral record from a lacustrine sediment core(ZB13-C2)from the Zoige Basin on the eastern Tibetan Plateau(TP).X-ray diffraction and scanning electron microscopy were used to identify the clay mineral assemblages and their micromorphological characteristics of core *** results revealed that the clay minerals in core ZB13-C2 are mainly illite,with small amounts of chlorite,kaolinite,and smectite(including irregular mixed-layers of illite-smectite(I/S)and chloritesmectite(C/S)).The clay mineral assemblages and proxies exhibit three stages of change,which are mainly controlled by the Zoige watershed range under different climate *** watershed was limited to the southeastern region with altitudes ranging from~3500 to~4200 meters above sea level(m a.s.l.),and glacial-interglacial hydraulic erosion controlled the input of bedrock debris during 800-621 ka *** expanded to higher altitudes(~4200 to~4700 m a.s.l.)due to stronger seasonal freezethaw weathering without significant glacial-interglacial variations under a cooling and drying climate during 621-100 ka ***,it expanded to its highest altitudes of~4700 to~5200 m *** of the watershed after 100 ka BP,and hydraulic erosion increased obviously under a warm climate of the interstadial MIS 3 on the *** watershed underwent two major expansions under different climatic conditions at~621 ka and 100 ka BP,with the wet/dry alternation became strong at~621 ka *** results reveal that long-term temperature changes and the wet/dry alternation at high altitudes controlled the watershed range and degree of the physical erosion,and that the indications of clay minerals should be carefully clarified before they are used as climate indicators,especi

关键词： Quaternary Zoige Basin Lacustrine sediments Paleoenvironment Weathering

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Multi-blade rubbing characteristics of the shaft-disk-blade-casing system with large rotation

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 111-136页

作者： Zhiyuan WU Linchuan ZHAO Han yan Ge yan Ao CHEN Wenming zhang State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Aerospace Systems Engineering Shanghai 201108China

Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.

关键词： shaft-disk-blade-casing(SDBC) large rotation spin and whirl multi-blade rubbing rotational effect

Combination of Nitrogen-Rich Skeleton and Coordination Group:Synthesis of a High-Energy Primary Explosive Based on 1H-Tetrazole-5-Carbohydrazide

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Defence Technology（防务技术） 2024年第1期31卷 271-277页

作者： Tingwei Wang Zujia lu Shu Bu Baolong Kuang lu zhang Zhenxin Yi Kun Wang Shunguan Zhu Jianguo zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing 210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei 230601China

The high energy coordination compounds Cu(TZCA)_(2)(ClO_(4))_(2)(ECCs-1) was prepared by 1H-tetrazole-5-carbohydrazide(TZCA) with a high energy skeleton and a strong coordination ability *** the same time,the reaction activity of the ligand was explored,and the single crystal structure of it and intermediate were *** structures of all substances were characterized by IR and *** the structure and composition of ECCs-1 are confirmed by ESP,AC,SEM and *** and chemical properties tests show that ECCs-1 has an acceptable thermal stability(T_(d)=177℃) and extremely sensitive mechanical stimulation(IS=1 J,FS=5 N).The comprehensive performance test results show that ECCs-1 has excellent initiation *** addition,the decomposition mechanism of ECCs-1 is explored from two aspects of experiment and theoretical calculation.

关键词： 1H-tetrazole-5-carbohydrazide Primary explosive Decomposition mechanism Coordination polymers Laser

Zeroth-Order Methods for Online Distributed Optimization with Strongly Pseudoconvex Cost Functions

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Journal of Systems Science and Information 2024年第1期12卷 145-160页

作者： Xiaoxi yan Muyuan MA Kaihong lu School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China School of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

This paper studies an online distributed optimization problem over multi-agent *** this problem,the goal of agents is to cooperatively minimize the sum of locally dynamic cost *** from most existing works on distributed optimization,here we consider the case where the cost function is strongly pseudoconvex and real gradients of objective functions are not *** handle this problem,an online zeroth-order stochastic optimization algorithm involving the single-point gradient estimator is *** the algorithm,each agent only has access to the information associated with its own cost function and the estimate of the gradient,and exchange local state information with its immediate neighbors via a time-varying *** performance of the algorithm is measured by the expectation of dynamic *** mild assumptions on graphs,we prove that if the cumulative deviation of minimizer sequence grows within a certain rate,then the expectation of dynamic regret grows ***,a simulation example is given to illustrate the validity of our results.

关键词： multi-agent systems strongly pseudoconvex function single-point gradient estimator online distributed optimization

On-Chip Sub-Picometer Continuous Wavelength Fiber-Bragg-Grating Interrogator

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Photonic Sensors 2024年第1期14卷 73-84页

作者： Yuan ZHUANG Jun ZOU Jiqiang zhang lu zhang Jiahe zhang Leixin MENG Qing yanG Research Center for Humanoid Sensing Zhejiang LabHangzhou 311121China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310014China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058China

Miniaturized fiber-Bragg-grating(FBG)interrogators are of interest for applications in the areas where weight and size controlling is important,e.g.,airplanes and aerospace or in-situ *** ultra-compact high-precision on-chip interrogator is proposed based on a tailored arrayed waveguide grating(AWG)on a silicon-on-insulator(SOI)*** on-chip interrogator enables continuous wavelength interrogation from 1544 nm to 1568 nm with the wavelength accuracy of less than 1 pm[the root-mean-square error(RMSE)is 0.73 pm]over the whole wavelength *** chip loss is less than 5 *** 1×16 AWG is optimized to achieve a large bandwidth and a low noise level at each channel,and the FBG reflection peaks can be detected by multiple output channels of the *** fabricated AWG is utilized to interrogate FBG sensors through the center of gravity(CoG)*** validation of an on-chip FBG interrogator that works with sub-picometer wavelength accuracy in a broad wavelength range shows large potential for applications in miniaturized fiber optic sensing systems.

关键词： Fiber optic sensing on-chip interrogator arrayed waveguide grating center of gravity