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Histopathological changes of Macaca mulatta infected with Plasmodium knowlesi

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Chinese Medical Journal 2001年第10期114卷 65-69,108页

作者：陈林李国桥卢耀增罗灼玲广州中医药大学热带医学研究所广州510405 广州中医药大学组织胚胎学教研室广州510405

Objective To study the histopathological changes of relevant intemal organs of Macaca mulatta infected with Plasmodium knowlesi ( P. knowlesi).Methods Histopathological examination of 3 monkeys who died of P. knowlesi infection, 2 P. knowlesi infected monkeys who died of treatment failure with artesunate suppository and 1 P. knowlesi infected monkey that was cured by piperaquine phosphate (PQP) but died of trauma and necrosis of the fore *** The heart, liver, spleen, lung, kidney, brain, pancreas, parathyriod, pituitary and lymph nodes showed severe pathological changes in 3 monkeys (No. 1, 7 and 12) who died of P. knowlesi infection and 1 infected monkey (No. 72) who died of treatment failure with artesunate suppository. Red blood cells containing rmalarial parasites and pigments were concentrated in the capillaries of these organs. Malarial pigments were deposited in many organs or phagocytized by macrophages in 1 monkey (No. 131 ), it was cured by piperaquine phosphate but died of trauma and necrosis of the fore limb; cellular atrophy and disappearance of pancreatic islets, parathyroid and pituitary cells were also observed. One monkey (No.33) treated with artesunate suppository, showed that blood parasites became negative but recrudesced and pituiary later died from a gavage accident. Its organs showed a significant difference to those of the infected monkeys receiving no treatment. Only the liver Kupffer cells and cerebral matrix contained malarial parasites and pigments; many relevant intemal organs showed *** The pathological changes of relevant internal organs of Macaca mulatta infected with P. knowlesi were examined in detail, especially cellular atrophy and the disappearance of pancreatic islets, parathyoid and pituitary cells and myolysis of cardiac muscles. These changes have not previously been reported elsewhere.

关键词： Plasmodium knowlesi · Macaca mulatta · necropsy · histopathology

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

SYNTHESIS　OF　4－S－（1＂－ARYL－TETRAZOLE－5＂－YL）－4－DEOXY－4＇－DEMETHYL－EPIPODOPHYLLOTOXIN　ANALOGUES

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Chinese Chemical Letters 1995年第3期6卷 197-198页

作者： lu, KK Liu, FM Chen, yz Lanzhou Univ Dept Chem Lanzhou 730000 Peoples R China

As continuation of our study, 6 title compouds were synthesized by con- densing 1-aryl-5-mercapto-tetrazoles with 4'-demethyl-epipodophyllotoxin in the presence of CF3COOH(TFA).

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Effects of Solution Temperature on Tensile Properties ofSiC_w/2024Al Composite

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Journal of Materials Science & Technology 1995年第4期11卷 291-294页

作者： MA, ZY lu, YX luO, M BI, J ZHANG, yz NE UNIV TECHNOL SHENYANG 110006PEOPLES R CHINA

The effects of solution (quench) temperature on the properties of SiCW/Al composite have been investigated using tensile tests. The experiments indicate that the solution temperature of the composite fabricated by P/M technique can be raised to 560 degrees C. The tensile strength of the composite is obviously dependent on solution (quench) temperature and the composite solutionized at 540 degrees C exhibits a maximum of tensile strength and elongation-to-failure. These results can be accounted for by the variation of the dislocation density in the composite.

关键词： Metallic matrix composites

Cancer-cell-intrinsic mechanisms shaping the immunosuppressive landscape of prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 171-178页

作者： Yini Zhu Loan Duong Xuemin lu Xin lu Department of Biological Sciences Boler-Parseghian Center for Rare and Neglected DiseasesHarper Cancer Research InstituteUniversity of Notre DameNotre DameIN 46556USA Integrated Biomedical Sciences Graduate Program University of Notre DameNotre DameIN 46556USA Tumor Microenvironment and Metastasis Program Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolisIN 46202USA

Although immunotherapy has revolutionized cancer treatment and achieved remarkable success across many different cancer types,only a subset of patients shows meaningful clinical *** particular,advanced prostate cancer exhibits overwhelming de novo resistance to immune checkpoint blockade *** is primarily due to the immunosuppressive tumor microenvironment of prostate ***,it is paramount to understand how prostate cancer cell-intrinsic mechanisms promote immune evasion and foster an immunosuppressive ***,we review recent findings that reveal the roles of the genetic alterations,androgen receptor signaling,cancer cell plasticity,and oncogenic pathways in shaping the immunosuppressive microenvironment and thereby driving immunotherapy *** on preclinical and clinical observations,a variety of therapeutic strategies are being developed that may illuminate new paths to enhance immunotherapy efficacy in prostate cancer.

关键词： immune checkpoint blockade immunosuppression immunotherapy neuroendocrine prostate cancer prostate cancer

Cell totipotency:molecular features,induction,and maintenance

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National Science Review 2015年第2期2卷 217-225页

作者： Falong lu Yi Zhang Howard Hughes Medical Institute Harvard Medical School Program in Cellular and Molecular Medicine Boston Children's HospitalHarvard Medical School Department of Genetics Harvard Medical School Harvard Stem Cell Institute Harvard Medical School

In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and hold great potential in regenerative medicine and disease modeling. Guided by the mechanism underlying pluripotency, pluripotent stem cells have been successfully induced through manipulating the transcriptional and epigenetic networks of various diferentiated cell types. However, the factors that confer totipotency, the ability to give rise to cells in both embryonic and extra-embryonic lineages still remain poorly understood. It is currently unknown whether totipotency can be induced and maintained in vitro. In this review, we summarize the current progress in the ield, with the aim of providing a foundation for understanding the mechanisms that regulate totipotency.

关键词： totipotency pluripotency epigenetics embryonic stem cell reprogramming somatic cell nuclear transfer(SCNT)

Hydroelastic interaction between water waves and a thin elastic plate of arbitrary geometry

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Science China(Physics,Mechanics & Astronomy) 2011年第1期54卷 59-66页

作者： XU Feng lu DongQiang Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai 200072 China

An analytical method is developed for the hydroelastic interaction between surface incident waves and a thin elastic plate of arbitrary geometry floating on an inviscid fluid of finite depth in the framework of linear potential *** kinds of edge conditions are considered and the corresponding analytical representations are derived in the polar coordinate *** to the surface boundary conditions,the fluid domain is divided into two regions,namely,an open water region and a plate-covered *** the assumption that all the motion is time-harmonic,the series solutions for the spatial velocity potentials are derived by the method of eigenfunction *** matching conditions for the continuities of the velocity and pressure are transformed by taking the inner products successively with respect to the vertical eigenfunction for the free surface and the angular eigenfunction.A system of simultaneous equations,including two edge conditions and two matching conditions,is set up for deriving the expansion *** an example,numerical computation for the expansion coefficients of truncated series is performed for an elliptic *** results show that the method suggested here is useful to revealing the physical features of the gravity wave scattering in the open water and the hydroelastic response in the plate.

关键词： wave scattering method of matched eigenfunction expansions elastic plate arbitrary geometry hydroelastic response

Review on the Application of Bamboo-Based Materials in Construction Engineering

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Journal of Renewable Materials 2020年第10期8卷 1215-1242页

作者： Biqing Shu Zhongping Xiao lu Hong Sujun Zhang Chen Li Naiqiang Fu Xiaoning lu The College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China College of Civil Engineering Yangzhou Polytechnic InstituteYangzhou225127China

Due to the continuously increasing demand for building materials across the world,it is necessary to use renewable materials in place of the existing nonrenewable materials in construction *** is a fast-growing flowering plant that may be used as a renewable material in *** use of bamboo in the construction of buildings can improve its long-term carbon fixation capacity and economic *** bamboo has the advantages of superior performance,low carbon content,high energy-saving and emission-reducing capacity,bamboo is an anisotropic material,which has many factors affecting its material performance,large variability of material performance,lack of systematic research,and the use of bamboo as the main building material is not always *** paper systematically summarizes the research status of bamboo as a building material from the aspects of bamboo composition,gradation,material properties,bamboo building components,connection nodes,and use of artificial *** this basis,some constructive suggestions are put forward for the further study of bamboo in the field of architecture.

关键词： Bamboo building element connection node glue-laminated bamboo bamboo scrimber binderless plywood

4-S-(5"-烃基-4"-氨基-1",2",4"-三唑-3"-基)-4-去氧-4'-去甲基表鬼臼毒素衍生物的合成及抗肿瘤活性

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药学学报 1999年第1期34卷 63-66页

作者：鲁宽科陈耀祖北京医科大学应用药物研究所兰州大学应用有机国家重点实验室

许多有显著抗肿瘤活性的鬼臼毒素类化合物，其母核Ｃ４侧链上往往连接有刚性较强的脂环或芳香环结构，而且侧链多含有一定数量的杂原子［１～３］。另外，三氮唑类化合物大都有广泛的生物活性，如抗菌［４～５］、抗病毒［６］、抗肿... 详细信息

许多有显著抗肿瘤活性的鬼臼毒素类化合物，其母核Ｃ４侧链上往往连接有刚性较强的脂环或芳香环结构，而且侧链多含有一定数量的杂原子［１～３］。另外，三氮唑类化合物大都有广泛的生物活性，如抗菌［４～５］、抗病毒［６］、抗肿瘤［７］等，据此，我们设计并合成了...

关键词：化学合成 4-S-(5″-烃基-4″-氨基-1″,2″,4″-三唑-3″-基)-4-去氧-4′-去甲基表鬼臼毒素衍生物抗肿瘤活性