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TMR Integrative Medicine 2017年第2期1卷 37-44页

作者： Dao-Rui Hou Li Zhu Ya-Hui Peng lu xiong Oncology Department Guang An Men Hospital China Academy of Traditional Chinese Medicine Beijing China Pharmacy Department Guang An Men Hospital China Academy of Traditional Chinese Medicine Beijing China

Objective： To analyze the experience of chief physician xiong lu in treating metaphase and advanced lung cancer through using TCM inheritance support system （V2.5）. Methods： Collecting the prescriptions used for metaphase and advanced lung cancer from November 1, 2014 to February 1, 2015, then the data were entered into the TCM inheritance support system. Based on principle analysis, revised mutual information, complex system entropy cluster and unsupervised hierarchical clustering composing principles were analyzed. Results： Based on the analysis of 228 cases of prescriptions, the frequency of each Chinese medicinal herb and association rules among herbs included in the database were computed. 15 core combinations and 2 new prescriptions were explored from the database. Conclusion： In treating metaphase and advanced lung cancer, chief physician xiong lu pay attention to Fuzheng Peiben （Therapy for support Zheng-qi to propup root）, according to the different situation cooperate with Tong luo （dredging collaterals）, San Jie （Dissipating a mass）, Huo Xue （Activating blood）, Gong Du （Counteracting toxic substance） and so on. xiong lu is also good at using toxic drugs and incompatible medicaments.

关键词： Metaphase and advanced lung cancer Data mining Fuzheng Peiben (Therapy for support Zheng-qi to propup root) Toxic drugs Incompatible medicaments

Environment adaptive hydrogels for extreme conditions:a review

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Biosurface and Biotribology 2019年第4期5卷 104-109页

作者： Yanan Jiang xiong lu Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong University610031 ChengduSichuanPeople’s Republic of China

Hydrogels have attracted extensive attention due to their excellent swellability,permeability,and *** recent years,the demand for multifunctional hydrogels has been on the increase;there is also an increased need to utilise hydrogels in more varied and extreme applications,such as low temperature,anoxic environment,ultraviolet damage,burns,and the marine ***,traditional hydrogel materials cannot meet the requirements of the application in extreme ***,it is necessary to design and develop hydrogels that are adaptable to certain extreme *** review summarises recent advances in hydrogels that meet application requirements under extreme conditions,particularly in the biomedical field and prospects for their future development.

关键词： conditions extreme hydrogel

Recursive Least Square Vehicle Mass Estimation Based on Acceleration Partition

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Chinese Journal of Mechanical Engineering 2014年第3期27卷 448-459页

作者： FENG Yuan xiong lu YU Zhuoping QU Tong School of Automotive Studies Tongji University Clean Energy Automotive Engineering Center Tongji University

Vehicle mass is an important parameter in vehicle dynamics control systems. Although many algorithms have been developed for the estimation of mass, none of them have yet taken into account the different types of resistance that occur under different conditions. This paper proposes a vehicle mass estimator. The estimator incorporates road gradient information in the longitudinal accelerometer signal, and it removes the road grade from the longitudinal dynamics of the vehicle. Then, two different recursive least square method （RLSM） schemes are proposed to estimate the driving resistance and the mass independently based on the acceleration partition under different conditions. A 6 DOF dynamic model of four In-wheel Motor Vehicle is built to assist in the design of the algorithm and in the setting of the parameters. The acceleration limits are determined to not only reduce the estimated error but also ensure enough data for the resistance estimation and mass estimation in some critical situations. The modification of the algorithm is also discussed to improve the result of the mass estimation. Experiment data on asphalt road, plastic runway, and gravel road and on sloping roads are used to validate the estimation algorithm. The adaptability of the algorithm is improved by using data collected under several critical operating conditions. The experimental results show the error of the estimation process to be within 2.6%, which indicates that the algorithm can estimate mass with great accuracy regardless of the road surface and gradient changes and that it may be valuable in engineering applications. This paper proposes a recursive least square vehicle mass estimation method based on acceleration partition.

关键词： mass estimation recursive least square method acceleration partition

Method of Electric Powertrain Matching for Battery-powered Electric Cars

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Chinese Journal of Mechanical Engineering 2013年第3期26卷 483-491页

作者： NING Guobao xiong lu ZHANG Lijun YU Zhuoping Clean Energy Automotive Engineering Center Tongji University

The current match method of electric powertrain still makes use of longitudinal dynamics, which can’t realize maximum capacity for on-board energy storage unit and can’t reach lowest equivalent fuel consumption as well. Another match method focuses on improving available space considering reasonable layout of vehicle to enlarge rated energy capacity for on-board energy storage unit, which can keep the longitudinal dynamics performance almost unchanged but can’t reach lowest fuel consumption. Considering the characteristics of driving motor, method of electric powertrain matching utilizing conventional longitudinal dynamics for driving system and cut-and-try method for energy storage system is proposed for passenger cars converted from traditional ones. Through combining the utilization of vehicle space which contributes to the on-board energy amount, vehicle longitudinal performance requirements, vehicle equivalent fuel consumption level, passive safety requirements and maximum driving range requirement together, a comprehensive optimal match method of electric powertrain for battery-powered electric vehicle is raised. In simulation, the vehicle model and match method is built in Matlab/simulink, and the Environmental Protection Agency (EPA) Urban Dynamometer Driving Schedule (UDDS) is chosen as a test condition. The simulation results show that 2.62% of regenerative energy and 2% of energy storage efficiency are increased relative to the traditional method. The research conclusions provide theoretical and practical solutions for electric powertrain matching for modern battery-powered electric vehicles especially for those converted from traditional ones, and further enhance dynamics of electric vehicles.

关键词： battery-powered electric vehicle electric powertrain electric driving system energy storage system optimization design

Biodegradable polymer hydrogel-based tissue adhesives:A review

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Biosurface and Biotribology 2021年第4期7卷 163-179页

作者： Xin Zhang Yanan Jiang lu Han xiong lu School of Materials Science and Engineering Key Lab of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengduSichuanChina School of Medicine and Pharmaceutics Laboratory for Marine Drugs and BioproductsPilot National Laboratory for Marine Science and TechnologyOcean University of ChinaQingdaoShandongChina

Tissue-adhesive materials are emerging biomaterials with potential applications in wound healing patches,tissue sealants,and haemostat *** adhesives based on synthetic polymers generally have good adhesion but are not ***,the long-term presence of non-biodegradable adhesives in the body can cause secondary harm to the *** ideal tissue adhesive should meet the following requirements:good adhesiveness,biodegradability,low cytotoxicity,and minimal inflammatory *** polymers with inherent biodegradation and biocompatibility show great potentials in biomedical engineering,and the development of tissue adhesives based on natural polymers has become a hot topic in biomaterials *** review systemat-ically summarises the latest progresses in biodegradable tissue adhesives based on natural polymers,such as chitosan,hyaluronic acid,alginate,gelatin,dextran,and *** for preparing natural polymer tissue adhesives are summarised and their ad-vantages and disadvantages are ***,potential trends in the future direction of biodegradable tissue adhesives are discussed.

关键词： biodegradable hydrogels tissue adhesive wound healing

The recent research progress of polyphenol-derived biomaterials in wound repair

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Biosurface and Biotribology 2023年第4期9卷 114-128页

作者： Shuya Zhao lu Han Liwei Yan xiong lu Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina School of Medicine and Pharmaceutics Key Laboratory of Marine DrugsMinistry of EducationOcean University of ChinaQingdaoShandongChina

The clinical requirements for wound care are increasing daily, and the global wound dressing market is expanding;however, the research and development of new wound dressings are imminent. Natural biomolecules such as polyphenols, have been widely used in this field of vision. Owing to their unique anti-oxidative, adhesive, antibacterial and other bioactive functions, researchers have developed a series of wound dressings with excellent performance and applied them to a variety of biomaterials, such as hydrogels, nanofibers, films and scaffolds. They can effectively promote angiogenesis and fibroblast migration and proliferation, scavenge active oxygen free radicals, inhibit excessive in-flammatory reactions at wound sites and ultimately accelerate wound healing. The authors summarise the latest progress in polyphenol-derived biomaterials in skin wound repair to provide inspiration for future wound dressing research.

关键词： biomaterials biomedical application injectable hydrogels physically cross-linked gel polydopamine wound healing

Polyphenol-mediated construction of highly stable and bioactive selenium nanoparticles

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Biosurface and Biotribology 2023年第4期9卷 151-160页

作者： Rong Hu Xiao Wang lu Han xiong lu School of Materials Science and Engineering Key Lab of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengduSichuanChina Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmaceuticsOcean University of ChinaQingdaoShandongChina Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina

Selenium(Se),a well-known essential element in human health,plays a vital role in regulating metabolism owing to its antioxidative ***,organic Se compounds are toxic and cannot be used for biomedical *** nanoparticles(SeNPs)exhibit low biological toxicity and high bioavailability;however,they are prone to ag-gregation and are extremely unstable,thereby diminishing their bioactivity and *** overcome these limitations,ultra-small,highly stable,and bioactive SeNPs were synthesised based on an in-situ hybridisation strategy by using polyphenol-grafted-chitosan(GA-CS)to control and restrict crystal growth of Se *** resul-tant GA-CS@nSe exhibited an average particle size of~30 nm and was highly stable in aqueous *** addition,GA-CS@nSe displayed improved biocompatibility and enhanced antioxidative *** together,the authors provide a basis for polyphenol-mediated construction of Se-based particles with increased bioactivity.

关键词： bioactivity biomaterials

Amorphous Formation in an Undercooled Binary Ni-Si Alloy under Slow Cooling Rate

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Journal of Materials Science & Technology 2009年第3期25卷 370-372页

作者： Yiping lu Gencang Yang xiong Li Yaohe Zhou State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xilan 710072 China

High undercooling up to 392 K was achieved in eutectic Ni70.2Si29.8 alloy melt by using glass fluxing combined with cyclic superheating. A small quantity of amorphous phase was obtained in bulk eutectic Ni70.2Si29.8 alloy when undercooling exceeds 240 K under slow cooling conditions （about 1 K/s）. The amorphous phase was confirmed by high-resolution transmission electron microscopy and differential scanning calorimetry.

关键词： Eutectic alloy Amorphous phase Rapid solidification

Multifunctional hydrogels for chronic wounds repairing

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Biosurface and Biotribology 2023年第4期9卷 85-100页

作者： Xiao Wang Rong Hu lu Han xiong lu School of Materials Science and Engineering Key Lab of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengduChina Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduChina Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmaceuticsOcean University of ChinaQingdaoChina

Because of their tissue-like mechanical performances,high biocompatibility,and adjust-able functionality,hydrogels have become increasingly attractive materials for promoting wound *** wounds include burn,diabetic,and infected *** common incision wounds,chronic wounds are more challenging to *** meet the clinical needs,multifunctional hydrogels should be fabricated and *** guide future studies on the fabrication of hydrogel-based chronic wound dressings,a review of advanced multifunctional hydrogels is *** hydrogels with advanced properties,such as antibacterial,antioxidant,bioadhesive,anti-inflammatory,and wound healing properties,that can be used for skin burn wounds and diabetic wounds are ***,the prospects of advanced hydrogels for wound healing are elaborated.

关键词： adhesive property antibacterial biomaterials biomedical application functionalisation wound healing

Sliding Mode Control Approach with Integrated Disturbance Observer for PMSM Speed System

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CES Transactions on Electrical Machines and Systems 2023年第1期7卷 118-127页

作者： Lei Yuan Yunhao Jiang lu xiong Pan Wang the Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy Hubei University of TechnologyWuhan430068China the Department of Radar System Ordnance NCO Academy of Army Engineering University of PLAWuhan430075China

The research on high-performance vector control of permanent magnet synchronous motor(PMSM)drive system plays an extremely important role in electrical drive *** further improve the speed control performance of the system,a fast non-singular end sliding mode(FNTSM)surface function based on traditional NTSM control is *** theoretical analysis proves that the FNTSM surface function has a faster dynamic response and more finite-time *** addition,for the self-vibration problem caused by high sliding mode switching gain,an FNTSM control method with anti-disturbance capability was designed based on the linear disturbance observer(DO),*** FNTSMDO method was employed to devise the PMSM speed *** comparative simulation and experiment results with traditional PI control and NTSM control methods indicate that the FNTSMDO method could improve the dynamic performance and anti-interference of the system.

关键词： PMSM Fast nonsingular terminal sliding-mode Disturbance observer PI control