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0D-1D coupling model and 3D fluid-structure interaction model based on coronary CT angiography for displaying hemodynamic characteristics of coronary artery stenosis

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中国医学影像技术 2024年第8期40卷 1236-1241页

作者： LIU Shanfeng lu xiaochen TIAN Hao WU Huiqun Department of Medical Informatics Medical School of Nantong UniversityNantong 226001China Department of Cardiology Affiliated Hospital of Nantong UniversityNantong 226001China Department of Medical Imaging Affiliated Hospital of Nantong UniversityNantong 226001China

Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery *** Based on CCTA data of the stenosed left anterior descending branch(LAD)in a patient with coronary heart disease,an 0D-1D coupling model and 3D FSI model were built,*** hemodynamic characteristic indexes,including the pressure,flow velocity and wall shear stress(WSS)were obtained in every 0.01 s during 1 s at 5 sampling points(*** point 1—5)using these 2 models,respectively,and the consistencies of the results between models were evaluated with Spearman correlation coefficient r *** The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min,*** models showed basically distribution of the pressure,flow velocity and WSS of the stenosed *** more details,the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher,which gradually decreased at the distal segment of stenosis,and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition,with significantly increased flow velocity and WSS at the stenosed *** with 3D FSI model,0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow *** sampling point 2 at the stenosed segment of LAD,no significant consistency for pressure between 2 models was found(P=0.118),but strong consistency for the flow velocity and WSS(r s=0.730,0.807,both Plusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results,while 3D FSI model show

关键词： coronary stenosis hemodynamics coronary angiography tomography,X-ray computed

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Conjugate Heat Transfer Analysis of Film Cooling Flows

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Journal of Thermal Science 2006年第1期15卷 85-91页

作者： xiaochen lu Peixue JIANG Hideaki SUGISHITA Hideyuki UECHI Kiyoshi SUENAGA Department of Thermal Engineering Tsinghua University Beijing 100084 China Takasago Research and Development Center Mitsubishi Heavy Industries Ltd. Takasago 676-8686 Japan

The objective of this study is to evaluate the potential of various grids to satisfactorily simulate the development of a cooling film, using a coupled computation that takes into account the full geometry. Detailed computations of a single row of 30 degrees round holes on a flat plate are presented for blowing ratios of 0.764, 1.01 and 1.54. The simulation results are compared well with experimental data. The two-layer model gave more accurate results but consumed much more computational time than the standard wall functions. The k-ε turbulence model with wall functions with appropriate values of y^＋ is suitable for practical use. The results show the importance of the conjugate calculation for accurately describing the influence of the heat transfer within the cooling film.

关键词： film cooling conjugate heat transfer blowing ratio.

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基于冠状动脉CT血管造影0D-1D耦合模型与3D流固耦合模型显示冠状动脉狭窄血流动力学特征

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中国医学影像技术 2024年第8期40卷 1236-1241页

作者：刘杉峰陆晓晨田浩吴辉群南通大学医学院医学信息学系江苏南通 226001 南通大学附属医院心血管内科江苏南通 226001 南通大学附属医院影像科江苏南通 226001

目的观察基于冠状动脉CT血管造影(CCTA)0D-1D耦合模型与3D流固耦合(FSI)模型显示冠状动脉狭窄血流动力学特征的价值。方法基于1例冠心病左前降支(LAD)狭窄患者的CCTA数据建立0D-1D耦合模型和3D FSI模型,于1 s内每间隔0.01 s分别采集2种... 详细信息

目的观察基于冠状动脉CT血管造影(CCTA)0D-1D耦合模型与3D流固耦合(FSI)模型显示冠状动脉狭窄血流动力学特征的价值。方法基于1例冠心病左前降支(LAD)狭窄患者的CCTA数据建立0D-1D耦合模型和3D FSI模型,于1 s内每间隔0.01 s分别采集2种模型5个相应采样点(即采样点1~5)的力学参数数据,包括压力、血流速度及壁面剪切应力(WSS),以Spearman相关系数rs评估模型间的一致性。结果构建0D-1D耦合模型和3D FSI模型分别用时0.033 min和704 min。2种模型显示的狭窄LAD内压力、血流速度及WSS分布基本一致,均为狭窄段及其近端压力较高而其远端压力值逐渐降低,狭窄近端血流较为匀速缓慢,而狭窄段流速加快且WSS明显增高;但相比3D FSI模型,0D-1D血管耦合模型的精细程度不足,且在显示血流速度时出现远端流线缺失。针对位于狭窄段的采样点2,2种模型所示压力未见明显一致性(P = 0.118)但血流速度及WSS均呈强一致性(r_s = 0.730、0.807,P均< 0.05),而狭窄近端及远端(采样点1、3~5)压力、血流速度及WSS具有弱至中等一致性(r_s = 0.237~0.669,P均< 0.05)。结论0D-1D耦合模型用于模拟LAD狭窄具有出色计算效率,可提供较为合理的结果;而3D FSI模型模拟局部细节和流线精度较高。

关键词：冠状动脉狭窄血流动力学冠状动脉造影体层摄影术,X线计算机

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A Novel Robust Zero-Watermarking Algorithm for Audio Based on Sparse Representation

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China Communications 2021年第8期18卷 237-248页

作者： Longting Xu Daiyu Huang Xing Guo Wei Rao Yunyun Ji Ruoyi Li xiaochen lu College of Information Science and Technology Donghua UniversityShanghai 200000China Tencent Ethereal Audio Lab China

Behind the prevalence of multimedia technology,digital copyright disputes are becoming increasingly *** digital watermarking prevention technique against the copyright infringement needs to be improved *** the proposed technologies,zero-watermarking has been favored *** order to improve the robustness of the zero-watermarking,a novel robust audio zerowatermarking method based on sparse representation is *** proposed scheme is mainly based on the K-singular value decomposition(K-SVD)algorithm to construct an optimal over complete dictionary from the background audio *** that,the orthogonal matching pursuit(OMP)algorithm is used to calculate the sparse coefficient of the segmented test audio and generate the corresponding sparse coefficient ***,the mean value of absolute sparse coefficients in the sparse matrix of segmented speech is calculated and selected,and then comparing the mean absolute coefficient of segmented speech with the average value of the selected coefficients to realize the embedding of *** results show that the proposed audio zerowatermarking algorithm based on sparse representation performs effectively in resisting various common *** with the baseline works,the proposed method has better robustness.

关键词： zero-watermarking K-singular value decomposition dictionary learning sparse representtion

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Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival

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Science China(Life Sciences) 2020年第9期63卷 1394-1405页

作者： Jizheng Guo Qixiang Zhang Ying Su xiaochen lu Yiping Wang Miao Yin Weiguo Hu Wenyu Wen Qun-Ying Lei Department of Biochemistry and Molecular Biology School of Basic Medical ScienceShanghai Medical CollegeFudan UniversityShanghai 200032China Fudan University Shanghai Cancer Center Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology Shanghai Medical College Fudan UniversityShanghai 200032China

Cancer cells remodel their metabolic network to adapt to variable nutrient availability. Pentose phosphate pathway(PPP) plays protective and biosynthetic roles by oxidizing glucose to generate reducing power and ribose. How cancer cells modulate PPP activity in response to glucose supply remains unclear. Here we show that ribose-5-phosphate isomerase A(RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1(CARM1) and is methylated at arginine 42(R42). R42 methylation up-regulates the catalytic activity of RPIA. Furthermore, glucose deprivation strengthens the binding of CARM1 with RPIA to induce R42 hypermethylation. Insufficient glucose supply links to RPIA hypermethylation at R42, which increases oxidative PPP flux. RPIA methylation supports ROS clearance by enhancing NADPH production and fuels nucleic acid synthesis by increasing ribose supply. Importantly, RPIA methylation at R42 significantly potentiates colorectal cancer cell survival under glucose starvation. Collectively, RPIA methylation connects glucose availability to nucleotide synthesis and redox homeostasis.

关键词： ribose-5-phosphate isomerase A CARM1 arginine methylation pentose phosphate pathway ribulose-5-phosphate reactive oxygen species colorectal cancer

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Two diversities meet in the rhizosphere:root specialized metabolites and microbiome

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Journal of Genetics and Genomics 2024年第5期51卷 467-478页

作者： xiaochen Wang Jingying Zhang Xinjun lu Yang Bai Guodong Wang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China College of Advanced Agricultural Sciences Chinese Academy of SciencesBeijing 100049China

Plants serve as rich repositories of diverse chemical compounds collectively referred to as specialized *** compounds are of importance for adaptive processes,including interactions with various microbes both beneficial and *** microbes as bioreactors,the chemical diversity undergoes dynamic changes when root-derived specialized metabolites(RSMs)and microbes encounter each other in the *** advancements in sequencing techniques and molecular biology tools have not only accelerated the elucidation of biosynthetic pathways of RSMs but also unveiled the significance of RSMs in plant-microbe *** this review,we provide a comprehensive description of the effects of RSMs on microbe assembly in the rhizosphere and the influence of corresponding microbial changes on plant health,incorporating the most up-to-date information ***,we highlight open questions that remain for a deeper understanding of and harnessing the potential of RSM-microbe interactions to enhance plant adaptation to the ***,we propose a pipeline for investigating the intricate associations between root exometabolites and the rhizomicrobiome.

关键词： Root specialized metabolites Microbiome Plant-microbe interactions Rhizosphere Diversity

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The website of Dow Corning expanded online sourcing platform of silicon

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橡塑机械时代 2009年第12期21卷 12-13页

作者： lu xiaochen

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Shaoxing Jingcheng Rubber ＆ Plastics Machinery Co.,Ltd

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橡塑机械时代 2010年第2期22卷 7-9页

作者： lu xiaochen

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Leap-style Development of Rubber Machinery Industry

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橡塑机械时代 2008年第6期20卷 10-11页

作者： lu xiaochen

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分裂义多义动词客体题元层级化分析

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外国语文 2019年第2期35卷 95-102页

作者：卢晓晨黑龙江大学俄语学院黑龙江哈尔滨150080

本文以分裂义动词为对象,对俄语多义动词语义衍生中的客体题元层级化问题展开讨论。我们首先将建立由题元数目层级(概括题元层级)、语义角色层级、语义次范畴层级、论元形式层级及角色配位层级所构成的客体题元层级化描写框架,进而在此... 详细信息

本文以分裂义动词为对象,对俄语多义动词语义衍生中的客体题元层级化问题展开讨论。我们首先将建立由题元数目层级(概括题元层级)、语义角色层级、语义次范畴层级、论元形式层级及角色配位层级所构成的客体题元层级化描写框架,进而在此基础上对分裂义多义动词语义变化的客体题元层级化现象进行分析和探讨。相关分析、研究将能深化我们对动词多义语义关系实质的认识,同时能够对客体题元理论及其相关的动词语义、句法问题研究产生积极影响。

关键词：分裂义动词多义性语义变化客体题元层级化分析

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