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Coaxial Wet Spinning of Boron Nitride Nanosheet‑Based Composite Fibers with Enhanced Thermal Conductivity and Mechanical Strength

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Nano-Micro Letters 2024年第2期16卷 126-138页

作者： Wenjiang lu qixuan Deng Minsu Liu Baofu Ding Zhiyuan Xiong Ling Qiu Tsinghua Shenzhen International Graduate School(TSIGS) Tsinghua UniversityShenzhen 518055People’s Republic of China Monash Suzhou Research Institute(MSRI) Monash UniversitySuzhou 215000People’s Republic of China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Shenzhen Key Laboratory of Energy Materials for Carbon Neutrality Shenzhen 518055People’s Republic of China School of Light Industry and Engineering South China University of TechnologyGuangzhou 510614People’s Republic of China

Hexagonal boron nitride nanosheets(BNNSs)exhibit remarkable thermal and dielectric ***,their self-assembly and alignment in macroscopic forms remain challenging due to the chemical inertness of boron nitride,thereby limiting their performance in applications such as thermal *** this study,we present a coaxial wet spinning approach for the fabrication of BNNSs/polymer composite fibers with high nanosheet *** composite fibers were prepared using a superacid-based solvent system and showed a layered structure comprising an aramid core and an aramid/BNNSs ***,the coaxial fibers exhibited significantly higher BNNSs alignment compared to uniaxial aramid/BNNSs fibers,primarily due to the additional compressive forces exerted at the core-sheath interface during the hot drawing *** a BNNSs loading of 60 wt%,the resulting coaxial fibers showed exceptional properties,including an ultrahigh Herman orientation parameter of 0.81,thermal conductivity of 17.2 W m^(-1)K^(-1),and tensile strength of 192.5 *** results surpassed those of uniaxial fibers and previously reported BNNSs composite fibers,making them highly suitable for applications such as wearable thermal management *** findings present a promising strategy for fabricating high-performance composite fibers based on BNNSs.

关键词： Boron nitride nanosheets Coaxial fiber Interfacial compression Nanosheet aligning Wearable thermal management

Review on piezoelectric actuators:materials,classifications,applications,and recent trends

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Frontiers of Mechanical Engineering 2024年第1期19卷 5-33页

作者： Xuyang ZHOU Shuang WU Xiaoxu WANG Zhenshan WANG qixuan ZHU Jinshuai SUN Panfeng HUANG Xuewen WANG Wei HUANG Qianbo lu Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710072China School of Automation Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical *** types of piezoelectric actuators have sprung up and gained widespread use in various applications in terms of compelling attributes,such as high precision,flexibility of stoke,immunity to electromagnetic interference,and structural *** paper systematically reviews the piezoelectric materials,operating principles,representative schemes,characteristics,and potential applications of each mainstream type of piezoelectric ***,we intend to provide a more scientific and nuanced perspective to classify piezoelectric actuators into direct and indirect categories with several *** addition,this review outlines the pros and cons and the future development trends for all kinds of piezoelectric actuators by exploring the relations and mechanisms behind *** rich content and detailed comparison can help build an in-depth and holistic understanding of piezoelectric actuators and pave the way for future research and the selection of practical applications.

关键词： piezoelectric actuator piezoelectric effect amplified piezoelectric actuator ultrasonic actuator stepping actuator piezoelectric polymer

Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy

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Cancer Biology & Medicine 2023年第4期20卷 297-316页

作者： Hongxia Chen luxi Yin Jie Yang Ningxin Ren Jinna Chen qixuan lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisBeijing Key Laboratory for Carcinogenesis and Cancer PreventionNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized *** study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative *** associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression *** experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 ***:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory ***:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment.

关键词： Rectal neoplasms genetic variation regulated cell death overall survival ALOX5

Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion

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Stroke & Vascular Neurology 2022年第3期7卷 190-199页

作者： Ximing Nie David Wang Yuehua Pu Yufei Wei qixuan lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstitutePhoenixArizonaUSA Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina Department of Radiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to *** Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct *** primary outcome was 90-day functional *** outcomes were assessed with adjusted OR(aOR)from the multivariable logistic *** addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with *** Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+*** EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),plusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of *** meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.

关键词： acute intravenous occlusion

PAK-1—cofilin pathway mediates apelin-13 promotes lung adenocarcinoma lines A549 cells migration

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PAK-1—cofilin pathway mediates apelin-13 promotes lung aden...

细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Lv Deguan lu qixuan Li Yao Cao Jianguang Yang Lingfang Liu Meiqing Zhang Hanjing Qin Xuping Li Lanfang Chen Linxi Institute of pharmacy and pharmacology University of South China

Background and objective:Apelin is a newly discovered bioactive peptides which had been proved to be an endogenous ligand of the APJ *** evidences had confirmed that apelin is a novel cancer factor involved in angiogenesis and anti-apoptosis in non-small cell lung cancer and oral squamous cell *** we evaluated whether apelin influences the migration of lung adenocarcinoma lines A549 cells,as well as whether PAK-1—cofilin signal pathway mediates the

关键词： Apelin APJ lung adenocarcinoma PAK-1 cofilin migration

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基于位置信息的波束成形算法及中断性能分析

空间电子技术 2023年第6期20卷 81-86页

作者：赵威豪卢麒轩马婧李洪南京邮电大学通信与信息工程学院南京210003

随着全球定位系统技术的发展,无线通信系统中发射端能够较为准确地获取接收端的位置信息。在此背景下,提出了基于接收端位置信息的波束成形码本设计方案,并分析了系统在该方案下的中断性能。首先,在莱斯衰落信道模型下,根据接收端的最... 详细信息

随着全球定位系统技术的发展,无线通信系统中发射端能够较为准确地获取接收端的位置信息。在此背景下,提出了基于接收端位置信息的波束成形码本设计方案,并分析了系统在该方案下的中断性能。首先,在莱斯衰落信道模型下,根据接收端的最大信噪比准则得到发射端的最佳波束成形权矢量。其次,给出均匀线阵天线模型下的波束成形码本设计方案。然后,推导出该方案下的中断概率表达式。最后,利用MATLAB软件仿真验证了该方法的有效性,并检验了相关参数对系统性能的影响。仿真结果表明,发射天线的数目和码本长度越大,阵列波束的指向就越精确,由此可以提高系统的中断概率和性能。所提算法可用于下行链路预处理,通过码本索引的方式,减少了通信系统中信令的开销和对信令的依赖。

关键词：波束成形均匀线阵码本设计中断性能

焦亡通路基因的遗传变异与直肠癌患者术后同步放化疗不良反应相关

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中华肿瘤杂志 2023年第2期45卷 146-152页

作者：陈红霞任宁馨杨洁陈进娜陆启璇冯燕茹黄莹尹露茜林东昕李晔雄金晶谭文国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室、病因及癌变研究室、癌发生及预防分子机理北京市重点实验室北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院放疗科北京100021

目的探讨焦亡通路关键基因的遗传变异与直肠癌患者术后同步放化疗不良反应的关系。方法抽取2005年1月至2015年6月中国医学科学院肿瘤医院347例Ⅱ~Ⅲ期直肠癌患者术后同步放化疗治疗前的外周血,提取DNA,采用Sequenom MassARRAY方法检测... 详细信息

目的探讨焦亡通路关键基因的遗传变异与直肠癌患者术后同步放化疗不良反应的关系。方法抽取2005年1月至2015年6月中国医学科学院肿瘤医院347例Ⅱ~Ⅲ期直肠癌患者术后同步放化疗治疗前的外周血,提取DNA,采用Sequenom MassARRAY方法检测焦亡通路中的黑色素瘤缺乏因子2(AIM2)、半胱天冬酶1(CASP1)、CASP4、CASP5、CASP11、消皮素D(GSDMD)、消皮素E(GSDME)和含Nod样受体家族pyrin域蛋白3(NLRP3)共8个关键基因的43个标签单核苷酸多态(htSNP)的基因分型,采用非条件logistic回归模型分析htSNP基因型与直肠癌患者术后同步放化疗不良反应发生的关系。结果347例患者术后接受持续5周的术后同步放化疗,发生中重度骨髓抑制101例(29.1%),发生中重度腹泻156例(45.0%),发生中重度放射性皮炎66例(19.0%)。手术方式、病灶距齿状线距离与直肠癌患者术后同步放化疗发生中重度腹泻和放射性皮炎有关(均P0.05)。结论焦亡通路相关基因CASP4、CASP11、GSDME和NLRP3的遗传变异与Ⅱ~Ⅲ期直肠癌患者术后同步放化疗的不良反应发生有关,可能是直肠癌个体化治疗的潜在遗传标志物。

关键词：直肠肿瘤多态性,单核苷酸焦亡同步放化疗不良反应

Single-atomic-site iron on N-doped carbon for chemoselective reduction of nitroarenes

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Nano Research 2022年第1期15卷 603-611页

作者： Guoping lu Kangkang Sun Yamei Lin qixuan Du Jiawei Zhang Kui Wang Pengcheng Wang School of Chemical Engineering Nanjing University of Science&TechnologyNanjing 210094China Institute of Chemical Industry of Forest Products Chinese Academy of ForestryNational Engineering Laboratory for Biomass Chemical UtilizationNanjing 210042China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210032China College of Materials Science and Engineering Hunan UniversityChangsha 410082China

A facile,gram-scale and sustainable approach has been established for the synthesis of single-atomic-site iron on N-doped carbon(Fe_(SA)@NC-20A)via the pyrolysis of aniline modified FeZn-ZIFs,in which the synthesis of zeolitic imidazolate frameworks(ZIFs)can be accomplished in water at room temperature,and no acid etching is *** as-synthesized catalyst exhibits better performance on the chemoselective hydrogenation of nitroarenes with a broad substrate scope(turnover frequency(TOF)up to 1,727 h^(-1),23 examples)than most of previously reported *** on high-angle annular dark field scanning transmission microscopy(HAADF-STEM)images in combination with X-ray photoelectron spectroscopy(XPS),X-ray absorption spectroscopy(XAS),electron spin resonance(ESR),and Mossbauer spectroscopy,Fe is dispersed as single atoms via forming FeNx(x=4-6).This work not only determines the active sites of FesA@NC-20A for hydrogenation(FeN4),but also proposes tentative pathways for both N-H activation of hydrazine and the reduction of nitroarene on FeN4 site,both of which are the key steps for the hydrogenation of *** addition,this catalyst shows excellent stability,and no significant activity degradation is observed when recycling for 10 times or restoring in air for 2 months.

关键词： single-atom-site iron zeolitic imidazolate framework the hydrogenation of nitroarene N-doped carbon drug synthesis

血管内机械血栓切除术联合持续窦内溶栓治疗严重出血性脑静脉窦血栓形成:病例系列研究

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国际脑血管病杂志 2023年第7期31卷 512-518页

作者：韩丽娟鲁启璇徐运李敬伟刘丽萍南京大学医学院附属鼓楼医院神经内科南京210009 首都医科大学附属北京天坛医院神经重症医学科北京100070

目的探讨血管内机械血栓切除术(endovascular mechanical thrombectomy,EMT)联合静脉窦内持续溶栓治疗严重出血性脑静脉窦血栓形成(cerebral venous sinus thrombosis,CVST)的可行性及安全性。方法回顾性分析2019年3月至2020年2月在北... 详细信息

目的探讨血管内机械血栓切除术(endovascular mechanical thrombectomy,EMT)联合静脉窦内持续溶栓治疗严重出血性脑静脉窦血栓形成(cerebral venous sinus thrombosis,CVST)的可行性及安全性。方法回顾性分析2019年3月至2020年2月在北京天坛医院接受EMT联合窦内持续尿激酶溶栓治疗的连续5例严重出血性CVST患者的临床及影像学资料。结果5例患者平均年龄39岁(范围19~65岁);男性2例,女性3例;3例有明确发病危险因素。4例患者有2个以上静脉窦受累,共10支CVST受累血管,受累静脉窦血栓负荷大、病灶体积大,临床表现重。EMT前平均肝素抗凝治疗时间为2.3 d(范围0.5~7 d),窦内溶栓平均持续时间为64 h(范围30~95 h)。治疗后8支血管再通,其中1支完全再通,7支部分再通。实现血管再通的4例患者长期临床转归良好(改良Rankin量表评分:3个月时0~2分,1年时0~1分)。1例患者未能实现血管再通,并因颅内高压行去骨瓣减压术,1年后遗留偏身瘫痪。5例患者均未发生手术相关并发症。结论EMT联合持续静脉窦内溶栓治疗是严重出血性CVST患者的潜在治疗手段。

关键词：窦血栓形成,颅内颅内出血血管内手术血栓切除术血栓溶解疗法尿激酶型纤维蛋白酶原激活剂抗凝药治疗结果