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Novel multi‐domain attention for abstractive summarisation

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 796-806页

作者： Chunxia Qu ling lu Aijuan Wang Wu Yang Yinong Chen College of Computer Science and Engineering Chongqing University of TechnologyChongqingChina School of Computing and Augmented Intelligence Arizona State UniversityTempeArizonaUSA

The existing abstractive text summarisation models only consider the word sequence correlations between the source document and the reference summary,and the summary generated by models lacks the cover of the subject of source document due to models'small *** order to make up these disadvantages,a multi‐domain attention pointer(MDA‐Pointer)abstractive summarisation model is proposed in this ***,the model uses bidirectional long short‐term memory to encode,respectively,the word and sentence sequence of source document for obtaining the semantic representations at word and sentence ***,the multi‐domain attention mechanism between the semantic representations and the summary word is established,and the proposed model can generate summary words under the proposed attention mechanism based on the words and ***,the words are extracted from the vocabulary or the original word sequences through the pointer network to form the summary,and the coverage mechanism is introduced,respectively,into word and sentence level to reduce the redundancy of sum-mary ***,experiment validation is conducted on CNN/Daily Mail *** evaluation indexes of the model without and with the coverage mechanism are improved respectively,and the results verify the validation of model proposed by this paper.

关键词： abstractive summarisation attention mechanism Bi‐LSTM coverage mechanism pointer network

Free radical mediated bromization of methylenecyclopropanes: Preparation of 2,4-dibromobutenes without transition metal

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Chinese Chemical Letters 2007年第2期18卷 121-123页

作者： Lei Yu[a] Bo Chen[a] Xian Huang[a][b]&Email:huangx@*** lu ling Wu[a] [a]Department of Chemistry Zhejiang University [Campus Xixi] Hangzhou 310028 China [b]State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

A series of 2,4-dibromobutenes were synthesized by the reaction of methylenecyclopropanes with KBr in HOAc in the presence of dibenzoyl peroxide, providing an environment friendly method for the synthesis of 2,4-dibro... 详细信息

关键词： Methylenecyclopropane Free radical Bromine

Lithium promotes proliferation and suppresses migration of Schwann cells

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Neural Regeneration Research 2020年第10期15卷 1955-1961页

作者： Xiao-Kun Gu Xin-Rui Li Mei-ling lu Hui Xu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Hand Surgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina State Key Laboratory of Natural Medicines School of Life Science and TechnologyChina Pharmaceutical UniversityNanjingJiangsu ProvinceChina

Schwann cell proliferation,migration and remyelination of regenerating axons contribute to regeneration after peripheral nervous system *** promotes remyelination by Schwann cells and improves peripheral nerve ***,whether lithium modulates other phenotypes of Schwann cells,especially their proliferation and migration remains *** the current study,primary Schwann cells from rat sciatic nerve stumps were cultured and exposed to 0,5,10,15,or 30 mM lithium chloride(LiCl)for 24 *** effects of LiCl on Schwann cell proliferation and migration were examined using the Cell Counting Kit-8,5-ethynyl-2′-deoxyuridine,Transwell and wound healing *** Counting Kit-8 and 5-ethynyl-2′-deoxyuridine assays showed that 5,10,15,and 30 mM LiCl significantly increased the viability and proliferation rate of Schwann ***-based migration assays and wound healing assays showed that 10,15,and 30 mM LiCl suppressed the migratory ability of Schwann ***,the effects of LiCl on the proliferation and migration phenotypes of Schwann cells were mostly *** data indicate that lithium treatment significantly promotes the proliferation and inhibits the migratory ability of Schwann *** conclusion will inform strategies to promote the repair and regeneration of peripheral *** of the animal experiments in this study were ethically approved by the Administration Committee of Experimental Animal Center of Nantong University,China(approval No.20170320-017)on March 2,2017.

关键词： 5-ethynyl-2′-deoxyuridine Cell Counting Kit-8 cell viability lithium migration peripheral nerve proliferation regeneration Schwann cell wound healing assay

Microwave-assisted hydrothermal synthesis of copper oxide-based gas-sensitive nanostructures

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Rare Metals 2021年第6期40卷 1477-1493页

作者： Ying Li Yu-ling lu Kai-Di Wu Dong-Zhi Zhang Marc Debliquy Chao Zhang College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China Service de Science des Materiaux Faculte PolytechniqueUniversite de MonsMons 7000Belgium

Hydrothermal methods are widely used in chemical synthesis of target products with specific morphology and *** methods are very efficient for the preparation of well-controlled structures but the reaction time is usually *** assistance of microwave makes the reaction system heat up faster,more uniformly and reactions are accelerated,it also can be utilized to change the morphology or structure of materials,which improves the physic-chemical properties of synthesized products and influences its gas-sensing *** oxide(CuO)is widely applied in semiconductor gas sensors because of its good reactivity and *** review article briefly introduces the principle,mechanism and recent development of CuO nanostructures obtained by microwave-as sis ted hydrothermal synthesis(MWHS)*** also discussed the relation between endopathic factors of material and its gas-sensitive *** technical challenges and prospective solutions for highperformance CuO-based gas-sensitive materials with unique nanostructure are *** is pointed out that the hierarchical CuO-based nanostructures and their composite materials prepared by MWHS process are efficacious methods to improve the gas-sensitive performance of the *** the basis of the morphology,the materials are divided into nanorods,nanoflowers,nanosheets,nanospheres and other *** influence of microwave parameters on the properties of synthetic products is *** influence followed by metal element loading on the structure and properties of CuO-based materials by MWHS process is further *** this review summarizes the research progress of graphene-CuO and metal oxide-CuO composites prepared by MWHS process in recent years.

关键词： Microwave-assisted Hydrothermal synthesis Copper oxide Gas-sensitive material Nanostructure

A Novel Efficient Method for Synthesis of β-Organoseleno Substituted Allyl Sulfoxides

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Chinese Chemical Letters 2005年第10期16卷 1333-1334页

作者： Zhi Meng WU Ru Wei SHEN lu ling WU Xian HUANG Department of Chemistry Zhejiang University （Xixi Campus） Hangzhou 310028

Hydroselenation of 1, 2-allenyl sulfoxides give 2-organoseleno substituted allyl sulfoxides in high yields and the reaction is absolute regioselective.

关键词： Hydroselenation allenyl sulfoxides regioselectivity.

Polymer-support Selenium-induced Electrophilic Cyclization:Solid-phase Synthesis of Flavonoids

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Chinese Chemical Letters 2006年第7期17卷 857-858页

作者： Jian CAO E TANG Xuan HUANG lu ling WU Xian HUANG Department of Chemistry Zhejiang University （Xixi Campus） Hangzhou 310028 State Key Laboratory of Organometallic-Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 354 Fenglin Lu Shanghai 200032

The Lewis acid mediated polystyrene supported selenium cyclization of chalcones and oxidative cleavage of selenium resins flavonoids in good yields and purities have been reported. induced intramolecular gave the cor... 详细信息

关键词： Flavonoids selenenyl bromide resin solid-phase synthesis electrophilic cyclization.

Regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines

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Chinese Chemical Letters 2009年第9期20卷 1015-1016页

作者： Jian Feng Xu Peng Bin Li lu ling Wu Xian Huang Department of Chemistry Zhejiang University (Campus Xixi) Hangzhou 310028 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

A regio- and stereo-selective synthesis of multi-substituted 3-pyrrolines has been developed. The multi-substituted 3-pyrrolines were synthesized in good yields by 1,3-dipolar cycloaddition of methyl 2-（phenylselanyl）acrylate with azomethine ylides, followed by N-acylation and oxidation-elimination of phenylseleno group. 2009 Xian Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： 3-Pyrrolines 1,3-Dipolar cycloaddition Regioselective Stereoselective

Tailoring micro/nano-fibers for biomedical applications

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Bioactive Materials 2023年第1期19卷 328-347页

作者： Bin Kong Rui Liu Jiahui Guo ling lu Qing Zhou Yuanjin Zhao Department of Cardio-Thoracic Surgery Institute of Translational MedicineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School210008NanjingChina Department of Otolaryngology Head and Neck Surgery Jiangsu Provincial Key Medical DisciplineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School210008NanjingChina State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast University210096NanjingChina Institute for Stem Cell and Regeneration Chinese Academy of Science100101BeijingChina

Nano/micro fibers have evoked much attention of scientists and have been researched as cutting edge and hotspot in the area of fiber science in recent years due to the rapid development of various advanced manufacturing technologies,and the appearance of fascinating and special functions and properties,such as the enhanced mechanical strength,high surface area to volume ratio and special functionalities shown in the surface,triggered by the nano or micro-scale *** addition,these outstanding and special characteristics of the nano/micro fibers impart fiber-based materials with wide applications,such as environmental engineering,electronic and biomedical *** review mainly focuses on the recent development in the various nano/micro fibers fabrication strategies and corresponding applications in the biomedical fields,including tissue engineering scaffolds,drug delivery,wound healing,and ***,the challenges for the fabrications and applications and future perspectives are presented.

关键词： Nano/micro fibers Bioprinting Electrospinning Microfluidic spinning Near field electrospinning Biomedical field

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

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Cellular & Molecular Immunology 2017年第6期14卷 521-528页

作者： Jian Gu Xuhao Ni Xiongxiong Pan Hao lu Yunjie lu Jie Zhao Song Guo Zheng Keli L Hippen Xuehao Wang ling lu Translational Medicine Research Center Affiliated Jiangning Hospital and Liver Transplantation Center First Affiliated Hospital Nanjing Medical University Nanjing 210029 China University of Minnesota Cancer Center and Division of Bone Marrow Transplantation Department of Pediatrics University of Minnesota Minneapolis MN 55455 USA Division of Rheumatology Penn State Milton S. Hershey Medical Center Hershey PA 17033 USA

Autoimmune diseases are characterized by an imbalance between regulatory T cells and effector T-cell subsets, such as Thl and Th17 cells. Studies have confirmed that natural CD4＋Foxp3＋ Tregs were unstable and dysfunctional in the presence of pro-inflammatory cytokines. In the current study, human CD39hi Tregs and CD39low Tregs were sorted from Tregs in vitro after 7 days of expansion. The functions of both Treg subsets were investigated under inflammatory conditions in vitro and in vivo. In the presence of IL-1β and IL-6, cultured CD4＋CD39hi Tregs maintained stable forkhead box protein 3 expression, whereas CD4＋CD39low Tregs lost Foxp3 expression and trans-differentiated into Thl or Th17 cells. Decreased IL-1βR and IL-6R expression on the CD39hi Tregs was the primary mechanism responsible for Treg stability. In addition, reduced activation of downstream molecules, such as STAT1 and STAT3, through the modulation of CpG demethylation played an important role. Finally, human CD4＋CD39hi Tregs but not CD4＋CD39low Tregs protected against xenograft versus host disease in model mice. These results strongly implied the physiological importance of CD39 expression and suggested that manipulation of CD39hi Tregs might represent a novel strategy for the treatment of autoimmune diseases.

关键词： CD39 stability Tregs xeno-GVHD