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Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae)

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Plant Diversity 2024年第4期46卷 448-461页

作者： Hai-Yao Chen Zhi-Rong Zhang Xin Yao Ji-Dong Ya Xiao-Hua Jin Lin Wang lu lu De-Zhu Li Jun-Bo Yang Wen-Bin Yu Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Huairou DistrictBeijing 101408China Plant Germplasm and Genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory of Plant Diversity and Specility Crops Institute of BotanyChinese Academy of SciencesHaidian DistrictBeijing 100093China School of Pharmaceutical Sciences Yunnan Key Laboratory of Pharmacology for Natural Productsand Yunnan College of Modern Biomedical IndustryKunming Medical UniversityKunmingYunnan 650500China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the ***,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this *** this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate *** dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle *** *** to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene *** analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon *** hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle *** transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification *** study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.

关键词： Cymbidium East Asia Asian monsoons Climate change Biogeographical patterns

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Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi Zhao Sulin Zhang lu Liu Yumin Zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian Li Wenhao Dai Zhen Ge Shulei Hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao lu lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

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Norwegian scabies presenting as erythroderma:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4802-4806页

作者： Hai-Ju Chen Chun-Ying lu Guo-Mei Huang lu-lu Tang Department of Dermatology and Venereology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina

BACKGROUND Norwegian scabies(NS)is a serious parasitic skin *** NS is one of the causes of erythroderma,it is frequently ***,it is essential to raise awareness regarding NS presenting as *** SUMMARY We present a case of NS that persisted for more than 3 *** following nonstandard treatment,the patient’s rash worsened and gradually progressed into ***,NS was diagnosed by skin microscopy and *** When patients with pruritic dermatosis have high-risk factors such as prolonged bed rest and immunodeficiency,clinicians need to enhance their awareness of NS and ensure prompt diagnosis and treatment.

关键词： Norwegian scabies Crusted scabies Erythroderma Diagnosis Case report

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Cytisine N-methylene-(5，7，4’-trihydroxy)-isoflavone induces neural stem cell proliferation and reverses cognitive deficits in early Alzheimer's disease models via canonical Wnt/β-catenin pathway

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Food Science and Human Wellness 2024年

作者： Yang-Yang lu Xiao-Wan Li Zhi-Ping Qin Wen-Jing Sun Yong-Biao Li Shao-Bo Liu lu lu Rong-Fei Yang Na-Na Zhang Yi-Ting Liu Jun Zhang Qing-Shan Liu Key Laboratory of Ethnomedicine for Ministry of Education Center on Translational Neuroscience Minzu University of China Center for Life Sciences School of Life Science and Technology Harbin Institute of Technology Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong First Medical University

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system. It results in cognitive dysfunction due to the loss of functional neurons and a deficit of new neurons， which can lead to death in severe cases. Repairing damaged neurons by promoting hippocampal neurogenesis has become therapeutic modality to combat neurodegenerative diseases. The novel isoflavone alkaloid LY01， found in the edible fruits of Sophora alopecuroides L.， has various neuroprotective effects. However， the molecular mechanism by which it promotes the proliferation of endogenous neural stem cells (NSCs) is not yet precisely known. The effects of LY01 were investigated in vivo and in vitro. In vivo experiments showed that LY01 could counteract the toxic damage of Aβ， enhance the learning ability and memory capacity of 5×FAD mice， and improve the morphology of neurons in the hippocampal region. In vitro experiments showed that LY01 was effective against antioxidant damage， improved the cell morphology of C17.2 mouse NSCs after hydrogen peroxide injury， and increased cell viability. Both in vitro and in vivo experiments promoted NSC proliferation by upregulating the mRNA and protein levels of the critical genes of the Wnt/β-catenin pathway， which increased levels of doublecortin to facilitate new neuronal generation. This indicates that the ability of LY01 to counteract Aβ toxicity and alleviate oxidative damage in early AD is associated with activation of the Wnt/β-catenin signaling pathway to promote NSC proliferation and thus repair damaged neurons.

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Preparation of Corncob-Like WO₃ Nanomaterials and Their Photocatalytic Treatment of Toluene

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Journal of Materials Science and Chemical Engineering 2024年第2期12卷 84-93页

作者： Jianhai Wang lu lu Bing Xu Hongfeng Xu Hongwen Liu Liaoning Provincial Key Laboratory of Metal Air New Energy Battery Dalian Jiaotong University Dalian China Dalian Ecological Environment Monitoring Center of Liaoning Province Dalian China

Corn rod-like WO3 nanomaterials were successfully synthesized by a simple hydrothermal method. The morphology, structure and optical absorption properties of the prepared samples were characterized by SEM, XRD, FTIR and UV-Vis-DRS. The WO3 materials were corn rod-like morphology with about 800 nm for length and 150 nm for diameter, especially there were plenty of corn particles (about 20 nm) on the surface of corn rods. The X-ray diffraction peaks of the products corresponded with WO3 standard card, and the characteristic peak of W-O bond was found in the infrared spectrum. The absorption band edge of the products was about 480 nm, indicating their potential visible-light-induced photocatalytic activity. In situ FTIR technology research showed that the prepared WO3 nanomaterials had visible photocatalytic activity to gas-phase toluene. After a photocatalytic reaction for 8 hours toluene was effectively degraded, and carboxylic acid and aldehyde could be regarded as the intermediate products, and CO2 was produced as the final product during the reaction process.

关键词： WO3 Nanomaterials Visiblelight Photocatalytic Degradation Toluene In Situ FTIR

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北朝元氏家族与外戚婚姻考

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江汉论坛 2024年第4期 108-113页

作者：陆路上海师范大学都市文化研究中心上海市中华典籍与国家文明重点创新团队上海200234

元氏作为北魏、东魏、西魏的皇族,其婚姻对当时社会政治影响甚大,婚姻是元氏笼络胡族各部族及汉族士族以加强统治的工具,外戚是元氏统治的重要力量,成为外戚的家族往往通过亲上做亲的婚姻,让元氏与家族成员继续通婚,以延续家族地位。现... 详细信息

元氏作为北魏、东魏、西魏的皇族,其婚姻对当时社会政治影响甚大,婚姻是元氏笼络胡族各部族及汉族士族以加强统治的工具,外戚是元氏统治的重要力量,成为外戚的家族往往通过亲上做亲的婚姻,让元氏与家族成员继续通婚,以延续家族地位。现可知元氏与外戚家族婚姻约63桩,占现可知北朝元氏家族424桩婚姻的15%,虽然婚姻总数不如元氏与胡族和汉族士族间的婚姻,但因外戚的特殊地位和影响力,与外戚间的通婚自然也是元氏家族婚姻的重要组成部分。元氏强大时期,外戚通过婚姻依附于元氏、并以此扩大自己家族的影响力,当元氏统治衰落时,权臣控制朝政,再通过婚姻成为外戚,进一步掌控元氏家族。元氏与外戚权臣间婚姻的考索可为元氏外戚家族、元氏与外戚间关系、北朝政治等研究提供相关学术视角和研究资料。

关键词：北朝元氏家族外戚婚姻

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环氧树脂基近红外吸收涂层的近红外光谱、力学及耐盐水性能研究

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光谱学与光谱分析 2024年第2期44卷 439-445页

作者：张伟钢潘露露吕丹丹滁州学院材料与化学工程学院安徽滁州239000

以环氧树脂为粘合剂,Sm2O3为功能颜料,硅烷偶联剂和石墨烯为改性剂,制备得到了一种同时具有突出力学性能和耐盐水性能的近红外低反射率涂层。系统研究了Sm2O3添加量、硅烷偶联剂种类、硅烷偶联剂添加量和石墨烯添加量对涂层性能的影响... 详细信息

以环氧树脂为粘合剂,Sm2O3为功能颜料,硅烷偶联剂和石墨烯为改性剂,制备得到了一种同时具有突出力学性能和耐盐水性能的近红外低反射率涂层。系统研究了Sm2O3添加量、硅烷偶联剂种类、硅烷偶联剂添加量和石墨烯添加量对涂层性能的影响。结果表明:Sm2O3添加量的增加可明显降低涂层对1.06μm近红外光的反射率,当Sm2O3添加量为50%,涂层对1.06μm近红外光的反射率可低至31.2%。此时,涂层的附着力和耐冲击强度分别可达到1级和50 kg·cm。用硅烷偶联剂改性涂层,偶联剂上的强极性基团分别可与涂层中的树脂基体和颜料形成共价键结合,从而可发挥桥连作用,进而可明显改善涂层的柔韧性,其中KH560的改性效果最佳。当KH560添加量为5%,涂层的柔韧性可从改性前的9 mm显著改善为改性后的4 mm。石墨烯具有特殊的共平面结构和超长共轭结构特征,使其对入射光的吸收可延伸到近红外区域。石墨烯特殊的片层结构使其具有很高的耐冲击强度和柔韧性,在涂层中添加石墨烯可明显改善涂层的力学性能。研究发现石墨烯的添加可在进一步改善涂层力学性能的前提下显著降低涂层对1.06μm近红外光的反射率。当石墨烯添加量为8%,涂层对1.06μm近红外光的反射率可低至12.6%,此时涂层可具备突出的激光隐身效能。同时,涂层的附着力、柔韧性和耐冲击强度分别可达到1级、2 mm和50 kg·cm,可很好地满足实际工程应用要求。在环氧树脂、硅烷偶联剂和石墨烯的协同界面优化作用下,最佳配方(Sm2O3添加量为50%、KH560添加量为5%、石墨烯添加量为8%)的涂层经盐水腐蚀21 d后,涂层的微结构、近红外低反射率性能和力学性能可保持稳定。此时,涂层对1.06μm近红外光的反射率为12.47%,涂层的附着力、柔韧性和耐冲击强度分别可保持在1级、2 mm和45 kg·cm,表明制备的涂层具有良好的耐盐水性能。

关键词：复合涂层近红外光谱力学性能耐盐水性能

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大运河国家文化形象的时代价值与符号传播

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南京社会科学 2024年第4期 154-164页

作者：路璐李胜疆南京农业大学人文与社会发展学院南京210095 南京农业大学中国资源环境与发展研究院南京210095

国家文化形象是国家形象的一个关键维度,而大运河对国家文化形象的传播具有积极意义,它历史悠久、沟通南北,蕴含联通价值、大一统意识以及开放包容的民族精神等文化内涵。这些丰厚的历史文化富矿促使大运河作为特殊的巨型文化符号,在当... 详细信息

国家文化形象是国家形象的一个关键维度,而大运河对国家文化形象的传播具有积极意义,它历史悠久、沟通南北,蕴含联通价值、大一统意识以及开放包容的民族精神等文化内涵。这些丰厚的历史文化富矿促使大运河作为特殊的巨型文化符号,在当下时代精神的征召下积极建构国家文化形象,有助于我国在“西方中心论”的话语陷阱中寻回文化意义上坚定的自我,进而担负起新文化使命的价值引领。符号是形象传播的重要载体,大运河这个巨型文化符号进入国家文化形象传播的实践场域,可具体分类为“联通性文化符号凝聚文化认同”“凝缩性文化符号建构记忆之场”“转换性文化符号推动现代转型”三重面向,并在古与今、传统与现代、中国与世界的多重张力中将深刻的文化主体性意识浸润到国家文化形象传播中。

关键词：大运河国家文化形象时代价值文化符号

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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming lu Qi-yun HE Liu SONG Wei SUN lu luO lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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论东汉发生了拉链式“元音大转移”——立足于河洛地区的音类、音值证据

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浙江大学学报（人文社会科学版） 2024年第6期54卷 120-136页

作者：边田钢卢鹭浙江大学汉语史研究中心浙江杭州310058

关于汉语史上首次“元音大转移”,一般认为是发生在西晋以后到北朝初期的“推链”音变。然而,根据东汉河洛地区音类、音值两方面的证据,即音注、韵段所呈现的音类重组关系和可靠译经音译词对应的原语言音值,可以证明该链移发生于东汉,... 详细信息

关于汉语史上首次“元音大转移”,一般认为是发生在西晋以后到北朝初期的“推链”音变。然而,根据东汉河洛地区音类、音值两方面的证据,即音注、韵段所呈现的音类重组关系和可靠译经音译词对应的原语言音值,可以证明该链移发生于东汉,且是“拉链”音变。“元音大转移”深刻调整了上古韵部的结构和数量,与声母系统的调整一道推动上古音系转变为全新的中古音系格局。古音质变发生于东汉,形成了上、中古音系的分水岭,这与词汇、语法学界的分期认识殊途同归。

关键词：上古音元音大转移音系重组语音史分期

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