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Variational Principles for Asymptotic Variance of General Markov Processes

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Acta Mathematica Sinica,English Series 2023年第1期39卷 107-118页

作者： lu jing huang Yong Hua MAO Tao WANG School of Mathematics and Statistics Fujian Normal UniversityFuzhou 350007P.R.China School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex SystemsMinistry of EducationBeijing 100875P.R.China

A variational formula for the asymptotic variance of general Markov processes is *** application,we get an upper bound of the mean exit time of reversible Markov processes,and some comparison theorems between the reve... 详细信息

关键词： Markov process asymptotic variance variational formula the mean exit time comparison theorem semi-Dirichlet form

RESEARCH ON THE HYDRODYNAMIC CHARACTERISTICS OF CAVITATING GRID FINS

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Journal of Hydrodynamics 2006年第5期18卷 537-541页

作者： WU Lei lu Chuan-jing huang Tao LI Jie Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200240 China

A two-phase mixture model based on the solution for the Navier-Stokes equations has been utilized in calculating the hydrodynamic characteristics of cavitating honeycomb grid fins with different configurations. The calculation results of lift, drag, and hinge moment coefficients are presented in various cavitation numbers and angles of attack, and its hydrodynamic features are also analyzed. The calculation results indicate that cavitation will reduce the lift/drag ratio of grid fins. The increment of horizontal blades as lift surface cannot unendingly improve lift because of the disturbance between the blades.

关键词： grid fin cavitating flow hydrodynamic characteristic equivalence

Electrophysiological characteristics of cardiomyocyte-like cells from rat bone marrow derived mesenchymal stem cells by four inductors

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Chinese Medical Journal 2013年第18期126卷 3528-3533页

作者： LIU Bo-wu lu An-lin HOU jing huang Wei HOU Hong HOU Zhao-lei DA jing AI Shi-yi Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China

Background Bone marrow derived mesenchymal stem cel induced by different inductors individually or collectively. In s （BMdMSCs） can differentiate into cardiomyocyte-like cells this study, by inducing BMdMSCs with p53 inhibitor （p-fifty three inhibitor-alpha, PFT-a）, 5-azacytidine （5-AZA）, angiotensin-II （Ang-II） and bone morphogenic protein-2 （BMP-2） we compared the influences of four inductors on the differentiation of rat BMdMSCs into caridomyocyte like-cells. Methods BMdMSCs were collected from the bone marrow of Sprague Dawley rats and after the fourth generation, the purified cells were divided into five groups： 5-AZA （10 μmol/L）, Ang-II （0.1 μmol/L）, PFT-α （20 μmol/L）, BMP-2 （10μg/L） and control. The purity of the BMdMSCs and the cardiac differentiation rates were obtained by flow cytometry. The expressions of cTnT in the BMdMSCs after four weeks of induction were detected by immunofluorescence and the expressions of cTnl and Cx43 detected by Western blotting. The green fluorescent levels reflecting intracellular calcium transient function were determined by laser scanning confocal microscopy. The total potassium current levels of cells were measured on patch clamp. Results All inductors affected to a different degree the differentiation of BMdMSCs into cardiomyocyte-like cells and the expressions of cTnT, cTnl and Cx43 suggesting that the combination of inductors could be an improved method for cardiac regenerative medicine. In addition, the total potassium current level and calcium transient in PFT-a cardiomyocyte-like cells were higher than other groups. Conclusions The cardiac differentiation of BMdMSCs induced by PFT-α, 5-AZA, Ang-II and BMP-2 has been improved at different levels. PFT-a has an advantage of differentiation rate and electrophysiological function over other inductors.

关键词： bone marrow mesenchymal stem cells differentiation cardiomyocyte electrophysiological characteristics

Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells

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Chinese Medical Journal 2012年第18期125卷 3318-3324页

作者： LIU Bo-wu lu An-lin HOU jing huang Wei LI Yao HOU Zhao-lei HOU Hong DA jing YANG Na Al Shi-yi Department of Cardiology Xijing Hospital Fourth MilitaryMedical University of Chinese People's Liberation Army Xi'an China Shaanxi 710032

Objective To review the progress of cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells. Data sources The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for papers published from January 2000 to January 2012 with the key words of ＂bone marrow mesenchymal stem cells, cardiac or heart, electrophysiology or electrophysiological characteristics＂. Study selection The articles concerned cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells were collected. After excluding papers that study purposes are not coincident with this review or contents duplicated, 56 papers were internalized at last. Results For the treatment of myocardial infarction and myocardiac disease, the therapeutic effects of transplantation of bone marrow mesenchymal stem cells which have the ability to develop into functional myocardial cells by lots of methods have been proved by many researches. But the arrhythmogenic effect on ventricles after transplantation of bone marrow mesenchymal stem cells derived myocardial cells is still controversial in animal models. Certainly, the low differentiation efficiency and heterogeneous development of electricial function could be the most important risk for proarrhythmia. Conclusion Many studies of cardiac differentiation of bone marrow mesenchymal stem cells have paid attention to improve the cardiac differentiation rate, and the electrophysiology characteristics of the differentiated cells should be concerned for the risk for proarrhythmia as well.

关键词： mesenchymal stem cell differentiation cardiac electrophysiology

A New Multi-sensor Data Fusion Algorithm Based on EMD-MMSE

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Journal of Shanghai Jiaotong university(Science) 2007年第2期12卷 153-158页

作者：张琦阙沛文陈天璐黄晶 Inst.of Automation Detection Shanghai Jiaotong Univ.

A new multi-sensor data fusion algorithm based on EMD-MMSE was *** mode decomposition(EMD)is used to extract the noise of every time series for estimating the variance of the *** minimum mean square error(MMSE)estimator is used to calculate the weights of the corresponding ***,the fused signal is the weighted addition of all these *** experiments in lab testified the efficiency of this *** addition,the comparison in fusion time and fusion results with existing fusion method based on wavelet and average technique shows the advantage of this method greatly.

关键词： data fusion empirical mode decomposition (EMD) minimum mean square error (MMSE) multisensor system

低密度聚乙烯熔体挤出胀大的实验和数值模拟预测

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上海交通大学学报 2003年第4期37卷 535-540页

作者：黄树新江体乾鲁传敬黄进上海交通大学工程力学系上海200030 华东理工大学化工学院上海200237

对一种国产低密度聚乙烯 ( LDPE)进行了经过长毛细管的挤出胀大流动实验测量 ,得到了挤出胀大比和流动曲线 .测定了材料的线性和非线性粘弹性 ,并用 PSM模型进行了表征 ,同时数值模拟了 LDPE熔体的挤出胀大流动 .预测结果与实验基本吻... 详细信息

对一种国产低密度聚乙烯 ( LDPE)进行了经过长毛细管的挤出胀大流动实验测量 ,得到了挤出胀大比和流动曲线 .测定了材料的线性和非线性粘弹性 ,并用 PSM模型进行了表征 ,同时数值模拟了 LDPE熔体的挤出胀大流动 .预测结果与实验基本吻合 ,但在较高剪切速率下两者间还存在一定的偏差。

关键词：低密度聚乙烯挤出胀大实验流变性测量实验 PSM模型数值模拟

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组蛋白乙酰化与癌症

生物化学与生物物理进展 2003年第1期30卷 19-23页

作者：刘春艳孙海晶陆军黄百渠东北师范大学遗传与细胞研究所长春130024

由于组蛋白被修饰所引起的染色质结构的改变 ,在真核生物基因表达调控中发挥着重要的作用 ,这些修饰主要包括甲基化、乙酰化、磷酸化和泛素化等 ,其中组蛋白乙酰化尤为重要 .组蛋白乙酰转移酶 (HAT)和组蛋白去乙酰化酶 (HDAC)参与决定... 详细信息

由于组蛋白被修饰所引起的染色质结构的改变 ,在真核生物基因表达调控中发挥着重要的作用 ,这些修饰主要包括甲基化、乙酰化、磷酸化和泛素化等 ,其中组蛋白乙酰化尤为重要 .组蛋白乙酰转移酶 (HAT)和组蛋白去乙酰化酶 (HDAC)参与决定组蛋白乙酰化状态 .HAT通常作为多亚基辅激活物复合体的一部分 ,催化组蛋白乙酰化 ,导致染色质结构的松散、激活转录 ;而HDAC是多亚基辅抑制物复合体的一部分 ,使组蛋白去乙酰化 ,导致染色质集缩 ,并抑制基因的转录 .编码这些酶的基因染色体易位易于导致急性白血病的发生 .另一方面 ,已经确定了一些乙酰化修饰酶的基因在染色体上的位置 ,它们尤其倾向定位于染色体的断裂处 .综述了HAT和HDAC参与的组蛋白乙酰化与癌症发生之间关系的最新进展 ,以期进一步阐明组蛋白乙酰化修饰酶的生物学功能以及它们在癌症发生过程中的作用 .

关键词：组蛋白乙酰化组蛋白乙酰转移酶组蛋白去乙酰化酶癌症肿瘤发生

Mucin-Producing Intrahepatic Biliary Papillomatosis

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Mucin-Producing Intrahepatic Biliary Papillomatosis

In Vivo Mediator Requirement for a Basal Level of Transcription

2009年浙江省外科学学术年会

作者： Department of 1 General Surgery Li Hui-Li Hospital Ningbo University School of Medicine Ningbo China Shengdong Wu Caide lu Changjiang lu jing huang Department of Pathology Li Hui Li Hospital Ningbo University School of Medicine Ningbo China Jue Zhou

Purpose Mucin-producing intrahepatic biliary papillomatosis(MPIBP)is an uncommon tumor. The purpose of this study was to evaluate the clinical,radiological,and histopathological characteristics of MPIBP,and its progno...

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In Vivo Mediator Requirement for a Basal Level of Transcript...