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Paraplegia from spinal intramedullary tuberculosis:A case report

World Journal of Clinical Cases 2020年第24期8卷 6353-6357页

作者： Li-Mei Qu Di Wu Liang Guo jin-lu Yu Department of Pathology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Neurosurgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Tuberculosis (TB) mostly attacks the lungs, and extrapulmonary TB involving thecentral nervous system is uncommon;among these cases, spinal intramedullaryTB is even more rare. The clinical manifestations of spinal intramedullary TB aresimilar to those of intramedullary spinal cord tumors. Therefore, it is necessary tomake a careful differential diagnosis of spinal intramedullary lesions to achievethe appropriate treatment and favorable prognosis. We report a rare case of ayoung male patient with paraplegia due to spinal intramedullary TB, which isuncommon and *** SUMMARY A 23-year-old male presented with fever accompanied by nausea and vomitinglasting for 2 mo and was then diagnosed with tubercular meningitis. After anti-TBtreatment, his symptoms were significantly improved. However, 2 mo after thediagnosis of tubercular meningitis, the patient felt numbness below the costal archlevel, which lasted for 1 wk, and he paid no attention to this symptom. Whatfollowed was paraplegia and urine/fecal incontinence. Magnetic resonanceimaging of the thoracic spine showed a ring-enhanced intramedullary cord lesionat T8-T9. Lesion exploration showed enlargement of the spinal cord at T8-T9, andthe lesion could be observed by incision. The lesion was adhered to the peripheraltissue and was grayish-white and tough with a poor blood supply and a diameterof approximately 0.8 cm. The lesion was resected completely. The results ofpathological examination by both hematoxylin-eosin staining and acid-fast bacillistaining confirmed TB, accompanied by acute and chronic suppurativeinflammation and granulation tissue formation. The patient was instructed tocontinue anti-TB treatment after the operation, but he did not follow the medicaladvice. Follow-up continued for ten years, the patient had persistent paraplegia,the numbness disappeared and urine/fecal sensation *** Although TB is a kind of benign disease, some cases progress rapidly. Moreover,spina

关键词： Tuberculosis Intramedullary Extrapulmonary Central nervous system Paraplegia Case report

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Hydrodynamic Instability Analysis of the Axial Flow Pump in an Ethylene Polymerization Loop Reactor

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China Petroleum Processing & Petrochemical Technology 2022年第1期24卷 135-148页

作者： lu jin Yang Yao Sun jingyuan Huang Zhengliang Yang Yongrong Wang jingdai Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058 State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058

The hydrodynamic instability of the axial flow pump in a loop reactor has long been a troubling issue to be solved in the polyethylene industry due to the lack of a better mechanismic ***,the instability of an axial flow pump can be reflected by the fluctuation of the pump *** this study,the transient computational fluid dynamics(CFD)simulation is adopted to study the hydrodynamic instability of the axial flow pump used in an ethylene polymerization loop *** results show that the pump head under single liquid phase nearly remains constant while the pump head under slurry phase fluctuates due to the variation of solid volume fraction distribution in the ***,under the combined effect of the maximum solid volume fraction difference in the pump and the turbulence intensity of the liquid phase,the fluctuation of the pump head under slurry phase increases when the solid volume fraction in the loop reactor increases from 0.10 to 0.29,and the fluctuation decreases,when the solid volume fraction increases from 0.29 to ***,there is a negative correlation between the pump head and the solid volume fraction in the pump;with the increase of solid volume fraction in the loop reactor,and the correlation coefficient increases as ***,a‘spiral particulate band’phenomenon is formed in the ascending leg caused by three mechanisms,viz.:the segregation of particles in all bends,the dispersion of particles by the secondary flow in the ascending leg,and the rotational movement of particles in the pump.

关键词： axial flow pump loop reactor CFD hydrodynamic instability polyethylene

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PPP1R14A is Associated with Immunotherapy Resistance in Head and Neck Squamous Cell Carcinoma Identified by Single-Cell and Bulk RNA-Sequencing

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Chinese Medical Sciences Journal 2024年第2期39卷 111-121页

作者： Jun-Jie Ma Lei Zhang jin lu Hao-Xuan Zhang Department of Clinical Medicine Bengbu Medical UniversityBengbu 233030AnhuiChina Department of General Surgery The Second Affiliated Hospital of Bengbu Medical UniversityBengbu 233030AnhuiChina Department of Human Anatomy Bengbu Medical UniversityBengbu 233030AnhuiChina Anhui Key Laboratory of Computational Medicine and Intelligent Health Bengbu Medical UniversityBengbu 233030AnhuiChina

Objective To identify nivolumab resistance-related genes in patients with head and neck squamous cell carcinoma(HNSCC)using single-cell and bulk RNA-sequencing *** The single-cell and bulk RNA-sequencing data downloaded from the Gene Expression Omnibus database were analyzed to screen out differentially expressed genes(DEGs)between nivolumab resistant and nivolumab sensitive patients using R *** Least Absolute Shrinkage Selection Operator(LASSO)regression and Recursive Feature Elimination(RFE)algorithm were performed to identify key genes associated with nivolumab *** enrichment of DEGs was analyzed with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** relationships of key genes with immune cell infiltration,differentation trajectory,dynamic gene expression profiles,and ligand-receptor interaction were *** We found 83 *** were mainly enriched in T-cell differentiation,PD-1 and PD-L1 checkpoint,and T-cell receptor *** six key genes identified using machine learning algorithms,only PPP1R14A gene was differentially expressed between the nivolumab resistant and nivolumab sensitive groups both before and after immunotherapy(P0,Plusions PPP1R14A gene is closely associated with resistance to nivolumab in HNSCC ***,PPP1R14A may be a target to ameliorate nivolumab resistance of HNSCC patients.

关键词： PPP1R14A head and neck squamous cell carcinoma immunotherapy drug resistance

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Effects of spaceflight and simulated microgravity on cell sub-microstructure and antioxidant enzyme activity in tomato

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Science China(Technological Sciences) 2015年第2期58卷 338-345页

作者： CHEN Yu lu jin Ying LI Hua Sheng SUN Qiao ZHAO Ying SU Liang LIU Min Space Molecular Biology Laboratory China Academy of Space Technology

Controlled ecological life support systems provide food, air, water, and other basic living resources for crew members on long-duration spaceflight missions. Plants are an important basic requirement of these systems and their biological characteristics in space have very high research value. Based on experiments of spaceflight in Shenzhou 8 spacecraft and simulating microgravity effects on three-dimensional （3-D） clinostat, the biological characteristics of tomato＇s leaf cell sub-microstructure and antioxidant enzyme activities were studied and compared in this work. Results showed that leaf cell sub-microstructure of the tomato samples experiencing spaceflight had more changes than effects, and both peroxidase （POD） and superoxide dismutase （SOD） that of the samples processed by simulated microgravity activities increase obviously in both the environments.

关键词： tomato plantlet spaceflight simulated microgravity sub-microstructure antioxidant enzyme

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Effect of Rapid Thermal Annealing Ambient on Photoluminescence of ZnO Films

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Chinese Physics Letters 2012年第3期29卷 190-192页

作者： XU Xiao-Yan MA Xiang-Yang jin lu YANG De-Ren State Key Laboratory of Silicon Materials and Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027

The effects of rapid thermal annealing(RTA)ambient on photoluminescence(PL)of sputtered ZnO films are *** RTA at 800℃under either oxygen(O_(2))or argon(Ar)ambient can remarkably enhance the PL of the ZnO films due to the improved crystallinities of the ZnO *** is somewhat unexpected that the ZnO film which received the RTA under O_(2)ambient exhibits weaker near-band-edge(NBE)PL than that which received the RTA under Ar *** is supposed that a certain amount of negatively charged oxygen species exist on the surface of the ZnO film that received the RTA under O_(2)ambient,leading to a build-in electric *** in turn reduces the recombination probability of photo-generated electrons and holes,resulting in the suppressed NBE PL.

关键词： ambient film films

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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

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Stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： Yujia jin Yu-hui Huang Yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye lu-hang jin Jian Wu Chang-zheng Yuan Feng Gao lu-sha Tong Neurology Department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina Department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(cSS)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of cSS and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(cSS-CMB−,cSS-CMB+,cSS+CMB−,cSS+CMB+)according to cSS and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin Scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had cSS and 468(69.5%)had *** with cSS+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** cSS−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of cSS+.Conclusions Patients with different combinations of cSS and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

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Major and trace element composition of surface sediments from the Southwest Indian Ridge:evidence for the incorporation of a hydrothermal component

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Acta Oceanologica Sinica 2016年第2期35卷 101-108页

作者： LI Zhenggang CHU Fengyou jin lu LI Xiaohu DONG Yanhui CHEN Ling ZHU Jihao Key Laboratory of Submarine Geoscience Second Institute of OceanographyState Oceanic Administration (SOA) Department of Earth Sciences Zhejiang University

Hydrothermal materials in deep-sea sediments provide a robust tracer to the localized hydrothermal activity at mid-ocean ridges. Major, trace and rare earth element（REE） data for surface sediments collected from the ultraslow spreading Southwest Indian Ridge are presented to examine the existence of hydrothermal *** carbonate oozes dominate all the sediment samples, with CaO content varying from 85.5% to 89.9% on a volatile-free basis. The leaching residue of bulk sediments by ~5% HCl is compositionally comparable to the Upper Continental Crust（UCC） in SiO_2, Al_2O_3, CaO, MgO, alkali elements（Rb, Cs） and high field strength elements（Nb, Ta, Zr, Hf, Ti）. These detritus-hosted elements are inferred to be prominently derived from the Australian continent by means of eolian dust, while the contribution of local volcaniclastics is insignificant. In addition, the residual fraction shows a clear enrichment in Fe, Mn, and Ba compared with the UCC. Combining the positive Eu anomaly of residual fraction which is opposed to the UCC but the characteristic of hydrothermal fluids and associated precipitates occurred at mid-ocean ridges, the incorporation of localized hydrothermal component can be constrained. REE mixing calculations indicate that more than half REE within the residual fraction（~55%–60%） are derived from a hydrothermal component, which is inferred to be resulted from a diffuse fluid mineralization. The low-temperature diffuse flow may be widely distributed along the slow-ultraslow spreading ridges where crustal faults and fissures abound, and probably have a great mineralization potential.

关键词： deep-sea sediments hydrothermal component diffuse fluid eolian dust Southwest Indian Ridge

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A UNICITY THEOREM FOR ENTIRE FUNCTIONS OF SEVERAL COMPLEX VARIABLES

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Chinese Annals of Mathematics,Series B 2004年第4期25卷 483-492页

作者： jinlu DepartmentofMathematics FudanUniversityShanghai200433China

A unicity theorem concerning the total derivative for entire functions of several complex variables is proved.

关键词： Unicitv theorem Entire function Total derivative

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Optimization Evaluation Test of Strength and Toughness Parameters for Hot-Stamped High Strength Steels

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Journal of Iron and Steel Research International 2013年第11期20卷 51-56页

作者： YING Liang lu jin-dong CHANG Ying TANG Xing-hui HU Ping ZHAO Kun-min School of Automotive Engineering State Key Laboratory of Structural Analysis for Industrial EquipmentDalian University of Technology

Use of hot-stamped high strength steels （HSHSS） not only reduces the vehicle weight, but also improves the crash safety, therefore more and more mentioned steels are used to produce automobile parts. However, there are several problems especially the low ductility and toughness, which have restricted the application of HSHSS in automobile body. Suitable process parameters are very crucial to improve strength and toughness. In order to study the effect of austenization temperature, soaking time and start deformation temperature on strength and toughness of boron steel 22MnB5, an L9 （34） orthogonal experiment which was analyzed by means of comprehensive evaluation was carried out based on Kahn tear method to obtain the value of fracture toughness. The results indicate that the ex- cellent formability, high strength and toughness of boron steel 22MnB5 with 1.6 mm in thickness are obtained when the austenization temperature is in the range of 920- 950 ℃, the soaking time is 1 min and the start deformation temperature is in the range of 650- 700 ℃. The optimal parameters were used for typical hot stamping structural parts tests. Properties of samples such as tear strength, unit initiation energy and ratio of strength to toughness （RST） were improved by 10.91%, 20.32% and 22.17%, respectively. Toughness was increased substantially on the basis of a small decrease of strength.

关键词： hot stamping Kahn tear ratio of strength to toughness (RST) orthogonal experimental design multi- objective optimization

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Abnormalities Occurring during Female Gametophyte Development Result in the Diversity of Abnormal Embryo Sacs and Leads to Abnormal Fertilization in indica/japonica Hybrids in Rice

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Journal of Integrative Plant Biology 2009年第1期51卷 3-12页

作者： Yu-Xiang Zeng Chao-Yue Hu Yong-Gen lu jin-Quan Li Xiang-Dong Liu ( Guangdong Provincial Key Laboratory of Plant Molecular Breeding South China Agricultural University Guangzhou 510642 China)

Embryo sac abortion is one of the major reasons for sterility in indicaljaponica hybrids in rice. To clarify the causal mechanism of embryo sac abortion, we studied the female gametophyte development in two indicaljaponica hybrids via an eosin B staining procedure for embryo sac scanning using confocal laser scanning microscope. Different types of abnormalities occurred during megasporogenesis and megagametogenesis were demonstrated. The earliest abnormality was observed in the megasporocyte. A lot of the chalazal-most megaspores were degenerated before the mono-nucleate embryo sac stage. Disordered positioning of nucleus and abnormal nucellus tissue were characteristics of the abnormal female gametes from the mono-nucleate to four-nucleate embryo sac stages. The abnormalities that occurred from the early stage of the eight-nucleate embryo sac development to the mature embryo sac stage were characterized by smaller sizes and wrinkled antipodals. Asynchronous nuclear migration, abnormal positioning of nucleus, and degeneration of egg apparatus were also found at the eight-nucleate embryo sac stage. The abnormalities that occurred during female gametophyte development resulted in five major types of abnormal embryo sacs. These abnormal embryo sacs led to abnormal fertilization. Hand pollination using normal pollens on the spikelets during anthesis showed that normal pollens could not exclude the effect of abnormal embryo sac on seed setting.

关键词： indicaljaponica hybrid megagametogenesis megasporogenesis Oryza sativa whole-mount eosin B-staining confocal laser scanning microscopy.

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