检索结果-南通市图书馆

Multiple Equilibria in a Land–Atmosphere Coupled System

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2018年第6期32卷 950-973页

作者： Dongdong LI Yongli HE Jianping HUANG lu bi Lei DING Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric Sciences Lanzhou University

Many low-order modeling studies indicate that there may be multiple equilibria in the atmosphere induced by thermal and topographic ***,most work uses uncoupled atmospheric model and just focuses on the multiple equilibria with distinct wave amplitude,i.e.,the high-and low-index ***,a low-order coupled land–atmosphere model is used to study the multiple equilibria with both distinct wave phase and wave *** model combines a two-layer quasi-geostrophic channel model and an energy balance *** truncated spectral expansions are used and the results show that there may be two stable equilibria with distinct wave phase relative to the topography:one(the other)has a lower layer streamfunction that is nearly in(out of)phase with the topography,i.e.,the lower layer ridges(troughs)are over the mountains,called ridge-type(trough-type)*** wave phase of equilibrium state depends on the direction of lower layer zonal wind and horizontal scale of the *** multiple wave phase equilibria associated with ridge-and trough-types originate from the orographic instability of the Hadley circulation,which is a pitch-fork *** with the uncoupled model,the land–atmosphere coupled system produces more stable atmospheric flow and more ridge-type equilibrium states,particularly,these effects are primarily attributed to the longwave radiation *** upper layer streamfunctions of both ridge-and trough-type equilibria are also characterized by either a high-or low-index flow ***,the multiple wave phase equilibria associated with ridge-and trough-types are more prominent than multiple wave amplitude equilibria associated with high-and low-index types in this study.

关键词： multiple equilibria land–atmosphere coupling wave phase longwave radiation stability

Pedestrian lane formation with following–overtaking model and measurement of system order

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第2期33卷 247-263页

作者：李碧璐李政周睿申世飞 Department of Engineering Physics Tsinghua UniversityBeijing 100084China School of Safety Science Tsinghua UniversityBeijing 100084China

Pedestrian self-organizing movement plays a significant role in evacuation studies and architectural *** formation,a typical self-organizing phenomenon,helps pedestrian system to become more orderly,the majority of following behavior model and overtaking behavior model are imprecise and unrealistic compared with pedestrian movement in the real *** this study,a pedestrian dynamic model considering detailed modelling of the following behavior and overtaking behavior is constructed,and a method of measuring the lane formation and pedestrian system order based on information entropy is *** and analysis demonstrate that the following and avoidance behaviors are important factors of lane formation.A high tendency of following results in good lane *** non-selective following behavior and aggressive overtaking behavior cause the system order to *** most orderly following strategy for a pedestrian is to overtake the former pedestrian whose speed is lower than approximately 70%of his *** influence of the obstacle layout on pedestrian lane and egress efficiency is also studied with this *** presence of a small obstacle does not obstruct the walking of pedestrians;in contrast,it may help to improve the egress efficiency by guiding the pedestrian flow and mitigating the reduction of pedestrian system orderliness.

关键词： pedestrian movement lane formation information entropy order degree

Aligned fibers enhance nerve guide conduits when bridging peripheral nerve defects focused on early repair stage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第5期14卷 903-912页

作者： Qi Quan Hao-Ye Meng biao Chang Guang-Bo Liu Xiao-Qing Cheng He Tang Yu Wang Jiang Peng Qing Zhao Shi-bi lu Department of Orthopedic Surgery Key Laboratory of Musculoskeletal Trauma & War Injuries PLA Beijing Key Lab of Regenerative Medicine in Orthopedics Chinese PLA General Hospital School of Materials Science and Engineering University of Science & Technology Beijing Department of Laser Medicine Chinese PLA General Hospital Neural Regeneration Co-innovation Center of Jiangsu Province Department of Orthopedic Surgery First Affiliated Hospital of PLA General Hospital

Nerve conduits enhance nerve regeneration in the repair of long-distance peripheral nerve defects. To help optimize the effectiveness of nerve conduits for nerve repair, we developed a multi-step electrospinning process for constructing nerve guide conduits with aligned nanofibers. The alignment of the nerve guide conduits was characterized by scanning electron microscopy and fast Fourier transform. The mechanical performance of the nerve guide conduits was assessed by testing for tensile strength and compression resistance. The biological performance of the aligned fibers was examined using Schwann cells, PC12 cells and dorsal root ganglia in vitro. Immunohistochemistry was performed for the Schwann cell marker S100 and for the neurofilament protein NF200 in PC12 cells and dorsal root ganglia. In the in vivo experiment, a 1.5-cm defect model of the right sciatic nerve in adult female Sprague-Dawley rats was produced and bridged with an aligned nerve guide conduit. Hematoxylin-eosin staining and immunohistochemistry were used to observe the expression of ATF3 and cleaved caspase-3 in the regenerating matrix. The recovery of motor function was evaluated using the static sciatic nerve index. The number of myelinated fibers, axon diameter, fiber diameter, and myelin thickness in the distal nerve were observed by electron microscopy. Gastrocnemius muscle mass ratio was also determined. The analyses revealed that aligned nanofiber nerve guide conduits have good mechanical properties and can induce Schwann cells, PC12 cells and dorsal root ganglia to aggregate along the length of the nanofibers, and promote the growth of longer axons in the latter two(neuronal) cell types. The aligned fiber nerve conduits increased the expression of ATF3 and cleaved caspase-3 at the middle of the regenerative matrix and at the distal nerve segment, improved sciatic nerve function, increased muscle mass of the gastrocnemius muscle, and enhanced recovery of distal nerve ultrastructure. Coll

关键词： nerve regeneration nerve guide conduit electrospinning peripheral nerve injury aligned fiber sciatic nerve structure mechanical function nerve scaffold nanofiber neural regeneration

Antenna planes based wall-clutter mitigation in through-wall-imaging applications

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2016年第10期23卷 2638-2646页

作者：孙鑫陆必应金添周智敏 College of Electronic Science and Engineering National University of Defense Technology

In ultra-wideband through-wall-imaging applications, wall clutters are always much stronger than the target reflections, and they tend to persist over a long period of time. As a result, targets are obscured and not visible in the image. In this work, an antenna planes-based wall clutter mitigation method was proposed. By using two imaging procedures in different scanning planes, this method can mitigate the wall clutter in both SAR and MIMO modes. The proposed method was tested using EM numerical data via the FDTD method. The processing results show that the imaging quality is improved significantly.

关键词： through-the-wall wall-clutter mitigation SAR mode MIMO mode

Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2012年第1期28卷 61-68页

作者： Wen-Zhen Shi Chun-Zhen Zhao bing Zhao Xiao-Liang Zheng San-Hua Fang Yun-bi lu Wei-Ping Zhang Zhong Chen Er-Qing Wei Department of Pharmacology and Institute of Neurobiology School of Medicine Zhejiang University Hangzhou 310058China

Objective To determine whether aquaporin-4 （AQP4） regulates acute lesions, delayed lesions, and the associated microglial activation after cryoinjury to the brain. Methods Brain cryoinjury was applied to AQP4 knockout （KO） and wild-type mice. At 24 h and on days 7 and 14 after cryoinjury, lesion volume, neuronal loss, and densities of microglia and astrocytes were determined, and their changes were compared between AQP4 KO and wild-type mice. Results Lesion volume and neuronal loss in AQP4 KO mice were milder at 24 h following cryoinjury, but worsened on days 7 and 14, compared to those in wild-type mice. Besides, microglial density increased more, and astrocyte proliferation and glial scar formation were attenuated on days 7 and 14 in AQP4 KO mice. Conclusion AQP4 deficiency ameliorates acute lesions, but worsens delayed lesions, perhaps due to the microgliosis in the late phase.

关键词： aquaporin-4 gene deficiency cryoinjury microglia astrocyte

Generation of h MSH2-gene knockdown lung cancer cell model with specific si RNAs in NCI-H520 cell line

在线全文

学校读者我要写书评

暂无评论

Generation of h MSH2-gene knockdown lung cancer cell model w...

Roles of NAMPT and NAD decline in patho⁃genesis of Parkinson disease in mice

第十一届全国免疫学学术大会

作者： Dai Yu Mei lu bi Chao 广州市妇女儿童医疗中心北京协和医学院&中国医学科学院基础医学研究所

Objective:To generate an h MSH2-gene knockdown lung cancer cell model with small RNA interference in NCI-H520 cell line,so as to verify the underlying mechanisms in h MSH2-mediated recognition and cytolyisis of lung cancer cells by Vγ9δ2 T ***:h MSH2 specific si RNAs were designed,synthesized and transfected into NCI-H520 *** knockdown efficiency was measured by q RT-PCR,Westernblot,flow cytometery and confocal microscopy 48 or 72 h after si RNAs ***:Transfection efficiency was up to 93% 6 h after si RNAs treatment.48 or 72 h after specific si RNAs transfection,si RNA duplex I and II respectively resulted in 97%,88% and 98%,97% reduction in h MSH2 m RNA expression when compared to mock *** h MSH2 protein expression was confirmed by Western *** surface expression of h MSH2 in si RNA-treated groups was revealed by flow cytometery and confocal ***:si RNA-h MSH2 gene knockdown lung cancer cell model was successfully generated in NCI-H520 cell line,providing a useful means to explore the recognition and cytolytic mechanism in Vγ9δ2 T cell-mediated anti-lung cancer innate immunity.

关键词： Small RNA interference Human Mut S homolog 2 Vγ9δ2 T cells lung cancer

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2021年第9期35卷 652-653页

作者： CHEN Cong SHEN Chen GAO Tong-yao WANG Tong lu Yun-bi ZHANG Wei-ping Zhejiang University School of Medicine Hangzhou 310043China

OBJECTIVE Nicotinamide phos⁃phoribosyltransferase(NAMPT)is the key enzyme for the synthesis of nicotinamide ade⁃nine dinucleotide(NAD)in the salvaging *** is an essential co-enzyme of multiple enzymes involved in cell metabolism and important enzymes such as *** level of both NAMPT and NAD decreases upon aging,which may cause neuronal ***,the roles of NAMPT and NAD in Par⁃kinson disease(PD)remain *** study was to explore the roles of NAMPT and NAD decline in the pathogenesis of PD in *** Floxed nampt gene C57BL/6J mice,including Namptwt/wt,Namptflox/wt and Namptflox/flox,were *** rAAV-hSyn-Cre-WPRE pA or rAAV-TH-Cre-WPRE pA adeno-associated virus(AAV)was used to conditioning knockout nampt gene in neurons or dopaminergic neurons,*** 2,4,6,and 8 weeks after AAV injection,the motor deficits of mice were evaluat⁃*** and immunohistochem⁃istry were used to evaluate the neuronal *** electron microscope was used to evaluate the axonal *** The knockout of nampt gene induced dopaminer⁃gic neuron loss in substantia nigra at 4 weeks but not 2 weeks after AAV *** 8 weeks after AAV injection,the Namptflox/flox mice showed a significantly decrease in motor activity in an open-field than Namptwt/wt and Namptflox/wt *** some Namptflox/flox mice showed spin behav⁃ior at 6-8 weeks after AAV *** dopa⁃minergic neurons in substantia nigra and ventral tegmental area are more susceptible to the knockout of nampt gene than the non-dopaminer⁃gic *** electron microscope examine showed degenerative changes of the myelin in striatum at 4 weeks after AAV injection for the Namptflox/flox *** orally supplementary of NAD precursor,nicotinamide ribose,improved the motor activity and decreased neuronal injury for the nampt gene knockout ***⁃SION Decline of NAMPT and NAD in dopaminer⁃gic neurons is a risk for developing PD,and NA

关键词： nicotinamide phosphoribosyltrans⁃ferase nicotinamide adenine dinucleotide myelin dopaminergic neurons

在线全文

学校读者我要写书评

暂无评论

汶川地震挤压综合征患者肌肉挤压伤的特点

中华骨科杂志 2008年第10期28卷 793-798页

作者：卢世璧解放军总医院全军骨科研究所北京100853

目的分析汶川地震挤压综合征患者肌肉挤压伤的特点。方法回顾性分析2008年5月12日汶川地震后成都军区总医院收治的挤压综合征患者8例，男女各4例；年龄25-45岁，平均35．4岁。压埋时间9-152h，平均52h。均行筋膜切开手术，截肢者6例8肢... 详细信息

目的分析汶川地震挤压综合征患者肌肉挤压伤的特点。方法回顾性分析2008年5月12日汶川地震后成都军区总医院收治的挤压综合征患者8例，男女各4例；年龄25-45岁，平均35．4岁。压埋时间9-152h，平均52h。均行筋膜切开手术，截肢者6例8肢。8例患者均行连续肾脏替代治疗。2例死于颅脑出血及肠穿孔。术后发生ARDS2例，DIC1例，气性坏疽1例。结果汶川地震肌肉挤压伤的特点：（1）挤压时间超长，导致急性肾衰；（2）挤压伤因皮肤破损轻微而被误诊，延误病情；（3）受压深层肌肉常比浅层肌肉损伤更严重；（4）肌肉坏死区多发且呈不规律分布；（5）早期坏死组织与正常肌肉混杂造成治疗困难；（6）创面在坏死组织脱落后，可有继发性出血。结论汶川地震中肌肉挤压伤有其自身特点。治疗中应注意观察，发现肌肉肿胀应行切开减压引流。创面易发生突发性出血及感染。隐匿的肌肉坏死区肌肉溶解、感染是长期发热的主要原因。肢体MR检查有助于发现病灶、及时处理肌肉坏死区。连续肾脏替代治疗是治疗挤压综合征的有效手段。

关键词：自然灾害挤压综合征横纹肌溶解肾功能衰竭

Syntheses of Divalent Rare Earth Ternary Halides KYbBr_(3), KYbCl_(3), KSm_(2)Br_(5), KSm_(2)C_(l5), KEu_(2)C_(l5) by Alkalimetallothermoreduction

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1990年第1期6卷 73-75页

作者： Lin Pingdi, Wu Guoqing, lu Xiukai and Xu bi (Department of Chemistry, Beijing Normal University, Beijing)

Introduction CsEuF;, CsYbF;and RbYbF;are the first members of divalent rare earth ternary halides obtained via reduction of trivalent rare earth halides by alkali metals. Recently we adopted a new synthesis route in p... 详细信息

关键词： Divalent rare earth ternary halides Synthesis Alkali-metallic thermoreduction