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Combination of Nitrogen-Rich Skeleton and Coordination Group:Synthesis of a High-Energy Primary Explosive Based on 1H-Tetrazole-5-Carbohydrazide

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Defence Technology（防务技术） 2024年第1期31卷 271-277页

作者： Tingwei Wang Zujia lu Shu Bu Baolong Kuang lu zhang Zhenxin Yi Kun Wang Shunguan Zhu Jianguo zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing 210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei 230601China

The high energy coordination compounds Cu(TZCA)_(2)(ClO_(4))_(2)(ECCs-1) was prepared by 1H-tetrazole-5-carbohydrazide(TZCA) with a high energy skeleton and a strong coordination ability group.At the same time,the reaction activity of the ligand was explored,and the single crystal structure of it and intermediate were obtained.The structures of all substances were characterized by IR and EA.And the structure and composition of ECCs-1 are confirmed by ESP,AC,SEM and ICP-OES.Physical and chemical properties tests show that ECCs-1 has an acceptable thermal stability(T_(d)=177℃) and extremely sensitive mechanical stimulation(IS=1 J,FS=5 N).The comprehensive performance test results show that ECCs-1 has excellent initiation ability.In addition,the decomposition mechanism of ECCs-1 is explored from two aspects of experiment and theoretical calculation.

关键词： 1H-tetrazole-5-carbohydrazide Primary explosive Decomposition mechanism Coordination polymers Laser

Material flow analysis and global warming potential assessment of an industrial insect-based bioconversion plant using housefly larvae

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Journal of Environmental Sciences 2024年第5期139卷 483-495页

作者： Tao lu Fan Lü Nanlin Liao Honghui Chai Hua zhang Pinjing He Institute of Waste Treatment and Reclamation Tongji UniversityShanghai 200092China State Key Laboratory of Pollution Control and Source Reuse Tongji UniversityShanghai 200092China Zhejiang Qihe Ecological Technology Co. Ltd.Hangzhou 310052China

The significant increase in the demand for biomass waste treatment after garbage classification has led to housefly larvae treatment becoming an attractive treatment option.It can provide a source of protein while treating biomass waste,which means that nutrients can be returned to the natural food chain.However,the performance of this technology in terms of its environmental impacts is still unclear,particularly with regards to global warming potential(GWP).This study used a life cycle assessment(LCA)approach to assess a housefly larvae treatment plant with a treatment capacity of 50 tons of biomass waste per day.The LCA results showed that the 95% confidence intervals for the GWP in summer and winter were determined to be 24.46-32.81 kg CO_(2) equivalent(CO_(2)-eq)/ton biomass waste and5.37-10.08 kg CO_(2)-eq/ton biomass waste,respectively.The greater GWP value in summer is due to the longer ventilation time and higher ventilation intensity in summer,which consumes more power.The main GWP contributions are from(1)electricity needs(accounting for 78.6% of emissions in summer and 70.2%in winter)and(2)product substitution by mature housefly larvae and compost(both summer and winter accounting for 96.8% of carbon reduction).

关键词： Biomass waste Musca domestica Housefly larvae Life cycle assessment Global warming potential

Convolution Neural Network-based Load Model Parameter Selection Considering Short-term Voltage Stability

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1064-1074页

作者： Ying Wang Chao lu Xinran zhang School of Technology Beijing Forestry UniversityBeijing 100083China State Key Laboratory of Control and Simulation of Power System and Generation Equipment Tsinghua UniversityBeijing 100084China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100083China IEEE

The recently proposed ambient signal-based load modeling approach offers an important and effective idea to study the time-varying and distributed characteristics of power loads.Meanwhile,it also brings new problems.Since the load model parameters of power loads can be obtained in real-time for each load bus,the numerous identified parameters make parameter application difficult.In order to obtain the parameters suitable for off-line applications,load model parameter selection(LMPS)is first introduced in this paper.Meanwhile,the convolution neural network(CNN)is adopted to achieve the selection purpose from the perspective of short-term voltage stability.To begin with,the field phasor measurement unit(PMU)data from China Southern Power Grid are obtained for load model parameter identification,and the identification results of different substations during different times indicate the necessity of LMPS.Meanwhile,the simulation case of Guangdong Power Grid shows the process of LMPS,and the results from the CNNbased LMPS confirm its effectiveness.

关键词： Ambient signal CNN field PMU data load model parameter selection short-term voltage stability

Birth weight, ideal cardiovascular health metrics in adulthood, and incident cardiovascular disease

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中华医学杂志(英文版) 2024年第10期137卷 1160-1168页

作者： Sun Ying Wang Bin Yu Yuefeng Wang Yuying Tan Xiao zhang Jihui Qi lu lu Yingli Wang Ningjian Department of Endocrinology and Metabolism Institute of Endocrinology and Metabolism Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China School of Public Health Zhejiang University Hangzhou Zhejiang China Department of Medical Sciences Uppsala University Uppsala Sweden Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou Guangdong China Department of Epidemiology School of Public Health and Tropical Medicine Tulane University New Orleans LA USA Department of Nutrition Harvard T.H. Chan School of Public Health Boston MA USA Channing Division of Network Medicine Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Boston MA USA

Background: Prenatal and postnatal factors may have joint effects on cardiovascular health, and we aimed to assess the joint association of birth weight and ideal cardiovascular health metrics (ICVHMs) prospectively in adulthood with incident cardiovascular disease (CVD).Methods: In the UK Biobank, 227,833 participants with data on ICVHM components and birth weight and without CVD at baseline were included. The ICVHMs included smoking, body mass index, physical activity, diet information, total cholesterol, blood pressure, and hemoglobin A1c. The Cox proportional hazards model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) in men and women.Results: Over a median follow-up period of 13.0 years (2,831,236 person-years), we documented 17,477 patients with incident CVD. Compared with participants with birth weights of 2.5-4.0 kg, the HRs (95% CIs) of CVD among those with low birth weights was 1.08 (1.00-1.16) in men and 1.23 (1.16-1.31) in women. The association between having a birth weight lusions: Birth weight and ICVHMs were jointly related to CVD risk. Attaining a normal birth weight and ideal ICVHMs may reduce the risk of CVD, and a simultaneous improvement of both prenatal and postnatal factors could further prevent additional cases in women.

关键词： Birth weight Health metrics Cardiovascular disease Adult Stroke Coronary heart disease

Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental Sciences 2024年第5期139卷 460-472页

作者： Sujie Sun Li zhang Xue Li lu Zang Ling Huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang lu Jianjun Chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research Institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and Vascular Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water environments.However,little is known regarding its toxic effects on cardiovascular development.Here,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L HFPO-TA.Results showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart rate.Furthermore,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart looping.Obvious sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic larvae.HFPO-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular development.HFPO-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism pathway.HFPO-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting apoptosis.Therefore,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid Heart development Vascular development Hemopoiesis Zebrafish embryos

Characteristics and geological significance of the stress state of the lithosphere in the Qinghai-Tibetan Plateau and its neighboring areas

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Science China Earth Sciences 2024年第6期67卷 1836-1855页

作者： Qianwen zhang Ya XU Wei CHU Shupeng lu Key Lab of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The present-day lithospheric stress state of the Qinghai-Tibetan Plateau and neighboring areas is controlled by both the lithosphere itself and the underlying mantle.In other words,the stress is affected by the gravitational potential energy(GPE)difference caused by the change in the density distribution within the lithosphere and the drag force on the base of the lithosphere caused by mantle convection.The study of the lithospheric stress state plays an important role in further understanding the dynamic background and mechanism for the evolution of the Qinghai-Tibetan Plateau.In this study,the Crust1.0 crustal density model combined with the S40RTS mantle shear wave velocity variation model was used to calculate the GPE.The EGM2008gravity field model was used to calculate the drag force from mantle convection at the base of the lithosphere.The lithospheric and joint stress fields of the two sources were obtained by solving the force balance under the thin sheet approximation.This way,we could comprehensively analyze the characteristics of the stress state within the Plateau.Six regions were classified according to the GPE stress field,mantle drag force stress field,the relative magnitude of the two stress fields,and correlation between the two stress fields and surface deformation.The lithospheric stress fields of the Tarim Basin and other stable blocks are mainly controlled by the GPE difference.The lithospheric stress field in the collision zone between the Indian Plate and the QinghaiTibetan Plateau is predominantly controlled by the deep mantle drag force.The lithospheric stress field in the interior of the Plateau is controlled by both GPE and mantle drag.The correlation between the lithospheric stress field and surface deformation at the southeast margin of the Qinghai-Tibetan Plateau is poor.It is hypothesized that the presence of lower crustal flow with lower effective viscosity leads to crust-mantle decoupling,and the mantle drag force has a weaker influence on the shallow crust,resulting in the incons

关键词： Qinghai-Tibetan Plateau Gravitational potential energy Mantle convection Lithospheric deviatoric stress field GPS strain rate field

Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis

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World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai zhang Chuan lu Sheng Zheng Guang Hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and biomineralization.Fracture repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing methods.AIM To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture healing.METHODS Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their properties.In vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing process.Hydrogels could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial osteoblasts.Furthermore,the effect of hydrogel on fracture healing was confirmed using a mouse fracture model.RESULTS The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone repair.These effects were further validated in fracture models.CONCluSION We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

Improved Data Stream Clustering Method: Incorporating KD-Tree for Typicality and Eccentricity-Based Approach

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Computers, Materials & Continua 2024年第2期78卷 2557-2573页

作者： Dayu Xu Jiaming lu Xuyao zhang Hongtao zhang College of Mathematics and Computer Science Zhejiang A&F UniversityHangzhou311300China College of Economics and Management Zhejiang A&F UniversityHangzhou311300China

Data stream clustering is integral to contemporary big data applications.However,addressing the ongoing influx of data streams efficiently and accurately remains a primary challenge in current research.This paper aims to elevate the efficiency and precision of data stream clustering,leveraging the TEDA(Typicality and Eccentricity Data Analysis)algorithm as a foundation,we introduce improvements by integrating a nearest neighbor search algorithm to enhance both the efficiency and accuracy of the algorithm.The original TEDA algorithm,grounded in the concept of“Typicality and Eccentricity Data Analytics”,represents an evolving and recursive method that requires no prior knowledge.While the algorithm autonomously creates and merges clusters as new data arrives,its efficiency is significantly hindered by the need to traverse all existing clusters upon the arrival of further data.This work presents the NS-TEDA(Neighbor Search Based Typicality and Eccentricity Data Analysis)algorithm by incorporating a KD-Tree(K-Dimensional Tree)algorithm integrated with the Scapegoat Tree.Upon arrival,this ensures that new data points interact solely with clusters in very close proximity.This significantly enhances algorithm efficiency while preventing a single data point from joining too many clusters and mitigating the merging of clusters with high overlap to some extent.We apply the NS-TEDA algorithm to several well-known datasets,comparing its performance with other data stream clustering algorithms and the original TEDA algorithm.The results demonstrate that the proposed algorithm achieves higher accuracy,and its runtime exhibits almost linear dependence on the volume of data,making it more suitable for large-scale data stream analysis research.

关键词： Data stream clustering TEDA KD-tree scapegoat tree

Association of complement components with risk of colorectal cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2168-2180页

作者： Xiao-Lin Zhu lu zhang Su-Xia Qi Department of Gastroenterology Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Department of Medical Administration Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND Complement components could contribute to the tumor microenvironment and the systemic immune response.Nevertheless,their role in colorectal cancer(CRC)remains a contentious subject.AIM To elucidate the relationship between complement components and CRC risk and clinical characteristics.METHODS Searches were conducted in PubMed,the Cochrane Library,and the China National Knowledge Infrastructure database until June 1,2023.We included cohort studies encompassing participants aged≥18 years,investigating the association between complement components and CRC.The studies were of moderate quality or above,as determined by the Agency for Healthcare Research and Quality.The meta-analysis employed fixed-effects or random-effects models based on the I^(2)test,utilizing risk ratio(RR)and their corresponding 95%confidence interval(CI)for outcomes.Sensitivity and subgroup analyses were performed to validate the robustness of the collective estimates and identify the source of heterogeneity.RESULTS Data from 15 studies,comprising 1631 participants that met the inclusion criteria,were included in the meta-analysis.Our findings indicated that protein levels of cluster of differentiation 46(CD46)(RR=3.66,95%CI:1.75-7.64,PluSION Our analysis underscores that increased levels of specific complement components are associated with a heightened risk of CRC,emphasi

关键词： Complement components Colorectal cancer Lymph node metastasis Systematic review Meta-analysis