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Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation:A Systematic Review

Chinese Journal of Integrative Medicine 2023年第3期29卷 268-279页

作者： Guilherme Vinicio de Sousa.silva Ana luiza Vieira Ferreira Guimaraes Lopes Isis Carolina Viali lucas Zannini Medeiros lima Matheus Ribeiro Bizuti Fabiana Brum Haag Débora Tavares de Resende e silva Department of Medicine Federal University of Fronteira SulChapecóSanta CatarinaBrazil Department of Nursing Federal University of Fronteira SulChapecóSanta CatarinaBrazil Department of Graduate Studies in Biomedical Sciences Federal University of Fronteira SulChapecóSanta CatarinaBrazil

Cancers have high morbidity and mortality rates *** anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of *** is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant ***,drugs aimed at autophagy can function as antitumor *** are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in *** this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"AND"mTOR pathway"AND"cancer"AND"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January *** current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor *** demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration ***42021243071 at PROSPERO)

关键词： anti-cancer effects apoptosis cell proliferation cell survival flavonoids

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Influence of physical-anatomical wood variables on charcoal physical-mechanical properties

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Journal of Forestry Research 2023年第2期34卷 531-538页

作者： Allan Motta Couto Thiago Campos Monteiro Paulo Fernando Trugilho JoséTarcísio lima JoséReinaldo Moreira da silva Alfredo Napoli Diego Pierre de Almeida Department of Forestry Science State University of Mato Grosso do Sul–UEMSAv.Graziela Maciel BarrosoKm 12 Zona RuralAquidauanaMS 79200000Brazil Department of Forestry Engineering and Technology Federal University of Paraná–UFPRA V.Pref.Lothário Meissner 632Jardim BotânicoCuritibaPR 80210170Brazil Department of Forestry Science Federal UniversityLavras–UFLALavrasMG 37200000Brazil Département de Performance Des Systèmes de Production Et de Transformation Tropicaux Centre de Coopération Internationale em Recherche Agronomique pour le Développement–CIRADMontpellierFrance

This research assessed the relationship between wood physical-anatomical variables and charcoal physical-mechanical *** trees were harvested and mechanically processed into standard pieces for laboratory *** following variables were determined:wood density,fiber length and width,fiber lumen diameter and wall thickness,fiber wall fraction,and vessel *** charcoal was produced in a laboratory and gravimetric yield,relative density,and mechanical properties ***’s correlation coefficients,multivariate statistical analysis of canonical correlation,and principal component analysis were used to evaluate the relationship between wood and charcoal *** width was not significantly correlated with charcoal *** bulk density,hardness,and strength were positively correlated with wood density,fiber length,wall thickness,and wall *** properties were negatively correlated with fiber lumen diameter and vessel *** results will help identify the best wood with adequate physical-mechanical properties for industrial charcoal proces sing.

关键词： Biomass Density Energy Fiber Vessel

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Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

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World Journal of Gastroenterology 2020年第43期26卷 6795-6809页

作者： Michelle Liz de Souza Pessoa Leiliane Macena Oliveira silva Maria Elaine Cristina Araruna Catarina Alves de lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira lima Leonia Maria Batista Department of Pharmaceutical Sciences IPeFarMFederal University of ParaibaJoao Pessoa 58051-970ParaibaBrazil Health Sciences Center Federal University of ParaibaJoaoPessoa 58051-970ParaibaBrazil Postgraduate Program in Natural and Synthetic Bioactive Products Universidade Federal da ParaibaJoão Pessoa 58051-900Brazil

BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal *** studies report its anti-inflammatory,antioxidant,and antinociceptive *** To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial *** A castor oil-induced diarrhea model was used to evaluate antidiarrheal *** transit and gastric emptying protocols were used to assess a possible antimotility *** receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory *** antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal ***(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation *** activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or *** the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/***,when it was associated with amphotericin B,no synergism was *** The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity.

关键词： (-)-Fenchone Monoterpenes Diarrhea Motility Antifungal

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Sociodemographic,biological,and psychosocial correlates of light-and moderate-to-vigorous-intensity physical activity during school time,recesses,and physical education classes

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Journal of Sport and Health Science 2019年第2期8卷 177-182页

作者： Bruno G.G.da Costa Kelly S.da silva Jaqueline A.da silva Giseli Minatto luiz R.A.de lima Edio L.Petroski Research Centre in Physical Activity and Health Federal University of Santa Catarina Department of Physical Education Federal University of Santa Catarina Research Centre in Kineanthropometry and Human Development Federal University of Santa Catarina

Background: Identifying factors associated with physical activity(PA) is useful in planning interventions and policies. The aim of this study was to identify sociodemographic, biological, and psychosocial factors associated with PA performed in school ***: Data collected for the present study included gender, age, socioeconomic status, body fat percentage, aerobic fitness, self-efficacy, attitudes,peer and parental support, and perception of school environment. Dependent variables were light-intensity PA(LPA) and moderate-to-vigorousintensity PA(MVPA) performed during school time, recesses, and physical education(PE) classes. Multiple regression analyses were ***: Participating adolescents(n = 567, 53% female, 12.9 ± 5.3 years) spent 5% of school time in MVPA and 27% in LPA, 15% of recesses in MVPA and 44% in LPA, and 16% of PE classes in MVPA and 41% in LPA. Boys engaged in more MVPA in all categories. Age was inversely related with MVPA and LPA in all periods, whereas body fat percentage was inversely related with MVPA in school time and PE classes. Attitude was inversely related with MVPA in all periods and with LPA in recesses. Considering PA to be good and enjoyable was positively associated with MVPA in school ***: Adolescents spent little time in PA during school. Future interventions should implement enjoyable activities at school.

关键词： Accelerometer Adolescents Attitude Physical education Public health Self-efficacy

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Ergatoid reproductives in the Neotropical termite Nasutitermes aquilinus (Holmgren) (Blattaria: Isoptera: Termitidae): developmental origin, fecundity, and genetics

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Insect Science 2020年第6期27卷 1322-1333页

作者： Iago Bueno da silva Ives Haifig Edward LVargo Fabiana Elaine Casarin Marcelo luiz da Mota Juliana Toledo lima Ana Maria Costa-Leonardo Laboratorio de Cupins Departamento de BiologiaInstituto de BiocienciasUniversidade Estadual Paulista-UN ESPRio ClaroSPBrazil Centro de Ciencias Naturais e Humanas Universidade Federal do ABCSao Bernardo do CampoSPBrazil Department of Entomology Texas A&M UniversityCollege StationTexasUSA Departamento de Ciencias Biologicas Universidade Federal de Sao Paulo-UNIFESPDiademaSPBrazil Instituto de Ciencias Agrarias Universidade Federal de Uberlandia—UFUMonte CarmeloMGBrazil Centro de Estudos em Recursos Naturais Universidade Estadual de Mato Grosso do SulDouradosMSBrazil

Termite colonies are usully headed by primary reproductives,which estab-listh nests during the swar ming ***,secondary reproductives may develop in some specics and become supplementary or replacement breeders,extending colony *** we investigate the developmental origin,fecundity and genetic characterizaion of ergatoid reproductives in the Neotropical termite Nasuitermes aquilinus(Holmgren),using morphometrical and histological techniques,five micosiallitle loci and the COI mitochondrial *** measurements performed on 208 apterous individuals of Nuauidius revealed 10 groups,including ergatoid females,which developed from major workers through two successive *** were characterized by the presence of imaginal features such as eyes andl wing *** difentiation of these features was correlated to physogastric development in these ergatoids,Histology revealed ooeytes in all matu-ration sages in worker-derived reproductives of N aquidinus,presence of nonflagellate spermatozoa inside the spermatheea,and royal fa ***,ergatoid reproduwetives were reproductively *** to the genotypes of 221 individuals from 11 nests,and mitochondrial haplotypes of 43 ergatoids,73%of the colomies were simple families,whereas 27%were extendbed *** the oecurenee of related reproductives,low inbreeding rates were detected within and among *** values could be explained given that sib mating itself cannot result in a higher inbreeding rate but depend on several factors discussed in *** is the first study to investigate the genetic structure of termite colonies influenced by the development of ergatoids and further investigations are encouraged 10 understand the inflwence of these reproductives on colony lifespan.

关键词： breeding syslem caste ifrentiation COI genotyping micosallites reproduction

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19-year remotely sensed data in the forecast of spectral models of the environment

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International Journal of Digital Earth 2021年第8期14卷 1040-1066页

作者： Fernando saragosa Rossi Carlos Antonio da silva Junior JoséFrancisco de Oliveira-Júnior Paulo Eduardo Teodoro luciano Shozo Shiratsuchi Mendelson lima Larissa Pereira Ribeiro Teodoro Auana Vicente Tiago Guilherme Fernando Capristo-silva State University of Mato Grosso(UNEMAT) Alta FlorestaMato GrossoBrazil Department of Geography State University of Mato Grosso(UNEMAT)SinopMato GrossoBrazil cFederal University of Alagoas(UFAL) MaceióAlagoasBrazil dFederal University of Mato Grosso do Sul(UFMS) Chapadão do SulMato Grosso do SulBrazil eAgCenter School of PlantEnvironmentaland Soil SciencesLouisiana State University(LSU)Baton RougeLouisianaUSA fPostgraduate Program in Agronomy Federal University of Mato Grosso(UFMT)SinopMato GrossoBrazil

The aims of this study were:i)to compare no-till areas in two municipalities located in different regions of Brazil,along with the influence on CO_(2)Flux and GPP,and ii)to verify the difference between environmental factors followed by the trends of these variables regarding future scenarios(ARIMA time-series model number).The study was carried out in two areas with different latitudes in the municipalities of Sinop-MT and Passo Fundo-RS,both in Brazil.A time series of 19 years was performed with data acquired by remote sensing from the following satellites:i)Landsat-8(OLI and TIRS),and ii)TERRA/AQUA(MODIS).The results propound that the spectro-temporal variables are directly influenced by soil management and agricultural practices over the observation time,with a satisfactory correlation in future predictions of the variables for the next ten years,in which presented that the variation of GPP and albedo values for the two study sites would gradually increase until 2028 and the temperature remained constant between the range of its seasonality,and CO_(2)Flux tends to decrease in its seasonality,indicating a higher CO_(2) absorption.

关键词： ARIMA numerical modeling remote sensing orbital products tillage

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From Helicobacter pylori infection to gastric cancer:Current evidence on the immune response

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World Journal of Clinical Oncology 2022年第3期13卷 186-199页

作者： Vinícius lima de Souza Gonçalves Maria luísa Cordeiro santos Marcel silva luz Hanna santos Marques Breno Bittencourt de Brito Filipe Antônio França da silva Cláudio lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Universidade Estadual do Sudoeste da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil Universidade Federal da Bahia Instituto Multidisciplinar em SaúdeVitória da Conquista 45029-094BahiaBrazil

Gastric cancer(GC)is the result of a multifactorial process whose main components are infection by Helicobacter pylori(***),bacterial virulence factors,host immune response and environmental *** development of the neoplastic microenvironment also depends on genetic and epigenetic changes in oncogenes and tumor suppressor genes,which results in deregulation of cell signaling pathways and apoptosis *** review summarizes the main aspects of the pathogenesis of GC and the immune response involved in chronic inflammation generated by ***.

关键词： Gastric cancer Helicobacter pylori Chronic inflammation Host immune response

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Rare earth metal as a dopant element:Cerium ion as an articulator in hexavalent chromium removal by magnetic iron oxides

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Journal of Rare Earths 2023年第10期41卷 1616-1626,I0006页

作者： Pricila Maria Batista Chagas Maísa M.M.lima Aline Aparecida Caetano lucas Bragança Carvalho Nayra Maria de Abreu Piva Maria Eduarda Resende luiz Iara do Rosário Guimarães Laboratory of Environmental Catalysis and New Materials Department of ChemistryFederal University of LavrasCEP 37200-900LavrasMGBrazil Department of Viticulture&Enology University of CaliforniaDavisCA95616USA Institute of Science and Technology São Paulo State University18087-180SorocabaBrazil

This study highlights introducing the rare earth metal cerium(Ce(Ⅳ))into the structure of magnetite(Fe_(3)O_(4))to achieve enhanced adsorptive properties for the removal of chromium(Cr(VI))from an aqueous *** ratios of Ce(Ⅳ)were introduced into the iron oxide matrix,termed FeCe-5,FeCe-10,and *** numerical values correspond to the nominal content of the dopant element added to the synthesis *** solid materials were characterized for morphology and chemical structure,and N_(2)physical adsorption/desorption measurements were *** solid materials doped with Ce(IV)have a high surface area compared to Fe_(3)O_(4),and the solid material with the highest content of the dopant ion(Ce(IV))has a 4-fold greater surface *** increase in the dopant content in the iron oxide structure leads to a total chromium removal of 93.3%.Isotherms studies on the solid materials show that chromium adsorption follows the Langmuir *** adsorption capacity to Fe_(3)O_(4)is 12.59 mg/g and FeCe-10 is 22.49 mg/g at 35℃.By fitting the kinetic and isothermal models,it is found that for the Fe_(3)O_(4)and FeCe-10 materials Cr(VI)removal occurs in very different ways,attributed to the different surface areas and compositions of the oxide,with the formation of the goethite(α-FeOOH)*** FeCe-10reuse process was performed and the removal capacity the Cr(VI)is reduced after the first *** result is attributed to a strong and irreversible adsorption of Cr(VI)on the FeCe-10.

关键词： Bimetallic oxides Fe-Ce interaction Oxygen vacancies Adsorption Cr(Ⅵ) Rare earths

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A Survey of the Homotopy Properties of Inclusion of Certain Types of Configuration Spaces into the Cartesian Product

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1223-1246页

作者： Daciberg lima GONCALVES John GUASCHI Departamento de Matematica IME-USPRua do Matao 1010CEP:05508-090Sao PauloSPBrazil Normandie Universite UNICAENLaboratoire de Mathematiques Nicolas Oresme UMR CNRS 6139CS 1403214032 Caen Cedex 5France

Let X be a topological *** this survey the authors consider several types of configuration spaces,namely,the classical(usual)configuration spaces F_n(X)and D_n(X),the orbit configuration spaces F_n^G(X)and F_n^G(X)/S_nwith respect to a free action of a group G on X,and the graph configuration spaces F_n~Γ(X)and F_n~Γ(X)/H,whereΓis a graph and H is a suitable subgroup of the symmetric group S_*** ordered configuration spaces F_n(X),F_n^G(X),F_n~Γ(X)are all subsets of the n-fold Cartesian product ∏_1~nX of X with itself,and satisfy F_n^G(X)?F_n(X)?F_n~Γ(X)?∏_1~*** A denotes one of these configuration spaces,the authors analyse the difference between A and ∏_1~nXfrom a topological and homotopical point of *** principal results known in the literature concern the usual configuration *** authors are particularly interested in the homomorphism on the level of the homotopy groups of the spaces induced by the inclusionι:A-→∏_1~nX,the homotopy type of the homotopy fibre I_ιof the mapιvia certain constructions on various spaces that depend on X,and the long exact sequence in homotopy of the fibration involving I_ιand arising from the inclusionι.In this respect,if X is either a surface without boundary,in particular if X is the 2-sphere or the real projective plane,or a space whose universal covering is contractible,or an orbit space S^k/Gof the k-dimensional sphere by a free action of a Lie group G,the authors present recent results obtained by themselves for the first case,and in collaboration with Golasi′nski for the second and third *** authors also briefly indicate some older results relative to the homotopy of these spaces that are related to the problems of *** order to motivate various questions,for the remaining types of configuration spaces,a few of their basic properties are described and proved.A list of open questions and problems is given at the end of the paper.

关键词： Configuration space Equivariant configuration space Fibration Homotopy fibre K(π,1)space Braid groups

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Fixed points of n-valued maps on surfaces and the Wecken property a configuration space approach

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Science China Mathematics 2017年第9期60卷 1561-1574页

作者： GONCALVES Daciberg lima GUASCHI John Departamento de Matemdtica&IME Universidade de Sao PauloSdo Paulo 05508-090Brazil Laboratoire de Mathematiques Nicolas Oresme UMR CNRS 6139 UNICAENNormandie UniversiteCS 1403214032 Caen Cedex 5France

Abstract In this paper, we explore the fixed point theory of n-vaiued maps using configuration spaces and braid groups, focusing on two fundamental problems, the Wecken property, and the computation of the Nielsen number. We show that the projective plane （resp. the 2-sphere S2） has the Wecken property for n-valued maps for all n ∈N （resp. all n ≥ 3）. In the case n = 2 and S2, we prove a partial result about the Wecken property. We then describe the Nielsen number of a non-split n-valued map φ ： X → X of an orientable, compact manifold without boundary in terms of the Nielsen coincidence numbers of a certain finite covering q：）→ X with a subset of the coordinate maps of a lift of the n-valued split map → q ： →X.

关键词： multivalued maps fixed points Wecken property Nielsen numbers braids configuration space

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