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Musculoskeletal Pain in Medical Students Subject to Remote Teaching during the COVID-19 Pandemic

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Journal of Biosciences and Medicines 2021年第8期9卷 92-19页

作者： Isabela de paiva Gomes Vivian Mitleton luiz Gustavo Benedetti Fiorin Camila dos santos Leite Oscar César Pires Medicine department Taubaté University Taubaté Brazil

Musculoskeletal pain is a consequence of repetitive strain, overuse, and work-related musculoskeletal disorders. In 2020, due to the new coronavirus pandemic, social isolation started, and so did online classes in a remote study strategy to replace classroom-based study routines. Thus, students adopted a different physical posture from the usual one for a longer time than usual, representing a possible risk factor for musculoskeletal pain. In this sense, this research aimed to identify the occurrence of musculoskeletal pain in medical students subject to distance learning during the COVID-19 pandemic. A cross-sectional, descriptive and exploratory study was applied through an online questionnaire, using the Google Forms application, to 154 students from the first to the fourth year of the medical course at a university in the countryside of the state of S?o Paulo. Among the participants, 99 (64.3%) were female, and 54 (35.7%) were male individuals with ages ranging from 18 and 34. In regards to the daily study time in sitting position, 83 (55.0%) reported staying more than 4 hours, 39 (25.8%) between 2 and 4 hours, and 29 (19.2%) less than 2 hours still. As for musculoskeletal pain before the pandemic;98 (63.6%) reported not feeling it, while 56 (36.4%) reported being affected by this type of pain. However, after the pandemic, 51 respondents (33.1%) continued not to feel anything, whereas 103 (66.9%) kept on having some type of musculoskeletal pain. The results obtained suggest an increase in musculoskeletal pain during the pandemic however other studies may confirm these findings.

关键词： Musculoskeletal Pain Medical Students Remote Teaching COVID-19 Pandemic

Vitamin D and Diabetes Mellitus: A Review

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 1-7页

作者： Cintia Linhares e Souza Larissa Bianca paiva Cunha de Sá denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Sao Paulo Brazil Visiting Scientist of the Harvard T. H. Chan School of Public Health Harvard University Boston USA

Vitamin D deficiency and Diabetes are both disorders of high prevalence in the world. Currently, evidences suggest a possible correlation of low levels of vitamin D with the diagnosis of Diabetes Mellitus. Hypovitaminosis D could be associated with insulin resistance and Diabetes Mellitus, which would in part explain mechanisms involved in the pathogenesis of Diabetes. The aim of this work is to discuss the association between Vitamin D and Diabetes, questioning if vitamin D can prevent the settlement of diabetes or slow down its clinical evolution, and improve the pancreatic function, thus providing a better glycaemic control.

关键词： Vitamin D Vitamin D deficiency Autoimmune Disease Diabetes Mellitus Insulin Resistance

Pathophysiology of Graves’ Ophthalmopathy: A Literature Review

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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 77-87页

作者： Mariela Carolina santos Carballo Bianca paiva Cunha de Sá denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School S&atilde o Paulo Brazil Diabetology department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Graves’ ophthalmopathy (GO), an autoimmune condition associated with Graves’ disease (GD), occurs at a prevalence of nearly 40% in patients diagnosed with GD. Ocular involvement is probably due to the presence of autoantibodies in the orbital tissues, regardless of the control state of thyroid hormones in individuals with GD, even during euthyroid or hypothyroid states, which are associated with thyroid hormone treatment. In addition to the immunological role present in the pathophysiology of GO, the genetic component, proteins and cytokines, minerals (e.g., selenium), and environmental factors (e.g., smoking) also contribute to its development and occurrence of clinical manifestations in varying degrees. Until now, the interaction of causal, intermediary, and triggering factors of GO is still unclear, so the purpose of this article is to review literature on the theme.

关键词： Ophthalmopathy Graves Disease Pathophysiology

EXTRACTION OF SILVER FROM CHLORIde SOluTIONS-HOW TO ESTABLISH THE CHEMICAL REACTIONS?

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EXTRACTION OF SILVER FROM CHLORIDE SOLUTIONS-HOW TO ESTABLIS...

BLEED-Myocardial Infarction Score:Predicting mid-term post-discharge bleeding events

International Solvent Extraction Conference 2005

作者： A.P.paiva departamento de Química e Bioquímica Centro de Química e Bioquímica Faculdade de Ciências da Universidade de Lisboa Rua Ernesto de Vasconcelos Bloco C8 1749-016 Lisboa-PORTUGAL

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World Journal of Cardiology 2013年第6期5卷 196-206页

作者： Sérgio Barra Rui Providência Francisca Caetano Inês Almeida luís paiva Paulo Dinis António Leito Marques Cardiology department Coimbra's Hospital and University Centre-General Hospital3041-801 S.Martinho do BispoCoimbraPortugal Faculty of Medicine University of Coimbra3046-853 CoimbraPortugal

AIM:To derive and validate a score for the prediction of mid-term bleeding events following discharge for myocardial infarction(MI).METHODS:One thousand and fifty patients admitted for MI and followed for 19.9 ± 6.7 mo were assigned to a derivation cohort.A new risk model,called BLEEDMI,was developed for predicting clinically significant bleeding events during follow-up(primary endpoint) and a composite endpoint of significant hemorrhage plus all-cause mortality(secondary endpoint),incorporating the following variables:age,diabetes mellitus,arterial hypertension,smoking habits,blood urea nitrogen,glomerular filtration rate and hemoglobin at admission,history of stroke,bleeding during hospitalization or previous major bleeding,heart failure during hospitalization and anti-thrombotic therapies prescribedat *** BLEED-MI model was tested for calibration,accuracy and discrimination in the derivation sample and in a new,independent,validation cohort comprising 852 patients admitted at a later ***:The BLEED-MI score showed good calibration in both derivation and validation samples(HosmerLemeshow test P value 0.371 and 0.444,respectively) and high accuracy within each individual patient(Brier score 0.061 and 0.067,respectively).Its discriminative performance in predicting the primary outcome was relatively high(c-statistic of 0.753 ± 0.032 in the derivation cohort and 0.718 ± 0.033 in the validation sample).Incidence of primary/secondary endpoints increased progressively with increasing BLEED-MI *** the validation sample,a BLEED-MI score below 2 had a negative predictive value of 98.7%(152/154) for the occurrence of a clinically significant hemorrhagic episode during follow-up and for the composite endpoint of post-discharge hemorrhage plus all-cause *** accurate prediction of bleeding events was shown independently of mortality,as BLEED-MI predicted bleeding with similar efficacy in patients who did not die during follow-up:Area Under the

关键词： Myocardial infarction Bleeding Prediction model Risk stratification

The Role of Fructose in Public Health and Obesity

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Health 2018年第4期10卷 434-441页

作者： Carla Torres Carvalho Maria Zélia de Souza Nawal Arbex Diana Sá luciana Corrêa de Souza Rodrigues de Souza Rodrigues Diana Aristotelis Rocha de Sá Larissa Bianca paiva Cunha de Sá de Sá Alberto Krayyem Arbex Endocrinology Division IPEMED Medical School Rio de Janeiro Brazil Gastronomy Faculty Centro de Ensino Superior Juiz de Fora Brazil Diabetology department Malteser Krankenhaus St. Franziskus Hospital Flensburg Germany Harvard T. H. Chan School of Public Health Boston MA USA

We are in the so-called nutritional transition, in which obesity and its comorbidities have emerged as an important research topic, and the information on food composition is fundamental to promote nutritional safety. Fructose is the sweetest carbohydrate, and this sweetness, along with its low cost, is the key factor for its use in commercial drinks and sweets. The global average consumption of fructose per capita has increased from 56 g/day in 1986 to 65 g/day in 2007. Experimental models associate high fructose intake with the development of obesity and induced insulin resistance. In recent studies, diabetic patients have been reported to use fructose more frequently than glucose. Fructose acts differently in the hypothalamus and generates less satiety than glucose;thus, fructose has a high lipogenic potential. Replacing fructose with another isocaloric carbohydrate is associated with better glycemic control.

关键词： Fructose Obesity Type 2 Diabetes Food Composition Carbohydrate

Thermal lens analysis in a diode-pumped 10 Hz 100 mJ Yb:YAG amplifier

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High Power Laser Science and Engineering 2020年第2期8卷 24-31页

作者： Victor Hariton Celso paiva Joao Hugo Pires Mario Galletti Goncalo Figueira GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisbonPortugal Central Laser Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcot OX110QXUK

We address the power scaling issue in end-pumped laser rod amplifiers by studying,experimentally and numerically,the magnitude of thermal lensing in a high-energy diode-pumped Yb:YAG *** spatio-temporal temperature profile of the gain medium and the focal length of the induced thermal lens are determined *** influence of the repetition rate and pumping power on the temperature distribution is *** measurements covered repetition rates between 1 and 10 Hz and up to 4 kW pumping power.

关键词： diode-pumped lasers high-energy laser amplifiers thermal effects in lasers ytterbium-doped laser media

Menopause and cognitive impairment:A narrative review of current knowledge

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World Journal of Psychiatry 2021年第8期11卷 412-428页

作者： Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares lucas F B Mella Adriana OrcesiPedro lucia Costa-paiva department of Gynecology and Obstetrics Federal University of GoiásGoiânia 74605-050GoiásBrazil department of Obstetrics and Gynecology School of Medical SciencesState University of CampinasCampinas 13083-881São PauloBrazil department of Medical Psychology and Psychiatry-Geriatric Psychiatry and Neuropsychiatric Division State University of CampinasCampinas 13083-887São PauloBrazil

A severe impairment of cognitive function characterizes *** cognitive impairment represents a transition between normal cognition and *** frequency of cognitive changes is higher in women than in *** on this fact,hormonal factors likely contribute to cognitive *** this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially ***,a tendency toward worsened cognitive performance has been reported in women during *** symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen *** therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal *** studies conducted to date have reported conflicting results regarding the effects of HT on *** article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive *** present and discuss the findings of the central observational and interventional studies on HT and cognition.

关键词： Menopause Cognition dementia Estrogens Hot flashes Cognitive decline

An Online mtDNA Tool for Identification of Neotropical Psittacid Species and Taxonomic Issues:A Study Case of the Amazona ochrocephala Complex

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Natural Resources 2014年第11期5卷 634-652页

作者： Anderson Vieira Chaves Rodrigo Octavio de paiva Queiroz-Filho Fabiano Augusto Assuncao Silva Cristina Yumi Miyaki Fabricio Rodrigues dos santos departamento de Biologia Geral Instituto de Ciencias Biologicas(ICB)Universidade Federal de Minas GeraisBelo HorizonteBrazil Policia Federal Belo HorizonteBrazil departamento de Genetica e Biologia Evolutiva Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil

Parrots are among the most popular pets in the world and they are also some of the most illegally traded, particularly in Brazil. Some computational tools were recently developed by researchers based on molecular databases for taxonomy support, forensic identification and conservation purposes. In this study, the DNA Surveillance platform was used to build an online database tool for molecular identification of Brazilian Psittacids using DNA sequences of six mitochondrial genes. To illustrate possible taxonomic issues of the online tool due to interspecific hybridization or unresolved taxonomy, we focused on Amazona aestiva that is considered as one of the most common parrots in Brazil, commonly bred as pets, and considered to be part of a species complex with Amazona ochrocephala from South America. We provide three curated sequence databases, which allow the species identification of individuals or tissue samples of birds of the Psittacidae family using mitochondrial DNA markers, and a comprehensive description of a taxonomic issue involving the A. ochrocephala complex. The results obtained corroborate previous studies suggesting that these species are not reciprocally monophyletic, due to either an ancient hybridization in central Brazil, or, they maybe just are morpho-varieties of the same species. Alternatively, if A. aestiva and A. ochrocephala were considered as sister species, the data could be interpreted either as a result of secondary contact or incipient speciation. Beyond the use of mtDNA for species identification, the high mtDNA haplotype diversity observed in A. aestiva indicates its potential use in discrimination of lineages that could be an important auxiliary tool to certify the captive origin of legally commercialized parrots.

关键词： Amazona aestiva Illegal Trade of Birds Psittaciformes Phylogeography DNA-Surveillance