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Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1056-1064页

作者： sandra Faias Marlene Duarte luísa pereira Paula Chaves Marília Cravo Antonio Dias pereira Cristina Albuquerque Department of Gastroenterology Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Faculty of Health Sciences University of Beira InteriorCovilhã6200-506Portugal Unidade de Investigação em Patobiologia Molecular(UIPM) Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Centro de Matemática e Aplicações(CMA-UBI) Universidade da Beira InteriorCovilhã6200-506Portugal Department of Pathology Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Department of Gastroenterology Hospital BeatrizÂngeloLoures 2674-514Portugal

BACKGROUND Guanine nucleotide-binding protein,alpha stimulating(GNAS)mutations are characteristic of intraductal papillary mucinous neoplasms(IPMNs).Pancreatic ductal adenocarcinomas(PDACs)harboring GNAS mutations originate in *** is a complex imprinted locus that produces five transcripts regulated by differential methylated regions,NESP55,GNAsaS,GNASXL,GNAS1A,and *** To evaluate if methylation changes in the differential methylated regions of GNAS locus contributed to malignant progression of pancreatic *** GNAS locus methylation was analyzed in archival pancreatic cyst fluid(PCF)obtained by endoscopic ultrasound with fine-needle aspiration by methylation specific–multiplex ligation dependent probe *** were normalized and analyzed using *** *** Fifty-two PCF samples obtained by endoscopic ultrasound with fine-needle aspiration and previously characterized for KRAS and GNAS mutations were *** final diagnoses were surgical(11)and clinicopathological(41),including 30 benign cysts,14 pre-malignant cyst,and eight malignant *** changes at NESP55,GNAsaS,GNAS1A,and especially GNASXL were more frequent in malignant cysts,and NESP55 and GNAsaS were useful for diagnosis.A combined variable defined as“GNAS locus methylation changes”was significantly associated with malignancy(6/8 malignant cysts and only 2/20 benign cysts)and improved *** in both maternally(NESP55)and paternally(GNASXL)derived promoters was found in 3/3 *** This is the first study to identify methylation changes in the GNAS locus,improving the diagnosis of malignant pancreatic cysts and suggesting a role in progression to PDAC.

关键词： Intraductal papillary mucinous neoplasms Pancreas cyst Methylation Biomarker GNAS locus Pancreatic neoplasm

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Axillary Lymph Node Metastasis of Colon Cancer—Case Report and Literature Review

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Case Reports in Clinical Medicine 2014年第12期3卷 669-673页

作者： Helena Devesa luísa pereira Alvaro Goncalves Telma Brito Teresa Almeida Rui Torres Alberto Midoes Servico de Cirurgia Geral Unidade Local de Saúde do Alto MinhoViana do CasteloPortugal

The most common metastatic sites of colon cancer are local lymph nodes, liver and lungs. Lymph node metastasis at distant sites is rare. In this article, we describe the case of a patient with ascending colon cancer with a metastasis in an axillary lymph node. The clinical presentation of this tumor was with an intestinal obstruction, and an emergency resection surgery was undertaken. The patient died at the third post-operative month, with lymph node and hepatic metastasis, and implants in the abdominal fat and in the mesentery, near the ileocolic anastomosis.

关键词： Lymphangioleiomyomatosis Everolimus Angiomyolipoma lung Transplant

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Major regulatory mechanisms involved in sperm motility

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Asian Journal of Andrology 2017年第1期19卷 5-14页

作者： Rute pereira Rosalia sa Alberto Barros Mario Sousa Department of Microscopy Laboratory of Cell Biology Institute of Biomedical Sciences Abel Salazar University of Porto (ICBAS-UP) Rua Jorge Viterbo Ferreira 2284050-313 Porto Portugal and Multidisciplinary Unit for Biomedical Research-UMIB ICBAS-UP Centre for Reproductive Genetics Alberto Barros Av. do Bessa 2401° Dto. Frente 4100-012 Porto Portugal Department of Genetics Faculty of Medicine University of Porto. Alameda Prof. Hernani Monteiro 4200-319 Porto Portugal and Institute of Health Research an Innovation (13S) University of Porto Portugal.

The genetic bases and molecular mechanisms involved in the assembly and function of the flagellum components as well as in the regulation of the flagellar movement are not fully understood, especially in humans. There are several causes for sperm immotility, of which some can be avoided and corrected, whereas other are related to genetic defects and deserve full investigation to give a diagnosis to patients. This review was performed after an extensive literature search on the online databases PubMed, ScienceDirect, and Web of Science. Here, we review the involvement of regulatory pathways responsible for sperm motility, indicating possible causes for sperm immotility. These included the calcium pathway, the cAMP-dependent protein kinase pathway, the importance of kinases and phosphatases, the function of reactive oxygen species, and how the regulation of cell volume and osmolarity are also fundamental components. We then discuss main gene defects associated with specific morphological abnormalities. Finally, we slightly discuss some preventive and treatments approaches to avoid development of conditions that are associated with unspecified sperm immotility. We believe that in the near future, with the development of more powerful techniques, the genetic causes of sperm immotility and the regulatory mechanisms of sperm motility will be better understand, thus enabling to perform a full diagnosis and uncover new therapies.

关键词： antioxidants calcium membrane channels protein kinases sperm genetic abnormalities sperm motility

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Production of bio-fertilizer from Ascophyllum nodosum and sargassum muticum (Phaeophyceae)

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Journal of Oceanology and Limnology 2019年第3期37卷 918-927页

作者： SILVA luís Daniel BAHCEVANDZIEV Kiril pereira Leonel Faculty of Science and Technology University of CoimbraCoimbra 3000-456Portugal Polytechnic Institute of Coimbra Agricultural CollegeⅡA-Institute of Applied ResearchCERNAS-Research Centre for Natural ResourcesEnvironmentand SocietyBencantaCoimbra 3045-601Portugal Faculty of Science and Technology University of CoimbraCoimbra 3000-548Portugal

Oceans and seas form a large body of water that contains a natural *** humans,represents a resource,which makes this a point of interest,from researches to improve the *** produce many compounds and secondary metabolites that can be used in different fi elds of industry such as food,agricultural,pharmaceutical and *** though seaweeds are ancestral resources,recently it was notorious a global interest in knowing more about its potentials,where biotechnology plays an important role in *** showed that seaweed has many bioactive compounds benefi cial to plant development,giving them a great potential as an agricultural *** seaweeds to the soil provides organic matter,minerals,trace elements,growth plant regulator,metabolites,vitamins,and amino acids and it can work as a soil *** Portugal,the use of seaweeds for agriculture is important since long time *** the past,populations that lived near coastal zone depended on the seaweeds as a family subsistence but,throughout the years,synthetic fertilizers replaced *** work aimed to assess the potential of the extracts obtained from Ascophyllum nodosum and from sargassum muticum as an agricultural *** evaluation was carried out with rice plants(Oryza sativa)and lettuce(Lactuca sativa),in germination bioassays,the culture of rice and lettuce plants in pots,and culture of lettuce plants in *** that,seaweed liquid extracts were used in different concentrations in different *** show that extracts obtained from two seaweeds,*** and ***,can be promissory plant biofertilizer at a concentration of 25% and had a positive effect on seed germination,plant development,and production.

关键词： fertilizer bioactive compounds Ascophyllum nodosum sargassum muticum Oryza sativa Lactuca sativa

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Rotating effects on the photoionization cross-section of a 2D quantum ring

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Communications in Theoretical Physics 2024年第10期76卷 151-157页

作者： Carlos Magno O pereira Frankbelson dos S Azevedo luís Fernando C pereira Edilberto O Silva Departamento de Física Universidade Federal do Maranhão65085-580 São LuísMaranhãoBrazil

In this article,we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame,taking into account the Aharonov–Bohm(AB)effect and a uniform magnetic *** analysis entails the derivation of the equation of motion and the corresponding radial equation to describe the *** the resulting radial equation enables us to determine the eigenvalues and eigenfunctions,providing a clear expression for the energy ***,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical ***,we evaluate the photoionization cross-section with and without the effects of *** elucidate the impact of rotation on the photoionization process of the system,we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.

关键词： photoionization cross-section rotating effect quantum ring Aharonov–Bohm effect

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Molecule-based kinetic modeling by Monte Carlo methods for heavy petroleum conversion

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Science China Chemistry 2013年第11期56卷 1608-1622页

作者： de OLIVEIRA luís pereira VERSTRAETE Jan J. KOLB Max IFP Energies nouvelles Rond-point de l'échangeur de Solaize-BP 369360 SolaizeFrance Laboratoire de Chimie cole Normale Supérieure69364 Lyon Cedex 07France

A methodology for kinetic modeling of conversion processes is *** proposed approach allows to overcome the lack of molecular detail of the petroleum fractions and to simulate the reactions of the process by means of a two-step *** the first step,a synthetic mixture of molecules representing the feedstock is generated via a molecular reconstruction method,termed SR-REM molecular *** the second step,a kinetic Monte Carlo method,termed stochastic simulation algorithm(Ssa),is used to simulate the effect of the conversion reactions on the mixture of *** resulting methodology is applied to the Athabasca vacuum residue *** adequate molecular representation of the vacuum residue is obtained using the SR-REM *** reaction simulations present a good agreement with the laboratory data for Athabasca vacuum residue *** addition,the proposed methodology provides the molecular detail of the vacuum residue conversion throughout the reactions simulations.

关键词： Monte-Carlo molecular reconstruction kinetic modeling stochastic simulation algorithm vacuum residue hydrocracking

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Artificial intelligence application in diagnostic gastrointestinal endoscopy-Deus ex machina?

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World Journal of Gastroenterology 2021年第32期27卷 5351-5361页

作者： Fábio pereira Correia luís Carvalho Lourenço Department of Gastroenterology Hospital Prof.Dr Fernando FonsecaLisbon 2720-276Portugal

The close relationship of medicine with technology and the particular interest in this symbiosis in recent years has led to the development of several computed artificial intelligence(AI)systems aimed at various areas of medicine.A number of studies have demonstrated that those systems allow accurate diagnoses with histological precision,thus facilitating decision-making by clinicians in real *** the field of gastroenterology,AI has been applied in the diagnosis of pathologies of the entire digestive tract and their attached glands,and are increasingly accepted for the detection of colorectal polyps and confirming their histological *** have shown high accuracy,sensitivity,and specificity in relation to expert endoscopists,and mainly in relation to those with less *** applications that are increasingly studied and with very promising results are the investigation of dysplasia in patients with Barrett's esophagus and the endoscopic and histological assessment of colon inflammation in patients with ulcerative *** some cases AI is thus better than or at least equal to human ***,additional studies are needed to reinforce the existing data,and mainly to determine the applicability of this technology in other *** review summarizes the state of the art of AI in gastroenterological pathology.

关键词： Artificial intelligence Computer-aided diagnosis Deep learning gastrointestinal endoscopy Colorectal polyps Dysplasia

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Temporal and spatial differences in human activities performed in Urban Green Spaces of Vilnius(Lithuania)

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Geography and Sustainability 2024年第2期5卷 302-317页

作者： luís Valença Pinto Carla Sofia santos Ferreira Paulo pereira Research Centre for Natural Resources Environment and Society(CERNAS) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Polytechnic Institute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green spaces(UGS)are relevant to city well-being,as recognized by the United Nations’Sustainable Development Goals(SDGs).However,few studies have studied the temporal use of *** work assessed the seasonal,weekly,and daily use of three urban green spaces(Vingis Park,Bernardino Garden,and Jomantas Park)in Vilnius(Lithuania).The study is based on an on-site observation-based survey,which recorded users’characteristics,activities,and weather conditions during summer and *** results showed that UGS’s seasonal,weekly,and daily use differed according to park and users’*** with a higher diversity of facilities had a high seasonal difference in the number of observed *** numbers were higher in the summer for activities with children,social activities,sports,and water activities than in the *** Park had the lowest variability in user *** variables were linked to changes in users’*** precipitation and lower temperature were associated with reducing the number of users and the diversity of registered *** of the stationary activities were observed during *** diversity of the observed activities was associated with the available facilities rather than the park *** distribution of stationary activities was spatially correlated with facility/equipment(benches,playgrounds,sports,and fitness equipment)and proximity to water *** results of this study are relevant for UGS design,planning,and management.

关键词： Urban parks Seasonal differences Temporal use Time of day Spatial distribution of UGS users

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A Novel Approach to Measuring Spatiotemporal Changes in Social Vulnerability at the Local Level in Portugal

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International Journal of Disaster Risk Science 2022年第6期13卷 842-861页

作者： Pedro Pinto santos Joséluís Zêzere Susana pereira Jorge Rocha Alexandre Oliveira Tavares Centre for Geographical Studies Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Centre for Social Studies Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

Social vulnerability,as one of the risk components,partially explains the magnitude of the impacts observed after a *** this study,a spatiotemporally comparable assessment of social vulnerability and its drivers was conducted in Portugal,at the civil parish level,for three census *** first challenging step consisted of the selection of meaningful and consistent variables over *** were normalized using the Adjusted Mazziotta-Pareto Index(AMPI)to obtain comparable adimensional-normalized values.A joint principal component analysis(PCA)was applied,resulting in a robust set of variables,interpretable from the point of view of their self-grouping around vulnerability drivers.A separate PCA for each census was also conducted,which proved to be useful in analyzing changes in the composition and type of drivers,although only the joint PCA allows the monitoring of spatiotemporal changes in social vulnerability scores and drivers from 1991 to 2011.A general improvement in social vulnerability was observed for *** two main drivers are the economic condition(PC1),and aging and depopulation(PC2).The remaining drivers highlighted are uprooting and internal mobility,and daily *** data proved their value in the territorial,social,and demographic characterization of the country,to support medium-and long-term disaster risk reduction measures.

关键词： AMPI normalization Portugal Social vulnerability Spatiotemporal changes

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An exotic Cretaceous kimberlite linked to metasomatized lithospheric mantle beneath the southwestern margin of the S?o Francisco Craton,Brazil

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Geoscience Frontiers 2022年第1期13卷 182-203页

作者： luísa D.V.Carvalho Tiago Jalowitzki Ricardo Scholz Guilherme O.Gonçalves Marcelo Peres Rocha Rogério Silvestre pereira Cristiano Lana Marco Paulo de Castro Gláucia Queiroga Reinhardt A.Fuck Universidade Federal de Ouro Preto(UFOP) Escola de MinasDepartamento de GeologiaCampus Morro do Cruzeiro35400-000 Ouro PretoMGBrazil Universidade de Brasília(UnB) Instituto de GeociênciasCampus Universitário Darcy Ribeiro70910-900 BrasíliaDFBrazil Independent Geologist Consultant

We present major and trace element compositions of mineral concentrates comprising garnet xenocrysts,ilmenite,phlogopite,spinel,zircon,and uncommon minerals(titanite,calzirtite,anatase,baddeleyite and pyrochlore)of a newly discovered Late Cretaceous kimberlite(U-Pb zircon age 90.0±1.3 Ma;2σ)named Osvaldo Franca 1,located in the Alto Paranaíba Igneous Province(APIP),southeastern *** grains are lherzolitic(Lherz-1,Lherz-2 and Lherz-3),harzburgitic(Harz-3)and wehrlitic(Wehr-2).The pyrope xenocrysts cover a wide mantle column in the subcratonic lithosphere(66–143 km;20–43 kbar)at relatively low temperatures(811–875°C).The shallowest part of this mantle is represented by Lherz-1 pyropes(20–32 kbar),which have low-Cr(Cr_(2)O_(3)=1.74–6.89 wt.%)and fractionated middle to heavy rare earth elements(MREE-HREE)*** deepest samples are represented by Lherz-2,Lherz-3,Harz-3,and Wehr-2 pyropes(36–43 kbar).They contain high-Cr contents(Cr_(2)O_(3)=7.36–11.19 wt.%)and are characterized by sinusoidal(Lherz-2 and Wehr-2)and spoon-like(Lherz-3 and Harz-3)REE *** to their REE and trace elements,pyrope xenocrysts have enriched nature(e.g.,Ce and Yb ***_(2)O_(3)),indicating that the cratonic lithosphere has been affected by a silicate melt with subalkaline/tholeiite composition due to their low Zr,Ti and Y *** minerals with typical kimberlitic signatures,such as ilmenite and zircon,the exotic compositions of phlogopite and ulvöspinel suggest an enriched component in the magma *** formation of rare mineral phases with strong enrichment of light-REE(LREE)and high field strength elements(HFSE)is attributed to the late-stage kimberlitic *** propose a tectonic model where a thermal anomaly,represented by the low-velocity seismic anomaly observed in P-wave seismic tomography images,supplied heat to activate the alkaline magmatism from a metasomatized cratonic mantle source during the late-stages of Gondwana fragmentation and conse

关键词： Osvaldo França 1 kimberlite Alto Paranaíba Igneous Province Metasomatized cratonic lithosphere Zircon U-Pb geochronology

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