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A noncoding secret to stay young—protecting T_(reg)cells to keep the balance in the liver

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science China(Life sciences) 2023年第11期66卷 2694-2696页

作者： Hiep Tai Nguyen Pedro J.batista Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesda MD 20892 USA

The liver plays a crucial role in maintaining whole-body metabolic homeostasis and harbors a distinct immune environment(Robinson et al.,2016).However,during the aging process,the liver undergoes structural and functional changes that can disrupt the delicate balance between the immune system and liver *** age-related alterations can lead to increased susceptibility to metabolic diseases,including non-alcoholic fatty liver disease(NAFLD),and impairments in immune cell regulation and tissue repair(Albillos et al.,2022;Anstee et al.,2019).

关键词： al. alterations homeostasis

social and Environmental Management in the Municipalities of Minas Gerais,Brazil

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Journal of Environmental Protection 2015年第1期6卷 64-76页

作者： Jose roberto Pereira Joao batista Rezende Ana Alice Vilas Boas Universidade Federal de Lavras LavrasMGBrazil Fundacao Joao Pinheiro Belo HorizonteMGBrazil

The objective of this study is to analyze the ability of the public management of environmental problems faced by the municipalities in the state of Minas Gerais, Brazil. The theoretical elements that underlie this article are related to environmental management and municipal public administration. We used the results of the natural vulnerability and the social potential of the indicator of municipal environmental management, as well as data on sanitation and waste disposal. The weaknesses of public administration are located in the counties of low population group. These municipalities do not have suitable structure, formal organization and power of decisiveness in dealing with environmental problems.

关键词： Municipalities Public Administration Environment sustainability

On the mechanism by which nose bluntness suppresses second-mode instability

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Theoretical & Applied Mechanics Letters 2020年第4期10卷 230-240页

作者： Armani batista Arham Amin Khan Joseph Kuehl Department of Mechanical Engineering University of DelawareNewarkDelaware 19716USA

A physical mechanism by which nose bluntness suppresses second-mode instability is *** are 7 degree half-angle straight cones with nose bluntness radii of 0.15 mm, 3.556 mm,5 mm, 9.525 mm, 12.7 mm and 25.4 mm at tunnel conditions relevant to the AFOsR-Notre Dame Large Mach 6 Quiet Tunnel. It is shown that second-mode suppression is achieved via entropy layer modulation of the basic state density gradient. A weakening of the density gradient disrupts the acoustic resonance necessary to sustain second-mode growth. These results are consistent with the thermoacoustic interpretation which posits that second-mode instability can be modeled as thermoacoustic resonance of acoustic energy trapped within an acoustic impedance ***, the generalized inflection point criterion of Lees and Lin is applied to develop a criterion for the existence of second-mode instability based on the strength of the basic state density gradient.

关键词： second mode instability Hypersonics boundary layer Blunt body paradox Entropy layer

Existence of Weakly Efficient solutions in Vector Optimization

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Acta Mathematica sinica,English series 2008年第4期24卷 599-606页

作者： lucelina batista sANTOs Marko ROJAs-MEDAR Gabriel RUIZ-GARZóN Departamento de Matemática Universidade Federal do Paraná.CP.019081CEP:81531990Curitiba-PRBrazil Universidad del Bío-Bío Facultad de Ciencias Departamento de Ciencias BásicasCampus Fernando MayCasilla 447ChillánChile Departamento de Estadística e I.O. Universidad de CádizE.U.E.EmpresarialesPor-vera 5411403 Jerez de la FronteraSpain

In this paper, we present an existence result for weak efficient solution for the vector optimization problem. The result is stated for invex strongly compactly Lipschitz functions.

关键词： vector optimization weak efficiency generalized convexity Clarke generalized gradient

Increasing the detail of European land use/cover data by combining heterogeneous data sets

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International Journal of Digital Earth 2020年第5期13卷 602-626页

作者： Konštantín Rosina Filipe batista e silva Pilar Vizcaino Mario Marín Herrera sérgio Freire Marcello schiavina European Commission Joint Research Centre(JRC)IspraItaly

Data on land use and land cover(luLC)are a vital input for policy-relevant research,such as modelling of the human population,socioeconomic activities,transportation,environment,and their *** Europe,CORINE Land Cover has been the only data set covering the entire continent consistently,but with rather limited spatial *** data sets have provided much better detail,but either have covered only a fraction of Europe(*** Atlas)or have been thematically restricted(*** High Resolution Layers).In this study,we processed and combined diverse luLC data to create a harmonised,ready-to-use map covering 41 *** doing so,we increased the spatial detail(from 25 to one hectare)and the thematic detail(by seven additional luLC classes)compared to the CORINE Land ***,we decomposed the class‘Industrial and commercial units’into‘Production facilities’,‘Commercial/service facilities’and‘Public facilities’using machine learning to exploit a large database of points of *** overall accuracy of this thematic breakdown was 74%,despite the confusion between the production and commercial land uses,often attributable to noisy training data or mixed land *** learnt from this exercise are discussed,and further research direction is proposed.

关键词： Data fusion land use land cover machine learning points of interest

Generation of nanomaterials by reactive laser-synthesis in liquid

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science China(Physics,Mechanics & Astronomy) 2022年第7期65卷 3-47页

作者： Laysa M.Frias batista Ashish Nag Victoria K.Meader Katharine Moore Tibbetts Department of Chemistry Virginia Commonwealth UniversityRichmond VA 23284USA

Nanomaterials with tailored structures and surface chemistry are in high demand, as these materials play increasingly important roles in biology, catalysis, energy storage, and manufacturing. Their heightened demand has attracted attention towards the development of synthesis routes, particularly, laser-synthesis techniques. These efforts drove the refinement of laser ablation in liquid(LAL) and related methods over the past two decades and have led to the emergence of reactive laser-synthesis techniques that exploit these methods’ characteristic, non-equilibrium conditions. Reactive laser-synthesis approaches foster unique chemical reactions that enable the formation of composite products like multimetallic nanoparticles, supported nanostructures, and complex minerals. This review will examine emerging reactive laser-synthesis methods in the context of established methods like *** focus will be on the chemical reactions initiated within the laser plasma, with the goal of understanding how these reactions lead to the formation of unique nanomaterials. We will provide the first systematic review of laser reaction in liquid(LRL) in the literature, and bring a focus to the chemical reaction mechanisms in LAL and reactive-LAL techniques that have not yet been emphasized in reviews. Discussion of the current challenges and future investigative opportunities into reactive laser-synthesis will impart guidance for researchers interested in designing reactive laser-synthesis approaches to novel nanomaterial production.

关键词： laser ablation in liquids laser reduction in liquids nanoparticles

Phylogeny,identification and pathogenicity of the Botryosphaeriaceae associated with collar and root rot of the biofuel plant Jatropha curcas in Brazil,with a description of new species of Lasiodiplodia

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Fungal Diversity 2014年第4期67卷 231-247页

作者： Alexandre Reis Machado Danilo batista Pinho Olinto Liparini Pereira Departamento de Fitopatologia Universidade Federal de VicosaVicosa 36570-000Brazil

The global expansion of cultivation areas of Jatropha has contributed to the emergence of various *** in Brazil,the occurrence of a new disease has been reported that not only reduces the productivity but also causes the death of *** disease is associated with collar and root rot of *** morphological and phylogenetic studies(based on Internal Transcribed spacers,β-tubulin and Translation Elongation Factor 1-αsequences),nine species of Botryosphaeriaceae were *** species include Lasiodiplodia egyptiacae,***,***,Macrophomina phaseolina,Neoscytalidium hyalinum and four Lasiodiplodia *** are proposed as new species(***,***,*** and ***).All the species in this study,except ***,are *** results show that root rot of physic nut plants is caused by complex *** study provides new information for future studies of disease management,quarantine programs and,especially,the development of resistant varieties for collar and root rot disease in ***.

关键词： Aetiology Botryosphaeriales Dothideomycetes Phylogeny Taxonomy Tropical fungi

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula souza e Guimarães Alex Brito souza Ana Roberta Fusco da Costa Karla Valéria batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the state of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium lung Disease

How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases?

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Neural Regeneration Research 2016年第7期11卷 1069-1070页

作者： Emerson s.silva Joao batista T.Rocha Diogo O.souza Marcos M.Braga Programa de Pos-Graduacao em Bioquimica Departamento de Bioquimica Instituto de ciencias basicas da saude Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil Programa de Pos-Graduacao em Bioquimica Toxicologica Departamento de Bioquimica e Biologia Molecular Centro de ciencias Naturais e Exatas Universidade Federal de Santa Maria Santa MariaRS Brazil Instituto Nacional de Ciencia e Tecnologia em Excitotoxicidade e Neuroprotecao Universidade Federal do Rio Grande do Sul PortoAlegre RS Brazil

Hypoxia is a condition found commonly in several disorders,such as ischemia,asthma,anemia and neonatal *** subjected suddenly to high altitude or extreme exercise are also challenged to low oxygen（O2）*** the brain p... 详细信息

关键词： How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases