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Light-Activated Virtual sensor Array with Machine Learning for Non-Invasive Diagnosis of coronary Heart Disease

Nano-Micro Letters 2024年第12期16卷 427-448页

作者： Jiawang Hu Hao Qian sanyang Han Ping Zhang Yuan lu Department of chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China Department of cardiology Xuanwu HospitalCapital Medical UniversityBeijing 100053People’s Republic of China Department of cardiology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218People’s Republic of China Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055People’s Republic of China

Early non-invasive diagnosis of coronary heart disease(cHD)is ***,it is challenging to achieve accurate cHD diagnosis via detecting *** this work,heterostructured complexes of black phosphorus(BP)and two-dimensional carbide and nitride(MXene)with high gas sensitivity and photo responsiveness were formulated using a self-assembly strategy.A light-activated virtual sensor array(LAVsA)based on BP/Ti_(3)c_(2)Tx was prepared under photomodulation and further assembled into an instant gas sensing platform(IGsP).In addition,a machine learning(ML)algorithm was introduced to help the IGsP detect and recognize the signals of breath samples to diagnose *** to the synergistic effect of BP and Ti_(3)c_(2)Tx as well as photo excitation,the synthesized heterostructured complexes exhibited higher performance than pristine Ti_(3)c_(2)Tx,with a response value 26%higher than that of pristine Ti_(3)c_(2)*** addition,with the help of a pattern recognition algorithm,LAVsA successfully detected and identified 15 odor molecules affiliated with alcohols,ketones,aldehydes,esters,and ***,with the assistance of ML,the IGsP achieved 69.2%accuracy in detecting the breath odor of 45 volunteers from healthy people and cHD *** conclusion,an immediate,low-cost,and accurate prototype was designed and fabricated for the noninvasive diagnosis of cHD,which provided a generalized solution for diagnosing other diseases and other more complex application scenarios.

关键词： Black phosphorus/MXene heterostructures Light-activated virtual sensor array Diagnosis of coronary heart disease Machine learning

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Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： c.Y.Morassuti A.P.L silva L.A.O.Nunes s.M.Lima L.H.c.Andrade Optical and Photothermal spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of são carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

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AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi Zhang Qian chen Pan cao chun-Xia shi lu-Yi Zhang lu-Wen Wang Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).c/EBP homologous protein(cHOP),reactive oxygen species(ROs),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,cHOP,ROs and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,cHOP,ROs and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,cHOP,ROs and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： sIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis

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causal relationship between circulating vitamin c and 25-hydroxyvitamin D concentrations and common mental disorders-a Mendelian randomization study

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Food science and Human Wellness 2024年第4期13卷 1877-1885页

作者： Yuanyuan Wang Lirong Dong Meng Zhao shiyu Yin Pan Da Dengfeng Xu Yifei lu Jiayue Xia Niannian Wang shaokang Wang Guiju sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Integrated service and Management Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China

Mental disorders seriously affect people’s health and social *** Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin c(Vc)or 25-hydroxyvitamin D(25(OH)D)levels and mental *** data used for the MR analysis were derived from the summary genome-wide association studies(GWAs)database for Vc and 25(OH)D and from the Finn Gen consortium for fourteen mental *** on the inverse variance weighted(IVW)method,we found a potential causal association between circulating Vc and anxiety disorders(IVW:OR=1.139,95%cI:1.023-1.269,P=0.018).However,no causal association was found between Vc or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating Vc(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between Vc or 25(OH)D and other mental *** addition,there was no causal association between circulating Vc and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.

关键词： circulating vitamin c 25-Hydroxyvitamin D Mental disorder Mendelian randomization

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Urinary exosomal microRNA-145-5p and microRNA-27a-3p act as noninvasive diagnostic biomarkers for diabetic kidney disease

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World Journal of Diabetes 2024年第1期15卷 92-104页

作者： lu-lu Han sheng-Hai Wang Ming-Yan Yao Hong Zhou Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina Department of critical care Medicine The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BAcKGROUND Diabetic kidney disease(DKD),characterized by increased urinary microalbumin levels and decreased renal function,is the primary cause of end-stage renal *** pathological mechanisms are complicated and multifactorial;Therefore,sensitive and specific biomarkers are *** exosome originate from diverse renal cells in nephron segments and partially mirror the pathological changes in the *** microRNAs(miRNAs)in urinary exosome are remark-ably stable and highly tissue-specific for the *** Type 2 diabetic mellitus(T2DM)patients were recruited from the second Hospital of Hebei Medical University and were divided into two groups:DM,diabetic pa-tients without albuminuria[urinary albumin to creatinine ratio(UAcR)c patients with albuminuria(UAcR≥30 mg/g).Healthy subjects were the normal control(Nc)*** exosomal miR-145-5p,miR-27a-3p,and miR-29c-3p,were detected using real-time quantitative polymerase chain *** correlation between exosomal miRNAs and the clinical in-dexes was *** diagnostic values of exosomal miR-145-5p and miR-27a-3p in DKD were determined using receiver operating characteristic(ROc)*** functions of miR-145-5p were investigated by performing REsULTs Urinary exosomal expression of miR-145-5p and miR-27a-3p was more upregulated in the DKD group than in the DM group(miR-145-5p:4.54±1.45 vs 1.95±0.93,Ps 1.71±0.76,Pc group(miR-145-5p:4.54±1.45 vs 1.55±0.83,Ps 1.10±0.51,Psomal miR-145-5p and miR-27a-3p positively correlated with albuminuria and serum creatinine and negatively correlated with the estimated glomerular filtration ***-27a-3p was also closely related to blood glucose,gly-cosylated hemoglobin A1c,and low-density lipoprotein *** analysis revealed that miR-145-5p had a better area under the curve of 0.88[95%confidence interval(cI):0.784-0.985

关键词： Urinary exosome MicroRNA-145-5p MicroRNA-27a-3p Diabetic kidney disease Diagnostic biomarkers

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Developing risk models and subtypes of autophagy-associated LncRNAs for enhanced prognostic prediction and precision in therapeutic approaches for liver cancer patients

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Oncology Research 2024年第4期32卷 703-716页

作者： lu ZHANG JINGUO cHU YUsHAN YU Department of General Practice The First Affiliated Hospital of Ningbo UniversityNingboChina

Background:Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs(ARLncRNAs)on the prognosis of hepatocellular carcinoma(Hcc).Methods:We analyzed 371 Hcc samples from TcGA,identifying expression networks of ARLncRNAs using autophagy-related *** for prognostically relevant ARLncRNAs involved univariate cox regression,Lasso regression,and multivariate cox regression.A Nomogram was further employed to assess the reliability of Riskscore,calculated from the signatures of screened ARLncRNAs,in predicting ***,we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis,using consensus clustering to identify subgroups related to ***:The screening process identified 27 ARLncRNAs,with 13 being associated with Hcc ***,a set of signatures comprising 8 ARLncRNAs was successfully constructed as independent prognostic factors for *** in the high-risk group showed very poor prognoses in most clinical *** Riskscore was closely related to immune cell scores,such as macrophages,and the DEGs between different groups were implicated in metabolism,cell cycle,and mitotic ***,high-risk group patients demonstrated a significantly lower Ic50 for Paclitaxel,suggesting that Paclitaxel could be an ideal treatment for those at elevated risk for *** further identified c2 as the Paclitaxel subtype,where patients exhibited higher Riskscores,reduced survival rates,and more severe clinical ***:The 8 signatures based on ARLncRNAs present novel targets for prognostic prediction in *** drug candidate Paclitaxel may effectively treat Hcc by impacting ARLncRNAs *** the identification of ARLncRNAsrelated isoforms,these results provide valuable insights for clinical exploration of autophagy mechanisms in Hcc pathogenesis and offer potential av

关键词： Autophagy Hepatocellular carcinoma(Hcc) Prognosis Precision medicine Paclitaxel

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Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1006-1018页

作者： Jun-Jun Lin Ye-cai lu Department of Gastrointestinal surgery Chaohu Hospital of Anhui Medical UniversityChaohu 238000Anhui ProvinceChina

BAcKGROUND colorectal cancer(cRc)is one very usual tumor together with higher death ***-specific protease 21(UsP21)has been confirmed to take part into the regulation of cRc progression through serving as a ***,the promotive function of UsP21 has also discovered in the progression of ***1 has illustrated to be modulated by UsP7,UsP22 and UsP51 in ***,the regulatory functions of UsP21 on ZEB1 in cRc progression need more *** To investigate the relationship between UsP21 and ZEB1 in cRc *** The mRNA and protein expressions were assessed through RT-qPcR,western blot and IHc *** interaction between UsP21 and ZEB1 was evaluated through co-IP and GsT pull down *** cell proliferation was detected through colony formation *** cell migration and invasion abilities were determined through Transwell *** stemness was tested through sphere formation *** tumor growth was evaluated through in vivo mice *** In this work,UsP21 and ZEB1 exhibited higher expression in cRc,and resulted into poor ***,the interaction between UsP21 and ZEB1 was further *** was demonstrated that UsP21 contributed to the stability of ZEB1 through modulating ubiquitination *** addition,UsP21 streng-thened cell proliferation,migration and stemness through regulating *** last,through in vivo assays,it was illustrated that UsP21/ZEB1 axis aggravated tumor *** For the first time,these above findings manifested that UsP21 promoted tumorigenicity and stemness of cRc by deubiquitinating and stabilizing *** discovery suggested that UsP21/ZEB1 axis may provide novel sights for the treatment of cRc.

关键词： Ubiquitin-specific protease 21 ZEB1 stemness colorectal cancer

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self-polarized RGB device realized by semipolar micro-LEDs and perovskite-in-polymer films for backlight applications

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Opto-Electronic Advances 2024年第3期7卷 35-49页

作者： Tingwei lu Yue Lin Tianqi Zhang Yue Huang Xiaotong Fan shouqiang Lai Yijun lu Hao-chung Kuo Zhong chen Tingzhu Wu Rong Zhang school of Electronic science and Engineering Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Innovation Laboratory for sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Department of Photonics and Graduate Institute of Electro-Optical Engineering College of Electrical and Computer EngineeringYang Ming Chiao Tung UniversityHsinchu 30010China semiconductor Research center Hon Hai Research InstituteTaipei 11492China.

In backlighting systems for liquid crystal displays,conventional red,green,and blue(RGB)light sources that lack polarization properties can result in a significant optical loss of up to 50%when passing through a *** address this inefficiency and optimize energy utilization,this study presents a high-performance device designed for RGB polarized *** device employs an array of semipolar blueμLEDs with inherent polarization capabilities,coupled with mechanically stretched films of green-emitting csPbBr3 nanorods and red-emitting csPbI3-cs4PbI6 hybrid *** csPbBr3 nanorods in the polymer film offer intrinsic polarization emission,while the aligned-wire structures formed by the stable csPbI3-cs4PbI6 hybrid nanocrystals contribute to substantial anisotropic emissions,due to their high dielectric *** resulting device achieved RGB polarization degrees of 0.26,0.48,and 0.38,respectively,and exhibited a broad color gamut,reaching 137.2%of the NTsc standard and 102.5%of the Rec.2020 *** compared to a device utilizing c-plane LEDs for excitation,the current approach increased the intensity of light transmitted through the polarizer by 73.6%.This novel fabrication approach for polarized devices containing RGB components holds considerable promise for advancing next-generation display technologies.

关键词： halide perovskite light-emitting-diodes polarized emission nanocrystals stability

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Frustrated superconductivity and sextetting order

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science china(Physics,Mechanics & Astronomy) 2024年第8期67卷 168-176页

作者： Zhiming Pan chen lu Fan Yang congjun Wu Institute for Theoretical sciences Westlake UniversityHangzhou 310024China New cornerstone science Laboratory Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China school of Physics Beijing Institute of TechnologyBeijing 100081China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural sciences Westlake Institute for Advanced StudyHangzhou 310024China

The superconducting state typically favors a uniform spatial distribution akin to ***,the pair-densitywave state exhibits sign changes in the pairing order,leading to potential frustrations in phase *** propose a mechanism to the sextetting order stemming from the frustrations in the phase coherence of a pair-density-wave state,whose spatial modulation manifests a vortex-antivortex honeycomb *** classical ground state configurations are mapped to Baxter's three-coloring model,revealing a macroscopic degeneracy accompanied by extensive *** phase coherence problem intertwines the U(1)phases and the vorticity *** the resultant color and phase fluctuations suppress the pair-densitywave order,they maintain the sextetting order above the superconducting transition temperature(T_(c)).The 1/3-fractional vortex emerges as the fundamental topological defect in the sextetting *** novel mechanism of frustrated superconductivity provides an alternative explanation for the experimental observed fractional oscillations in csV_(3)sb_(5).

关键词： frustrated superconductivity pair density wave charge-6e order

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classification of Rings Associated with the Genus of clean Graphs

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Algebra colloquium 2024年第3期31卷 451-466页

作者： V.Ramanathan c.selvaraj Aaqib Altaf s.Pirzada Department of Mathematics Periyar UniversitySalem 636011Tamil NaduIndi Department of Mathematics University of KashmirHazratbalSrinagarKashmirIndia

Let R be a ring(not necessarily commutative)with identity 1 and let cL(R)be its clean *** this paper,we investigate the genus number of the compact Riemann surface in which cL(R)can be embedded and explicitly determine all commutative rings R(up to isomorphism)such that cL(R)has genus at most *** is shown that for any Artinian ring R,cL(R)is a projective graph if and only if R is isomorphic to ***,we determine all isomorphism classes of commutative rings whose clean graphs have crosscap two.

关键词： clean graph commutative ring planar graph genus crosscap

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