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Prognostic Values of Soluble PD-L1 in Nasopharyngeal Carcinoma

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Prognostic Values of Soluble PD-L1 in Nasopharyngeal Carcino...

Diagnostic and prognostic Value of Circulating EBV-miR BART 7-3p and miR BART13-3p in Naspharyngeal Carcinoma

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Chen,Yiping lu,tianzhu Guo,Qiaojuan Ye,Yunbin Pan,Jianji Fujian Medical University Cancer Hospital

Background/Objectives:The blockades of the immune checkpoint proteins play significant roles in tumor immunotherapies,particularly the inhibitors of the PD-1/*** aim of this study is to explore the expression difference of immune checkpoint proteins between NPC patients and healthy donors,and investigate the prognostic values of soluble form of programmed death-ligand1 (sPD-L1) in NPC.

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Diagnostic and prognostic Value of Circulating EBV-miR BART ...

Effects of oral maintenance chemotherapy and predictive value of circulating EBV DNA in metastatic nasopharyngeal carcinoma

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： lu,tianzhu Guo,Qiaojuan Lin,Keyu Su,Ying Chen,Yan Lin,Shaojun Zong,Jingfeng Pan,Jianji Fujian University Cancer Hospital Fujian Cancer Hospital

Background Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV) associated *** BamHI A rightward transcripts (BART) encode miRNAs,especially miR BARTs,abnormally highly expressed,and play an essential role in the d...

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Effects of oral maintenance chemotherapy and predictive valu...

大兴安岭南段内蒙古白音查干Sn多金属矿床石英斑岩的锆石U-Pb年龄、地球化学和Nd-Hf同位素特征及地质意义

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Zhou,Han lu,tianzhu Guo,Qiaojuan Chen,Yan Chen,Mengwei Chen,Yansong Lin,Yingying Chen,Chuanben Ma,Liqin Xu,Yun Lin,Shaojun Pan,Jianji Department of Radiation Oncology Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Department of Clinical Laboratory Fujian Cancer Hospital and Fujian Medical University Cancer Hospital

Oral maintenance chemotherapy can effectively prolong overall survival(OS) in many types of metastatic cancer,but its role in metastatic nasopharyngeal carcinoma(mNPC) is *** this study,the efficacy of oral maintenance chemotherapy in mNPC and the effectiveness of circulating tumor EBV-DNA for screening patients were *** June 2016 and December 2017,141 patients with mNPC who received platinum-based systemic chemotherapy were included(median follow-up time,21 months).Patients were classified into two groups according to the administration of oral maintenance *** samples were collected before,during,and after treatment for the measurement of circulating EBV *** 2-year OS was higher for patients who received maintenance chemotherapy than for patients without maintenance chemotherapy(78.9% vs.62.7%,p = 0.016).Patients with undetectable post-treatment EBV-DNA after 4–6 cycles of systemic chemotherapy(n = 73) had a higher 2-year OS than that of patients with detectable EBV-DNA(n = 68)(82.16% vs.51.45%,p = 0.001).For patients with undetectable post-treatment EBV-DNA,OS was better for those with maintenance chemotherapy than for those without(86.7% vs.73%,p = 0.027).For patients with detectable post-treatment EBV-DNA,maintenance chemotherapy did not improve outcomes(49.5% vs.55.4%,p = 0.824).The most common acute events were hematological toxicity,and all were tolerable and *** maintenance chemotherapy with S1 or capecitabine can improve OS in ***-treatment EBV-DNA was an independent prognostic factor for m *** patients with detectable EBV-DNA after systematic chemotherapy,maintenance chemotherapy was not sufficient.

关键词： metastatic nasopharyngeal carcinoma oral maintenance chemotherapy EBV-DNA prognosis

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岩石学报 2017年第10期33卷 3183-3199页

作者：姚磊吕志成叶天竺庞振山贾宏翔张志辉吴云峰李睿华中国地质调查局发展研究中心北京100037 中国地质大学地球科学与资源学院北京100083 国土资源部矿产勘查技术指导中心北京100083 西乌珠穆沁旗银漫矿业有限责任公司西乌珠穆沁旗026200 中国地质科学院矿产资源研究所北京100037

白音查干矿床位于内蒙古自治区西乌珠穆沁旗,是大兴安岭南段新发现的一处大型Sn多金属矿床,也是该地区近些年来Sn矿找矿的重大突破。本文利用LA-ICP-MS锆石U-Pb法首次测得与成矿有关的石英斑岩成岩年龄为141.7±0.8Ma至140.2±1.1Ma。... 详细信息

白音查干矿床位于内蒙古自治区西乌珠穆沁旗,是大兴安岭南段新发现的一处大型Sn多金属矿床,也是该地区近些年来Sn矿找矿的重大突破。本文利用LA-ICP-MS锆石U-Pb法首次测得与成矿有关的石英斑岩成岩年龄为141.7±0.8Ma至140.2±1.1Ma。这一年龄与区内其他Sn多金属矿床成矿岩体的成岩年龄范围基本一致,说明大兴安岭南段与Sn成矿作用有关的花岗质岩石主要形成于早白垩世(140Ma左右)。全岩主量、微量和稀土元素地球化学特征显示,石英斑岩具有较高的SiO_2含量(70.99%~76.98%)、FeOT/(FeOT+MgO)值(0.90~0.97)、FeOT/MgO值(9.45~36.3)及10000×Ga/Al值(5.9~8.2)和较低的MgO(0.13%~0.18%)、TiO_2(0.10%~0.12%)及P2O5含量(0.02%~0.03%);稀土元素总量较低,配分模式呈轻稀土元素富集和明显负δEu异常的特点;微量元素富集Rb、U、Ta、Nd、Hf等元素,亏损Ba、K、Sr、P、Ti等元素。以上这些特征均说明,石英斑岩具备A型花岗岩的特点。微量元素、全岩Nd同位素和锆石Hf同位素结果显示,岩石具有较高的εNd(t)(+3.6^+3.8)和εHf(t)(+8.2^+11.6)值以及年轻的二阶段模式年龄(t_(NdDM2)为0.63~0.62Ga;t_(HfDM2)为0.67~0.45Ga),说明石英斑岩可能为幔源新生地壳物质部分熔融的产物,并在岩浆演化过程中经历了结晶分异作用。结合区域地质特征、成岩年代学、岩石地球化学和Nd-Hf同位素数据可知,大兴安岭南段晚中生代与Sn成矿作用有关的花岗岩以源区富含大量幔源新生地壳物质为特点,主要形成于晚中生代软流圈上涌所导致的岩石圈伸展的背景下。

关键词：大兴安岭南段白音查干Sn矿床石英斑岩锆石U-Pb年龄 Nd-Hf同位素

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Assessing the potential of crop residue recycling in China and technology options based on a bottom-up model

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Frontiers of Environmental Science & Engineering 2014年第4期8卷 570-579页

作者： Lili QU tianzhu ZHANG Wei lu Institute of Environmental Management and Policy School of Environment Tsinghua University Beijing 100084 China

Crop residues are an important biomass, and are significant in the sustainable development of China. This paper uses the Grey-Markov modeling approach, the cost-benefit analysis method, and the constraint optimiza- tion method to establish the potential of crop residue recycling in China （CRRC） using a bottom-up analysis. Taking 2010 as the baseline year, the CRRC model is used to determine the quantity trends of crop residue resources, simulating the recycling potential and selecting key crop residue recycling technologies for operation between 2010 and 2030. The results illustrate that the total residue output from different crops will gradually increase to 1062 million tons in 2030. The proportion of crop residue for field burning is expected to decrease as a result of guidance and support from the government. Market mechanisms are also improving the development of the crop residue recycling industry. The economic benefit of crop residue recycling is expected to be worth 132 billion CNY in 2030 according to technology structure options. Key crop residue recycling technologies preferred such as liquefaction, amination, silo, co-firing straw power and composting will account for more than 85% of the total benefits.

关键词： China crop residue recycling potential technology options

An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

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Earth and Planetary Physics 2025年第1期9卷 148-158页

作者： ChenChen Zhan RongSheng Wang QuanMing lu San lu XinMin Li Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Anhui Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly *** this article,we present an electron current layer detected at the edge of the magnetotail plasma *** ions were demagnetized inside the electron current layer,but the electrons were still frozen in with the magnetic field ***,this decoupling of ions and electrons gave rise to a strong Hall electric field,which could be the reason for the formation of the embedded thin current *** magnetized electrons,the absence of the nongyrotropic electron distribution,and negligible energy dissipation in the layer indicate that magnetic reconnection had not been triggered within the embedded thin current *** highly asymmetric plasma on the two sides of the current layer and low magnetic shear across it could suppress magnetic *** observations indicate that the embedded electric current layer,probably generated by the Hall electric field,even down to electron scale,is not a sufficient condition for magnetic reconnection.

关键词： magnetotail plasma sheet magnetic reconnection

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： Wen Huang Zeng Lian Kening lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts