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骨髓单个核细胞复合异种骨修复坏死股骨头

中国组织工程研究与临床康复 2007年第14期11卷 2716-2718页

作者：卢伟付松张元和辽宁医学院附属医院骨科辽宁省锦州市121001

目的:观察骨髓单个核细胞复合异种骨对坏死股骨头的修复效果。方法:实验于2006-04/10在辽宁医学院附属第一医院骨科实验室完成。15只新西兰白兔采用杨述华等液氮冷冻法的改进方法建立双侧股骨头坏死模型,即术中只切开关节囊,不切断股骨... 详细信息

目的:观察骨髓单个核细胞复合异种骨对坏死股骨头的修复效果。方法:实验于2006-04/10在辽宁医学院附属第一医院骨科实验室完成。15只新西兰白兔采用杨述华等液氮冷冻法的改进方法建立双侧股骨头坏死模型,即术中只切开关节囊,不切断股骨头圆韧带,股骨头不脱位行液氮冷冻。手术后行自体对照,一侧髋关节为实验组,另一侧为对照组。实验组为髓芯减压后植入复合骨髓单个核细胞的异种骨,对照组髓芯减压后植入异种骨。术后2,4,8周两组分别行X射线检查、Masson染色检查及计算机图像分析。观察坏死股骨头修复情况。结果:纳入新西兰白兔15只,均进入结果分析。X射线及Masson染色检查示实验组股骨头坏死修复效果优于对照组。术后2,4,8周实验组新生骨小梁体积比分别高于对照组,差异有显著性意义[分别为(25.49±0.60)%,(24.44±0.76)%;(32.45±0.37)%,(31.08±0.38)%;(37.93±0.40)%,(36.30±0.74)%,t=2.901,4.936,6.627,P<0.05]。结论:骨髓单个核细胞复合异种骨对坏死股骨头有良好的修复效果。

关键词：股骨头坏死骨髓单个核细胞异种骨

Corrigendum to“Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating wnt/β-catenin signaling pathway”[***.5(2020)334-347]

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Bioactive Materials 2021年第8期6卷 2643-2645页

作者： Xu Cui Yadong Zhang Jianyun wang Chengcheng Huang Yudong wang Hongsheng Yang wenlong Liu Ting wang Deping wang Guocheng wang Changshun Ruan Dafu Chen william w.lu wenhai Huang Mohamed N.Rahaman Haobo Pan Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Schools of Materials Science and Engineering Tongji UniversityShanghai201804PR China Department of Orthopaedics Shanghai Fengxian Central HospitalSouth Campus of the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai201499PR China Department of Orthopaedics Fengxian Central Hospital Affiliated to Southern Medical UniversityShanghai201499PR China Shenzhen Healthemes Biotechnology Co.Ltd Shenzhen518102PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of OrthopaedicsThe University of Hong Kong-Shenzhen HospitalUniversity of Hong KongShenzhen518053PR China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing100035PR China Department of Orthopaedics and Traumatology The University of Hong KongRoom 907Lab Block21 Sassoon RoadHong KongChina Department of Materials Science and Engineering Missouri University of Science and TechnologyMO65409-0340USA

The authors regret that the printed version of the above article contained a number of errors which were not identified during the proofing *** correct and final version *** authors would like to apologies for any inconvenience *** authors regret:1.“…and the underlying molecular mechanism of this simulation is yet to be determined”,Page 335,needs to be corrected to“and the underlying molecular mechanism of this stimulation is yet to be determined”.

关键词： silicate corrected stimulation

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu Sijia Tian Yanmei Zhao wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Computational protein design and structure prediction—the 2024Nobel prize in chemistry

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Science China Chemistry 2025年

作者： Peilong lu Lei Liu School of Life Sciences and Research Center for Industries of the Future Westlake University Tsinghua-Peking Joint Center for Life Sciences Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Center for Synthetic and Systems Biology Department of Chemistry Tsinghua University

The 2024 Nobel prize in chemistry recognizes groundbreaking advancements in protein science, highlighting the power of artificial intelligence (AI) to decipher and design the molecular machinery of life. Half of the prize was awarded to David Baker for the computational design of proteins; the other to Demis Hassabis and John Jumper for their AI-driven predictions of protein structures. This article briefly reviews their achievements, and discusses the opportunities and directions that their work has enabled (Figure1).

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First observation results of Macao Science Satellite-1 on lightning-induced electron precipitation

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Science China Earth Sciences 2025年第1期68卷 1-10页

作者： Yongping wANG Yixin SUN Qiugang ZONG Gaopeng lu Xudong GU Ze-Jun HU Bin LI Key Laboratory for Polar Science Ministry of Natural Resources Polar Research Institute of China Institute of Space Physics and Applied Technology Peking University State Key Laboratory of lunar and Planetary Science Macau University of Science and Technology School of Earth and Space Sciences University of Science and Technology of China School of Electronic Information Wuhan University

The Medium-energy Electron Spectrometers(MES) is a space-borne instrument onboard Macao Science Satellite-1(MSS-1) dedicated to monitoring the typical charged particle radiation characteristics in the satellite orbit and the process of their occurrence and development, including short bursts of lightning-induced electron precipitation(LEP).This paper presents the first results of the LEP measurements by the MSS-1.47 LEP events are identified with the routine operation for 3 months since satellite launch, all within the range of 1.5where L represents the McIlwain L-parameter), and the causative lightning discharges are definitively geo-located for these LEP *** LEP events occur within with medium-energy electron detectors, MSS-1can present in-situ observations of large regions of enhanced background precipitation and reveal their fine spatiotemporal characteristics and spectral *** collaborative VLF ground-based measurements at the Great wall Station, Antarctica also have a good correspondence with LEP measurements of *** observations also imply that lightning activity has a modulation effect on the energetic electron energy-spatial structure.

关键词： Lightning-induced electron precipitation Inner radiation belts Energetic electrons Macao Science Satellite-1

Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun HAN Ming lu Shaomin YU Jing JU Hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

Effect of environmental factors on corrosion behavior of L360QCS pipeline steel in H2S/CO2 environments

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Effect of environmental factors on corrosion behavior of L36...

指骨粉碎骨折的不同固定方法——生物力学研究(英文)

2015年第十四届全国应用化学年会

作者： X.S.huang Y.M.Qi C.F.Chen H.B.Yu G.w.lu

The present research investigated the effect of HS/CO partial pressure, sulphur deposition and corrosion inhibitor on the corrosion behaviour of L360 QCS pipeline steel in HS/CO environments by immersion tests, scanning electron microscope analysis and electrochemical measurements. The results show that the corrosion rate(CR) of L360 QCS steel decreased first and then increased with increasing P and *** CR is closely associated with the protectiveness of corrosion film. Sulphur deposition can cause an acceleration of the corrosion of steel in HS/CO environments. Furthermore, the CR increased obviously with increasing P and PCO in sulphur deposition environments. After addition of continuous corrosion inhibitor, the CR decreased significantly in HS/CO environments. Prefilming corrosion inhibitor could enhance the inhibition effect in the presence of continuous corrosion inhibitor.

关键词： L360QCS pipeline steel Sulphur deposition H2S/CO2 corrosion Continuous and prefilming corrosion inhibitor Immersion tests

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医用生物力学 1997年第2期12卷 65-72页

作者： w.w.lu K.Furumachi w.Y.Ip S.P.Chow 香港大学骨科

本实验对指骨粉碎骨折的五种固定方法的刚度进行了研究,每种固定方法进行了压缩、弯曲和扭转,得出了一些有参考价值的数据.带6孔螺钉的侧方钢板似乎提供了更坚强的固定.假如存在蝶形骨片而不能进行钢板固定(如在多块骨折的情况下,没有... 详细信息

本实验对指骨粉碎骨折的五种固定方法的刚度进行了研究,每种固定方法进行了压缩、弯曲和扭转,得出了一些有参考价值的数据.带6孔螺钉的侧方钢板似乎提供了更坚强的固定.假如存在蝶形骨片而不能进行钢板固定(如在多块骨折的情况下,没有足够的皮质供螺钉固定),选用克氏针固定也可达到满意的效果.本结果将为临床上手术医师选择固定方法提供参考.

关键词：指骨骨折粉碎骨折固定刚度骨折生物力学

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI Feng wANG Tao DUAN Kaijie YANG Bin YANG Chunmei wANG Xin TIAN Qi lu Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FwVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FwVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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