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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

SYNTHESIS　OF　ANALOGUES　OF　HUPERZINE　A　***　PREPARATION　　OF　A　PYRIMIDONE　ANALOGUE　OF　HUPERZINE　A

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Chinese Chemical Letters 1996年第2期7卷 111-114页

作者： Li, yl He, XC Bai, DL CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

The preparation of a pyrimidone analogue 2 of huperzine A is described, in which the pyridone ring of the natural alkaloid is replaced by pyimidone. The key intermediate β-ketoester 9was obtained from cyclohexane-1,4-dione Monoethylene ketal via 6 *** using the methodology of total synthesis of huperzine A. the construction of bicyclo[3.3.1]nonane moiety substructure was achieved, and 2 was finally afforded in low yield.

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Studies on the Synthesis of Preverecynarmin

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Chinese Chemical Letters 1997年第10期8卷 861-862页

作者： Xing, YC Cen, W Li, yl QINGDAO UNIV DEPT CHEMQINGDAO 266071PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA LANZHOU UNIV NATL LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

A precursor 9 of preverecynarmin was prepared by starting from isoprene and geraniol. The key steps in synthesis are the addition of sulfurstabilized carbanion to aldehyde and alkylation with allylic chloride.

关键词： MHz OCH EI

Specialist predator in a multi-species prey community:boreal voles and weasels

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Integrative Zoology 2008年第1期3卷 51-63页

作者： Janne SUNDELL Hannu ylÖNEN Metapopulation Research Group Department of Biological and Environmental SciencesUniversity of HelsinkiHelsinkiFinland Konnevesi Research Station Department of Biological and Environmental ScienceUniversity of JyväskyläJyväskyläFinland

Dissimilar vulnerabilities of different prey types and preferences of predators are factors likely to contribute to community *** may happen via differential individual properties of prey animals(***,escape)or via habitat effects making hunting by a predator easier and more rewarding in some habitats,or ***,community dynamics may be influenced by predator mediated apparent competition,in which an increase in one prey type has negative effects on another prey type indirectly via the shared *** summarize the current knowledge from the field in a model predator–prey system consisting of sympatric boreal vole species and their common specialist predator and review field studies using predator manipulation and studies on the responses of individuals in the laboratory and in outdoor *** vole species studied represent different prey types that are thought to have different *** observations on the main resident specialist predator,the least weasel(Mustela nivalis nivalis L.),show that it hunts according to prey availability and suitability of the hunting *** voles respond to the presence of the predator behaviorally in various ways to avoid *** conclude that even if the least weasel is a specialized predator of small rodents it acts like a generalist predator within the small rodent guild and may facilitate the coexistence of prey species via predator *** may lead to interspecific synchrony between prey populations,which has often been *** suggest that the processes determining the community impact of predator–prey interactions are driven by the behavioral arms race between the predator and the prey,together with the habitat-dependent density of prey and net gain for the predator.

关键词： apparent competition predator–prey interaction prey choice vole cycle

The　Stereochemistry　of　the　Migrating　Groups　in　the　Pyrolysis　of　Stable　Steroidal　Ozonides

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Chinese Chemical Letters 1996年第11期7卷 997-998页

作者： Yang, J Li, TS Li, yl LANZHOU UNIV STATE KEY LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA HEBEI UNIV DEPT CHEMBAODING 071002PEOPLES R CHINA

Diacholest-13(17)-ene ozonide(1a andlb) and 4, 4-dimethyldiacholest-13 (17)-eneozonides(2a and 2b) underwent pyrolysis to afford the coressponding 17-oxo-13,14;13,17- dis14-lactones (3a and 3b)and 4.4-dimethyl-17-oxo-13,14; 13,17-disecodiacholestano-13,14-lactones(4 and 4b), respectively. The stereochemi-stry of the migratingpoups was Proven to be conserved by comparison with the Baeyer-Villiger oxidation of the corresponding 13,17-secodiacholesta-13,17-diones (5) and 4,4-dimethyl-13, 17-secodiacholesta13, 17-diones(6).

关键词： Stereochemistry the Groups

Microstructural Characteristics and Stability in a RapidlySolidified Al-Fe-Nb-Si Alloy

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Journal of Materials Science & Technology 1997年第6期13卷 515-517页

作者： Guan, SK Shen, NF Gong, yl Hu, HQ Zhengzhou Univ Technol Dept Mat Sci & Engn Zhengzhou 450002 Peoples R China Cent China Petr & Nat Gas Dev Corp Henan Province Zhengzhou 450002 Peoples R China Univ Sci & Technol Beijing Inst Mat Beijing 100083 Peoples R China

The microstructure and stability in a rapidly solidified Al-Fe-Nb-Si alloy were studied by using transmission electron microscopy (TEM) with energy dispersive X-ray spectrometry (EDXS) and X-ray diffraction technique. It is shown that the addition of Nb to Al-Fe-Si alloy may increase undercooling of melt, and form the featureless zone structure, the size of the intercellular phases and the distance between intercellulars of Al-Fe-Nb-Si alloy are two times smaller than that of AI-Fe-V-Si alloy under the same conditions. Further, the microstructure of the featureless zone has the better thermal stability after annealing at 623 K for 24 h.

关键词： Aluminum alloys

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欧美硕博论文中的中国武术研究现状及特征

湖北科技学院学报 2025年第1期45卷 86-94页

作者：卢安淮北师范大学体育学院安徽淮北235000

为了解中国武术在欧美高校的学术影响力,帮助中国学者洞悉他者眼中的中国武术的样态,运用数理分析和文本分析的方法,对世界著名的学位论文数据库(ProQuest)2000-2023年间收录的有关中国武术的83篇硕博论文进行梳理。研究发现:1)从年度... 详细信息

为了解中国武术在欧美高校的学术影响力,帮助中国学者洞悉他者眼中的中国武术的样态,运用数理分析和文本分析的方法,对世界著名的学位论文数据库(ProQuest)2000-2023年间收录的有关中国武术的83篇硕博论文进行梳理。研究发现:1)从年度发文量上看,随着人口老龄化和慢性病的流行,以太极拳为代表的中国武术在治未病和慢性病方面的疗效已经逐渐得到关注;2)从研究生的培养单位来看,有关中国武术的硕博论文主要集中在美国,其它国家尚无这个领域的研究团队或者即使有团队,但是研究方向尚不稳定;3)从导师阵容来看,非华裔导师居多;4)从研究内容来看,人文社会科学领域主要集中在武侠文学、功夫影片、武术教学、功夫哲学等方面,自然科学领域关注点在于太极拳对心理疾病、平衡能力、肥胖症、记忆力等的效用。进一步分析得出欧美硕博论文中的中国武术研究具有以下特征:1)研究理念上追求特异性;2)研究内容上具有多元性;3)研究方法上崇尚跨界性;4)研究趋势上呈现离散性。该研究对于我国民族传统体育学研究生培养体系的完善和中国武术全球化发展战略的实施,具有重要的镜鉴意义。

关键词：欧美中国武术硕博论文学术研究

Zr-Cr-Ni BASED MULTICOMPONENT METAL HYDRIDE ELECTRODES

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中国有色金属学会会刊：英文版 1997年第3期7卷 2-7页

作者： Yang, XG Lei, YQ Chen, yl Wang, QD ZHEJIANG UNIV DEPT MAT SCI & ENGNHANGZHOU 310027PEOPLES R CHINA

ＺｒＣｒＮｉＢＡＳＥＤＭＵＬＴＩＣＯＭＰＯＮＥＮＴＭＥＴＡＬＨＹＤＲＩＤＥＥＬＥＣＴＲＯＤＥＳ①ＹａｎｇＸｉａｏｇｕａｎｇ，ＬｅｉＹｏｎｇｑｕａｎ，ＣｈｅｎＹａｎｇｌｉｎ，ＷａｎｇＱｉｄｏｎｇＤｅｐａｒｔｍｅｎｔ... 详细信息

ＺｒＣｒＮｉＢＡＳＥＤＭＵＬＴＩＣＯＭＰＯＮＥＮＴＭＥＴＡＬＨＹＤＲＩＤＥＥＬＥＣＴＲＯＤＥＳ①ＹａｎｇＸｉａｏｇｕａｎｇ，ＬｅｉＹｏｎｇｑｕａｎ，ＣｈｅｎＹａｎｇｌｉｎ，ＷａｎｇＱｉｄｏｎｇＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃ...

关键词： Zr based hydride electrodes alloying effect electrochemical discharge capacity cyclic stability self discharge properties