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MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model

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Neural Regeneration Research 2020年第7期15卷 1274-1282页

作者： xi lu Hui-Yuan Zhang Zhi-Yi He First Affiliated Hospital of China Medical University

Apoptosis is an important factor during the early stage of intracerebral ***-181 c plays a key regulatory role in ***,whether miR-181 c is involved in apoptosis of prophase cells after intracerebral hemorrhage remains ***,in vitro and in vivo experiments were conducted to test this *** vivo experiments:collagenase type VII was injected into the basal ganglia of adult Sprague-Dawley rats to establish an intracerebral hemorrhage ***-181 c mimic or inhibitor was injected in situ 4 hours after intracerebral *** functional defects(neurological severity scores)were assessed 1,7,and 14 days after model *** deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling and western blot assay were conducted 14 days after model *** vitro experiments:PC12 cells were cultured under oxygen-glucose deprivation,and hemins were added to simulate intracerebral hemorrhage in ***-181 c mimic or inhibitor was added to regulate miR-181 c expression.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,luciferase reporter system,and western blot assay were *** results revealed differences in miR-181 c expression in brain tissues of both patients and rats with cerebral *** addition,in vitro experiments found that miR-181 c overexpression could upregulate the Bcl-2/Bax ratio to inhibit apoptosis,while inhibition of miR-181 c expression could reduce the Bcl-2/Bax ratio and aggravate apoptosis of *** of apoptosis occurred through the phosphoinositide 3 kinase(PI3 K)/Akt pathway by targeting of phosphatase and tensin homolog deleted on chromosome ten(PTEN).Higher miR-181 c overexpression correlated with lower neurological severity scores,indicating better recovery of neurological *** conclusion,miR-181 c affects the prognosis of intracerebral hemorrhage by regulating apoptosis,and these effects might

关键词： apoptosis Bcl-2/Bax intracerebral hemorrhage miR-181c nerve cells neurological function neuroprotection PTEN regulation

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论新时代生态文明建设的人民性特征

黑龙江生态工程职业学院学报 2024年第1期37卷 69-73,86页

作者：李陆喜邓永芳江西理工大学马克思主义学院江西赣州341000

人民性是新时代我国生态文明建设的鲜明特征,主要表现为“为了人民”“依靠人民”和“引领人民”三重逻辑的内在统一。其中,为了人民是新时代生态文明建设的价值旨归,依靠人民是新时代生态文明建设的内生动力,引领人民是新时代生态文明... 详细信息

人民性是新时代我国生态文明建设的鲜明特征,主要表现为“为了人民”“依靠人民”和“引领人民”三重逻辑的内在统一。其中,为了人民是新时代生态文明建设的价值旨归,依靠人民是新时代生态文明建设的内生动力,引领人民是新时代生态文明建设的实践导向。新时代生态文明建设必须坚守人民立场,葆有人民情怀,让人民共享发展成果,尊重人民主体地位,发挥人民首创精神,坚持群众路线,创新引领方式,努力实现人民美好生态愿景。

关键词：新时代生态文明建设人民性特征

基于ALE方法的加筋圆柱壳水下接触爆炸计算研究

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沈阳理工大学学报 2024年第4期43卷 70-78页

作者：董金鑫黄伟佳卢熹中国人民解放军92337部队辽宁大连116023 沈阳理工大学装备工程学院沈阳110159

随着水下制导技术的发展,接触爆炸对水下结构的毁伤问题越加受到关注。为研究加筋圆柱壳结构水下接触爆炸毁伤特性,采用LS-DYNA软件的任意拉格朗日-欧拉(ALE)方法模拟爆炸冲击波的形成、传播及其对圆柱壳结构的毁伤过程,探讨水下接触爆... 详细信息

随着水下制导技术的发展,接触爆炸对水下结构的毁伤问题越加受到关注。为研究加筋圆柱壳结构水下接触爆炸毁伤特性,采用LS-DYNA软件的任意拉格朗日-欧拉(ALE)方法模拟爆炸冲击波的形成、传播及其对圆柱壳结构的毁伤过程,探讨水下接触爆炸作用下单、双层加筋圆柱壳的毁伤响应特性,并分析不同药量和爆距条件下加筋圆柱壳的破坏模式。研究结果表明:在不同药量和爆距的水下接触爆炸条件下,加筋圆柱壳呈现多种破坏模式,加筋和加肋位置处易出现撕裂状破口,板壳结构的破坏主要表现为凹陷变形及沿着加筋位置处扩展的裂纹,其中爆距对破坏模式的影响更明显。本文结果可为水下接触爆炸冲击波作用下水下航行体结构强度分析和防护设计提供参考。

关键词：水下接触爆炸加筋圆柱壳数值模拟破坏模式

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智能算法优化XGBoost的聚能-爆破装药比冲量预测

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小型微型计算机系统 2024年第5期45卷 1076-1082页

作者：刘芳李士伟卢熹郭策安马元婧沈阳理工大学理学院沈阳110159 辽宁省兵器工业智能优化与控制重点实验室沈阳110159 沈阳理工大学自动化与电气工程学院沈阳110159 沈阳理工大学装备工程学院沈阳110159

为了探索聚能-爆破装药结构、爆破距离等参数与比冲量间的复杂关系,提出一种智能算法优化极端梯度提升(eXtreme Gradient Boosting,XGBoost)的聚能-爆破装药比冲量预测模型.采用相关性分析方法,探寻聚能-爆破装药结构参数、爆破距离参... 详细信息

为了探索聚能-爆破装药结构、爆破距离等参数与比冲量间的复杂关系,提出一种智能算法优化极端梯度提升(eXtreme Gradient Boosting,XGBoost)的聚能-爆破装药比冲量预测模型.采用相关性分析方法,探寻聚能-爆破装药结构参数、爆破距离参数与比冲量之间的关联程度.使用具有数据并行处理能力和集成学习思想的XGBoost算法,挖掘结构参数、爆破距离参数与比冲量间的潜在非线性关系.基于粒子群算法(Particle Swarm Optimization,PSO)良好的全局搜索能力和蚁群算法(Ant Colony Optimization,ACO)优良的局部搜索能力,设计双智能算法优化XGBoost的融合预测模型PSO-ACO-XGBoost,提高聚能-爆破装药比冲量预测精度.PSO和ACO分别用于搜索XGBoost超参数解空间的全局最优解与局部最优解.实验结果表明,PSO-ACO-XGBoost模型相较于BP、XGBoost、PSO-BP、ACO-XGBoost等其它8种预测模型,在预测精度、拟合程度、速度和稳定性等方面具有最佳性能.

关键词：聚能装药爆破装药比冲量极端梯度提升粒子群算法蚁群算法

NUMERICAL STUDY OF SOLITARY WAVE FISSION OVER AN UNDERWATER STEP

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Journal of Hydrodynamics 2008年第3期20卷 398-402页

作者： lu Ji YU xi-ping State Key Laboratory of Hydroscience and Engineering Department of Hydraulic Engineering TsinghuaUniversity Beijing 100084 China

Solitary wave fission over an underwater step is numerically investigated. The numerical model is based on the enhanced Boussinesq equations, which appropriately represent both the nonlinearity and dispersivity of surface water waves. The finite difference method defined on the staggered grid in space with an implicit scheme for time stepping is employed for the numerical solution of the governing equations. It is demonstrated that Boussinesq type equations, though they are vertically integrated, can describe the details of the solitary wave fission process with very good accuracy. Numerical results of the reflected and transmitting wave heights, the number of solitons emitted from the transmitting wave and their amplitudes all agree very well with the analytical solution derived from KdV equation by virtue of a linear long wave approximation in the vicinity of the underwater step.

关键词： enhanced Boussinesq equations solitary wave fission underwater step numerical computation

浅析绿色工厂评价要点及创建方法——以湖北省绿色工厂创建为例

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中国标准化 2024年第19期 192-196页

作者：鲁曦黄荣顾鑫谢泽宇湖北省标准化与质量研究院

绿色工厂作为制造业的生产单元,是绿色制造的实施主体,属于绿色制造体系的核心支撑单元。绿色工厂的评价从最初的评价指标框架和指标表发展到目前比较健全的以国家标准为基础,行业标准拉高线的现行标准体系,积累了大量的实践经验。本文... 详细信息

绿色工厂作为制造业的生产单元,是绿色制造的实施主体,属于绿色制造体系的核心支撑单元。绿色工厂的评价从最初的评价指标框架和指标表发展到目前比较健全的以国家标准为基础,行业标准拉高线的现行标准体系,积累了大量的实践经验。本文以湖北省绿色工厂创建为例,将绿色工厂评价要点进行了介绍,并结合评价要点对企业如何创建绿色工厂给出了建议,以期发挥标准化的基础性和引领性作用,促进制造业绿色发展。

关键词：制造业绿色制造绿色工厂标准管理体系

Online automatic grading of salted eggs based on machine vision

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International Journal of Agricultural and Biological Engineering 2015年第1期8卷 35-41页

作者： Xu Kunrui lu xi Wang Qiaohua Ma Meihu College of Engineering Huazhong Agricultural UniversityWuhan 430070China National Research and Development Center for Egg Processing Huazhong Agricultural UniversityWuhan 430070China College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China

The quality of salted eggs differs in curing *** need to be tested and graded before factory *** dynamic images of salted eggs were acquired on ***,preprocessing of color images must be done:the target area of the binary image was determined by mathematical morphology and removal of the object of a small *** to the binary image is a convex or concave figure,the target region light leaked or not was *** effects of leaked region were eliminated by searching for mutation points,fitting salted egg boundary by the Least Square algorithm,labeling the binary image and extracting single target ***,six characteristic parameters were extracted in color space,and quality testing model was established by minimum error *** experimental results indicated that the detection accuracy reached above 93%and classification efficiency was 5400/*** is proved the model is feasible for salted egg grading.

关键词： salted egg automatic grading image processing machine vision nondestructive detection

Synthesis of unnatural amino acids through palladium-catalyzed C(sp^3)-H functionalization

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Chinese Chemical Letters 2016年第3期27卷 305-311页

作者： xi lu Bin xiao Rui Shang Lei Liu Tsinghua-Peking Center for Life Sciences Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education)Department of ChemistryTsinghua University Department of Chemistry University of Science and Technology of China

Unnatural a-amino acids have been extensively used in the modern drug discovery and protein engineering studies. They have also found applications in the development of chiral molecular catalysts and the total synthesis of diverse natural products. Accordingly the development of cost-effective approaches for the preparation of unnatural a-amino acids has received increasing attentions. Among all the available methods for this purpose, direct C–H functionalization of simple amino acids represents one of the most attractive approaches because it exhibits good atom-economy and step-efficiency. In particular, selective functionalization of either the primary or secondary C（sp^3）–H bonds in the amino acids has been explored to make versatile C–C, C–N, C–O, C–B and C–F bonds to modify the side chain of amino acids and even peptides. The present review surveys the recent advances of synthesis of chiral unnatural a-amino acids and peptides through palladium-catalyzed functionalization of un-activated C（sp^3）–H bonds.

关键词： Palladium C–H functionalization Unnatural amino acids Carbon-carbon coupling Carbon-heteroatom coupling

Interaction between strain and vorticity in compressible turbulent boundary layer

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2316-2329页

作者： CHU You Biao WANG Li lu xi Yun Department of Modern Mechanics University of Science and Technology of China

The interaction of strain and vorticity in compressible turbulent boundary layers at Mach number 2.0 and 4.9 is studied by direct numerical simulation(DNS)of the compressible Navier-Stokes *** fundamental characteristics have been studied for both the enstrophy producing and destroying *** is found that large enstrophy production is associated with high dissipation and high enstrophy,while large enstrophy destruction with moderate *** enstrophy production and destruction are also correlated with the dissipation production and ***,the enstrophy producing region has a distinct tendency to be‘sheet-like’structures and the enstrophy destroying region tends to be‘tube-like’in the inner ***,the tendency to be‘sheet-like’or‘tube-like’structures is no longer obvious in the outer ***,the alignment between the vorticity vector and the strain-rate eigenvector is analyzed in the flow *** is noticed that the enstrophy production rate depends mainly on the alignment between the vorticity vector and the intermediate eigenvector in the inner layer,and the enstrophy production(destruction)mainly on the alignment between the vorticity vector and the extensive(compressive)eigenvector in the outer layer.

关键词： direct numerical simulation compressible flow turbulent boundary layer