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China CDC weekly 2024年第32期6卷 811-815,I0002页

作者： Ran An lu cui Liyuan Yang Han Zhang Shige Qi Haoyan Guo National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina School of Public Health Capital Medical UniversityBeijingChina Chengnan Community Health Service Center of Changping District BeijingChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?More than half of Chinese older adults over 60 are suffering from hearing loss(HL),which might increase the risk of depressive *** is added by this report?The results indicated a significant association between severe or profound HL and depressive symptoms,characterized by notable age and gender disparities,particularly among women aged 60–74 years *** are the implications for public health practice?Timely intervention and treatment for elderly individuals with HL,particularly younger female elders suffering from severe or profound HL,are pivotal in reducing depressive symptom rates and are key policy considerations.

关键词： younger policy suffering

Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state

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Neural Regeneration Research 2024年第10期19卷 2229-2239页

作者： Yubo Wang Ling Zhang Tianjie Lyu lu cui Shunying Zhao Xuechun Wang Meng Wang Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state interleukin neuroinflammation stroke TET2

Hearing Loss and Cognitive Impairment Among Community-Dwelling Older Adults-Liaoning,Henan,and Guangdong Provinces,China,2019-2020

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China CDC weekly 2024年第32期6卷 816-820,I0003页

作者： Shige Qi Yuzhang Huang Liyuan Yang Haoyan Guo Ran An lu cui Han Zhang Jing Wu National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Health Policy Management Johns Hopkins University Bloomberg School of Public HealthBaltimoreMDUSA Chengnan Community Health Service Center of Changping District BeijingChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina School of Public Health Capital Medical UniversityBeijingChina

Summary What is already known about this topic?Many studies have shown that hearing loss(HL)is a risk factor for cognitive decline and dementia,but there are still limited studies on this association among Chinese older *** is added by this report?Based on the results of pure-tone audiometry tests,HL is associated with cognitive impairment in communitydwelling older *** odds ratios(ORs)were 1.23(1.08–1.40)for mild HL,1.55(1.32–1.82)for moderate HL,and 1.87(1.47–2.39)for severe or profound *** are the implications for public health practice?Enhanced public awareness of hearing protection is important for preventing cognitive *** is advocated to promote the screening of HL and cognitive function assessment in elderly health examinations or management in primary care services.

关键词： hearing Guangdong Henan

双氰胺涂层修饰二氧化锰复合材料的构建及其储锌性能提升机制

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Journal of Central South University 2024年第5期31卷 1443-1460页

作者：卢翠红杜丹 School of Chemistry and Chemical Engineering Changsha University of Science and TechnologyChangsha 410633China Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan UniversityChangsha 410114China

二氧化锰(MnO_(2))由于具有高理论容量、高工作电压和环境友好等优点被认为是水系锌离子电池中最有应用潜力的正极材料之一。然而,由于不稳定的晶体结构及放电时锰溶解等导致其严重的容量衰减。基于此,本论文采用双氰胺(DCDA)对α-MnO_... 详细信息

二氧化锰(MnO_(2))由于具有高理论容量、高工作电压和环境友好等优点被认为是水系锌离子电池中最有应用潜力的正极材料之一。然而,由于不稳定的晶体结构及放电时锰溶解等导致其严重的容量衰减。基于此,本论文采用双氰胺(DCDA)对α-MnO_(2)进行表面包覆,并研究了DCDA包覆层对α-MnO_(2)电化学性能的影响机制。结果表明,DCDA包覆层的物理限域作用提高了α-MnO_(2)的结构稳定性并抑制了放电时锰的溶解。更重要的是,DCDA中具有孤对电子的氮原子与阳离子的静电相互作用,放电时可抑制Mn^(2+)的溶解,充电时可促进Mn^(2+)沉积,从而有效地抑制了锰活性物质的流失。与未改性的α-MnO_(2)阴极相比,α-MnO_(2)@DCDA正极的循环稳定性显著提高,在3 A/g的大电流密度下,1500次循环后仍然具有102.6 mA·h/g的稳定容量,容量保持率超过60%。这项工作为实现MnO_(2)基锌离子电池的稳定循环提供了一条有效途径。

关键词：水系锌离子电池 α-MnO_(2)正极含氮官能团

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-lu Hong Ming-Chen Wang Fang-Zhi Yan Kai Ding Ya-lu cui Bai-Nan Zheng Jin Ding Cheng luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

Epidemiological Characteristics of Fracture Among Children Aged 6-17 Years-China,2019-2021

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China CDC weekly 2024年第32期6卷 799-803,I0001页

作者： lu cui Qian Gan Juan Xu Peipei Xu Titi Yang Wei Cao Hongliang Wang Haoyan Guo Ruihe luo Jianfen Zhang Hui Pan Wenhua Zhao Zhenyu Yang Yuxiang Yan Qian Zhang Department of Epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijingChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina Key Laboratory of Public Nutrition and Health National Health Commission of the People’s Republic of ChinaBeijingChina

Summary What is already known about this topic?Fractures are a common and serious injury among *** many studies have utilized clinical data,there is a lack of large-scale community-based research in *** is added by this report?This cross-sectional study provides national and regionally representative data on the prevalence of fractures among Chinese children aged 6–17 years(6.93%),with higher rates observed in males than in females(8.13%vs.5.71%)and in rural areas compared to urban areas(7.22%vs.6.62%).The most common site of fracture was the upper limbs(4.24%,accounting for 63.0%of fractures).What are the implications for public health practice?The need to enhance awareness of fracture prevention is critical,particularly for children in rural areas and males in middle *** recommend that local authorities increase investments in educational programs and child safety ***,promoting balanced diets for children,training in proper exercise techniques,and reinforcing participation in outdoor sports are essential.

关键词： prevention utilized children

大牛地气田奥陶系岩溶缝洞型储层识别预测方法

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石油地质与工程 2024年第4期38卷 33-38页

作者：崔璐中国石化华北油气分公司河南郑州450006

大牛地气田下古生界气藏主要发育中小尺度岩溶缝洞型储层,与塔里木盆地、四川盆地相比,缝洞定量识别评价难度大。通过岩心、薄片、常规-成像测井及物探等资料,明确了岩溶缝洞型储层类型和发育特征,形成一套储层定量识别和储层预测方法,... 详细信息

大牛地气田下古生界气藏主要发育中小尺度岩溶缝洞型储层,与塔里木盆地、四川盆地相比,缝洞定量识别评价难度大。通过岩心、薄片、常规-成像测井及物探等资料,明确了岩溶缝洞型储层类型和发育特征,形成一套储层定量识别和储层预测方法,主要取得了以下认识:①结合地质特点,将研究区储集岩的孔隙类型划分为孔隙型、裂缝-孔洞型和缝洞型三大类,建立了岩溶缝洞型储层综合识别模板;②通过基于贝叶斯准则的逐步判别法实现了不同类型储层定量划分,判别模型解释的储层类型与实钻资料对比基本一致;③利用基于极大似然属性的蚂蚁体和瞬时频率属性分别对岩溶缝洞型储层及含气性进行预测,形成一套井震联合的岩溶储层预测方法,为储层空间展布研究、井位部署优化及压裂改造提供重要依据。

关键词：大牛地气田岩溶缝洞型储层综合识别模板判别分析储层预测方法

线粒体功能障碍在糖尿病肾病足细胞脂代谢中作用的研究现状

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中国临床药理学杂志 2024年第17期40卷 2601-2605页

作者：孙铭辰赵翠荣卢翠翠沈承武山东第一医科大学附属省立医院药学部山东济南250021 山东第一医科大学研究生部山东济南250117

糖尿病肾病(DKD)作为终末期肾病(ESRD)的主要发病原因,其中线粒体功能障碍和脂代谢紊乱发挥关键作用。线粒体功能障碍导致过量活性氧(ROS)产生,抑制脂肪酸β氧化,形成脂毒性,是DKD足细胞损伤的关键。同时,脂质代谢紊乱加剧脂肪的异位积... 详细信息

糖尿病肾病(DKD)作为终末期肾病(ESRD)的主要发病原因,其中线粒体功能障碍和脂代谢紊乱发挥关键作用。线粒体功能障碍导致过量活性氧(ROS)产生,抑制脂肪酸β氧化,形成脂毒性,是DKD足细胞损伤的关键。同时,脂质代谢紊乱加剧脂肪的异位积聚,激活炎症和氧化应激,并影响胰岛素信号传导,进一步抑制线粒体功能,推动DKD进展。因此,深入了解DKD中线粒体功能障碍与足细胞脂代谢的关联对DKD治疗十分重要。本文论述DKD、线粒体功能障碍、足细胞脂代谢的基本概况,及其相互作用,同时探讨了DKD治疗现状,以期为DKD的研究和治疗提供参考。

关键词：糖尿病肾病终末期肾病线粒体功能障碍足细胞脂代谢

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糖核苷酸的生物合成和应用

生物化学与生物物理进展 2024年第4期51卷 822-838页

作者：郝萌连佳琪张翠璐关婉怡河北师范大学分子细胞生物学教育部重点实验室河北省分子细胞生物学重点实验室河北师范大学生命科学学院石家庄050024

糖基化是生物体中最重要的反应之一,通过糖基化作用可以形成具有多种生物功能的糖缀合物。糖核苷酸作为Leloir型糖基转移酶催化的转糖基反应的糖基供体,在聚糖和糖缀合物的生物合成中必不可少。然而,糖核苷酸的成本较高、可用性有限等... 详细信息

糖基化是生物体中最重要的反应之一,通过糖基化作用可以形成具有多种生物功能的糖缀合物。糖核苷酸作为Leloir型糖基转移酶催化的转糖基反应的糖基供体,在聚糖和糖缀合物的生物合成中必不可少。然而,糖核苷酸的成本较高、可用性有限等因素阻碍了生物催化级联反应在工业中大规模的应用。因此,人们越来越关注糖核苷酸的合成策略,以实现其在多种领域的广泛应用。目前,糖核苷酸及其衍生物的化学合成方法已经建立起来,但合成反应的产量通常很低,而酶法(化学-酶法)和细胞工厂法在合成糖核苷酸过程中具有显著优势。本文主要围绕哺乳动物中常见的9种糖核苷酸,概述了其类型和结构、酶法(化学-酶法)和细胞工厂法两种制备方法。伴随糖核苷酸的高效合成,其多种功能逐渐被发现和应用。本文进一步概述了糖核苷酸在聚糖及糖缀合物合成、糖基转移酶生化性质表征以及生物正交标记策略等方面的应用,对生物化学、糖生物学的研究以及相关医药产品的研发具有十分重要的意义。

关键词：糖核苷酸糖基转移酶激酶焦磷酸化酶

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近代广东医药报刊研究述评

中医文献杂志 2024年第2期42卷 95-98页

作者：崔璐广州中医药大学广州510006

近代广东医药报刊是中国医史文献研究的重要内容之一,历来为学界所重视。文章通过搜集与梳理相关文献,发现全国性期刊目录、医药类专业期刊目录、地方史志、医学史著作均对近代广东医药报刊有所收录、调查与整理。关于近代广东医药报刊... 详细信息

近代广东医药报刊是中国医史文献研究的重要内容之一,历来为学界所重视。文章通过搜集与梳理相关文献,发现全国性期刊目录、医药类专业期刊目录、地方史志、医学史著作均对近代广东医药报刊有所收录、调查与整理。关于近代广东医药报刊的理论研究主要有医药报刊史、单个医药报刊研究、综述研究3个方面,此外,对于近代广东医药报刊的数字化也日益受到重视。文章提出要进一步全面普查整理与出版近代广东医药报刊,深入近代广东医药报刊的理论研究,加强近代广东医药报刊的数字化。

关键词：近代报刊广东医药