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Reduced-order H∞ filtering for navigation with carrier phase

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Science China(Information Sciences) 2014年第2期57卷 27-36页

作者： lu chenxi TAN YunHua ZHU BoCheng ZHOU LeZhu School of Electronics Engineering and Computer Science Peking University

A reduced-order H∞filtering algorithm for navigation with carrier phase is *** taking advantage of decoupling between filtering states in a navigation solution,this algorithm reduces computational cost and is robust in colored ***,the estimation precision is also improved by taking ambiguities as nuisance states when the filtering process *** to kinetic simulations under diferent noise are presented to demonstrate robustness and efciency of the algorithm.

关键词： navigation reduced-order H∞ filtering carrier phase

Piperazine-derived ionizable lipids for enhanced mRNA delivery and cancer immunotherapy

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Nano Research 2024年第8期17卷 7357-7364页

作者： Kai Xu Yujia Xu Jin Sun Xinwei Cheng chenxi lu Wenzhong Chen Bingfang He Tianyue Jiang School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 211816China Department of Nano Formulation Nanjing GeneLeap BiotechnologyNanjing 210061China

Messenger ribonucleic acid(mRNA)-based therapeutics hold great prospects in disease treatment and lipid nanoparticles(LNPs)are the most extensively applied non-viral platform for RNA delivery in *** the clinical success of LNPs as vehicles have been achieved,developing LNPs with enhanced mRNA transmembrane delivery and transfection efficiency in a non-toxic manner is highly desirable and *** this study,we designed a series of new ionizable amino lipids with piperazinederived headgroups and constructed a group of LNPs to promote the transfection activity of mRNA *** them,LNP formulated with lipid 10(L10-LNP)can efficiently package mRNA and perform superior transfection efficiency both in vitro and in vivo,which is mainly attributed to the improved intracellular uptake and effective endosomal *** verified that a single administration of L10-LNP packaging interleukin(IL)-12 mRNA induced tumor shrink and even regression by robust activation of immune effector CD8^(+)T cells and stimulating the generation of IFN-γwithout causing systemic toxicity,which provides a promising platform for clinical cancer immunotherapy.

关键词： ionizable lipid lipid nanoparticle piperazine-derived lipid mRNA therapeutics cancer immunotherapy

Near-Real-Time Carbon Emission Accounting Technology Toward Carbon Neutrality

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Engineering 2022年第7期8卷 44-51页

作者： Zhu Liu Taochun Sun Ying Yu Piyu Ke Zhu Deng chenxi lu Da Huo Xiang Ding Department of Earth System Science Tsinghua UniversityBeijing 100084China Gillings School of Global Public Health University of North Carolina at Chapel HillChapel HillNC 27599USA College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

Climate change is the greatest environmental threat to humans and the planet in the 21st *** anthropogenic greenhouse gas emissions are one of the main causes of the increasing number of extreme climate *** carbon dioxide(CO_(2))emissions showed a linear relationship with cumulative temperature rise since the pre-industrial stage,and this accounts for approximately 80%of the total anthropogenic greenhouse ***,accurate and reliable carbon emission data are the foundation and scientific basis for most emission reduction policymaking and target ***,China has made clear the ambitious goal of achieving the peak of carbon emissions by 2030 and achieving carbon neutrality by *** development of a finer-grained spatiotemporal carbon emission database is urgently needed to achieve more accurate carbon emission monitoring for continuous implementation and the iterative improvement of emission reduction ***-real-time carbon emission monitoring is not only a major national demand but also a scientific question at the frontier of this *** article reviews existing annual-based carbon accounting methods,with a focus on the newly developed real-time carbon emission technology and its current application *** also present a framework for the latest near-real-time carbon emission accounting technology that can be widely *** development of relevant data and methods will provide strong database support to the policymaking for China’s“carbon neutrality”***,this article provides an outlook on the future of real-time carbon emission monitoring technology.

关键词： Carbon neutrality Carbon accounting Carbon monitoring

Architectural Design and Additive Manufacturing of Mechanical Metamaterials:A Review

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Engineering 2022年第10期17卷 44-63页

作者： chenxi lu Mengting Hsieh Zhifeng Huang Chi Zhang Yaojun Lin Qiang Shen Fei Chen Lianmeng Zhang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 90095USA

Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent *** macroscale and simple layouts can be realized by conventional top-down manufacturing approaches,many of the sophisticated designs at various length scales remain elusive,due to the lack of adequate manufacturing *** progress in additive manufacturing(AM)has led to the realization of a myriad of novel metamaterial *** methods capable of fabricating microscale architectures with high resolution,arbitrary complexity,and high feature fidelity have enabled the rapid development of architected meta materials and drastically reduced the design-computation and experimental-validation *** paper first provides a detailed review of various topologies based on the desired mechanical properties,including stiff,strong,and auxetic(negative Poisson’s ratio)metamaterials,followed by a discussion of the AM technologies capable of fabricating these ***,we discuss current challenges and recommend future directions for AM and mechanical metamaterials.

关键词： Mechanical metamaterials Auxetic materials Architectural design Additive manufacturing

Liquid exfoliation of stanene as degradable nanoagents for NIR-II photothermal therapy

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Journal of Materials Science & Technology 2023年第17期148卷 186-198页

作者： Xueqiao Li Weijian Li Zhaohua Miao chenxi lu Hongna Ma Yan Xu Deyan Gong Cheng-Yan Xu Zhengbao Zha School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China College of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518052China

Stanene,the two-dimensional form of elemental tin(Sn),is easily oxidized in the ambient environ-ment,significantly hindering its applications in biomedical ***,the degradation mechanism of stanene remains ***,combined DFT calculations and proof-of-concept experiments were conducted to elucidate the underlying degradation mechanism of *** results reveal that the degradation of stanene in an oxygenated water environment is a water-accelerated oxidation process.H_(2) O molecules could not only facilitate the electron transfer from stanene to O_(2) because of the polarization effect of H_(2) O,but also directly react with the defect sites of stanene due to enhanced absorption ***,several protective strategies like alcohol protection were proposed to avoid or mitigate the oxidation of stanene for further ***,stanene was explored as the second near-infrared(NIR-II)photonic agents for ablation of 4T1 tumor,depicting a tumor-growth inhibition ratio up to 96.7%,much better than that of the first near-infrared(NIR-I)group(65.5%).This work reveals the degradation mechanism of stanene and demonstrates its biomedical applications in the NIR-II region.

关键词： Stanene Degradation mechanism DFT calculations Photothermal therapy NIR-II

A low-dimensional crystal growth model on an isotropic and quasi-free sustained substrate

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Chinese Physics B 2020年第3期29卷 420-426页

作者： chenxi lu Senjiang Yu Lingwei Li Bo Yang Xiangming Tao Gaoxiang Ye College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China Department of Physics Zhejiang UniversityHangzhou 310027China

A new crystal growth theoretical model is established for the low-dimensional nanocrystals on an isotropic and quasifree sustained substrate. The driven mechanism of the model is based on the competitive growth among the preferential growth directions of the crystals possessing anisotropic crystal structures, such as the hexagonal close-packed and wurtzite structures. The calculation results are in good agreement with the experimental findings in the growth process of the lowdimensional Zn nanocrystals on silicone oil surfaces. Our model shows a growth mechanism of various low-dimensional crystals on/in the isotropic substrates.

关键词： crystal growth low-dimensional nanocrystals isotropic substrates preferential growth

Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway

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Journal of Traditional Chinese Medicine 2020年第2期40卷 236-244页

作者： Wang Jiepeng Fang Chaoyi Wang Shaoxian Fang Fang Chu Xinqiao Liu Na lu chenxi Wang Shuo Li Wei School of Preclinical Medicine Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease Hebei University of Chinese MedicineShijiazhuang 050091China

OBJECTIVE: To investigate the effect of Danggui Buxue Tang(DBT), a decoction from Traditional Chinese Medicine, on bleomycin-induced pulmonary fibrosis in rats, and to propose the possible underlying ***: Forty male Sprague-Dawley rats were randomly divided into sham group, model group,prednisone group and DBT group. Pulmonary fibrosis rat model was established by intratracheal injection with bleomycin. Body weight and lung index were monitored. Histopathologic examination and collagen deposition were determined using Hematoxylin and eosin(HE) and Masson's trichrome staining. Immunohistochemistry staining was applied to observe the expression of alpha-smooth muscle actin(α-SMA). m RNA expression of α-SMA,collagen Ⅰ and collagen Ⅲ were measured by realtime fluorescence quantitative PCR(RT-q PCR). Inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6) and IL-1β in serum were detected by Enzyme-linked immunosorbent assay. Alkali hydrolysis method was conducted to investigate the content of hydroxyproline(HYP). Transforming growth factor-β1(TGF-β1),Smad3 and plasminogen activator inhibitor-1(PAI-1) protein level were examined by Western blot ***: DBT significantly reduced the severity of bleomycin-induced pulmonary fibrosis and inflammation as indicated by minimizing the lost of weight, and by lowering the levels of lung index, inflammation score, Ashcroft score, collagen volume fraction(%), HYP, α-SMA, collagen Ⅰ, collagen Ⅲ,TNF-α, IL-6, IL-1β, TGF-β1, Smad3 and PAI-1, consistent with the effect of ***: Our findings suggest that DBT is able to ameliorate the pulmonary fibrosis, the possible mechanism may involve inhibition of pulmonary inflammation and collagen deposition, possibly via suppressing TGF-β1/Smad3/PAI-1 signaling pathway.

关键词： Pulmonary fibrosis Transforming growth factor beta 1 Smad3 protein Plasminogen inactivators Danggui Buxue Tang

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背囊化紧急医学救援小分队建设现状与思考

中国急救复苏与灾害医学杂志 2025年第1期20卷 27-31,35页

作者：卢晨曦赵欣余明高树田袁晶王运斗军事科学院系统工程研究院天津300161

目的探讨背囊化紧急医学救援小分队的队伍建设问题。方法采用文献回顾、系统分析等方法,分析背囊化紧急医学救援小分队建设现状,总结不足,提出对策建议。结果我国背囊化紧急医学救援小分队正在抓紧建设,目前存在尚无背囊配备指南、... 详细信息

目的探讨背囊化紧急医学救援小分队的队伍建设问题。方法采用文献回顾、系统分析等方法,分析背囊化紧急医学救援小分队建设现状,总结不足,提出对策建议。结果我国背囊化紧急医学救援小分队正在抓紧建设,目前存在尚无背囊配备指南、装备功能有待加强、人员编配不尽合理等问题。结论在背囊化紧急医学救援小分队的今后建设中,制定统一规范指南,加强装备建设,优化人员配置等策略,是提升队伍现场应急处置能力的关键。

关键词：背囊化小分队紧急医学救援

Improved innovation-based adaptive Kalman filter for dual-frequency navigation using carrier phase

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Science China(Information Sciences) 2010年第12期53卷 2653-2663页

作者： lu chenxi,TAN YunHua ,ZHU BoCheng & ZHOU LeZhu School of Electronics Engineering and Computer Science,Peking University,Beijing 100871,China School of Electronics Engineering and Computer Science Peking University Beijing China

A new adaptive Kalman filtering algorithm for dual-frequency navigation using carrier phase is *** algorithm gives consideration to both robustness and sensitivity by combining the two main approaches of adaptive Kalman filtering based on innovation-based adaptive estimation(IAE) and fading *** to the navigation using carrier phase measurements typically,this algorithm can balance the weights of observations and predicted states *** to both practical static data and kinetic simulations are presented to demonstrate the validity and efficiency of the algorithm.

关键词： navigation adaptive Kalman filter carrier phase