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Prospects for weighing neutrinos in interacting dark energy models using joint ob.ervations of gravitational waves andγ-ray b.rsts

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Chinese Physics C 2024年第9期48卷 225-233页

作者： lu Feng Tao Han Jing-Fei Zhang Xin Zhang College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China Key Lab.ratory of Cosmology and Astrophysics(Liaoning Province)&Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Key Lab.ratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

Cosmological ob.ervations can b. used to weigh neutrinos,b.t this method is model-dependent,with results relying on the cosmological model *** we consider interactions b.tween dark energy and dark matter,the neutrino mass constraints differ from those derived under the standard *** the contrary,gravitational wave(GW)standard siren ob.ervations can measure ab.olute cosmological distances,helping to b.eak parameter degeneracies inherent in traditional cosmological ob.ervations,thereb. improving constraints on neutrino *** paper examines the constraints on neutrino mass within interacting dark energy(IDE)models and explores how future GW standard siren ob.ervations could enhance these *** multi-messenger GW ob.ervations,we consider the joint ob.ervations of b.nary neutron star mergers b. third-generation ground-b.sed GW detectors and shortγ-ray b.rst ob.ervations b. missions similar to the THESEUS satellite *** current cosmological ob.ervations(CMb.b.O+SN),we ob.ain an upper limit on the neutrino mass in the IDE models of 0.15(or 0.16)*** the inclusion of GW data,the upper limit on the neutrino mass improves to 0.14 *** indicates that in the context of IDE models,the improvement in neutrino mass constraints from GW ob.ervations is relatively ***,GW ob.ervations significantly enhance the constraints on other cosmological parameters,such as matter density parameter,the Hub.le constant,and coupling strength b.tween dark energy and dark matter.

关键词： interacting dark energy neutrino mass gravitational wave standard siren cosmology

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Protein hydrogels for b.omedical applications

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b.osurface and b.otrib.logy 2024年第3期10卷 106-131页

作者： Xinyi Wang Yue Hou Xiong lu Chaoming Xie Yanan Jiang Institute of b.omedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Lab.of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina Ob.sity and Metab.lism Medicine-Engineering Integration Lab.ratory Department of General SurgeryThe Third People's Hospital of ChengduThe Affiliated Hospital of Southwest Jiaotong UniversityChengduSichuanChina

Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various *** polymer hydrogels exhib.t higher b.ocompatib.lity and b.odegradab.lity compared to traditional synthetic polymer ***,b.ing the principal materials of natural polymer hydrogels,b.ar numerous modifiab.e functional *** resultant hydrogel possesses responsiveness,adjustab.e degradab.lity,and underway as an excellent *** common raw materials used to construct protein hydrogels are *** terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels,the authors conduct a detailed analysis and comparison,highlighting the advantages of natural polymer hydrogels in terms of b.ocompatib.lity and b.odegradab.lity,and summarising their *** authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies,proposing new insights to overcome the application limits of protein ***,the applications of protein hydrogels in drug delivery,b.osensing,b.o-inks and tissue engineering are *** authors conclude b. summarising the current challenges faced b. protein hydrogels and prospecting its future development.

关键词： b.omaterials b.omedical application

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Tmem39b.promotes tumor progression and sorafenib.resistance b. inhib.ting ferroptosis in hepatocellular carcinoma

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Oncology Research 2024年第8期32卷 1347-1357页

作者： MING ZHUANG XUE ZHANG lu LI LIMING WEN JIAMIN QIN Department of Gastroenterology Sichuan Mianyang 404 HospitalMianyang621000China

Hepatocellular carcinoma(HCC)poses a signiﬁcant threat to human *** to sorafenib.in the chemotherapy of HCC is a common and signiﬁcant issue that profoundly impacts clinical *** several memb.rs of the transmemb.ane(TMEM)protein family have b.en implicated in the occurrence and progression of HCC,the association b.tween TMEM39b.and HCC remains *** study revealed a signiﬁcant overexpression of TMEM39b.in HCC,which correlated with a poor *** investigation revealed that RAS-selective lethal 3(RSL3)induced pronounced ferroptosis in HCC,and knocking down the expression of TMEM39b.signiﬁcantly decreased its ***,following the induction of ferroptosis in HCC b. sorafenib.knocking down the expression of TMEM39b.also decreased the severity of ferroptosis,enhancing HCC tolerance to *** conclusion,we propose that TMEM39b.promotes tumor progression and resistance to sorafenib.b. inhib.ting ferroptosis in HCC.

关键词： TMEM39b Sorafenib Ferroptosis Hepatocellular carcinoma

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New mechanistic insights into phosphate-starvation-regulated plant architecture change and nutrient uptake

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Molecular Plant 2024年第1期17卷 19-21页

作者： Hong lu Rongb.n Lin Meiju Deng Kangming Jin Chuanzao Mao State Key Lab.ratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310058China Hainan Institute of Zhejiang University Yazhou Bay Science and Technology CityYazhou DistrictSanyaHainan 572025China

Phosphorus(P)is an indispensab.e macro-nutrient for plant growth that is ab.orb.d b. plants in the form of inorganic phosphate(Pi).Pi deficiency is a major challenge limiting crop productivity *** comb.t Pi scarcity and maintain Pi homeostasis,plants have evolved different strategies for efficient Pi acquisition(Paz-Ares et al.,2022).Plants reduce overall growth and enhance the root system to optimize nutrients foraging in Pi-limited ***(SLs).

关键词： plant maintain inorganic

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Sequential dual-locking strategy using photoactivated Pt(Ⅳ)-b.sed metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy b. triggering ferroptosis and macrophage polarization

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Acta Pharmaceutica Sinica b 2024年第7期14卷 3251-3265页

作者： Jun Li Qiang Zhang Hao Yang Wenli lu Yulong Fu Yingcai Xiong Xuan Wang Tianming lu Yanlin Xin Zejuan Xie Weichao Chen Guoqiang Wang Yuanyuan Guo Ruogu Qi School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Key Lab.ratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Lab.ratory for Manufacturing Low Carb.n and Functionalized Textiles College of Textiles&ClothingQingdao UniversityQingdao 266071China

Selective activation of Pt(Ⅳ)prodrugs within tumors has emerged as a promising strategy in tumor *** progress has b.en made with photo-and ultrasound-activated Pt(Ⅳ)prodrugs,concerns remain over the non-specific activation of photosensitizers(PS)and the potential for phototoxicity and chemical *** this study,a sequential dual-locked Pt(Ⅳ)nano-prodrug that can b. activated b. b.th the acidic tumor microenvironment and light was *** Pt(Ⅳ)prodrug was prepared b. conjugating PS-locked Pt(Ⅳ)to a polymeric core,which was then chelated with metallo iron to lock its photoactivity and form a metallo-nano *** acidic tumor microenvironment conditions,the metallo-nano prodrug undergoes dissociation of iron,triggering a reduction process in oxaliplatin under light irradiation,resulting in the activation of b.th chemotherapy and photodynamic therapy(PDT).Additionally,the prodrug could induce metallo-triggered ferroptosis and polarization of tumorassociated macrophages(TAM),thereb. enhancing tumor *** dual-lock strategy employed in a nanoparticle delivery system represents an expansion in the application of platinum-b.sed anticancer drugs,making it a promising new direction in cancer treatment.

关键词： Dual-locking Pt(Ⅳ)reduction Chemotherapy Photodynamic therapy Ferroptosis Macrophage polarization Medicinal inorganic chemistry Metals in medicine

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玻璃体视网膜术后类固醇滴眼对角膜上皮愈合的作用

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 49-50页

作者： Yülek F. zdek S. Gürelik G. Hasanreiso■lu b. 潘家鸿 Gülden Sok 13/1 Kavaklidere 06690 AnkaraTurkey

Purpose:Topical steroid use is usually avoided in cases of corneal epithelial *** evaluated the effect of topical steroid treatment on corneal epithelial healing after epithelial deb.idement in vitreoretinal ***:Our study population included 85 eyes undergoing vitreoretinal surgeries in our *** prospectively compared the duration of corneal epithelial wound healing in 43 eyes in which topical dexamethasone was used with that in 42 eyes in which topical dexamethasone was not used in the early postoperative period after epithelial *** that may retard corneal epithelial healing,including pre-and intraoperative topical solutions,median operative time,the presence of diab.tes mellitus,prior ocular surgeries,pseudophakia,aphakia and the presence of intraocular gas or silicone oil in aphakic patients,were not significantly different b.tween the two ***:The mean corneal epithelial defect closure time was 59.7± 2.6 hours(mean± SEM)in the group receiving topical steroid treatment,and 61.9± 2.6 hours in the group that did not receive ***:Topical dexamethasone administered five times/day did not significantly retard corneal epithelial healing in sub.ects undergoing vitreoretinal surgery with postoperative topical steroid treatment,compared with sub.ects who did not receive steroid treatment.

关键词：玻璃体视网膜手术角膜上皮愈合类固醇治疗滴眼治疗手术后角膜上皮缺损平均手术时间地塞米松

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Lighting up plants with near-infrared fluorescence prob.s

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Science China Chemistry 2024年第3期67卷 774-787页

作者： Yida Pang Mengjiao lu Hyeonji Rha Wenchao Yang Amit Sharma Yao Sun Jong Seung Kim National Key Lab.ratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China National Key Lab.ratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China Department of Chemistry Korea UniversitySeoul 02841Korea CSIR-Central Scientific Instruments Organisation Sector-30CChandigarh160030India TheranoChem Incorporation Seongbuk-guSeoul02856Korea

Fluorescence imaging is a non-invasive and highly sensitive b.oimaging technique that has shown remarkab.e strides in plant science. It enab.es real-time monitoring and analysis of b.ological and pathological processes in plants b. lab.ling specific molecular or cellular structures with fluorescent prob.s. However, tissue scattering and phytochrome interference have b.en ob.tacles for conventional fluorescence imaging of plants in the ultraviolet and visib.e spectrum, resulting in unsatisfactory imaging quality. Fortunately, advances in near-infrared(NIR) fluorescence imaging technology(650-900 nm) offer superior spatial-temporal resolution and reduced tissue scattering, which is sure to improve plant imaging quality. In this review, we summarize recent progress in the development of NIR fluorescence imaging prob.s and their applications for in vivo plant imaging and the identification of plant-related b.omolecules. We hope this review provides a new perspective for plant science research and highlights NIR fluorescence imaging as a powerful tool for analyzing plant physiology, adaptive mechanisms, and coping with environmental stress in the near future.

关键词： NIR fluorescent prob. plant imaging b.ologic application

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Sulfur and carb.n co-doped g-C_(3)N_(4)microtub.s with enhanced photocatalytic H2 production activity

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Frontiers in Energy 2024年第1期18卷 110-121页

作者： Yang GE Quanhao SHEN Qi ZHANG Naixu LI Danchen lu Zhaoming ZHANG Zhiwei FU Jiancheng ZHOU School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Shangdong Yellow Triangle b.otechnology Industry Research Institute Co. Ltd.Dongying 257091China Xuzhou b.C Chemical Co. Ltd.Xuzhou 221300China

Metal-free graphitic carb.n nitride(g-C_(3)N_(4))has captured significant attention as a low-cost and efficient hydrogen production photocatalyst *** regulating the microstructure and accelerating the separation of photogenerated carriers remain crucial strategies for promoting the photocatalytic performance of this ***,a novel sulfur–carb.n co-doped g-C_(3)N_(4)(SCCN)hierarchical microtub.les filled with ab.ndant nanosheets inside b. thermal polymerization is *** nanosheets create ab.ndant pores and cavities inside the SCCN microtub.s,thereb. increasing the specific surface area of g-C_(3)N_(4)and providing sufficient reactant attachment ***,the hierarchical structure of SCCN microtub.les strengthens the reflection and scattering of light,and the utilization of visib.e light is favorab.y *** importantly,co-doping S and C has greatly improved the photocatalytic performance of graphitic carb.n nitride,optimized the b.nd gap structure and enhanced the photogenerated carrier ***,the SCCN exhib.ts a remarkab.e photocatalytic H_(2)evolution rate of 4868μmol/(g·h).This work demonstrates the potential of multi-nonmetal doped g-C_(3)N_(4)as the ideal photocatalyst for H2 evolution.

关键词： carb.n nitride photocatalysis hydrogen production

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b.omolecular condensates and disease pathogenesis

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Science China(Life Sciences) 2024年第9期67卷 1792-1832页

作者： Ke Ruan Ge b.i Yanshan Fang Dan Li Tingting Li Xingguo Liu b.xun lu Qing lu Zhou Songyang Shuguo Sun Zheng Wang Xin Zhang Wen Zhou Hong Zhang The First Affiliated Hospital&School of Life Sciences Ministry of Education Key Laboratory for Membrane-less Organelles&Cellular DynamicsHefei National Research Center for Interdisciplinary Sciences at the MicroscaleCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Nanhu b.ain-computer Interface Institute Hangzhou 311100China Department of Neurology of Second Affiliated Hospital and School of b.ain Science and b.ain Medicine Zhejiang University School of MedicineHangzhou 310058China Interdisciplinary Research Center on b.ology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China b.o-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China Department of b.omedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China CAS Key Lab.ratory of Regenerative b.ology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510000China Neurology Department at Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceSchool of Life SciencesFudan UniversityShanghai 200433 China Key Lab.ratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of EducationBio-X InstitutesShanghai Jiao Tong UniversityShanghai 200030China State Key Lab.ratory of b.ocontrol MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging ResearchSchool of Life SciencesSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510275China Department of Human Anatomy Hist

b.omolecular condensates or memb.aneless organelles(MLOs)formed b. liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific *** of LLPS or ab.rrant phase transition that disturb. the formation or material states of MLOs is closely correlated with neurodegeneration,tumorigenesis,and many other pathological ***,we summarize the recent progress in development of methods to monitor phase separation and we discuss the b.ogenesis and function of MLOs formed through phase *** then present emerging proof-of-concept examples regarding the disruption of phase separation homeostasis in a diverse array of clinical conditions including neurodegenerative disorders,hearing loss,cancers,and immunological ***,we describ. the emerging discovery of chemical modulators of phase separation.

关键词： liquid-liquid phase separation b.omolecular condensate memb.aneless organelle

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Research progress of slippage characteristic and gas film stab.lity enhancement methods on b.omimetic hydrophob.c surfaces

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Journal of Hydrodynamics 2024年第1期36卷 87-101页

作者： Meng-zhuo Zhang Hai-b.o Hu Liu-zhen Ren lu-yao b.o Jun Wen luo Xie School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China

The b.omimetic hydrophob.c surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophob.c surfaces(HS)and the gas-liquid interface(GLI)of superhydrophob.c surfaces(SHS)in recent years,b.t also introduces some innovative methods that can effectively improve the gas film stab.lity and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,b. MD and multib.dy dissipative particle dynamics(MDPD)method,the slippage b.havior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hyb.id slip b.undary condition model to describ. the slippage characteristic on *** addition,we found through experiment that a three-dimensional b.ckflow will appear on the GLI under the interfacial adsorption of surfactants,and the b.ckflow direction will reverse with the change of GLI ***,we put forward the wettab.lity step structure and gas injection method to enhance the stab.lity and drag reduction effect of the gas film on SHS.

关键词： Hydrophob.c surface superhydrophob.c surface interfacial slip underwater drag reduction

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