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Neuromodulation and ablation with focused ultrasound-toward the future of noninvasive brain therapy

Neural Regeneration Research 2019年第9期14卷 1509-1510页

作者： Anton Fomenko Andres m.lozano Krembil Research Institute University Health NetworkTorontoCanada Division of Neurosurgery Toronto Western HospitalTorontoCanada

With an aging patient population and an increased burden of neurological disease,the demand for noninvasive alternatives to open neurosurgical procedures is *** or minimally invasive approaches to targeting brain regions include transcranial magnetic stimulation(TmS),transcranial direct current stimulation,temporally interfering electric fields,and focused ultrasound(FUS).Among these modalities,FUS offers a unique combination of target specificity,deep brain penetration,and compatibility with real-time structural and thermal monitoring using magnetic resonance imaging(mRI)and mR *** on the intensity and frequency used,ultrasound can have either modulating or ablative effects on brain ***-intensity mR-guided FUS(mRgFUS)is a noninvasive and effective alternative to conventional deep-brain stimulation and radiofrequency lesioning for essential tremor(ET),and is being investigated for other movement disorders,particularly Parkinson’s *** clinical implementation of high-intensity ultrasound is challenged by limitations in target selection precision,technical barriers(such as variable penetration and heat deposition)and the possibility of lesion-related adverse effects(Schwartz et al.,2018).Emerging studies,including those from our group(Boutet et al.,2018)are striving to refine targeting of mRgFUS to improve safety and patient clinical *** the same time,low-intensity FUS(LIFUS)has been found to safely modulate brain activity in rodents,primates,and healthy human subjects(Fomenko et al.,2018).Clinical translation of LIFUS has been hampered however,by a poor understanding of the mechanisms of action,uncertainty over effective sonication parameters and intensities,and conflicting study results due to heterogeneous experimental *** this perspective,the current state of both mRgFUS ablation and LIFUS neuromodulation will be *** technical challenges to delivering ultrasound to the brain,recen

关键词： precision procedures Parkinson human same FUS can has

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Current surgical treatments for Parkinson's disease and potential therapeutic targets

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Neural Regeneration Research 2018年第8期13卷 1342-1345页

作者： Darrin J.Lee Robert F.Dallapiazza Philippe De Vloo Andres m.lozano Division of Neurosurgery Toronto Western Hospital Department of Surgery University of Toronto

Currently, the most common surgical treatment for Parkinson＇s disease is deep brain stimulation（DBS）. This treatment strategy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer respond to medication in a predictable manner or who suffer medication-induced dyskinesias. In addition to DBS, ablative procedures like radiofrequency, radiosurgery and focused ultrasound are also utilized for select tremor symptoms. In this review, we discuss evolving surgical techniques, targets, and emerging technology. In addition, we evaluate potential paradigm shifts in treatment, including gene therapy, immunotherapy and cell transplantation. While these new techniques and treatment options are still in their infancy, advances in Parkinson＇s disease treatment are rapidly expanding.

关键词： Parkinson's disease deep brain stimulation pallidotomy thalamotomy focused ultrasound gene therapy immunotherapy cell transplantation

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Operational definitions and measurement of externalizing behavior problems:An integrative review including research models and clinical diagnostic systems

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World Journal of Psychiatry 2023年第6期13卷 278-297页

作者： Lidia Torres-Rosado Oscar m lozano manuel Sanchez-Garcia Fermín Fernández-Calderón Carmen Diaz-Batanero Department of Clinical and Experimental Psychology University of HuelvaHuelva 21071Spain Research Center for Natural Resources Health and EnvironmentUniversity of HuelvaHuelva 21071Spain

measurement of externalizing disorders such as antisocial disorders,attentiondeficit/hyperactivity disorder or borderline disorder have relevant implications for the daily lives of people with these *** the Diagnostic and Statistical manual of mental Disorders(DSm)and the International Classification of Diseases(ICD)have provided the diagnostic framework for decades,recent dimensional frameworks question the categorical approach of psychopathology,inherent in traditional *** and instruments develop under the DSm or ICD framework preferentially adopt this categorical approach,providing diagnostic *** contrast,dimensional measurement instruments provide an individualized profile for the domains that comprise the externalizing spectrum,but are less widely used in *** paper aims to review the operational definitions of externalizing disorders defined under these different frameworks,revise the different measurement alternatives existing,and provide an integrative operational ***,an analysis of the operational definition of externalizing disorders among the DSm/ICD diagnostic systems and the recent Hierarchical Taxonomy of Psychopathology(HiTOP)model is carried ***,in order to analyze the coverage of operational definitions found,a description of measurement instruments among each conceptualization is *** phases in the development of the ICD and DSm diagnosis systems can be observed with direct implications for *** and DSm versions have progressively introduced systematicity,providing more detailed descriptions of diagnostic criteria and categories that ease the measurement instrument ***,it is questioned whether the DSm/ICD systems adequately modelize externalizing disorders,and therefore their *** recent theoretical approaches,such as the HiTOP model seek to overcome some of the criticism raised towards the classification ***,several issues

关键词： Externalizing disorders measurement Diagnostic and Statistical manual of mental Disorders International Classification of Diseases Hierarchical Taxonomy of Psychopathology Psychopathology

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Hepatic rupture secondary to HELLP syndrome: outcomes in three cases

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World Journal of Emergency medicine 2024年第1期15卷 56-58页

作者： Salvador Gomez-Carro Ruben R.lozano-Salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer Nina méndez-Domínguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico National Institute of Perinatology.mexico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver *** identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

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Simulation of multi-Frequency Induced Currents in Biophysical models and Agar Phantoms of Breast Cancer

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Journal of Electromagnetic Analysis and Applications 2012年第8期4卷 317-325页

作者： César A. González Jesús G. Silva Lucila m. lozano Salvador m. Polo Universidad del Ejército y FAm/EmGS-Laboratorio multidisciplinario de Investigación DF México

Breast cancer is the most frequent malignant neoplasm and the leading cause of cancer death in women in the world. Early detection techniques have been proposed on the basis of bioelectrical measurements. The aim of this study was to evaluate analytically and experimentally the inductive phase shift as a function of multi-frequency induced currents in breast cancer conditions. Virtual simulation by biophysical models and experimental measurements by magnetic induction in agar phantoms were developed to estimate the inductive phase shift as a function of the bulk electrical properties in typical breast volumes with tumors in specific positions. The analytical and experimental results are qualitatively consistent and provide evidence that the inductive phase shift has a potential clinical value to detect cancerous tumors toward inside a typical volume of breast tissue.

关键词： Inductive Phase Shift Breast Cancer

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Doping Effect of Poly(vinylidene fluoride) on Carbon Nanofibers Deduced by Thermoelectric Analysis of Their melt mixed Films

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Chinese Journal of Polymer Science 2024年第11期 1802-1810页

作者： A.J.Paleo V.m.Serrato J.m.mánuel O.Toledano E.mu?oz m.melle-Franco B.Krause P.P?tschke K.lozano 2C2T-Centre for Textile Science and Technology University of Minho Campus de Azurém Florida Institute of Technology The Aerospace Corporation Department of Condensed matter Physics and Institute of Research on Electron microscopy and materials(ImEYmAT) Faculty of Sciences University of Cádiz CICECO – Aveiro Institute of materials Department of Chemistry University of Aveiro UNED-Universidad Nacional de Educación a Distancia Facultad de Física Pontificia Universidad Católica de Chile Leibniz-Institut für Polymerforschung Dresden e.V.IPF Department of mechanical Engineering University of Texas Rio Grande Valley

The effect of temperature on the electrical conductivity （σ） and Seebeck coefficient （S） of n-type vapor grown carbon nanofibers （CNFs）and poly（vinylidene fluoride）(PVDF) melt-mixed with 15 wt%of those CNFs is *** 40°C,the CNFs show stable n-type character (S=-4.8μV·K-1) with anσof ca.165 S·m-1,while the PVDF/CNF composite film shows anσof ca.9 S·m-1and near-zero S (S=-0.5μV·K-1).This experimental reduction in S is studied by the density functional tight binding （DFTB） method revealing a contact electron transfer from the CNFs to the PVDF in the ***,in the temperature range from 40°C to 100°C,theσ（T） of the CNFs and PVDF/CNF film,successfully described by the 3D variable range hopping （VRH） model,is explained as consequence of a thermally activated backscattering *** the contrary,the S（T）from 40°C to 100°C of the PVDF/CNF film,which satisfactorily matches the model proposed for some multi-walled carbon nanotube （mWCNT）doped mats;however,it does not follow the increase in S（T） found for *** these findings are presented with the aim of discerning the role of these n-type vapor grown carbon nanofibers on theσand S of their melt-mixed polymer composites.

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帕金森病研究新进展

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科学（中文版） 2005年第9期 58-65页

作者： Andres m.lozano Suneil K.Kalia 蒋青伟多伦多西部医院

帕金森病,最早在19世纪初被英国内科医生James Parkinson描述为"震颤麻痹",是最常见的神经系统疾病之一.

关键词：帕金森病细胞学遗传学

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American tegumentary leishmaniasis mimicking myiasis and granulomatous vasculitis:A case report

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Asian Pacific Journal of Tropical medicine 2024年第10期17卷 473-476,I0001,I0002页

作者： Victoria J Arrieta Gastón morea Leticia m Tennerini maría VSanchez Esteban S lozano Diego E Cargnelutti Instituto de medicina y Biología Experimental de Cuyo(ImBECU) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Universidad Nacional de Cuyo(UNCuyo)MendozaArgentina Hospital Luis C.Lagomaggiore MendozaArgentina Facultad de Ciencias médicas(FCm) Universidad Nacional de Cuyo(UNCuyo)MendozaArgentina

Rationale:American tegumentary leishmaniasis comprises cutaneous and mucocutaneous manifestations caused by parasitic infections by various Leishmania *** report details the clinical interventions for a patient with American tegumentary leishmaniasis in mendoza,Argentina,a non-endemic *** concerns:A 43-year-old male was admitted to a tertiary care hospital in mendoza,Argentina Republic with a history of progressive nasal discharge,septal perforation,facial pain,and *** treatment for presumed nasal myiasis and vasculitis with granulomatosis,symptoms ***:American tegumentary ***:Intravenous liposomal amphotericin ***:Follow-up at 30 days showed no recurrence of symptoms with a remarkable clinical improvement of the nasal ***:This case sheds light on the necessity of accurate identification for timely intervention and the need to recognize the diverse manifestations of American tegumentary leishmaniasis to avoid misdiagnosis.

关键词： Leishmania American tegumentary leishmaniasis Diagnosis methods myasis Vasculitis and granulomatosis Case report

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From Simulation to Reality: A Comprehensive Study on the Efficacy of a Rotating monopolar and Bipolar Radiofrequency System through In-Silico modeling and Pre-Clinical and Clinical Validation

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Journal of Biomedical Science and Engineering 2024年第6期17卷 107-128页

作者： Gregorio Viera mármol Ana Lorena Urbano Bojorge Alicia Robledo Jorge José Antonio Ferrández martínez Olalla Calvo lozano High Technology Products S.L.U. (Sinclair) Barcelona Spain

Background: Skin aging is an unavoidable process aggravated by environmental agents. Among other energy devices, non-invasive radiofrequency (RF) technology is widely used for skin tightening and body contouring as it is simpler and more affordable than other technologies that also minimize pain and side-effects. However, most of the current RF devices do not provide automatic skin temperature control and it is difficult to achieve controlled, deep, and harmless thermal increase, so treatment performance and safety is dependent on the operator’s movements and expertise. Objective: To show the potential of numerical simulations for optimizing the design of monopolar and bipolar RF electrodes that are capable of providing homogeneous, deep and controlled heating. materials and methods: In-silico models were developed and analyzed using Comsol multiphysics software to simulate the RF effect produced in tissue by rotating monopolar and bipolar electrodes with different geometries from the Sculpt & Shape RF device (Sinclair, Spain), operating at frequencies of 0.5 and 1 mHz. Ex-vivo and in-vivo proof-of-concept tests were carried out to validate the simulations. Finally, treatments were performed on 16 subjects and a total of 78 body areas to assess the clinical results generated by the RF electrodes for skin tightening and body contouring. Results: In-silico studies emulated the superficial and deep dispersion of heat due to the release of RF energy into human skin tissue. The rotating electrodes (monopolar and bipolar) and the selected RF frequency (0.5 and 1 mHz) determined the homogeneity of the thermal distribution, the penetration depth (between 4.37 mm and 25.0 mm) and the heating dynamics (between 30 and 100 seconds to reach the target skin temperature), which were confirmed by ex-vivo and in-vivo tests. In addition, real treatments on facial and body areas using skin temperatures of between 43˚C and 44˚C showed consistent results with good clinical efficacy for

关键词： Comsol multiphysics Simulations Radiofrequency Skin Tightening Fat Reduction Body Contouring Cellulite

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游离丙型肝炎病毒核心抗原酶联免疫吸附试验不适用于粒细胞集落刺激因子动员的造血祖细胞捐献者的筛查

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国外医学（输血及血液学分册） 2005年第6期28卷 548-550页

作者： lozano m L Candela mJ Cano H 张新华赵凤绵韩卫张燕河北省血液中心

市售的酶联免疫试验试剂盒抗-丙型肝炎病毒(HCV)核心抗原酶联免疫(ELISA)检测系统(Ortho Clinical Diagnostics,Raritan,NJ),能够检测患者感染HCV后窗口期的HCV核心抗原,即在产生HCV RNA后的1 d～2 d内检测到HCV核心抗原,灵敏度为94%,... 详细信息

市售的酶联免疫试验试剂盒抗-丙型肝炎病毒(HCV)核心抗原酶联免疫(ELISA)检测系统(Ortho Clinical Diagnostics,Raritan,NJ),能够检测患者感染HCV后窗口期的HCV核心抗原,即在产生HCV RNA后的1 d～2 d内检测到HCV核心抗原,灵敏度为94%,总的特异性为99%.

关键词：丙型肝炎病毒核心抗原酶联免疫吸附试验粒细胞集落刺激因子造血祖细胞丙型肝炎病毒(HCV) HCV核心抗原捐献者 Clinical 筛查

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