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Status of autoimmune diabetes 20-year after generation of BDC2.5-TCR transgenic non-obese diabetic mouse

World Journal of Diabetes 2013年第4期4卷 88-91页

作者： lourdes ramirez Abdel Rahim A Hamad Department of Pathology Johns Hopkins University School of Medicine

Type 1 diabetes(T1D) is an autoimmune disease that results from the destruction of insulin-producing cells by autoreactive T cells,leading to lifelong dependency on insulin therapy and increased risk of long-term cardiovascular *** we take the opportunity of the 20thanniversary of the generation of the BDC2.5 TCR transgenic non-obese diabetic(NOD) mouse model,to provide a brief overview of the significant progress that has been made in understanding the role of T cells in the disease pathogenesis *** included development of hundreds of reagents that block or even reverse new-onset disease by directly or indirectly controlling T *** also reflect on the sobering fact that none of these strategies has shown significant efficacy in clinical trials and discuss potential reasons hindering translation of the preclinical findings into successful therapeutic strategies and potential ways forward.

关键词： Autoimmune diabetes Immunotherapy T cells BDC2.5 T cells Anti-CD3 Immunosuppression

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From non-obese diabetic to Network for the Pancreatic Organ Donor with Diabetes: New heights in type 1 diabetes research

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World Journal of Diabetes 2015年第16期6卷 1309-1311页

作者： lourdes ramirez Abdel Rahim A Hamad Department of Pathology Johns Hopkins University School of Medicine

Since the discovery of therapeutic insulin in 1922 and the development of the non-obese diabetic spontaneous mouse model in 1980,the establishment of Network for Pancreatic Organ Donor with Diabetes(n POD) in 2007 is arguably the most important milestone step in advancing type 1 diabetes(T1D) research. In this perspective,we briefly describe how n POD is transforming T1 D research via procuring and coordinating analysis of disease pathogenesis directly in human organs donated by deceased diabetic and control subjects. The successful precedent set up by n POD is likely to spread far beyond the confines of research in T1 D to revolutionize biomedical research of other disease using high quality procured human cells and tissues.

关键词： Type 1 diabetes Network for the Pancreatic Organ D

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Effect of the thin cell layer technique in the induction of somatic embryos in Pinus patula Schl. et Cham

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Journal of Forestry Research 2019年第4期30卷 1535-1539页

作者： Marco A.ramirez-Mosqueda lourdes G.Iglesias-Andreu Arturo A.Armas-Silva Esmeralda J.Cruz-Gutierrez Jose F.de la Torre-Sanchez Otto R.Leyva-Ovalle Carlos M.Galan-Paez Instituto de Biotecnologfa y Ecologfa Aplicada(INBIOTECA) Universidad Veracruzana.Av.de las Culturas Veracruzanas No.101Campus para la Culturalas Artes y el DeporteCol.Emiliano ZapataC.P.91090 XalapaVeracruzMexico Centro Nacional de Recursos Geneticos-INIFAP Boulevard de la Biodiversidad No.400 Rancho las CrucesC.P.47600 Tepatitlan de MorelosJaliscoMexico Facultad de Ciencias Bioldgicas y Agropecuarias Region Cordoba-Orizaba Universidad VeracruzanaC.P.94945 Amatlan de los ReyesVeracruzMexico

Pinus patula is a species commonly used for reforestation in ***,efficient methods for the mass production seedlings are *** particularly by somatic embryogenesis provides an option for the rapid multiplication of high-quality,genetically improved *** study induces somatic embryogenesis in this species using the thin cell layer(TCL)*** sources of explants(complete immature embryos;lTCL segments from immature embryos)were *** efficiency of TCL from longitudinal sections[lTCL]and transverse[tTCL]was *** results show using thin cell layers from immature embryos cultivated in 16 light/8 dark hours achieves induction of somatic embryos.A higher percentage of embryogenic callus was obtained when tTCL segments were used as an explant *** results produced somatic embryos from tTCL segments of an immature embryo without germinating the seed,making the process more time *** addition,this technique can be used to generate somatic embryogenesis in forest species that have low germination rates.

关键词： Pinus patula Somatic embryos Micropropagation Thin cell layer Maturation

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Satisfaction of the Service Provider with the Organization of the Timely Cervical Cancer Detection Program

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Health 2017年第2期9卷 289-298页

作者： Gutierrez-Enriquez Sandra Olimpia Teran-Figueroa Yolanda Gaytan-Hernandez Dario Diaz-Oviedo Aracely Zuniga-Martinez Ma.de lourdes Hernandez-Nava Nereyda Cruz Ortiz Maribel Perez Rodriguez Maria del Carmen ramirez-ramirez Rocio Faculty of Nursing and Nutrition Autonomous University of San Luis PotosiSan Luis PotosiMexico Academic Coordination Altiplano Region Autonomous University of San Luis PotosiSan Luis PotosiMexico

Cervical cancer is a priority health problem in Mexico. The objective of this work was to know the degree of satisfaction of the service provider with the organization of the program of Timely Detection of Cervical Cancer, specifically in taking of the cervical cytology. The study design was observational, transversal and prospective conducted from January to May 2015 in Jurisdiction 1 of the Health Services of San Luis Potosí, Mexico, in 20 health centers. Participants were 87 service providers whose function is to take cervical cytology (Pap smears). A 32-question questionnaire was applied, with Likert scale with 5 levels of response: 1 (dissatisfied), 2 (little satisfied), 3 (indifferent), 4 (satisfied) and 5 (very satisfied). The score range was 32 points (minimum job satisfaction) up to 160 points (Maximum job satisfaction). We analyzed 2 dimensions: 1) intrinsic factors that have to do with motivation and professional recognition, and 2) extrinsic factors related to infrastructure, materials, remuneration and labor policies. Each factor consisted of four categories. Descriptive statistics and linear correlation of Pearson were applied for the analysis of data. Participants signed an informed consent letter. Of 4 categories, in the intrinsic dimension, the one with the highest percentage of satisfaction was “delegation of activities” with 28.8%. In the extrinsic dimension, the category with the highest percentage of satisfaction was “infrastructure and materials” with 49.4%;while satisfaction increase in intrinsic dimensions also does in extrinsic dimensions, such correlations are significant (p < 0.05), except between delegation of activities and remuneration (r = 0.074 and p = 0.497). The higher hierarchical level, the men, the bachelor academic level and older people showed the highest level of satisfaction.

关键词： Job Satisfaction Cervical Cancer Health Providers

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