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Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer:A systematic review of observational studies

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World Journal of Gastroenterology 2023年第7期29卷 1219-1234页

作者： lourdes pilar chávez-hidalgo Silvia Martín-Fernández-de-Labastida Marian M de Pancorbo Marta Arroyo-Izaga Department of Pharmacy and Food Sciences Faculty of PharmacyUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain Department of Z.and Cellular Biology A. University of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain BIOMICs Research Group MICROFLUIDICs and BIOMICs Cluster UPV/EHULascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain

BACKGROUND Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer(CRC).However,whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still *** To improve the current understanding of the molecular basis of *** A literature search in the Medline database,Reference Citation Analysis(https://***/),and manual reference screening were performed to identify observational studies published from inception to May *** A total of fourteen case-control studies and five cohort studies were *** studies included information on dietary methyl donors,dietary components that potentially modulate the bioavailability of methyl groups,genetic variants of methyl metabolizing enzymes,and/or markers of CpG island methylator phenotype and/or microsatellite instability,and their possible interactions on CRC *** Several studies have suggested interactions between methylenetetrahydrofolate reductase polymorphisms,methyl donor nutrients(such as folate)and alcohol on CRC ***,vitamin B6,niacin,and alcohol may affect CRC risk through not only genetic but also epigenetic *** of specific mechanisms in these interactions associated with CRC may assist in developing targeted prevention strategies for individuals at the highest risk of developing CRC.

关键词： Colorectal cancer DNA methylation Epigenetics Methyl donors Microsatellite instability Nutrients

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Predictive Score for Pulmonary Ultrasound and Factors Associated to Mortality and Hospitalization during the Covid-19 Pandemic

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Open Journal of Emergency Medicine 2022年第4期10卷 210-219页

作者： Leandro Seoane Adrian Ruggiero Anabela Martinelli Cristian Noriega Martin Diana Menendez Marcelo Rodriguez Natalia Cano lourdes Posadas Hospital Universitario Austral Pilar Argentina Hospital Italiano de Buenos Aires Buenos Aires Argentina

Pulmonary ultrasound is a non-invasive bedside resource that has showed to be useful for the assessment of patients presenting with respiratory insufficiency as well as the diagnosis of several pleural and other pulmonary pathologies. The pulmonary ultrasound score (LUS) is a semi quantitative scale that measures the loss of pulmonary aeration cause by many pathologic conditions. Our primary objective was to describe factors associated to death and hospitalization in patients aged 16 or older that were admitted to the emergency department (ED) with signs or symptoms of COVID-19 infection through the diagnosis of viral pneumonia with pulmonary ultrasound (PU). It was a cohort retrospective study through a one-year period. Emergency physicians performed lung ultrasounds and calculated LUS. Results: 672 patients suspected of COVID-19 infection with a PU finding of viral pneumonia were included. 495 patients had a positive COVID-19 PCR test, 73.6% of the population. 258 patients presented with high probability of COVID-19 pneumonia following the patterns in PU. 55% were male with a median age of 45 years old. The average LUS score at admission was 8. Global hospitalization rate was 51.5%, 7.5% were admitted to the ICU. Patients with a LUS > 10 had a mortality of 6%, and patients admitted to the ICU had a 50% mortality rate. They presented with an average LUS score at admission of 15.2. Conclusions: LUS was a good predictor of death, hospitalization to general ward or ICU of patients with COVID-19 admitted from the emergency department.

关键词： Pulmonary Ultrasound COVID-19 Pulmonary Ultrasound Score Emergency Physicians Viral Pneumonia

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Acalculous cholecystitis due to Salmonella enteritidis

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World Journal of Gastroenterology 2008年第41期14卷 6408-6409页

作者： Maria lourdes Ruiz-Rebollo Gloria Sánchez-Antolín Félix García-Pajares Maria Antonia Vallecillo-Sande pilar Fernández-Orcajo Rosario Velicia-Llames Agustín Caro-Patón Gastroenterology Unit Hospital Río Hortega

Acute acalculous cholecystitis (AAC) is defi ned as an acute infl ammation of the gallbladder in the absence of stones. We herein report a case of a young man who developed AAC after a Salmonella enteritidis gastroint... 详细信息

关键词：胆囊炎年轻人传染性沙门氏菌属肠炎

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Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 137-146页

作者： Huascar Ramos Pedro Linares Ester Badia Isabel Martín Judith Gómez Carolina Almohalla Francisco Jorquera Sara Calvo Isidro García pilar Conde Begona álvarez Guillermo Karpman Sara Lorenzo Visitación Gozalo Mónica Vásquez Diana Joao Marina de Benito lourdes Ruiz Felipe Jiménez Federico Sáez-Royuela 无 Department of Gastroenterology and Hepatology Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial Universitario de León Department of Gastroenterology and Hepatology Hospital Universitario de Salamanca Department of Hepatology Hospital Universitario Rio Hortega CIBERehd IBIOMED Fundación Burgos por la Investigación de la Salud Hospital Universitario de Burgos Department of Gastroenterology and Hepatology Complejo Asistencial de Palencia Department of Gastroenterology and Hepatology Complejo Asistencial de Zamora Department of Gastroenterology and Hepatology Hospital El Bierzo Department of Gastroenterology and Hepatology Hospital Clínico Universitario de Valladolid Department of Gastroenterology and Hepatology Hospital Santos Reyes Asociación Castellano y Leonesa de Hepatología(ACyLHE)

AIM To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).METHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RNA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RNA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RNA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).CONCLUSION A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized.

关键词： Hepatitis C virus infection Genotype 1-4 Real world treatment Direct-acting antiviral agents

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