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Journal of Cancer Therapy 2014年第12期5卷 1059-1064页

作者： Peter K. Donnelly louise robinson Matt Halkes Andy Goodman Department of Breast Surgery Torbay Hospital South Devon Healthcare NHS Foundation Trust Torquay UK Department of Anaesthesia Torbay Hospital South Devon Healthcare NHS Foundation Trust Torquay UK Department of Oncology Torbay Hospital South Devon Healthcare NHS Foundation Trust Torquay UK

The aim of this case report is to present a novel approach to the management of very severe anaphylactic reaction to Patent Blue Dye used in Sentinel Node Biopsy for breast cancer treatment. The severity and duration of cardiovascular effects has not been described previously in this setting. Comprehensive ICU support including heamofiltration resulted in the patients’ complete recovery and successful long-term well-being despite a change to our routine cancer care plan.

关键词： Blue Dye Anaphylaxis Sentinel Node Haemofiltration Breast Cancer

痴呆:评估、管理和支持:NICE指南更新概要

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英国医学杂志中文版 2019年第5期22卷 283-289页

作者： Joshua Pink John O Brien louise robinson Damien Longson 毛晨晖(译) National Institute for Health and Care Excellence Manchester M1 4BTUK Department of Psychiatry University of CambridgeCambridge Biomedical CampusCambridge CB2 OSPUK Newcastle University Institute for Ageing and Institute for Health & Society Newcastle UniversityNewcastle Biomedical Research BuildingCampus for Ageing and VitalityNewcastle upon Tyne NE4 5PLUK Greater Manchester Mental Health Foundation Trust Bury New RoadPrestwichManchester M25 3BLUK 北京协和医院神经科

痴呆是指一系列的认知、行为和精神症状,包括记忆减退、推理和交流能力障碍,以及人格改变等,并导致了个人的日常生活能力下降。2013年阿尔茨海默病协会公布的报告显示,在英国,有815 000名痴呆患者(相当于65岁以上人群的患病率为1/14),... 详细信息

痴呆是指一系列的认知、行为和精神症状,包括记忆减退、推理和交流能力障碍,以及人格改变等,并导致了个人的日常生活能力下降。2013年阿尔茨海默病协会公布的报告显示,在英国,有815 000名痴呆患者(相当于65岁以上人群的患病率为1/14),并且这个数字预计到2025年,将增加到1 143 000人。

关键词：痴呆指南管理日常生活能力阿尔茨海默病精神症状记忆减退交流能力

Non-invasive means of measuring hepatic fat content

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World Journal of Gastroenterology 2008年第22期14卷 3476-3483页

作者： Sanjeev R Mehta E louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-robinson Division of Medicine Imperial College London St Mary's Campus Praed Street London W2 1NY United Kingdom Imaging Sciences Depart-ment Division of Clinical Sciences Imperial College London Hammersmith Campus Du Cane Road London W12 OHS United Kingdom

Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions.

关键词：脂肪纤维异常肥胖脂肪肝胰岛素耐药性超声检查

Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2006年第36期12卷 5813-5819页

作者： E louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-robinson The Robert Steiner MR Unit MRC Clinical Sciences Centre Department of Nutrition and Dietetics The Robert Steiner MR Unit MRC Clinical Sciences Centre Faculty of Medicine Imperial College London Hammersmith Hospital Du Cane Rd London W12 0HS United Kingdom and Histopathology Department Faculty of Medicine Imperial College London St Mary's Hospital Praed Street London W2 1NY United Kingdom Faculty of Medicine Faculty of Medicine Imperial College London St Mary's Hospital Praed Street London W2 1NY United Kingdom

AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs.

关键词：营养咨询肝疾病肌肉疾病脂肪分布