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Black Hole Singularities and Planetary Formation

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1079-1088页

作者： louise Riofrio Insight Optics Houston USA Quantum Astrobiology Center of Manizales Manizales Colombia

The goal of this research is to explore the effects of black hole singularities. Methodology is to start with large objects like galaxies and continue to smaller objects within our solar neighbourhood. High-redshift observations from the James Webb Space Telescope reveal that distant galaxies and their central black holes formed shortly after the Big Bang. An innovation about the speed of light explains how supermassive black holes could have formed primordially. Predictions of Hawking radiation include the possibility of black holes contributing to the energy of stars such as the Sun. Black holes have also been suggested as a source of radiation and magnetic fields in giant planets. Observations of Enceladus raise the possibility that this moon and other objects near Saturn’s Rings contain small singularities. Extrapolations of this methodology indicate that black holes could exist within solar system bodies including planets. Extended discussion describes how their presence could explain mysteries of internal heat, planetary magnetic fields, and processes of solar system formation.

关键词： Black Holes Galaxies Magnetic Fields Planets Planetary Formation Speed of Light

Evaluation and salivary biochemistry associations of sour-salty taste interaction

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Journal of Future Foods 2024年第4期4卷 376-382页

作者： Hongnan Jiang Ye Chen Jianshe Chen louise Dye Xinmiao Wang Laboratory of Food Oral Processing School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang-UK Joint Laboratory of Food Sensory Science Zhejiang Gongshang UniversityHangzhou 310018China School of Food Science and Nutrition University of LeedsLeeds LS29JTUK

Taste interaction is a well-known phenomenon in sensory stodies,but how to quantify the magnitode of the effect of one tastant on other taste attribute(s)is still largely unsolved,let alone further explorations from a salivary biochemistry *** acquiring the individual taste threshold and evaluating the just noticeable difference(JND).this stody firstly established a quantitative method to assess the magnitude of taste interaction in a binary taste mixture by evaluating the concentration difference upon psychologically-comparable *** change of salty taste intensity(CSI)was therefore defined as the subtraction of JND using sour-salty taste stimulant from JND using pure salty taste stimulant,with a dimension of concentration in mmol/*** was then used to demonstrate how citric acid affected salty taste perception in a salty-sour binary taste mixture in 16 young and healthy *** of citric acid used in the binary taste mixtore were 0.***.0.09.0.***.0.24 and 0.40 mmolL,*** results showed that salty taste perception was enhanced(average CSI of 0.93 mmolL)when the citric acid concentration was low(at 0.05 and 0.09 mmolL).but with an increasing concentration of citric acid ranging from 0.14 to 0.40 mmol/L,this effect gradually turned from enhancement to suppression of salty taste perception(correspondingly a continoously decreasing CSI all the way down to an average of-2.94 mumol/L).It was also found that cystatin SN concentration in participants'unstimulated saliva samples was significantly negatively correlated with salty taste threshold(with and without the presence of citric acid),and it was one of the most significant factors affecting CSI,s shown in multiple regression *** anhydrase VI concentration in participants'unstimulated saliva sanples was also found to be significantly negatively correlated with salty taste recognition(with and without presence of citric acid).but it did not pose signific

关键词： Taste interaction evaluation Sensory analysis Salty taste perception Salivay biochemical components

Psychiatric outcomes in outpatients affected by long COVID:A link between mental health and persistence of olfactory complaint

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World Journal of Psychiatry 2024年第4期14卷 507-512页

作者： Victoria Metelkina-Fernandez louise-Emilie Dumas Clair Vandersteen David Chirio Auriane Gros Arnaud Fernandez Florence Askenazy Valeria Manera Department of Psychiatry Nice University HospitalNice 06000France Department of Child and Adolescent Psychiatry UniversitéCôte d’AzurNice 06200France ENT Head and Neck InstituteNice 06100France Department of Infectiology Nice University HospitalNice 06200France Department of Orthophony UniversitéCôte d’AzurNice 06100France Cobtek UniversitéCôte d’AzurNice 06100France

BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory *** We conducted a prospective case control study from March 2020 to May *** recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by ***-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology *** medical histories were collected by a psychiatrist during the *** Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the *** percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 *** control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 *** rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent *** therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk *** prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.

关键词： COVID-19 Anosmia Psychiatry Stress Neuroplasticity Psychiatric history

Theories behind Bacillus Calmette-Guerin failure in high-risk non-muscle-invasive bladder cancer and update on current management

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Cancer Pathogenesis and Therapy 2024年第2期2卷 74-80页

作者： Hanna Maroof louise Paramore Ahmed Ali Department of Urology Frimley Park HospitalPortsmouth RdFrimleyCamberley GU167UJUnited Kingdom

Bladder cancer encapsulates a wide spectrum of disease severities,with non-muscle invasive bladder cancer(NMIBC)representing an entirely different entity from muscle-invasive *** Calmette-Guerin(BCG)is one of the most successful intravesical treatment methods for patients ***,a considerable pro-portion of patients fail to respond to BCG *** the propensity for recurrence in patients with high-risk bladder cancer,these patients present with surgical *** is currently no gold standard for salvage treatment post-BCG failure or unified definition as to what that *** this review,we discuss the mechanisms of action and pathophysiology of BCG,potential theories behind BCG failure,and the scope of novel treatments forthis surgical conundrum.

关键词： Cystectomy Hyperthermia Induced Immunotherapy Mycobacterium bovis Non-muscle-invasive bladder cancer

The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua David Wong louise McEwan James Walters Rachel Esler Matthew J.Roberts Geoff Coughlina John W.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)ordered at Department of Urology,The Wesley Hospital,Brisbane,QLD,Australia for non-PCa related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/CT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concordant with the 18F-FDG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** was no statistically significant difference in the 18F-FDG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity

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Cancer Communications 2024年第8期44卷 884-888页

作者： Sung Hee Choi Jay Thomas Myers Suzanne louise Tomchuck Melissa Bonner Saada Eid Daniel Tyler Kingsley Kristen Ashley Van Heyst Seong-Jin Kim Byung-Gyu Kim Alex Yee-Chen Huang Department of Pediatrics CaseWestern Reserve University School of MedicineClevelandOhioUSA Case Comprehensive Cancer Center CaseWestern Reserve University School of MedicineClevelandOhioUSA Department of Pathology CaseWestern Reserve University School of MedicineClevelandOhioUSA MedPacto Inc. SeoulRepublic of Korea Center for Pediatric Immunotherapy Angie Fowler AYA Cancer InstituteUH Rainbow Babies and Children’s HospitalClevelandOhioUSA

Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young *** 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma *** survival ou... 详细信息

关键词： osteosarcoma immunity patients

The Experience and Impact of a Fitbit-Based Physical Activity and Sleep Hygiene Intervention for Older Adults Experiencing Cognitive Decline

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Advances in Aging Research 2024年第3期13卷 41-59页

作者： Kate Walker Chris Griffiths Jen Yates louise Birkett-Swan Farah Hina Chee Siang Ang Research and Innovation Department Northamptonshire Healthcare NHS Foundation Trust Northampton UK Institute of Mental Health University of Nottingham Nottingham UK Dementia and Older People’ s Psychology Provision Northamptonshire Healthcare NHS Foundation Trust Northampton UK School of Computing University of Kent Canterbury UK

Objectives: This study aimed to understand the experience and impact of a physical activity and sleep wrist-worn tracker (Fitbit)-based healthy lifestyle intervention for older patients attending a memory assessment service, who are experiencing cognitive impairment but do not receive a dementia diagnosis. Methods: A qualitative design was employed. Semi-structured interviews were conducted with a purposeful sample of thirteen participants recruited from a memory assessment service. Thematic analysis, that was data driven and inductive, was undertaken to analyse the data. Results: Two global themes were developed. “Understanding exercise and sleep as part of my lifestyle” was made up of themes representing how participants viewed exercise and sleep as part of their lifestyles in terms of acknowledging the positive impacts and the barriers to exercise and sleep. The second global theme “Understanding my experience of the healthy lifestyle intervention” was made up of themes that identified the positive impact of the intervention regarding improving health and wellbeing, enabling validation of proactive behaviours and motivation to engage in healthy lifestyle behaviours, so promoting positive behaviour change. Conclusion: Patients experiencing age-related cognitive impairment, applied and benefited from a healthy lifestyle Fitbit-based intervention to facilitate and promote physical activity, better sleep hygiene and healthy lifestyles.

关键词： Cognitive Impairment Healthy Lifestyle Intervention Fitbit Health and Wellbeing Behaviour Change

β-1，3-glucans-rich Euglena gracilis supplementation alleviates high-fat-high-fructose diet-induced cognitive impairment in middle-aged mice via the gut-brain axis

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Food Science and Human Wellness 2024年

作者： Haoxie Xu Yachao Wang Xiangzhu Li Xuli Wu louise Weiwei Lu Jiayi He Mingfu Wang Bin Liu Hui Xu Jiehua Chen Kawing Cheng Shenzhen Key Laboratory of Marine Microbiome Engineering， Institute for Advanced Study， Shenzhen University Department of Food Science and Engineering， College of Chemistry and Environmental Engineering， Shenzhen University Institute for Innovative Development of Food Industry， Shenzhen University Department of Neurosurgery， The Institute Translational Medicine， The First Affiliated Hospital of Shenzhen University， Shenzhen Second People's Hospital Shenzhen Traditional Chinese Medicine Hospital School of Public Health， Shenzhen University School of Biological Sciences， Faculty of Science， the University of Auckland

The growing aging population along with the shifting dietary paradigm to Western-type diet worldwide has been implicated in the increasing prevalence of cognitive impairment. Emerging evidence suggests that a high-fiber diet may help improve cognitive function through the gut-brain axis. Euglena gracilis， a unicellular microalga rich in β-1，3-glucans， has gained attention due to its modulatory effect on gut dysbiosis and inflammatory response. This study aimed to explore the efficacy and mechanism of β-1，3-glucans-rich Euglena gracilis powder (EG) against high-fat-high-fructose (HFHF) diet-induced cognitive disorders in mice. A middle-aged (52-week-old C57BL/6J) mouse model with the following groups was adopted: HFHF， HFHF+EG， and control. At the end of the dietary intervention (8 weeks)， cognitive behaviors， metabolic parameters， endotoxin levels， gut microbiota composition， and colon and brain pathology were examined. The results showed that EG supplementation attenuated HFHF-induced cognitive impairment， promoted synaptogenesis in the hippocampus， and improved synaptic ultrastructure. These beneficial effects were partly mediated through the upregulation of PTP1B-IRS-pAKT-pGSK3β-pTau signaling. Furthermore， it prevented gut dysbiosis as evidenced by an increase in β-diversity and enrichment of Akkermansia relative to control. EG supplementation was also able to partly reverse the HFHF-induced disruption of intestinal barrier， which was accompanied by reduced systemic and neuronal inflammation， normalized short-chain fatty acid production， and decreased serum lipopolysaccharide concentration. The findings from the present study support that β-1，3-glucans-rich EG is a promising natural agent for the prevention of HFHF diet-induced deterioration in cognitive function that merits further investigation.

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2011年日本东北地区近海大地震最大位移区的应力状态

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国际地震动态 2013年第8期34卷 6-11页

作者： Weiren Lin Marianne Conin J Casey Moore Frederick M Chester Yasuyuki Nakamura James J Mori louise anderson Emily E Brodsky Nobuhisa Eguchi 343勘查队科技人员冯万鹏(译) 许忠淮(校) 不详中国地震局地球物理研究所

2011年MW9.0的日本东北地区近海大地震在日本海沟附近产生了最大超过50m的同震滑动,这可能导致该区域进入了应力近乎完全卸载的状态。为检验上述假设,我们利用综合大洋钻探计划在震后1年左右时间得到的钻孔资料,以及对震前应力状态的推... 详细信息

2011年MW9.0的日本东北地区近海大地震在日本海沟附近产生了最大超过50m的同震滑动,这可能导致该区域进入了应力近乎完全卸载的状态。为检验上述假设,我们利用综合大洋钻探计划在震后1年左右时间得到的钻孔资料,以及对震前应力状态的推断结果,确定了陆楔前缘的原地应力状态。根据孔壁崩落法对水平应力方向与应力大小的估算结果,以及在破裂向海沟轴方向传播过程中同震位移增大的现象,可推断原地水平应力在地震过程中变小了。这种应力变化显示出板块界面的前缘发生了相对自由的滑动,该结论与地震引起了断层弱化和发生了近乎全部的应力降等观测结果是吻合的。

关键词：地应力状态日本海沟东北地区大地震最大位移近海综合大洋钻探计划水平应力