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BRD7 plays an anti-inflammatory role during early acute inflammation by inh.biting activation of th. NF-кB signaling path.ay

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Cellular & Molecular Immunology 2017年第10期14卷 830-841页

作者： Ran Zh.o Yukun Liu h.ran Wang Jing Yang Weih.ng Niu Songqing Fan Wei Xiong Jian Ma Xiaoling Li Josh.a B phillips Ming Tan Yuanzh.ng Qiu Guiyuan Li Ming Zh.u Xiangya h.spital Central South UniversityChangshaHunan 410008China Cancer Research.Institute Central South UniversityChangshaHunan 410078China Key Laboratory of Carcinogenesis and Ministry of h.alth.and Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of EducationChangshaHunan 410078China Th. Second Xiangya h.spital Central South UniversityChangshaHunan 410011China Mitch.ll Cancer Institute University of South AlabamaMobileAL 36604USA

Increasing evidence h.s sh.wn a strong association between tumor-suppressor genes and ***,th. role of BRD7 as a novel tumor suppressor in inflammation remains *** th.s study,by observing BRD7 knockout mice for 6–12 month.,we discovered th.t compared with.BRD7+/+mice,BRD7^(−/−)mice were more prone to inflammation,such.as external inflammation and abdominal *** using mouse embryo fibroblast(MEF)cells from th. BRD7 knockout mouse,an in vitro lipopolysacch.ride(LPS)-stimulated MEF cell line was *** mRNA levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),ch.mokine(C-X-C motif)ligand 1(CXCL-1)and inducible nitric oxide synth.se(iNOS)were significantly increased in BRD7^(−/−)MEF cells compared with.BRD7+/+MEF cells after LPS stimulation for 1 or 6 *** addition,th. cytoplasm-to-nucleus translocation of nuclear factor kappa-B(NF-κB;p65)and an increased NF-κB reporter activity were observed in BRD7^(−/−)MEF cells at th. 1 h.time point but not at th. 6 h.time ***,an in vivo dextran sodium sulfate(DSS)-induced acute colitis model was *** expected,th. disease activity index(DAI)value was significantly increased in th. BRD7^(−/−)mice after DSS treatment for 1–5 days,wh.ch.was demonstrated by th. presence of a significantly sh.rter colon,splenomegaly and tissue ***,h.gh.r expression levels of IL-6,TNF-α,p65,CXCL-1 and iNOS,and an increased level of NF-κB(p65)nuclear translocation were also found in th. DSS-treated BRD7^(−/−)*** findings suggest th.t BRD7 h.s an anti-inflammatory role during early acute inflammation by inh.biting activation of th. NF-кB signaling path.ay,wh.ch.provides evidence to aid in understanding th. th.rapeutic effects of BRD7 on inflammatory diseases.

关键词： acute inflammation BRD7 DSS LPS NF-κB path.ay

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Intensive outpatient compreh.nsive beh.vioral intervention for tics: A case series

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World Journal of Clinical Cases 2014年第10期2卷 569-577页

作者： Tabath. h.Blount Ann-louise T Lockh.rt Rocio V Garcia Jeslina J Raj Alan L Peterson Department of Psych.atry The University of Texas Health Science Center at San AntonioSan Antonio TX 78229 United States Ch.ld and Adolescent Psych.logy San Antonio Military Medical Center Joint Base San Antonio Ft. Sam Houston TX 78234 United States

Recent randomized clinical trials h.ve establish.d th. efficacy of Compreh.nsive Beh.vioral Intervention for Tics(CBIT) in treating ch.ldren and adults with.Tourette syndrome and persistent tic disorders. h.wever, th. standard CBIT protocol uses a weekly outpatient treatment format(i.e., 8 sessions over 10 wk), wh.ch.may be inconvenient or impractical for some patients, particularly patients, wh. are required to travel long distances in order to receive care. In contrast, an intensive outpatient program may increase accessibility to evidence-based beh.vioral treatments for Tourette syndrome and oth.r persistent tic disorders by eliminating th. necessity of repeated travel. Th.s case series evaluated th. use of an intensive outpatient program CBIT(IOP CBIT) for th. treatment of 2 preadolescent males(ages 10 and 14 years) with.Tourette syndrome. Th. IOP CBIT treatment protocol included several h.urs of daily treatment over a 4-d period. Both.ch.ldren evi-denced notable reductions in th.ir tics and maintained treatment gains at follow-up. Moreover, both.patients and th.ir parents expressed treatment satisfaction with.th. IOP CBIT format. Th.s case series addresses an important research.gap in th. beh.vioral treatment of tic disorders literature. Th. patients' treatment outcomes indicate th.t IOP CBIT is a promising treatment th.t warrants more systematic investigation.

关键词： Tourette syndrome Tics h.bit reversal Intensive outpatient Beh.vior th.rapy

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Species of Lasiodiplodia associated with.papaya stem-end rot in Brazil

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Fungal Diversity 2014年第4期67卷 127-141页

作者： Mariote S.B.Netto Iraíldes P.Assuncao Gaus S.A.Lima Marília W.Marques Waléria G.Lima Jean h.A.Monteiro Valdir de Queiroz Balbino Sami J.Mich.reff Alan J.L.phillips Marcos P.S.Camara Departamento de Agronomia Universidade Federal Rural de Pernambuco52171-900 RecifePernambucoBrazil Centro de Ciencias Agrárias Universidade Federal de Alagoas57100-000 Rio LargoAlagoasBrazil Departamento de Genética Universidade Federal de Pernambuco50732-970 RecifeBrazil Centro de Recursos Microbiológicos Departamento de Ciencias da VidaFaculdade de Ciencias e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal

Th.s study aims to identify and ch.racterize species of Lasiodiplodia associated with.stem-end rot of papaya in six different populations in th. North.ast of *** identifications were made using a combination of morph.logy togeth.r with.a ph.logenetic analysis based on partial translation elongation factor 1-αsequence(EF-1α)and internal transcribed spacers(ITS).Five species of Lasiodiplodia were identified:Lasiodiplodia brasiliense ***.,***,*** ***.,*** and *** *** h.d previously been reported in papaya,wh.le all th. oth.r species are reported for th. first time in association with.th.s h.st in Brazil and *** th.obromae was th. most prevalent *** species of Lasiodiplodia were path.genic on papaya fruit,with.*** being th. most virulent.

关键词： Botryosph.eriaceae Carica papaya Fruit rot EF1-α ITS Ph.logeny Virulence

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苏州与法国斯特拉斯堡院外心脏骤停患者生存链质量比较

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中国急救医学 2015年第2期35卷 142-146页

作者：朱建良刘励军 phillips Sauder 苏州大学附属第二医院急诊科江苏苏州215004

目的比较我国苏州地区与法国斯特拉斯堡院外心脏骤停（CA）患者生存链具体环节完成质量的差异。方法采用回顾性队列研究方法，比较苏州地区十家综合性医院（苏州组）与法国斯特拉斯堡新民众医院（斯堡组）ICU收治的CA患者院前心肺复苏（... 详细信息

目的比较我国苏州地区与法国斯特拉斯堡院外心脏骤停（CA）患者生存链具体环节完成质量的差异。方法采用回顾性队列研究方法，比较苏州地区十家综合性医院（苏州组）与法国斯特拉斯堡新民众医院（斯堡组）ICU收治的CA患者院前心肺复苏（CPR）质量，以及入住ICU后患者48h.，其血压（BP）、血氧饱和度（SpO2）、二氧化碳分压（PaCO2）、血糖和体温等集束化治疗质量的差异。结果在院前急救环节的质量方面，斯堡组患者中44％接收了旁人实施心肺复苏，而苏州组中只有16％，差异有统计学意义（P〈0．05）；斯堡组患者CA至CPR时间和CA至恢复自主循环（ROSC）时间中位数分别为5min和27min，而苏州组患者上述相关时间的中位数分别为15min和40min，两组比较差异有统计学意义（P均〈0．01）。在复苏后集束化治疗方面，斯堡组患者CA后6h.aCO2达标的比率（61％vs27％）和48h.的达标率（59％vs 29％）均明显高于苏州组（P〈0．01）。另外，斯堡组患者接受治疗性低温的比率（88％vs 57％）、达到目标温度的比率（84％vs13％）及低温达标率（44％vs7％）均明显高于苏州组（P均〈0．01）。结论苏州地区院外CA患者生存链总体质量明显低于西欧发达地区，尤其是院前急救质量差距最大，而院内低温治疗实施率和质量还需提高。

关键词：院外心脏骤停(CA) 心肺复苏(CPR) 生存链质量

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金刚石薄膜中SP^2／SP^3键价比拉曼光谱分析

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光散射学报 1995年第2期7卷 123-123,112页

作者：张兵临 h.M.phillips 郑州大学物理系，郑州450052

金刚石薄膜中ＳＰ￣２／ＳＰ￣３键价比拉曼光谱分析张兵临Ｈ，Ｍ．Ｐｈｉｌｌｌｉｐｓ（郑州大学物理系郑州４５００５２）ＡｎａｌｙｓｉｓｏｆＳＰ￣２／　ＳＰ￣２／ＳＰ￣３ＢｏｎｄｉｎｇＲａｔｉｏｉｎＤｉａｍｏｎｄＴｈｉｎＦ... 详细信息

金刚石薄膜中ＳＰ￣２／ＳＰ￣３键价比拉曼光谱分析张兵临Ｈ，Ｍ．Ｐｈｉｌｌｌｉｐｓ（郑州大学物理系郑州４５００５２）ＡｎａｌｙｓｉｓｏｆＳＰ￣２／　ＳＰ￣２／ＳＰ￣３ＢｏｎｄｉｎｇＲａｔｉｏｉｎＤｉａｍｏｎｄＴｈｉｎＦｉｌｍｓｂｙＲａｍａｎＳｐｅｃｔｒ...

关键词：金刚石薄膜 SP^2/SP^3键价比拉曼光谱分析布里渊中心光学模拉曼活性模

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Ranking h.gh.r taxa using divergence times:a case study in Doth.deomycetes

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Fungal Diversity 2017年第3期84卷 75-99页

作者： Jian-Kui Liu Kevin D.h.de Rajesh.Jeewon Alan J.L.phillips Sajeewa S.N.Mah.rach.h.kumbura Martin Ryberg Zuo-Yi Liu Qi Zh.o Key Laboratory for Plant Diversity and Biogeograph. of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Guizh.u Institute of Biotech.ology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China Guizh.u Key Laboratory of Agricultural Biotech.ology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Departmental of h.alth.Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius University of Lisbon Faculty of SciencesBiosystems and Integrative Sciences InstituteCampo Grande1749-016 LisbonPortugal Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Department of Organismal Biology Uppsala UniversityNorbyvägen 18D75236 UppsalaSweden

Th. current classification system for th. recognition of taxonomic ranks among fungi,especially at h.gh.anking level,is *** th. development of molecular approach.s and th. availability of fossil calibration data,th. use of divergence times as a universally standardized criterion for ranking taxa h.s now become *** can th.refore date th. origin of Ascomycota lineages by using molecular clock meth.ds and establish.th. divergence times for th. orders and families of *** ch.se Doth.deomycetes,th. largest class of th. ph.lum Ascomycota,wh.ch.contains 32 orders,to establish.ages at wh.ch.points orders h.ve split;and Pleosporales,th. largest order of Doth.deomycetes with.55 families,to establish.family divergence *** h.ve assembled a multi-gene data set(LSU,SSU,TEF1 and RPB2)from 391 taxa representing most family groups of Doth.deomycetes and utilized fossil calibration points solely from with.n th. ascomycetes and a Bayesian approach.to establish.divergence times of Doth.deomycetes *** separated datasets were analysed:(i)272 taxa representing 32 orders of Doth.deomycetes were included for th. order level analysis,and(ii)191 taxa representing 55 families of Pleosporales were included for th. family level *** results indicate th.t divergence times(crown age)for most orders(20 out of 32,or 63%)are between 100 and 220 Mya,wh.le divergence times for most families(39 out of 55,or 71%)are between 20 and 100 *** believe th.t divergence times can provide additional evidence to support establish.ent of h.gh.r level taxa,such.as families,orders and *** advantage of th.s added approach.we can strive towards establish.ng a standardized taxonomic system both.with.n and outside *** th.s study we found th.t molecular dating coupled with.ph.logenetic inferences provides no support for th. taxonomic status of two currently recognized orders,namely Bezerromycetales and Wiesneriomycetales and th.se are treated as sy

关键词： BEAST Clade age Classification Calibration Family Order Ph.logeny Pleosporales

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亲密伴侣暴力相关的影像表现

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国际医学放射学杂志 2019年第3期 361-362页

作者：景瑞 E.George C.h.phillips N.Sh.h.A.L.Connor B.Rosner h.M.Stoklosa Departments of Radiology Brigham and Women's Hospital

摘要目的评估与亲密伴侣暴力(IPV)相关的影像表现。材料与方法回顾性分析了2015年1月—2016年10月期间从急诊科(ED)转诊到IPV支持计划的185例病人的电

关键词：亲密伴侣暴力影像检查影像表现

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打浆对绿液预处理阔叶木酶水解的促进作用

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南京林业大学学报（自然科学版） 2013年第6期37卷 116-120页

作者：金永灿 h.umin Ch.ng h.san Jameel Rich.rd phillips 南京林业大学江苏省制浆造纸科学与工程重点实验室江苏南京210037 美国北卡罗菜那州立大学森林生物材料系罗利NC27965

以总碱用量为12%(Na2O计)的绿液预处理的混合阔叶木浆为原料,探讨了PFI打浆处理对改善浆料酶水解效率的作用。结果表明:酶水解糖的得率随着PFI磨浆转数的增加而提高,其中葡聚糖得率的增加较木聚糖显著,在较低的酶用量下提高PFI磨浆转数... 详细信息

以总碱用量为12%(Na2O计)的绿液预处理的混合阔叶木浆为原料,探讨了PFI打浆处理对改善浆料酶水解效率的作用。结果表明:酶水解糖的得率随着PFI磨浆转数的增加而提高,其中葡聚糖得率的增加较木聚糖显著,在较低的酶用量下提高PFI磨浆转数有利于提高浆料的酶水解糖化得率;经打浆处理的绿液预处理浆可以在较短的时间内大幅度提高酶水解糖总糖得率,随着酶水解时间的延长,得率的增值逐渐减小;与清水介质比较,浆料在1%NaOh.磨浆对提高酶水解糖得率具有更好的促进作用。

关键词：混合阔叶木打浆绿液预处理酶水解糖

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Management information systems for th. information age / 6th ed.

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2007年

作者： Steph.n h.ag Maeve Cummings Amy phillips.

来源：畅想之星图书光盘版（南... 评论

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Preserved liver regeneration capacity after partial h.patectomy in rats with.non-alcoh.lic steatoh.patitis

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World Journal of h.patology 2018年第1期10卷 8-21页

作者： David h.ldrup Sara h.eboll Karen louise Th.msen Kasper Jarlh.lt Andersen Mich.lle Meier Frank Viborg Mortensen Jens Randel Nyengaard Steph.n h.milton-Dutoit h.nning Gronbaek Department of h.patology and Gastroenterology Aarhus University HospitalAarhus C DK-8000Denmark Department of Internal Medicine Randers Regional HospitalRanders NO DK-8930Denmark Department of Surgical Gastroenterology Aarhus University HospitalAarhus C DK-8000Denmark Stereology and Electron Microscopy Laboratory Centre for Stochastic Geometry and Advanced BioimagingAarhus University HospitalAarhus C DK-8000Denmark Institute of Path.logy Aarhus University HospitalAarhus C DK-8000Denmark

AIM To evaluate th. liver regeneration capacity(LRC) after partial h.patectomy(Ph. in experimental non-alcoh.lic steatoh.patitis(NASh..METh.DS Fifty-four female rats were fed a h.gh.fat, h.gh.ch.lesterol diet(h.CD, 65% fat, 1% ch.lesterol) or standard diet(STD) for 16 wk. A 70% Ph.was performed and th. animals were euth.nised before Ph.or 2 or 5 d postPh. LRC was evaluated using: Th. total number of Ki-67 positive h.patocytes in th. caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, th. regenerated protein ratio(RPR), proth.ombin-proconvertin ratio(PP), and m RNA expression of genes related to *** Th. h.CD NASh.model sh.wed significant steatosis with.ballooning and inflammation, wh.le no fibrosis was present. Mortality was similar in h.CD and STD animals following Ph. h.CD groups were compared to respective STD groups and h.CD animals h.d a significantly elevated alanine transaminase at baseline(P h.P h.CD animals h.d a h.gh.r N(Ki-67, lobe) at baseline,(P h.P = 0.06) and day 5 after Ph.P h.r 2 or 5 d post-Ph. Expression of liver regeneration genes(e.g., h.patic growth.factor) was h.gh.r at both.day 2 and 5 post-Ph.in h.CD groups(P h.rats h.d a preserved LRC after h.patectomy wh.n compared to STD rats. Th. meth.ds and models of NASh.are essential in understanding and evaluating LRC.

关键词： Rat Non-alcoh.lic fatty liver Non-alcoh.lic steatoh.patitis Liver regeneration h.patectomy Ki-67 Gene expression

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