检索结果-南通市图书馆

Influence of the aspect ratio on the endovascular treatment of intracranial aneurysms: A computational investigation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2012年第8期5卷 422-431页

作者： Abraham Yik-Sau Tang Siu-Kai Lai Kar-Ming Leung Gilberto Ka-Kit Leung Kwok-wing chow Department of Mechanical Engineering University of Hong Kong Pokfulam Hong Kong Department of Neurosurgery Kwong Wah Hospital Hong Kong Division of Neurosurgery Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Queen Mary

Intracranial aneurysm, a localized dilation of arterial blood vessels in the Circle of Willis and its branches, is potentially life threatening, due to massive bleeding in the subarachnoid space upon rupture. In clinical practice, one minimally invasive surgical procedure is the implantation of a metallic stent to cover the aneurysm neck. This flow diverting device can reduce the flow into the aneurysm and enhance the prospect of thrombosis, a condition expected to reduce the risk of growth and rupture. The biomechanical and haemo-dynamic factors in stented and nonstented situations are studied by computational fluid dynamics. Unlike earlier models with straight or curved parent blood vessels, the aneurysm is now located near an arterial bifurcation. The influence of the aspect (depth to neck) ratio of the aneurysm on the flow dynamics will be emphasized, especially in the post-operation stages. More precisely, the maximum flow velocity, the variations of wall shear stress, the risk of stent migration and volumetric flow rate after endovascular treatment will be studied. Aneurysms with larger aspect ratios (i.e. smaller neck sizes for constant depth) generally pose a greater risk in terms of these flow parameters. These results will assist the applications and design of stents in future neurosurgical therapy. The approach is limited to a nonelastic model, without taking into account of questions like stent expansion and interaction with tissue.

关键词： Intracranial Aneurysm Endovascular Treatment Stent Aspect Ratio Computational Fluid Dynamics

Methods of early detection:would clinical breast examination and breast ultrasonography be a good alternative to mammography?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华乳腺病杂志（电子版） 2011年第6期5卷 1-9页

作者： Adrian YS Yip louis WC chow wings TY Loo Eleanor YY Ong Wincy Chan Organisation for Oncology and Translational Research Hong Kong Clinical Trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Comprehensive Centre for Breast Diseases UNIMED Medical InstituteHong Kong

Breast cancer is one of the leading causes of cancer deaths among women[1].In the past 40 years,breast cancer incidence has doubled or even tripled in developed countries such as South Korea and Japan; whereas it is a... 详细信息

关键词：摘要编辑部编辑工作读者

维普期刊数据库

Hypertensive-Nimodipine Therapy for Middle Cerebral Artery Vasospasm after Resection of Glioblastoma Multiforme: A Case Report and Literature Review

在线全文

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2015年第3期5卷 76-83页

作者： Peter Yat Ming Woo Ka wing Michael See Jason Kwan Ho chow Yung Chan Hoi Tung Wong Kwong Yau Chan Department of Neurosurgery Kwong Wah Hospital Hong Kong China

Delayed cerebral ischemia (DCI) due to post-brain tumor resection vasospasm is an often unrecognized yet debilitating complication. We present a patient with DCI after the resection of glioblastoma multiforme (GBM). To our knowledge, this is the first report on DCI after GBM resection. A 52-year-old female patient with headache for one month underwent subtotal resection of a left temporal GBM encasing the proximal middle cerebral artery (MCA). She was well during the immediate postoperative period but developed right upper limb dense monoparesis on postoperative day four with computed tomographic angiography confirming left MCA vasospasm. Symptoms were significantly alleviated with weeklong hypertensive therapy and nimodipine administration;however they recurred soon after cessation of treatment. A high index of clinical suspicion is needed for the diagnosis of post-tumor resection DCI. Any new postoperative neurological deficit that cannot be explained by hemorrhage, seizures or infection should be expeditiously investigated by angiography or transcranial Doppler sonography. Prompt initiation of hypertensive and nimodipine therapy can possibly reverse neurological deficit. Treatment should be guided by Doppler, angiographic or perfusion imaging studies and not by clinical improvement alone.

关键词： Cerebral Vasospasm Delayed Cerebral Ischemia Glioblastoma Multiforme Hypertensive Therapy Nimodipine

Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第14期12卷 2223-2228页

作者： Kam Hoi Chan Chun wing Chan Wai Hung chow Wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau Department of Medicine Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Surgery Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Radiology Yah Chai Hospital Tsuen Wan Hong Kong SAR Chin Department of Pathology Yah Chai Hospital Tsuen Wan Hong Kong SAR China

瞄准：用香港汉语调查流行和胃肠的基质肿瘤(大意) 的临床的模式，并且估计发病率的 CD117 的介绍的影响。方法：从 Yan Chai 医院的病理的部门的数据库， 47 个病人，在这研究与到 2003 年 12 月的从 1995 年 9 月的大意被包括。十大意... 详细信息

瞄准：用香港汉语调查流行和胃肠的基质肿瘤(大意) 的临床的模式，并且估计发病率的 CD117 的介绍的影响。方法：从 Yan Chai 医院的病理的部门的数据库， 47 个病人，在这研究与到 2003 年 12 月的从 1995 年 9 月的大意被包括。十大意在 CD117 的介绍前被诊断。临床的特征，肿瘤特征，和治疗被分析。预言肿瘤的因素联系了死亡或复发与比例的危险建模的考克斯一起被学习。结果：病人包括了 26 男性和 21 女性，与 66.6 年的吝啬的年龄(SD 13.1，范围 29-87 年) 。大意的估计的流行每 100,000 个人是 13.4-15.6，与每 100,000 个人的 1.68-1.96 的年度发生。在 CD117 的介绍前后的大意的年度发生每 100,000 个人是 1.1 并且 2.1 每 100,000 个人分别地。胃(34 个病人， 72.3%) 是为肿瘤的最普通的地点，由小肠列在后面(8 个病人， 17.0%) ，食管(2 个病人， 4.3%) ，网膜(2 个病人， 4.3%) 并且冒号(1 个病人， 2.1%) 。31 个病人(66%) 有完全的肿瘤切除术。十一从 16 死亡(23%) 是肿瘤相关的。中部的生存时间是 26 瞬间。五年的幸存率是 61.3% 。与肿瘤相关的死亡或复发联系的重要因素是不完全的切除术，肿瘤尺寸 5 厘米以上，侵略到转移的邻近的机关或存在。结论：在香港的大意的发生在美国比得上那，但是在芬兰比那降低。大意的真发生能在 CD117 的介绍前被低估。不完全的切除术，肿瘤尺寸 5 厘米以上，到转移的邻近的机关或存在的侵略是预言肿瘤相关的死亡或复发的因素。

关键词：胃肠肿瘤中国香港疾病预防

广泛使用玻璃的现代建筑设计中存在的消防安全问题(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

广泛使用玻璃的现代建筑设计中存在的消防安全问题(英文)

Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle

2003火灾科学与消防工程国际学术会议

作者： HUNG wing-Yan chow Wan-Ki(Department of Building Services Engineering The Hong Kong Polytechnic University Hunghom Hong Kong)

新建筑设计中广泛使用玻璃有多方面的原因。除了玻璃的那些长处之外,我们更应看到它的缺点,特别是在安全方面。现在,我们对玻璃的设计还没有明确的法规规定,也没有设计指南。本文简要介绍了目前玻璃的使用情况,讨论了其带来的好处以及... 详细信息

新建筑设计中广泛使用玻璃有多方面的原因。除了玻璃的那些长处之外,我们更应看到它的缺点,特别是在安全方面。现在,我们对玻璃的设计还没有明确的法规规定,也没有设计指南。本文简要介绍了目前玻璃的使用情况,讨论了其带来的好处以及作为不安全建筑材料的局限性;重点介绍了大量使用玻璃所带来的消防安全问题。尽管很多文献都提到了对玻璃的实验工作,但我们还应做类似的研究,以适应当地的需要并提供足够的设计数据。

关键词：玻璃破碎幕墙窗户消防安全

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2020年第9期12卷 266-275页

作者： Chi wing chow Syeda Asma Haider Krish Ragunath Guruprasad P Aithal Martin W James Jacobo Ortiz-Fernandez-Sordo Aloysious Dominic Aravinthan Suresh Vasan Venkatachalapathy National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals National Health Service Trust and University of NottinghamNottingham NG72UHUnited Kingdom Department of Pathology Nottingham University Hospitals National Health Service TrustNottingham NG72UHUnited Kingdom Nottingham Digestive Diseases Centre School of MedicineUniversity of NottinghamNottingham NG72RDUnited Kingdom National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals National Health Service Trust and University of NottinghamNottingham NG27UHUnited Kingdom

BACKGROUND Reverse bevel(RB)needle is widely used for endoscopic ultrasound fine needle biopsy(EUS-FNB).A 3-plane symmetrical needle with Franseen geometry(FG)has recently become *** To compare the clinical efficacy of FG to that of RB *** A retrospective cohort study of all adult patients who underwent EUS-FNB for solid and mixed lesions either with 22G RB needle or 22G FG needle between January 2016 and February 2019 was *** cytology slides were reviewed by an independent gastrointestinal cytopathologist blinded to the needle used and the initial cytology *** primary and secondary outcomes were to assess the sample adequacy using Euro-cytology criteria and the number of cell clusters,*** Two hundred and twenty six procedures were included in the *** needle was used in 128 procedures and FG needle in 98 *** baseline characteristics of both groups were *** multivariable analysis,FG needle(P=0.02)and location of the lesion(P<0.01)were independently associated with adequate ***,the use of FG needle(P=0.04)and the size of the lesion(P=0.02)were independently associated with acquisition of increased number of cell *** FG needle is superior to RB needle in acquiring adequate tissue and attaining higher number of cell clusters for solid and mixed lesions.

关键词： Endoscopic ultrasound Fine needle aspiration Fine needle biopsy Reverse bevel Franseen geometry Tissue acquisition

The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2013年第8期6卷 812-822页

作者： Abraham Yik-Sau Tang Hiu-Ning Chan Anderson Chun-On Tsang Gilberto Ka-Kit Leung Kar-Ming Leung Alfred Cheuk-Hang Yu Kwok-wing chow Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Neurosurgery Kwong Wah Hospital Hong Kong China Division of Neurosurgery Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Queen Mary Hos-pital Hong Kong China Medical Engineering Program Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China

Intracranial aneurysm occurs when a cerebral artery develops an abnormal sac-like dilatation, and will cause massive bleeding in the subarachnoid space upon rupture. Endovascular stenting is a minimally invasive procedure in which a flow-diverting stent is deployed to cover the aneurysm neck, thereby restricting blood from entering the aneurysm and reducing the risk of rupture. The stent porosity, a crucial factor determining the intra-aneurysmal hemodynamics following treatment, is investigated by computational fluid dynamics techniques. Based on the computational results, a low porosity stent will dramatically reduce the flow velocity and the flow rate inside the side branch vessel. Conversely, a high porosity stent may not provide adequate flow reduction inside the aneurysm, possibly causing treatment failure. An advisable range of optimal stent porosity would be 60% to 75%, which can drastically reduce the flow rate into the aneurysm while preserving enough blood flow for the side branch vessel. Clinically, deployment of two or more flow-diverting stents may not increase treatment efficacy but can potentially lead to adverse effects due to side-branch hypoperfusion. The present quantitative analysis can also provide practical insight for future stent design.

关键词： Intracranial aneurysm Endovascular Treatment Stent Stent Porosity Computational Fluid Dynamics

Application of single and combination therapy of clarithromycin and tamoxifen to suppress breast cancer cell proliferation and metabolism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华乳腺病杂志（电子版） 2012年第1期6卷 26-31页

作者： wings T.Y.Loo louis W.C.chow Adrian Y.S Yip Mary N.B.Cheung UNIMED Medical Institute Organization for Oncology and Translational Research Hong Kong Organization for Oncology and Translational Research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong Clinical Trial Center Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective This study compares the anti-tumor effects of single and combination use of clarithromycin and tamoxifen on estrogen receptor (ER) positive breast cancer cell lines,BT-483 and MCF-7 as well as triple negative cell line,MBA-MD-231,which acts as a negative *** effect of solid breast tumor inhibition by clarithromycin is also *** BT-483,MCF-7 and MBA-MD-231 were cultured in 6-well plates in a 37 ℃ humidified incubator without CO2 for 24 h prior to the addition of the test *** test groups were clarithromycin (Group 1),tamoxifen (Group 2),clarithromycin and tamoxifen (Group 3),and control (Group 4).Group 3 was prepared in 1 to 1 ratio at a concentration of 1.5 mmol/L clarithromycin and 25 μmol/L *** the other hand,1 mm3 solid breast tumors were submerged into various groups as above for 24 *** the harvest day,the proliferation of cancer cells and solid breast tumor samples were measured by WST-1 proliferation reagent while ATP bioluminescence assay was employed to measure the metabolic rate of the three cell *** The proliferation of BT-483 and MCF-7 was suppressed most by combination use of clarithromycin and tamoxifen with statistical *** two drugs did not have an inhibitory effect on the hormonal negative cancer *** solid breast tumor samples,all the test groups showed reduced metabolic rate as compared with the control group (P<0.05).Conclusion Combination use of tamoxifen and clarithromycin are effective in suppressing cell proliferation and metabolism rate of breast cancer cells while single use of clarithromycin effectively inhibits the proliferation of solid breast tumor.

关键词：摘要编辑部编辑工作读者

维普期刊数据库

The Dynamics and Evolution of Poles and Rogue Waves for Nonlinear Schrdinger Equations

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2017年第9期67卷 290-294页

作者：趙天樂柳天陽陳曉寧周國榮 Department of Mechanical Engineering University of Hong Kong

Rogue waves are unexpectedly large deviations from equilibrium or otherwise calm positions in physical systems, e.g. hydrodynamic waves and optical beam intensities. The profiles and points of maximum displacements of these rogue waves are correlated with the movement of poles of the exact solutions extended to the complex plane through analytic continuation. Such links are shown to be surprisingly precise for the first order rogue wave of the nonlinear Schr¨odinger(NLS) and the derivative NLS equations. A computational study on the second order rogue waves of the NLS equation also displays remarkable agreements.

关键词：非线性薛定谔方程极点动力学 NLS方程演化物理系统解析延拓最大位移

维普期刊数据库