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Management of granulomatous mastitis

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中华乳腺病杂志（电子版） 2018年第4期12卷 198-201页

作者： louis wing-cheong chow Organization for 0ncology and Translation Research Hong KongChina

Granulomatous mastitis can be a disturbing *** patients have been affected in recent *** need to understand the etiology and course of disease before they can formulate a useful treatment *** paper aims to review the ... 详细信息

关键词：乳腺病妇科病女性预防措施

Individualized therapy for breast cancer:a decade of improvement

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中华乳腺病杂志（电子版） 2015年第4期9卷 223-230页

作者： louis wing cheong chow wings Tjing Yung Loo Qing Liu Institute for Applied Research in Medicine and Health Macao University of Science and Technology Organisation for Oncology and Translational Research and UNIMED Medical Institute

Breast cancer is the most prevalent female cancer in both the developed and less developed *** to WHO 2013 estimates,there were over 522 000 female breast cancer deaths in2012[1].Breast cancer(1.7 million)was the second commonly diagnosed cancer worldwide after lung cancer(1.8 million),and followed by colorectal cancer(1.4 million)[1].In

关键词：乳腺病临床诊断治疗

Aberrant methylation of Glutathione S-transferase P1 and E-cadherin in invasive ductal breast carcinoma and fibroadenoma

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中华乳腺病杂志（电子版） 2010年第5期4卷 14-19页

作者： wings Tjing Yung Loo Mary Ngan Bing Cheung louis wing cheong chow UNIMED Medical Institute Organisation for Oncology and Translational Research Hong Kong School of Chinese Medicine The University of Hong Kong Clinical Trial Centre Li Ka Shing Faculty of MedicineThe University of Hong Kong

Objective To investigate the hypermethylation status of glutathione transferase P1(GSTP1)and E-cadherin(ECAD),TSGs(tumor suppressor genes)in our breast cancer samples and explore their correlation with clinicopathological features of corresponding cancer *** One hundred and thirty-six IDC(invasive ductal carcinoma)patients were recruited for analysis and 16 fibroadenoma patients acted as *** extraction and methylation-specific PCR(MSP)were subsequently performed preceded by pathological *** The percentage of hypermethylated GSTP1 in carcinoma and fibroadenoma groups was 34.92% and 15.79% respectively and the percentage of hypermethylated ECAD in carcinomas and fibroadenomas was 18.00% and 0.00% *** had the highest percentage of c-erbB2 overexpression being 54.55% among the clinicopathological *** Hypermethylation patterns are frequent in IDC and seem to relate to c-erbB2 overexpression,and such epigenetic change should not be neglected in *** methylation status in cancer patients can be determined at early stage and it may be a reference for better treatment planning.

关键词：乳腺癌临床治疗疗效

Overview of breast cancer prevention:what's the next?

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中华乳腺病杂志（电子版） 2013年第6期7卷 1-5页

作者： louiswingcheongchow wingsTjingYungLoo AdrianYunSanYip louis wing cheong chow wings Tjing Yung Loo Adrian Yun San Yip Organisation for Oncology and TranslationalResearch Hong Kong UNIMED Medical Institute Comprehensive Centre for Breast Diseases Hong Kong Maeau University of Science and Technology Macao

Breast cancer is the leading cause of death among women at the ages of 20-59 years[1].The incidence of breast cancer in Asia is also shown to be increasing recently,especially in the more affluent cities,and the peak incidence of breast cancer is at the age of 45-50 years[2].Breast cancer prevention has started from secondary prevention strategy of early detection of the disease with different modalities in Asia[3-5]despite the absence of unified nationwide screening *** are a lot

关键词：摘要编辑部编辑工作读者

Expression of cancer stem cell surface markers after chemotherapeutic drug treatment to reflect breast cancer cell regrowth

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中华乳腺病杂志（电子版） 2014年第1期8卷 28-32页

作者： Qing Liu wings Tjing Yung Loo louis wing cheong chow Kelly Wei Yu Rui UNIMED Medical Institute and Organizationfor Oncology and Translational Research

Objective To detect the cell viability and the expressions of stem cell surface markers after chemotherapeutic drug *** We observed the cytotoxic effects of three chemotherapeutic agents[epirubicin(Epi),fluorouracil(5-FU)and cyclophosphamide(Cyc)]in three cell lines,and the cell viabilities after removed these chemotherapeutic *** of stem cell surface markers CD44,CD24,CD90,CD14 and aldehyde dehydrogenase1(ALDH1)in breast cancer cells were analyzed by real-time *** post hoc analysis(Tukey’s tests)in conjunction with one-way ANOVA was used for statistical *** The initial cytotoxic efficacy was most *** the treatment of the same therapeutic agents,cell viability was decreased by 64.8%35.14%,32.25%in BT-483 cells,66.4%,22.94%and 45.88%in MDA-MB-231 cells,97.1%,99.5%and 76.4%in MCF *** difference was significant compared with that before treatment(P=0.000).However,the inhibitory effects were diminished after chemotherapeutic agent *** viabilities were increased to 167.9%,212.04%and 188.66%in MDA-MB-231 cells at48 h after *** 72 h after withdrawal,cell viability was increased with a significant difference in three cell lines(all P values=0.000).Expressions of CD44 and ALDH1 were most prevalent for MDA-MB-231,BT-483 and MCF-7 ***1 mRNA level was significant higher in BT-483(HER-2 overexpression cell line)than MDA-MB-231(triple negative cell line)(P=0.012).CD14 mRNA level in MCF-7 cells were significantly lower than that in MDA-MB-231 and BT-483(P=0.003,0.001).BT-483 showed significantly higher level of CD44 than MDA-MB-231 and MCF-7 cell line(P=0.013,0.020),and no significant difference was detected between MDA-MB-231 and MCF-7 breast cancer cells(P=0.955).CD90 mRNA expressions were detected in MDA-MB-231 cells and MCF-7 cells,but not in BT-483 *** Some malignant cells could survive in vitro and begin to proliferate again between cycles of chemotherapy.

关键词：乳腺癌细胞活性治疗方法临床分析

Potential of a COX-2 inhibitor in lowering chemotherapy-induced neutropenia

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中华乳腺病杂志（电子版） 2010年第5期4卷 8-13页

作者： louis wing-cheong chow Adrian Yun-San Yip Eleanor Yuen-Yuen Ong Chi-Kei Lam Masakazu Toi Clinical Trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Organisation for Oncology and Translational Research Comprehensive Centre for Breast Diseases UNI MED Medical Institute Department of Surgery Kyoto UniversityJapan

Objective This study was initially designed to evaluate the effect of celecoxib on the regimen of 5-fluorouracil,epirubicin,and cyclophosphamide(FEC)combination,followed by docetaxel(T)in neoadjuvant *** unplanned preliminary review on safety was conducted after a halt of the study due to the concerned potential cardiovascular risk of using COX-2 *** We studied 23 consecutive cases of operable breast cancer having received four cycles of FEC(500 mg/m2,100 mg/m2,500 mg/m2)followed by four cycles of T(100 mg/m2)with concurrent celecoxib(400 mg twice daily)(group A)or same chemotherapy regimen but without concurrent celecoxib(group B).These combined chemotherapies were administered every 3 *** Chi-square test or Fisher's exact test were used to assess the difference in incidence of limiting hematological toxicites between *** 23 patients(group A:n=12;group B,n=11)received a total of 183 out of 184 planned treatment cycles;one(4%,1/23)of them omitted the fourth cycle of FEC owing to repeated incidences of febrile *** dose intensity(RDI)for FEC in group A(90%±11%)was higher than that in group B(80%±8%)while RDI for T was similar between group A(93%±8%)and group B(96%±9%).Of the first 91 treatment cycles of FEC,limiting hematological toxicity,severe neutropenia including febrile neutropenia,was significantly different between group A and B [(10.4%,5/48)vs.(32.6%,14/43),P=0.009].Other toxicities commonly observed in chemotherapy receiving patients were *** Neoadjuvant use of FEC followed by T with concurrent celecoxib appeared to be safe for treatment of operable invasive breast *** observed lower incidence of chemotherapy-induced neutropenia is possibly contributed by the administration of *** believe that further investigation might provide more evidence on the use of COX-2 inhibitors in breast cancer.

关键词：血疗法乳腺癌治疗临床

Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer

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中华乳腺病杂志（电子版） 2012年第6期6卷 11-15页

作者： Qing Liu wings Tjing Yung Loo Adrian Yun San Yip louis wing cheong chow Elizabeth Lam Yan Ng Mary Ngan Bing Cheung UNIMED Medical Institute Organization for Oncology and Translational Research

Objective Sentinel lymph node in breast cancer is a predictor of the tumor's metastatic *** emerging from antitumor immune response might also target sentinel lymph node (SLN).In this study,we evaluated the cytokine profile including interleukin-8 (IL-8),interleukin-12 (IL-12),interferon-gamma (IFN-γ),and tumor necrosis factor alpha (TNF-α) for the T-cell *** From January 2008 to August 2010,35 patients with breast mass underwent SLN biopsy in UNIMED Medical *** specimens were formalin-fixed and paraffin-embedded for hematoxylin and eosin staining and immunohistochemistry with following markers:IL-8,IL-12,IFN-γ and TNF-α.The staining intensity was scored according to four grades:negative (-),weak expression (+),moderately positive expression (+ +),strong positive expression (+ + +).The correlation between the expression of cytokines and pathological characteristics were also analyzed using the Spearman Rank Correlation *** Out of 35 patients,SLN metastases were observed in 20 patients and among them,75% (15 /20) were strongly stained (+ + +) with IL-8 and moderately stained (+ +) with IL-12,but only 25% (5 /20) were strongly stained (+ + +) with IFN-γ and TNF-α.The expression of IL-8 was significantly associated with all tumor grades (r=0.639,P=0.00),estrogen receptor (r=0.778,P=0.01),progesterone receptor (r=0.759 P=0.00) and HER-2 /neu receptor (r=0.863 P=0.00).Conclusion The strong association between IL-8 expression and SLN metastases might highlight the prognostic significance of IL-8 in SLN.

关键词：临床治疗乳腺疾病医学

Effect of Tai Chi Chuan on serotonin and cortisol for monitoring stress and quality of life in post-treatment breast cancer patients

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中华乳腺病杂志（电子版） 2014年第4期8卷 34-40页

作者： William Wai Nam Tsang wings Tjing Yung Loo louis wing cheong chow Elizabeth Lam Yan Ng Adrian Yun San Yip Jianping Chen Department of Rehabilitation Sciences Hong Kong Polytechnic University UNIMED Medical Institute and Organisation for Oncology and Translational Research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective Immediate physical exercise has been recommended for patients in the recovery phase to improve survival and quality of life(QOL)and reduce recurrence of *** new NCCN Guidelines for Survivorship also highlighted the role of exercise in post-cancer health,encouraging patients to perform light physical activity following *** aim of our study is to effect of Tai Chi Chuan(TCC)on serotonin and cortisol for monitoring stress and QOL in post-treatment breast cancer *** Totally85 post-treatment breast cancer patients were enrolled in this study to observe the effects of practicing TCC on recovery,as well as stress and happiness which are indicators of QOL of in *** blood was drawn from study subjects to analyze the levels of serotonin,cortisol and high sensitive C-reactive protein(HSCRP)at baseline,and at 3,6 and 12 months of TCC *** was drawn from healthy subjects only at baseline.A QOL questionnaire was administered to study subjects at three time points throughout the study,and once for healthy *** data were processed by analysis of variance of repeated *** At 3,6 and 12 months time points following regular TCC exercise,WBC,RBC,hemoglobin in blood samples showed a statistically significant difference(F=161.55,172.14,289.73;all P=0.00);the level of serotonin(biomarker for well-being),cortisol(indicator of stress)and HS-CRP(biomarker for inflammation)showed a statistical improvement(F=307.46,182.85,102.23;all P=0.00).After 3,6 and 12 months of regular TCC exercise,according to the results of QOL questionnaire,the indicators including quality of sleep,perceived hunger,fatigue,contentment,stress and social interaction presented a significant difference(F=312.98,222.64,543.90,46.05,28.10,78.92,all P<0.05),while there was no statistical difference in life dissatisfaction(F=56.61,P=0.166)Conclusions TCC physical activity for post-treatment breast cancer patients improved QOL and overall

关键词：乳腺病患者临床分析治疗方法

Adjuvant therapy for hormone receptor-positive breast cancer: Perspective from a survey on breast cancer physicians' acceptance of practice-changing data

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Chinese Journal of Cancer Research 2023年第2期35卷 191-196页

作者： Asian Institute of Clinical Oncology(AICO)Expert Panel louis W.C.chow 不详 Organisation for Oncology and Translational Research Unit 160416/FStrand 5050 Bonham StrandSheung WanHong Kong SARChina

A cross-sectional online survey was conducted.A high proportion of the Chinese breast cancer(BC)physician respondents(n=77)would prescribe extended adjuvant endocrine therapy(AET)with aromatase inhibitors(AI)beyond 5 years for postmenopausal females with BC,especially those with higher *** with≥15 years of clinical experience were more likely to prescribe a longer duration of AET for low-risk *** of the respondents considered intermittent letrozole as an acceptable *** respondents would prescribe adjuvant chemotherapy to genomic high-intermediate risk[Oncotype DX recurrence score(RS)21-25]females aged≤50 years regardless of the clinical risk classification.

关键词： Breast neoplasms surveys and questionnaires chemotherapy adjuvant practice patterns physicians