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Progressive Obesity in Female Rats from Synergistic Interactions between Drugs and Whole Body Application of Weak, Physiologically Patterned Magnetic Fields

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Journal of Behavioral and Brain Science 2014年第6期4卷 268-283页

作者： Linda S. st-pierre Michael A. Persinger Behavioural Neuroscience Program Laurentian University Sudbury Canada

Prepubescent female rats treated with the atypical neuroleptic acepromazine but not ketamine, prazosin, or doxepin, after lithium/pilocarpine-induced seizures gradually became obese over their lifetimes if spontaneous seizures developed. Mild increases in weight gain were induced when prepuberal females were given pilocarpine and acepromazine while being exposed briefly (1.5 hr) to a frequency-modulated magnetic field known to induce seizures. Weekly (1.5 hr) exposures to physiologically-patterned magnetic fields over 36 wks had no effect on weight gain while continuous periseizure exposure to 50 Hz fields above about 1 μT facilitated mild weight gains and protracted aggression. Perinatal exposure to a very weak, a 7 Hz magnetic field or a nitric oxide inhibitor retarded the weight gain induced by the obesity procedure. These results indicate that synergisms during a single episode between neuronal electrical lability and pharmacological states can initiate a process of weight gain that progresses to extreme obesity. We suggest that at least a component of the global “epidemic of obesity” could be related to a synergism between the insidious emergence of amplitude modulations within biologically compatible electromagnetic frequencies from the proliferation of communication systems and the pervasive utilization of pharmacology to treat transient disorders of ontogeny within the human population.

关键词： Obesity Drug-Induce Obesity Weak Magnetic Fields Drug-Magnetic Field Synergisms

Uranium,rare metals,and granulite-facies metamorphism

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Geoscience Frontiers 2014年第5期5卷 729-745页

作者： Michel Cuney pierre Barbey CNRS Georessources.UMR 7359.BP 239F-54506 Vandauvre-les-NancyFrance b CNRS.CRPC.UMR 7359.BP 20F-54501 Vandoeuvre-les-Nancy Cedex.France Universite de Lorraine.CS 25233.F-54042 Nancy.France

During granulite-facies metamorphism of metasedimentary rocks by the infiltration of carbonic fluids, the disappearance of hydrated minerals leads to the liberation of aqueous fluids. These fluids are strongly enriched in F and C1, and a series of Large-lon-Lithophile （LIL） elements and rare metals, resulting in their depletion in granulites. To sum up the fate of these elements, we focus on three domains representing different crustal levels and showing distinct behaviours with respect to these elements. The Lapland metasedimentary granulites illustrate the behaviour of the LILE and rare metals during lower crustal metamorphism. There is no change in Ba, moderate loss in Rb, and extreme depletion in Cs, Li, and Sn. F and CI contents are also very low compared to the protoliths or average upper continental crust. Biotite and amphibole breakdown leads to the incorporation of their partitioning into a fluid or a melt. The Tranomaro metasomatized marbles recrystallizing under granulite-facies conditions represent a demonstrative example of fluid transfer from granulite-facies supracrustals to traps represented by regional scale skarns. Such fluids may be at the origin of the incompatible element enrichment detected in leucosomes of migmatites from st Malo in Brittany （France） and Black Hills in South Dakota, The northern French Massif Central provides us with an example of a potential association between incompatible element enrichment of granitic melts and granulite-facies metamorphism. U- and F- enriched fine-grained granites are emplaced along a crustal scale shear zone active during the emplacement within the st Sylvestre peraluminous leucogranitic complex, We propose that during granulite-facies metamorphism dominated by carbonic waves in a deep segment of the continental crust, these shear zones control：（i） the percolation of F-, LILE-, rare metal-rich fluids liberated primarily by the breakdown of biotite; （ii） the enhancement of partial melting by F-rich flui

关键词： GranuliteCarbonic waveUraniumRare metalsPartial meltingFluorine

Modeling the antigen recognition by B-cell and T-cell receptors through thermostatted kinetic theory methods

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International Journal of Biomathematics 2017年第5期10卷 263-299页

作者： Carlo Bianca louis Brezin Laboratoire de Recherche en Eco-innovation Industrielle el Energetique ECAM-EPMI 13 Boulevard de l'Hautil 95092 Cergy Pontoise Cedex France Laboratoire de Physique statistique Ecole Normale Supdrieure PSL Research University Universite Paris Diderot Sorbonne Paris-Cite Sorbonne Universites UPMC Univ Paris 06 CNRS 24 rue Lhomond 75005 Paris France Institut Universitaire de Cancdrologie Facultg de Medecine Universite Pierre et Marie Curie-Paris 6 91 Bd de l'Hopital 75013 Paris France

The activation and the resulting response of the immune system to antigens comprise different complex processes and cells. This paper aims at modeling the processes of recognition and learning of the immune system by means of the thermostatted kinetic theory methods. Specifically, the thermostatted kinetic framework is firstly generalized for taking into account that in some processes of proliferation of the cells, the rate is also function of the degree of information exchanged amongst cells. In particular, within the new framework, a mathematical model is proposed for miming the recognition process of the immune system through the definition of interactions between the cytoto^ic and humoral components of the adaptive immune system via T- and B-cells. The model validation is obtained by performing a sensitivity analysis on the parameters which depicts the main emerging phenomena and the different phases of the recognition and learning of the immune system.

关键词： Thermostatted kinetic theory integro-differential models learning and memory biological complexity immune system.

Is There a Geomagnetic Component Involved with the Determination of G?

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International Journal of Geosciences 2014年第4期5卷 450-452页

作者： Michael A. Persinger Linda S. st-pierre Laurentian University Sudbury Canada

We compared the small quantitative changes (range) in G over repeated measures (days) with recently improved methods of determinations and those recorded over 20 years ago. The range in the Newtonian constant of gravitation G is usually in the order of 400 ppm as reflected in experimentally-determined values. The moderate strength negative correlation between daily fluctuations in G, in the range of 3 × 10-3 of the average value, and an index of global geomagnetic activity reported by Vladimirsky and Bruns in 1998 was also found for the daily fluctuations in the angular deflection θ (in arcseconds) and geomagnetic activity within 24 hr for the Quinn et al. 2013 data. A temporal coupling between increases of geomagnetic activity in the order of 10-9 T with decreases in G in the order of 10-14 m3·kg-1·s-2 could suggest a recondite shared source of variance. The energy equivalence for this change in G and geomagnetic activity within 1 L of water is ~3 × 10-14 J.

关键词： Gravitational Constant Variations Geomagnetic Activity Energy Convergence Electromagnetic-Gravitational Interactions

Interventional radiology therapies for liver cancer

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Hepatoma Research 2016年第1期2卷 1-9页

作者： Romaric Loffroy louis Estivalet Sylvain Favelier pierre Pottecher pierre-Yves Genson Jean-pierre Cercueil Denis Krause Department of Vascular Oncologic and Interventional RadiologyLe2i UMR CNRS 6306University of Dijon School of MedicineBocage Teaching Hospital21079 Dijon CedexFrance

Hepatocellular carcinoma(HCC)is the fifth most frequently found primary malignant tumor in the *** surgery and liver transplantation are considered optimal for the curative treatment of ***,only 15-20%of HCCs may be surgically *** of the surgically-non-eligible patients have to receive locoregional image-guided interventional treatments including intra-arterial and percutaneous ablative *** goal of this paper is to review these interventional oncology *** therapeutic approaches include chemical therapies(such as ethanol or acetic acid injection),and thermal therapies(such as radiofrequency ablation,laser-induced thermotherapy,microwave ablation,cryoablation,and high-intensity focused ultrasound ablation).Catheter-based therapies include embolotherapy/chemotherapy-based treatments(such as transcatheter arterial chemoembolization,bland embolization,transcatheter arterial chemoinfusion,and chemoembolization with drug-eluting beads),and radiotherapy-based treatments(such as radioembolization with yttrium-90 and injection of iodine-131-labeled lipiodol).As a result of the technical development of locoregional approaches for HCC during the recent decades,the range of combined interventional therapies has been continuously *** this article,an evidence-based approach will be used to review the current role of interventional radiology therapies in the management of unresectable HCC.

关键词： Hepatocellular carcinoma local ablative therapy radioembolization transarterial chemoembolization

Simulations of the Performance of Maximum Power Point Tracking Algorithms Based on Experimental Data According to the Topologies of DC-DC Converters

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Journal of Power and Energy Engineering 2021年第5期9卷 76-92页

作者： Abraham Dandoussou pierre Kenfack stève Ngoffe Perabi Martin Kamta University of Buea Department of Electrical and Power Engineering Higher Technical Teachers’ Training College (HTTTC) Kumba Cameroon University of Douala Department of Electrical Engineering and Industrial Computing Institut Universitaire de Technologie Douala Cameroon University of Ngaoundere Department of Electrical Engineering Energetic and Automation National School of Agro-Industrial Sci-ences Ngaoundere Cameroon

Maximum Power Point Tracking (MPPT) algorithms are now widely used in PV systems independently of the weather conditions. In function of the application, a DC-DC converter topology is chosen without any previous performance test under normal weather conditions. This paper proposes an experimental evaluation of MPPT algorithms according to DC-DC converters topologies, under normal operation conditions. Four widely used MPPT algorithms i.e. Perturb and Observe (P & O), Hill Climbing (HC), Fixed step Increment of Conductance (INCF) and Variable step Increment of Conductance (INCV) are implemented using two topologies of DC-DC converters i.e. buck and boost converters. As input variables to the PV systems, recorded irradiance and temperature, and extracted photovoltaic parameters (ideality factor, series resistance and reverse saturation current) were used. The obtained results show that buck converter has a lot of power losses when controlled by each of the four MPPT algorithms. Meanwhile, boost converter presents a stable output power during the whole day. Once more, the results show that INCV algorithm has the best performance.

关键词： MPPT Algorithms DC-DC Converters Photovoltaic Parameters Normal Operating Conditions

Vaccine Yield Uncertainty with Demand Substitution

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Vaccine Yield Uncertainty with Demand Substitution

Evaluation of the Quality of Micturition in Patients Who Underwent Anastomotic Urethroplasty at the Yaounde Central Hospital, Cameroon

第九届中国不确定系统年会、第五届中国智能计算大会、第十三届中国青年信息与管理学者大会

作者： Renyu Zhang Olin Business School,Washington University in st.louis,st.louis,Missouri 63130

A standard problem in operations literature is the optimal stocking of substitutable products. We,however,consider a similar optimization problem with demand substitution where uncertainty occurs at the supply(production)level. This is motivated by the very common production yield uncertainty in vaccine *** our paper, substitution is modeled by letting the unsatisfied demand for one type of vaccine flow to other vaccines in deterministic *** obtain,analytically, tractable solutions that facilitate comparisons between centralized and competitive optimal production quantities under substitution.A variant of revenue sharing contract is then proposed that coordinates vaccine manufacturers so that the system achieves global optimization in the Nash equilibrium. The model developed in this paper is of newsvendor type.

关键词： inventory/production substitution game theory coordination with contracts

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Open Journal of Urology 2024年第2期14卷 115-127页

作者： Achille Aurele Mbassi Landry Oriole Mbouche Junior Mekeme Mekeme Jean Crepin Eloundou Nkolo Bright Che Awondo Jean Cedrik Fouda Frantz Guy Epoupa Ngalle Cyril Kamadjou Pamela Anaba Laure pierre Joseph Fouda Fru Forbuzshi III Angwafo Higher Institute of Medical Technology Yaounde Cameroon Higher Institute of Health Sciences Bangangte Cameroon Urology and Andrology Department Yaounde Central Hospital Yaounde Cameroon Department of Surgery and Subspecialties Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Yaounde Gynecology Obstetrics and Pediatric Hospital Yaounde Cameroon

Introduction: Radiological investigation which is the gold standard to perform following anastomotic urethroplasty in order to evaluate the quality of micturition is costly. In our context, due to financial limitations, reconstructive urologists prefer to use the uroflowmetry in order to assess the micturition post-surgery. Therefore, the objective of the study was to assess the quality of micturition using the uroflowmetry after anastomotic urethroplasty. Methodology: We conducted an 11-year retrospective review (1st January 2006-31st December 2017) and a cross-sectional descriptive observational study for a period of 8 months (November 2017-June 2018) at the Urology and Andrology Department of the Yaounde Central Hospital (YCH) of patients who were diagnosed with urethral stenosis and underwent an anastomotic urethroplasty at the YCH. We excluded patients who had incomplete files, patients lost to follow-up and did not do pre-operative uroflowmetry. Quality of micturition was evaluated using a uroflowmetry. Data was analyzed using EPI info 7.0. Parametric variables were reported as means and standard deviations and percentages and counts were used to report categorical variables. Results: We had a sample of 60 patients. The mean age was 42 ± 5 years with extremes ranging from 20 to 76 years. Twenty-seven (27) patients, or 45%, had no post-operative complications, and those who did had a urinary tract infection (26.70%). In our series, we had 82% excellent results (patient satisfied with his urination with bell-shaped urinary stream and urinary flow greater than or equal to 15 ml/sec);15% good results (patient with moderate dysuria with average urinary stream and urinary flow between 10 and 14.9 ml/sec) and 3% poor results (severe dysuria with urinary flow less than 10 ml/sec, urinary retention or urinary incontinence). Based on these results we can say that the success rate in our series was 97%. 96.70% of patients were satisfied against 3.3%

关键词： Urethra stricture Anastomotic Urethroplasty

Does the incubator control mode influence outcomes of low-birth-weight neonates during the first days of life and at hospital discharge?

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Health 2013年第8期5卷 6-13页

作者： Pauline Décima Erwan stéphan-Blanchard André Léké Loic Dégrugilliers stéphane Delanaud Jean-pierre Libert pierre Tourneux Laboratory PériTox EA 4285-UMI 01 INERIS Amiens France

Background: The thermal environment surrounding neonates in closed incubators can be regulated via two different modes: skin servocontrol mode (SSC) and air temperature control mode (ATC). These produce different patterns of incubator air and infant body temperatures. Objective: To assess the effects of incubator control mode on clinical outcomes of low-birth-weight-infants during the first days of life and at hospital discharge. Methods: 52 low-birth-weight neonates were nursed over ten days in closed incubators functioning either with SSC mode (n = 29), or with ATC mode (n = 23). Results: The anthropomorphic characteristics of the two groups of neonates were homogenous (gestational age = 29.4 ± 1.4 vs. 29.9 ± 1.2 weeks and birthweight = 1214 ± 347 vs. 1263 ±292 gin the SSC-group and the ATC-group, respectively) and the caregiving (energy and fluid intakes, ventilator assistance and drug administration) did not differ statistically. Daily means of incubator air temperature were similar in the SSC and the ATC-group, however, the SSC mode resulted in more variable incubator air temperature but more stable skin abdominal temperature whereas the reverse was found when using the ATC mode. Those differences had no impact on the body weight of the neonates or their clinical outcomes at hospital discharge which were not statistically different. Conclusion: The clinical outcomes do not differ depending on the incubator control mode after the first ten days of life and at hospital discharge.

关键词： Clinical Outcomes Preterm Neonates Closed Incubators Incubator Control Mode