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世界核心医学期刊文摘(神经病学分册) 2006年第1期 12-13页

作者： Bermel R.A. Puli s.R. Rudick R.A. R. Bakshi 郭俊 center for Neurological Imaging Brigham and Women's Hospital Harvard Medical School 77 Avenue Louis Pasteur-HIM 730 Boston MA 02115 United States Dr.

Background: Gray matter magnetic resonance imaging T2 hypointensity, a marker of iron deposition, is associated with clinical impairment and brain atrophy in cross-sectional studies of multiple sclerosis. Treatment with intramuscular interferon beta-1a limits brain atrophy in the second year of treatment. Objective: To test whether T2 hypointensity predicts brain atrophy and whether interferon affects this relationship. Design: Post hoc analysis. setting: A multicenter treatment trial conducted at tertiary care comprehensive multiple sclerosis centers. Patients: Patients with multiple sclerosis who took part in a 2-year clinical trial in which they received intramuscular interferon beta-1a (30 μg/wk) or placebo. Main Outcome Measures: Deep gray matter T2 hypointensity, brain parenchy-mal fraction (BPF), and total T2, gadolinium-enhancing, and T1 lesion volumes. Results: T2 hypointensity in various gray matter areas correlated with baseline BPF (r=0.19-0.39; P=.001-.03). In placebo-treated patients (n=68), baseline T2 hypointensity predicted the change in BPF in the first year and throughout 2 years (r=0.26-0.42; P sity was chosen in regression modeling as the best predictor of BPF change at the 1-year (R2=0.23; P=.002) and 2-year (R2=0.33; P s after accounting for all magnetic resonance imaging variables. In the interferon group (n=65), no relationship existed between baseline T2 hypointensity and BPF change. conclusions: Gray matter T2 hypointensity predicts the progression of brain atrophy in placebo-but not interferon beta-1a-treated patients. This predictive effect is seen as early as the first year. We hypothesize that interferon beta may exert its effect on brain atrophy in part by reducing a cascade of events that involve iron deposition as a mediator of neurotoxicity or as a disease epiphenomenon.

关键词：多发性硬化症低密度脑萎缩 T2 磁共振成像灰质

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极低出生体重儿死亡率的风险因素

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 16-17页

作者： Bacak s.J. Baptiste-Roberts K. Amon E. 朱国栋 Department of community Health Saint Louis UniversitySchool of Public HealthSt Louis MO United States

Objective: The purpose of this study was to examine characteristics associated with neonatal mortality among extremely low- birth- weight infants (≤ 1000 g). study design: A population- based, case- control study using linked Missouri birth and death certificates from 1989 to 1997 was conducted. cases (n = 835) were defined as extremely low- birth- weight infants that died within 28 days of birth. controls (n = 907) were randomly selected from extremely low- birth- weight infants that were alive at 1 year and were frequency matched to subjects by birth year and birth weight. Results: Infants born with severe congenital anomalies and at the youngest gestational ages were at greatest risk for neonatal mortality. Other significant risk factors included maternal age (34 years), vaginal delivery, nontertiary hospital care, malpresentation, male gender, and small for gestational age. Black race and preeclampsia were protective against early death. conclusions: The risk of neonatal mortality among extremely low- birth- weight infants was associated with several maternal, infant, and obstetric factors, some of which may be preventable.

关键词：极低出生体重儿先天性缺陷出生后产科因素死亡资料病例对照研究阴道分娩保护性因素先兆子痫死亡风险

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大鼠体内前哨淋巴结:临床超声成像系统的无创性光声和超声成像

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国际医学放射学杂志 2010年第5期 471-472页

作者： T.N.Erpelding c.Kim M.Pramanik L.Jankovic K.Maslov 袁友红 Optical Imaging Laboratory Department of Biomedical EngineeringWashington University in St Louis

关键词：前哨淋巴结超声成像系统 sLN 光声

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少汗性外胚叶发育不良家族中毛发和汗腺的进一步观察

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 58-59页

作者： Rouse c. siegfried E. BreerW. Nahass G. 罗素菊冯义国 Department ofDermatology Saint LouisUniversity 1034 S Brentwood Blvd St. Louis MO 63117 United States Dr.

Objectives: To gather and compare clinical and histologic information from individuals affected by hypohidrotic ectodermal dysplasia (HED) and unaffected control subjects and to assess the value of these data in the diagnosis of HED. Design: Volunteer subjects attending the 20th Annual Family conference of the National Foundation for Ectodermal Dysplasia answered a questionnaire and performed a starch-iodide sweat-function test. A subset of the subjects also donated samples of hair and 4-mm punch biopsy specimens of palmar and scalp skin. specimens from each of these tests were assessed in a blinded fashion. Analysis was performed comparing affected and control subjects for each of the following parameters: quantification of eccrine structures in the skin biopsy specimens, analysis of hair sample trichograms for hair shaft defects, and qualitative classification of starchiodide palm-print sweat-function test results. settings: An international conference for families and individuals with ectodermal dysplasias. subjects: A total of 40 subjects were included in the final analysis: 15 unaffected control subjects and 25 subjects with HED. Nine affected subjects and 9 unaffected subjects donated skin biopsy specimens. Main Outcome Measure: This study was designed to assess the value of 4 simple tests in supporting the diagnosis of HED. Results: Investigators were blinded to group during analysis of the test samples. Trichogram examination identified 3 hair shaft abnormalities, with a slightly higher prevalence in the affected group: variable shaft thickness, trichorrhexis nodosa, and pili torti. The sensitivity and specificity for each of these findings was less than 40%. starch-iodide paper palm imprints identified a higher likelihood of diminished or absent sweat in the affected group, but this test had a low sensitivity (44%) and an imperfect specificity (93%). Examination of horizontally sectioned skin biopsy specimens from the palm were devoid of eccrine structures

关键词：外胚叶发育不良活检标本掌部盲法定性结果形态学诊断毛干功能试验水平切片

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齿状核MRI T2加权低信号与多发性硬化症患者步行能力损伤有关

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 45-46页

作者： Tjoa c.W. Benedict R.H.B. Weinstock-Guttman B. R. Bakshi 周永 Departments of Neurology and Radiology Brigham and Women’s Hospital Harvard Medical School 77 Avenue Louis Pasteur-HIM 730 Boston MA 02115 United States

Objectives: MRI T2 hypointensity in multiple sclerosis (Ms)-gray matter, suggesting iron deposition, is associated with physical disability, disease course, lesion load, and brain atrophy. Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor. Methods: Normalized intensity on T2-weighted images was obtained in the basal ganglia, thalamus, red nucleus, and dentate nucleus in 47 Ms patients and 15 healthy controls. Brain T1-hypointense and FLAIR-hype-rintense lesion volume, third ventricle width, brain parenchymal fraction and timed 25 foot walk (T25FW)-were measured in the Ms group. Results: T2 hypointensity was present throughout gray matter in Ms vs. controls (all p sity was the only MRI variable significantly correlated with T25FW (Pearson r=-0.355, p=0.007) and was also the best MRI correlate of physical disability (EDss) score in regression modeling (r=-0.463, R2=0.223, p=0.004). conclusions: T2 hypointensity is present in subcortical gray matter nuclei in patients with Ms vs. normal controls. Dentate nucleus T2 hypointensity is independently related to ambulatory impairment and disability, accounting for more variance than conventional lesion and atrophy measures. This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in Ms.

关键词：多发性硬化症 MRI T2加权步行能力齿状核病灶体积 EDss FLAIR 基底神经节第三脑室铁沉积

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血管造影示明显冠状动脉疾病患者的血中内皮祖细胞克隆数增加

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 48-49页

作者： Güven H. shepherd R.M. Bach R.G. D.c.Link 郭俊 Division of Oncology Washington University School of MedicineSt.LouisMOUnited States Dr.

目的:本研究旨在确定外周血中内皮祖细胞(EPc)和循环生血管细胞(cAc)数量是否与接受冠状动脉造影患者的冠状动脉疾病(cAD)及其严重程度相关。背景:先前研究提示。

关键词：祖细胞血管造影血管细胞循环血血运重建血管危险因素急性缺血细胞亚群负相关

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Associations of the serum/Glucocorticoid Regulated Kinase（sGK）genes with BP changes and hypertension incidence：The Gensalt study

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中国循环杂志 2016年第Z1期31卷 -页

作者： Dingding Zhang Dongfeng Gu Jiang He James E Hixson Dabeeru c Rao changwei Li Jichun chen Jianfeng Huang Jing chen Treva K Rice shufeng chen tanika N Kelly Department of Evidence Based Medicine State Key Laboratory of Cardiovascular Disease FuwaiHospital NationalCenter for Cardiovascular Diseases Chinese Academy of MedicalSciences and Peking Union MedicalColege Beijing China Department of Epidemiology Tulane University Schoolof Public Health and TropicalMedicine New 0rleans Louisiana USA. Department of Epidemiology Human Genetics and Environmental Sciences University of Texas Schoolof Public Health Houston Texas USA. Division of Biostatistics Washington University Schoolof Medicine St. Louis Missouri USA

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睫状体扁平部玻璃体切割联合内界膜剥除治疗无后部玻璃体牵拉的难治性糖尿病黄斑水肿

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 42-43页

作者： Rosenblatt B.J. shah G.K. sharma s. Bakal J. 张磊 Dept. of Ophthalmol./Visual sciences Washington School of Medicine 1600 S. Brentwood Blvd. St. Louis MO 63114 United States

Background: This is a retrospective study designed to investigate the effect of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling on diabetic macular edema in eyes that do not have a taut hyaloid and have been refractory to standard laser treatment. Methods: Review of 26 eyes of 20 patients consecutively were treated with PPV with ILM peel for refractory diabetic macular edema. Eyes were included if they had been unresponsive to conventional treatment defined as at least two focal laser applications by a retina specialist. Paired t- testing was performed to determine if a change in both optical coherence tomography (OcT)-Measured retinal thickness and logarithm of the minimum angle of resolution (logMAR) visual acuity occurred prior to and following PPV with epiretinal membrane vitrectomy. In addition, we performed multivariate regression analysis to determine if any clinical variables predicted a change in visual acuity. Results: The mean age in the sample was 65 years (range 29- 81 years). The mean follow-up time was 242 days (range35- 939). sixteen of the 26 eyes were phakic and the remaining ten were pseudophakic. There was a statistically significant improvement of mean visual acuity from a preoperative logMAR vision of 1.0 to a best postoperative vision of 0.75 (P=0.016, paired t-test). Thirteen (50% ) of the 26 eyes gained at least two lines of best-corrected snellen acuity, three (11.5% ) had a decline of at least two lines, and ten (38.5% ) showed stable visual acuity. Regression analysis demonstrated that baseline worse visual acuity was the only clinical variable that was associated with improvement in visual acuity (beta=0.602, P=0.016; R2=28.7). Fourteen eyes had preoperative and postoperative OcT. Thirteen eyes (93% )-had a significant decrease in foveal thickness; with an average preoperative thickness of 575 μ m compared to a postoperative average of 311 μ m (t=3.65, P=0.002). No surgical complications were observed during the

关键词：内界膜玻璃体牵拉玻璃体切割难治性糖尿病黄斑水肿视力变化人工晶体眼视网膜表面视网膜厚度低视力

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高极化^3He MRI对100例连续研究对象的生理检测观察和安全性评估

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国际医学放射学杂志 2008年第5期31卷 408-408页

作者： B.A. Lutey s.s. Lefrak J.c. Woods T. tanoli J.D. Quirk A. Bashir 郭雪梅（译）唐光健（校） Divisions of Pulmonary and critical care Medicine Washington University School of Medicine 510 S Kingshighway Blvd St Louis MO 63110 USA. 不详

目的评价高极化氦3（^3He）MR成像的安全性。方法本研究经伦理审查委员会批准并取得受试者的知情同意。100例连续受试者[男57例，女43例；平均年龄（52±14）岁1在进行高极化^3HeMR成像之前、过程中及之后分别采集生理检测数据。受试者... 详细信息

目的评价高极化氦3（^3He）MR成像的安全性。方法本研究经伦理审查委员会批准并取得受试者的知情同意。100例连续受试者[男57例，女43例；平均年龄（52±14）岁1在进行高极化^3HeMR成像之前、过程中及之后分别采集生理检测数据。受试者吸入含有300～500mL的^3He和0～2700mL的N2的混合气体10L，在MR检查中屏气长达15s。在每次检查中采用脉冲血氧监测仪连续检测心率、心律和血红蛋白氧饱和度（spO2）。分别评价^3HeMR成像对于生命体征和spO2的影响，以及spO2最低观测值与肺功能、药物剂量、临床分类（正常志愿者、哮喘病人、大剂量吸烟者、因为严重肺气肿而行肺部减容手术的病人以及肺癌病人）的关系。

关键词：安全性评估生理检测极化 MRI 伦理审查委员会 MR成像 MR检查 spO2

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ZMPsTE24的纯合子和复合杂合子突变引起核纤层病变性限制性皮病

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 18-19页

作者： Moulson c.L. Go G. Gardner J.M. J.H. Miner 朱国兴 Renal Division Box 8126Washington University School of Medicine 660 S. Euclid Ave. St Louis MO 63110 United States Dr.

Restrictive dermopathy (RD) is a lethal human genetic disorder characterized by very tight, thin, easily eroded skin, rocker bottom feet, and joint contractures. This disease was recently reported to be associated with a single heterozygous mutation in ZMPsTE24 and hypothesized to be a digenic disorder (Navarro et al, Lamin A and ZMPsTE24 (FAcE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. Hum Mol Genet 13:2493- 2503, 2004). ZMPsTE24 encodes an enzyme necessary for the correct processing and maturation of lamin A, an intermediate filament component of the nuclear envelope. Here we present four unrelated patients with homozygous mutations in ZMPsTE24 and a fifth patient with compound heterozygous mutations in ZMPsTE24. Two of the three different mutations we found are novel, and all are single base insertions that result in messenger RNA frameshifts. As a consequence of the presumed lack of ZMPsTE24 activity, prelamin A, the unprocessed toxic form of lamin A, was detected in the nuclei of both cultured cells and tissue from RD patients, but not in control nuclei. Abnormally aggregated lamin A/c was also observed. These results indicate that RD is an autosomal recessive laminopathy caused by inactivating ZMPsTE24 mutations that result in defective processing and nuclear accumulation of prelamin A.

关键词：复合杂合子突变位点纯合子皮病核纤层变性信使RNA 4基因特征表现

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