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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 23-24页

作者： Dehen L. Taieb c. Myon E. Dubertret L. 冯义国 service de Dermatologie H■pital Saint-Louis1avenue Claude Vellefaux75010 Paris

*** diseases modify and impair patients’self-image and can result in considerable psychological *** purpose of this study was to determine the prevalence of depressive symptoms in patients consulting for dermatological *** and methods.A prospective study was carried out on 5 successive days at the dermatology department of the saint-louis Hospital in Paris.A questionnaire designed to assess depressive symptoms,the cEs-D,was given to all patients consulting throughout the study *** self-assessment scale for depression was devised by the National Institute of Mental Health and has been validated over more than 20 years by means of hundreds of large-scale epidemiological studies in both general and selected patient *** completion of the 5-day study,879 questionnaires had been *** sex-ratio was 53.4%women 46.6%*** prevalence of depressive symptoms as evaluated by the questionnaire was 23.6%for a total of 774 evaluable *** consulting without an appointment(n = 172)represented 22%of study subjects versus 78%attending a scheduled visit(n = 602).Depressive symptoms were found in 31.4%of patients consulting without an appointment versus 21.4%of patients with an appointment(p s consulting without an appointment constituted the most fragile group,with depressive symptoms being seen in 38.8%of this *** prevalence of depressive symptoms among patients seen at a hospital dermatology department was 23.6%in this *** figure was significantly higher among patients consulting without an appointment,and among men in *** was equal to or higher than that seen among patients considered as having more incapacitating or painful conditions as assessed using the same *** incidence of concomitant depression should prompt dermatologists to investigate for its existence and to take appropriate therapeutic measures in order t

关键词：圣路易斯问卷调查精神痛苦证实有效易感群体精神损害自我形象精神健康性别比自我评价

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cadence先进封装EDA工具高效赋能coWos-s硅中介层设计和签核

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中国集成电路 2023年第10期32卷 76-82页

作者：谷雨徐兴隆陈恺立刘华宝孙晨王海三祁芮徐国治沐曦集成电路(上海)有限公司上海楷登电子科技有限公司

随着摩尔定律的放缓,通过制程微缩来提高芯片性能越来越难,基于芯粒集成的先进封装方案的重要性随之日益显现。尤其是在一些高算力芯片产品的设计上,采用芯粒集成已逐渐成为设计者们一个绕不开的性能提高手段。在2.5D先进封装方案中,coW... 详细信息

随着摩尔定律的放缓,通过制程微缩来提高芯片性能越来越难,基于芯粒集成的先进封装方案的重要性随之日益显现。尤其是在一些高算力芯片产品的设计上,采用芯粒集成已逐渐成为设计者们一个绕不开的性能提高手段。在2.5D先进封装方案中,coWos-s(chip on wafer on substrate)封装因其高带宽、低延迟及丰富的成功量产案例而被广泛应用于片上系统芯片(soc-system on chip)与高带宽内存(HBM-high bandwidth memory)的互连。然而,在coWos-s技术的硅中介层设计过程中,设计人员将面临严苛的信号完整性与电源完整性的综合挑战。为了解决这些挑战,cadence作为EDA领域的创新者和领导者,开发了完整的EDA解决方案,以协助设计人员完成硅中介层的设计及签核任务。本文将介绍如何利用cadence EDA解决方案来高效率地实现coWos-s硅中介层的设计与签核,内容聚焦于大电流区域的电源完整性设计以及HBM互连区域的信号完整性设计。

关键词： coWos-s 硅中介层深沟电容 HBM Integrity 3D-Ic平台 XcitePI Extraction clarity Optimality Explorer

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国家肺气肿治疗试验中手术死亡率和心肺患病率的预测因素

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 56-57页

作者： Naunheim K.s Wood D.E Krasna M.J. 程敏 Division of cardiothoracic surgery St. Louis University Health Sciences Center 3635 Vista Ave St LouisMO63110- 0250United StatesDr.

Objective: We sought to identify predictors of operative mortality, pulmonary morbidity, and cardiovascular morbidity after lung volume reduction surgery. Methods: Univariate and multivariate logistic regression analyses were performed. candidate predictors included demographic characteristics, physical condition characteristics, pulmonary function measures, measures of the distribution of emphysema as determined by radiologists and by means of computerized analysis of chest computed tomographic scans, and measures of exercise capacity, dyspnea, and quality of life. End points analyzed were operative mortality(death within 90 days of the operation), major pulmonary morbidities(tracheostomy, failure to wean, reintubation, pneumonia, and ventilator for ≥ 3 days), and cardiovascular morbidites(infarction, pulmonary embolus, or arrhythmia requiring treatment). Results: Five hundred eleven patients in the non-high-risk group of the National Emphysema Treatment Trial underwent lung volume reduction. The incidence of operative mortality was 5.5% , major pulmonary morbidity occurred in 29.8% of patient, and cardiovascular morbidity occurred in 20.0% of patients. Predictors for these end points are as follows: Relative odds P value Operative mortality Non-upper-lobe predominance(radiologist) 2.99 .009 Pulmonary morbidity Age in yeas 1.05 .02 FEV1 % predicted 0.97 .05 Dlco % predicted 0.97 .01 cardiovascular morbidity Age in years 1.07 .004 Oral steroid use 1.72 .04 Non-upper-lobe predominance(QIA α measure) 2.67 ced expiratory volume in 1 second; Dlco, diffusion capacity; QIA, quantitative image analysis. conclusions: Although lung volume reduction can be performed in selected patients with acceptable mortality, the incidence of major cardiopulmonary morbidity remains high. The lone predictor for operative mortality of lung volume reduction was the presence of non-upper-lobe-predominant emphysema, as assessed by the radiologist. Pulmonary morbidity can be exp

关键词：手术死亡率预测因素治疗试验病患病率肺气肿 Logistic回归分析心肺心血管疾病胸部cT扫描肺减容术

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*** and facilitators related to the use of optical low vision aids,a scoping review

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Annals of Eye science 2018年第1期 503-503页

作者： Marie-céline Lorenzini Jonathan Jarry Walter Wittich school of Optometry Universitéde MontréalQCCanada cRIR/Institut Nazareth et louis-Braille du cIsss de la Montérégie-centre QCCanada cRIR/centre de réadaptation MAB-Mackay du cIUsss du centre-Ouest-de-l’Île-de-Montréal QCCanada

Background:In recent decades,several studies have been performed in the field of(non-)use of assistive technology devices(ATs)and have found that many variables are likely to be involved in the decision-making process of whether a person with a disability uses or abandons their *** low vision rehabilitation,high variability rates and a variety of reasons for non-use of low vision aids has been *** of non-use of ATs have previously been categorized into personal factors,ATs factors,environmental factors of the user,and intervention *** is probable that some of these factors are also associated with the use of optical low vision aids(OLVAs).Thus,using a framework about adherence with medical interventions,the aim of this scoping review was to explore barriers and facilitators related to OLVAs(non-)***:Existing guidelines of the scoping review Methods were used to examine and summarize the extent,range,and nature of findings regarding factor categories associated to OLVAs *** were conducted using the following online databases:Embase,MedLine,and ERIc without limitation on publication dates.A combination of key words and MesH terms was used based upon the identified core concepts of the research question:(I)low vision;(II)assistive technology;and(III)adherence.A charting form,a flow chart of the study selection process,and a combination of a descriptive numerical analysis and a thematic analysis of 24 studies were ***:The results of this review indicate high variability rates(range:13-50%,M=24%,sD=10%)of people possessing OLVAs but not using *** authors do not use a precise definition of“non-use”,and when a definition is provided,the terminology is *** expected,the four categories of variables identified are likely to be involved in OLVAs’(non-)use:(I)the largest number of concerns were personal *** aspects regarding personal characteristics were identified,such as demographic,ph

关键词： Low vision assistive technology optical low vision aid(OLVA) adherence

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成人多层cT辐射剂量优化:临床审查的短期和长期影响

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国际医学放射学杂志 2014年第2期 188-188页

作者： D,Tack A,Jahnen s,Kohler N,Harpes V,De Maertelaer c,Back 崔兆国 Department of Radiology EpiCURA Hospital Clinique Louis Caty Rue Louis Caty 136 B 7331 BaudourBelgium

目的总结汇报一次剂量审查对于多层cT(MDcT)扫描剂量优化的短期和长期影响。方法以2007年卢森堡地区8个MDcT部门检查最频繁的部位(头、鼻窦、颈椎、胸、腹

关键词： cT 辐射剂量头部cT 质量控制身体cT

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Ⅱ型糖尿病患者微粒体甘油三酯转移蛋白基因多态性与肝脂肪变生物学表征间的联系

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德国医学 2001年第6期18卷 322-324页

作者：李元红欧阳金芝 s.Bernard s.Touzer I.Personne V.Lapras P.J.Bondon F.Berthezène P.Moulin 华中科技大学同济医学院附属同济医院 Department of Endocrinology and Nutrition Cardiovascular Hospital Louis-PradelBronFrance

非酒精性脂肪肝(NAsH)指在组织学上与酒精性肝脏疾病相似,但患者无过量使用酒精史. 诊断NAsH有两个必需的组织学标准:脂肪变性和炎症或纤维化.后一条标准把NAsH与单纯脂肪肝区别开来.在西方国家,NAsH是肝脏酶学升高的主要原因,仅次于饮... 详细信息

非酒精性脂肪肝(NAsH)指在组织学上与酒精性肝脏疾病相似,但患者无过量使用酒精史. 诊断NAsH有两个必需的组织学标准:脂肪变性和炎症或纤维化.后一条标准把NAsH与单纯脂肪肝区别开来.在西方国家,NAsH是肝脏酶学升高的主要原因,仅次于饮酒和丙型肝炎.它与肥胖(40%)、Ⅱ型糖尿病(20%)、高脂血症(20%)有关,最终有多达20%～30%的NAsH 患者可发生肝硬化.NAsH的发生可能需要经过两个过程.第一个过程导致肝脂肪变性,第二个过程是由脂肪变性变为NAsH.可能导致NAsH发生的因素包括:①胰岛素抵抗、异常脂肪酸代谢和肝内甘油三酯沉积等代谢紊乱;②氧化张力升高;③细胞因子产量增加.

关键词： Ⅱ型糖尿病微粒体甘油三酯转移蛋白基因多态性肝脂肪变生物学

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Author correction:Automated generation and ensemblelearned matching of X-ray absorption spectra

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npj computational Materials 2018年第1期4卷 477-477页

作者： chen Zheng Kiran Mathew chi chen Yiming chen Hanmei tang Alan Dozier Joshua J.Kas Fernando D.Vila John J.Rehr louis F.J.Piper Kristin A.Persson shyue Ping Ong Department of NanoEngineering University of California San Diego9500 Gilman DriveMail Code 0448La JollaCA 92093-0448USA Department of Materials science University of California BerkeleyBerkeleyCA 94720USA Division of Applied Research and Technology National Institute for Occupational Safety and HealthCenters for Disease ControlCincinnatiOH 45226USA Department of Physics University of WashingtonSeattleWA 98195USA Department of Physics Applied Physics and AstronomyBinghamton UniversityBinghamtonNY 13902USA Materials science&Engineering Binghamton UniversityBinghamtonNY 13902USA

correction to:npj computational Materials https://***/10.1038/s41524-018-0067-x,published online 20 March 2018 The following text has been added to the Acknowledgements section:“*** support from the National science ... 详细信息

关键词： matching knowledge ensemble

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夏之眠

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考试与评价（英语高二专刊） 2018年第7期 1-1页

作者：罗伯特·路易斯·斯蒂

冬日里我夜里起床．借着昏黄的烛光穿着衣裳。夏日里可不，一样。我不得不白日里就睡觉上床。小鸟儿仍在树上蹦蹦跳跳。大人们的脚步声，还在大街上回响，我却得早早睡觉上床。

关键词：高中英语课外阅读阅读材料

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玻璃体腔pegaptanib注射后发生视网膜色素上皮撕裂

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 16-17页

作者： Dhalla M. s. Blinder K. J. Tewari A. 曹绪胜(译) Dhalla Barnes Retina Institute St Louis MO United States 不详

PURPOsE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib *** our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor ***:Observational case ***:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular *** patients were treated with an intravitreal injection of pegaptanib ***:One patient developed a retinal pigment epithelium tear one week after the intravitreal *** second patient developed a retinal pigment epithelium tear eight weeks after ***:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib *** studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.

关键词：色素上皮撕裂玻璃体腔视网膜注射后隐匿性脉络膜新生血管抗血管内皮生长因子老年性黄斑变性色素上皮脱离

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5%咪喹莫特乳膏治疗外生殖器疣的有效性及安全性:6个月随访评估

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 20-21页

作者： Vexiau D. Decuypére L. Moyse D. Aractingi s. 周少娜 centre des MsT Hpital Saint-Louis 1 avenue Claude Vellefaux 75010 Paris

Introduction. One of the main issues raised by the management of external genital warts is their potential risk of recurrence. However, nearly all studies assessing recurrences have been conducted with a 3 month follow-up. since the latency of the human papillomavirus is long, such 3 month follow-up might be too short to detect the true recurrence rate. We therefore conducted a study evaluating patients with external genital warts, treated with an immune response modifier, 5% imiquimod cream, and followed up to 6 months after total clearance. Methods. This was an open, non comparative, multicenter study conducted in 51 private or hospital practices in France. 5% imiquimod cream was applied 3 times per week until the clearance of external genitalwarts, with amaximum application period of 16 weeks. Patients were followed-up for 6 months after complete clearance. Results. One hundred ninety-one patients (103 males and 88 females), with a mean age of 31.4 years (18.1- 70.4) were included in this study, between Nove November 29 1999 and February 1st 2001. complete clearance of external genital warts was noted in the ITT analysis in 103/191 cases (54 p. 100; cI95 p. 100: 40- 61). Fifteen out of 92 (16 p. 100; cI95 p. 100: 9.4- 25.5) had a recurrence within the 6 months follow-up period, 13 of these 15 recurrences were noted at the 3 month follow-up visit. conclusion. The rate of recurrence of external genital warts at 6 months was similar to the rate noted at 3 months, suggesting that after the 3-month period, the risk of developing a recurrence was low. The mode of action of imiquimod through the induction of cytokines and the stimulation of the local immune response could explain these results.

关键词：外生殖器疣乳膏治疗 5%咪喹莫特随访安全性咪喹莫特乳膏人类乳头瘤病毒免疫调节剂多中心研究复发风险

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