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《微孢子虫:机会性病原体》

生命世界 2018年第4期 2-2页

作者： louis M.Weiss James J.Becnel 潘国庆

出版:高等教育出版社出版时间:2018年4月ISBN:978-7-04-047765-8定价:160.00元微孢子虫是一种典型而又引人关注的寄生虫,是一种对全球的农业和水产养殖业有重要影响的病原体。《微孢子虫:机会性病原体》阐述了脊椎动物和无脊椎动物中寄... 详细信息

出版:高等教育出版社出版时间:2018年4月ISBN:978-7-04-047765-8定价:160.00元微孢子虫是一种典型而又引人关注的寄生虫,是一种对全球的农业和水产养殖业有重要影响的病原体。《微孢子虫:机会性病原体》阐述了脊椎动物和无脊椎动物中寄生的微孢子虫,并且第一次系统性地内容简介综述了微孢子虫的分子生物学和系统发育学相关进展。全书共25章,包含了从事微孢子虫研究的进化生物学家、分子生

关键词：微孢子虫病原体机会性

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上皮性卵巢癌的治疗

英国医学杂志中文版 2022年第4期25卷 216-232页

作者： Lindsay Kuroki Saketh r Guntupalli 韦建辉(译) Division of Gynecologic Oncology Department of Obstetrics and GynecologyWashington University School of MedicineSt LouisMOUSA Division of Gynecologic Oncology Department of Obstetrics and GynecologyUniversity of Colorado School of MedicineDenverCOUSA 广西医科大学外国语学院

卵巢癌是全球第三大常见的妇科恶性肿瘤,死亡率居妇科恶性肿瘤之首。阶段式评估、诊断和治疗对于正确管理该疾病非常重要。整合妇科肿瘤学、医学肿瘤学、病理学和放射学等学科方法对改善预后至关重要。肿瘤细胞减灭术达到无肉眼残留(r0... 详细信息

卵巢癌是全球第三大常见的妇科恶性肿瘤,死亡率居妇科恶性肿瘤之首。阶段式评估、诊断和治疗对于正确管理该疾病非常重要。整合妇科肿瘤学、医学肿瘤学、病理学和放射学等学科方法对改善预后至关重要。肿瘤细胞减灭术达到无肉眼残留(r0)是主要的治疗手段,其次是辅助化疗。检测可能影响治疗的基因突变是所有上皮性卵巢癌的治疗标准。几乎所有卵巢癌都会复发,复发性卵巢癌的治疗仍存争议,需要对最新疗法开展广泛审查,以平衡疗效以及治疗对患者生活质量的影响。多聚腺苷二磷酸核糖聚合酶抑制剂、贝伐单抗和/或同源重组缺陷药物的维持治疗应用越来越广泛,免疫疗法的发展进一步改变了治疗靶点。

关键词：上皮性卵巢癌妇科恶性肿瘤肿瘤细胞减灭术复发性卵巢癌贝伐单抗妇科肿瘤学医学肿瘤学维持治疗

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慢性溃疡对局部及全身的影响

外科学报 1952年第10期04卷 702-702页

作者： louis T.Byars Gordon S.letterman 牛芳儒(译)

血管造影示明显冠状动脉疾病患者的血中内皮祖细胞克隆数增加

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 48-49页

作者： Güven H. Shepherd r.M. Bach r.G. D.C.Link 郭俊 Division of Oncology Washington University School of MedicineSt.LouisMOUnited States Dr.

目的:本研究旨在确定外周血中内皮祖细胞(EPC)和循环生血管细胞(CAC)数量是否与接受冠状动脉造影患者的冠状动脉疾病(CAD)及其严重程度相关。背景:先前研究提示。

关键词：祖细胞血管造影血管细胞循环血血运重建血管危险因素急性缺血细胞亚群负相关

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光影·梦境

现代装饰 2018年第7期 84-91页

作者： Erik Bele Hoglund Slamp Tuomas Markunpoika Parachilna Partisans louis Lim Makingworks & 3form we+ Hokuto Ando & Toshiya Hayashi Judith rozas Cabanas Yuji Okitsu Filippo Mambretti Daisuke Kitagawa Graypants Seth Grizzle & Jon Junker Andrea Trimarchi Simone Farresin Formafantasma 彭佳 Dechem Studio Zaha Hadid Design

一梦忽觉夏日长。倏忽间,夏天似乎已经停留了好久好久。燥热的天气、黏人的衬衫、提不起的食欲,所有这些都与冗长的夏季有关。但所幸还有些可喜的地方：例如小店里刚买的绿豆糖水、道路两旁悦耳的蝉鸣,以及微风轻拂的凉爽夏夜。也许正... 详细信息

一梦忽觉夏日长。倏忽间,夏天似乎已经停留了好久好久。燥热的天气、黏人的衬衫、提不起的食欲,所有这些都与冗长的夏季有关。但所幸还有些可喜的地方：例如小店里刚买的绿豆糖水、道路两旁悦耳的蝉鸣,以及微风轻拂的凉爽夏夜。也许正因为白日里的夏天过于＂毒辣＂,所以它的夜晚才显得那么温柔可爱。

关键词：梦境光影夏天

齿状核MrI T2加权低信号与多发性硬化症患者步行能力损伤有关

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 45-46页

作者： Tjoa C.W. Benedict r.H.B. Weinstock-Guttman B. r. Bakshi 周永 Departments of Neurology and radiology Brigham and Women’s Hospital Harvard Medical School 77 Avenue Louis Pasteur-HIM 730 Boston MA 02115 United States

Objectives: MrI T2 hypointensity in multiple sclerosis (MS)-gray matter, suggesting iron deposition, is associated with physical disability, disease course, lesion load, and brain atrophy. Ambulatory dysfunction limits quality of life; however correlation with conventional MrI remains poor. Methods: Normalized intensity on T2-weighted images was obtained in the basal ganglia, thalamus, red nucleus, and dentate nucleus in 47 MS patients and 15 healthy controls. Brain T1-hypointense and FLAIr-hype-rintense lesion volume, third ventricle width, brain parenchymal fraction and timed 25 foot walk (T25FW)-were measured in the MS group. results: T2 hypointensity was present throughout gray matter in MS vs. controls (all p rI variable significantly correlated with T25FW (Pearson r=-0.355, p=0.007) and was also the best MrI correlate of physical disability (EDSS) score in regression modeling (r=-0.463, r2=0.223, p=0.004). Conclusions: T2 hypointensity is present in subcortical gray matter nuclei in patients with MS vs. normal controls. Dentate nucleus T2 hypointensity is independently related to ambulatory impairment and disability, accounting for more variance than conventional lesion and atrophy measures. This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS.

关键词：多发性硬化症 MrI T2加权步行能力齿状核病灶体积 EDSS FLAIr 基底神经节第三脑室铁沉积

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第四种中微子:宇宙的至暗物质

环球科学 2020年第15期 36-43页

作者：威廉·查尔斯·路易斯理查德·范德沃特李玉峰(翻译) 美国洛斯阿拉莫斯国家实验室美国物理学会美国科学促进协会中国科学院高能物理研究所

故事开始于1996年,当时我们发布了美国洛斯阿拉莫斯国家实验室(Los Alamos National Laboratory)的液体闪烁中微子探测器(Liquid Scintillator Neutrino Detector,LSND)的实验数据,表明中微子理论可能存在问题。中微子是一种微小的基本... 详细信息

故事开始于1996年,当时我们发布了美国洛斯阿拉莫斯国家实验室(Los Alamos National Laboratory)的液体闪烁中微子探测器(Liquid Scintillator Neutrino Detector,LSND)的实验数据,表明中微子理论可能存在问题。中微子是一种微小的基本粒子,它无处不在,可以穿过绝大多数物质。过去,学界广泛认为,中微子只存在三种类型,或者说味道(flavor)。然而,我们的实验结果显示,可能存在第四种味道的中微子。学界一直对此持怀疑态度,事实上后续的实验数据也与19%年的结果相俘,没能探测到第四种中微子。

关键词：中微子暗物质基本粒子液体闪烁

AB090. MOG1, the genetic modifier at 20q13, delays the age-at-onset of glaucoma by 8 to 10 years

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Annals of Eye Science 2018年第1期 496-496页

作者： Vincent raymond Pascal Belleau rose Arseneault Stéphane Dubois Jean-louis Anctil Gilles Côté Marcel Amyot Fahed Elian Michael AWalter Québec Glaucoma Network Département d’ophtalmologie Centre de rechrechr du CHU de QuébecQuébecQCCanada

Background:Primary open-angle glaucoma(POAG)is a genetically complex disorder caused primarily by gene-gene *** identify these interactions,we studied the CA family,a large French-Canadian pedigree in which the myocilin K423E mutation(MYOCK423E)causes autosomal dominant glaucoma with diagnoses ranging from juvenile-onset OAG(JOAG)to late adult-onset POAG in the heterozygotes(HTZ).To explain this extreme variability,we hypothesized that a second gene,called a modifier,was interacting with MYOC,the primary disease *** goals were(I)to map the modifier on the human genome and;(II)to characterize the symptoms affected genetically by the *** symptoms are called ***:Three hundred seventy-five CA members were studied using four quantitative endophenotypes:age of maximal intra-ocular pressures(IOPmax),IOPs progression,progression of cup to disk ratios and age-at-onset(AAO)defined as age at which ocular hypertension(OHT)was first detected with IOP≥22 ***-wide linkage analysis was performed by genotyping 408 genetic markers in 184 CA *** unbiased pedigree-based algorithm was designed to identify the individuals who were double-mutants,i.e.,these individuals carried one MYOCK423E mutation(i.e.,they were HTZ,affected or not)and they also carry simultaneously a DNA mutation within the ***:Out of the 375 CA family members investigated,156 were HTZ for the MYOCK423E mutation.120 HTZ were affected with OAG or OHT with treatment while the remaining 36 HTZ were *** ranged from 7 to 63 years old;4 individuals over 50 years old were still *** preceded optic nerve damage in>98%of the HTZ carriers,confirming that AAO reflected the true severity of the *** modifier showed strong inherited effects on 2 of the 4 endophenotypes:AAO and *** next mapped with very high confidence the modifier locus for AAO at chromosome *** genotyping with additional markers refined th

关键词： Blindness genomics complex genetic disorder gene-gene interactions biostatistics

Correction to:Addressing vulnerability,building resilience:community-based adaptation to vector-borne diseases in the context of global change

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Infectious Diseases of Poverty 2018年第1期7卷 59-59页

作者： Kevin louis Bardosh Sadie Jryan Kris Ebi Susan Welburn Burton Singer Department of Anthropology University of FloridaGainesvilleUSA Emerging Pathogens Institute University of FloridaGainesvilleUSA Department of Geography University of FloridaGainesvilleUSA Department of Global Health University of WashingtonSeattleUSA Center of Infectious Disease University of EdinburghEdinburghUK

Correction After publication of this article[1]it came to our attention that the name of the author Sadie ryan was incorrectly *** correct name is Sadie *** original article has been updated to reflect this change.

关键词： change. adaptation correctly