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中国处方药 2010年第11期9卷 18-页

作者： louis M.Aledort 张海燕

重组活化因子Ⅶ(rfⅦa)将血友病的治疗带入了一个新的历史阶段.最初,rfⅦa获批用于存在凝血因子Ⅷ和Ⅸ抑制物的血友病患者的止血治疗.对于体内产生抑制物的患者,rfⅦa既可以直接产生治疗效果,也可以通过免疫机制发挥作用,因此,该药已成... 详细信息

重组活化因子Ⅶ(rfⅦa)将血友病的治疗带入了一个新的历史阶段.最初,rfⅦa获批用于存在凝血因子Ⅷ和Ⅸ抑制物的血友病患者的止血治疗.对于体内产生抑制物的患者,rfⅦa既可以直接产生治疗效果,也可以通过免疫机制发挥作用,因此,该药已成为血友病的一种重要辅助治疗药物.

关键词：说明书重组活化因子Ⅶ 血友病辅助治疗药物抑制物凝血因子Ⅷ 治疗效果止血治疗免疫机制患者发挥作用体内历史

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《牛津传记史》主编扎卡里·里德尔谈话录

现代传记研究 2022年第1期 1-11页

作者：让-路易·让奈尔布鲁诺·特里布扎卡里·里德尔索邦大学阿伯丁大学不详

访谈背景:“自我书写”是让-路易·让奈尔与让-克利斯朵夫·伊加兰斯共同主持的项目(CELLF 16-21,索邦大学),其目的之一是对欧洲各国传记的研究现状展开调查。在该项目工作中,我们采访了《牛津传记史》主编扎卡里·里德尔。

关键词：自我书写克利斯朵夫里德尔谈话录传记欧洲各国研究现状奈尔

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德国人正在为CT的过度使用而担心

放射学实践 2007年第8期22卷 829-829页

作者： louis Charbonneau 傅强（译）李松柏（校）不详沈阳中国医科大学附属第一医院放射线科

“德国人正在不必要地接受着大剂量的X线照射。这种照射不是源于真正的健康所需,而是滥用CT检查所致”。这一警告来自德国环境部长Sigmar Gabriel在7月12日发表的一份有关“德国的射线辐射”年度报告中。[第一段]

关键词： CT检查德国人过度使用担心 X线照射年度报告射线辐射

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打开时间的任意门——远洋·春秋里样板间

中国建筑装饰装修 2022年第13期 22-27页

作者：刘荣禄陈竹卫周逸莹陈阳康刘琳吉如你所见·王厅(摄影) 刘荣禄国际空间设计台湾室内设计协会中国不详

当你抽离已知的感官,将意识置于当下的生活语境,任凭光与线的牵引,去穿越时光的穹廊,便会一同坠入美的化境。1F似神秘的虫洞一般,推开时光的任意门,空间便和时间、光影一同流动起来。取自原始建筑元素的的凝灰岩,有着天然的自然呼吸感... 详细信息

当你抽离已知的感官,将意识置于当下的生活语境,任凭光与线的牵引,去穿越时光的穹廊,便会一同坠入美的化境。1F似神秘的虫洞一般,推开时光的任意门,空间便和时间、光影一同流动起来。取自原始建筑元素的的凝灰岩,有着天然的自然呼吸感。质朴肌理摆脱过多的装饰性,保留着某种简化的赤裸美感,vintage气息的陈设,为空间在新与旧痕迹之间达到折中平衡。

关键词：自然呼吸建筑元素生活语境样板间新与旧凝灰岩装饰性

Vascularized omental tissue transfer for the treatment of lymphedema:a review

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Plastic and Aesthetic research 2023年第1期10卷 46-55页

作者： rachel Skladman William r.Moritz Elijah J.Tenenbaum Joani M.Christensen Justin M.Sacks Division of Plastic and reconstructive Surgery Washington University School of MedicineSt.LouisMO 63108USA

Lymphedema is a debilitating disorder caused by impaired drainage of the lymphatic *** the Western world,lymphedema most often arises secondary to the treatment of *** with lymphedema experience progressive swelling,pain,numbness,and tingling,and decreased quality of *** with persistent symptoms may be subject to chronic *** advent of microsurgery has enabled clinicians to transplant donor lymph nodes and their blood supply from a healthy site to the affected area in a procedure known as vascularized lymph node transplant(VLNT).One donor region is the *** omental lymph node transfer(VOLT)has been shown to decrease limb volume,circumference,and subjective symptoms of *** immunologic properties of the omentum make it a particularly useful lymph node donor site for patients with lymphedemarelated *** omentum may be harvested laparoscopically,with robotic assistance,or through a small laparotomy *** this review,we describe the relevant anatomy and history of VOLT as well as operative *** risks,benefits,and relevant outcome studies will be *** applications of robotic surgery to VOLT will be addressed.

关键词： Lymphedema VOLT VLNT laparoscopy laparotomy gastroepiploic vessels cellulitis

Suppressing fatty acid synthase by type Ⅰ interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SArS-CoV-2

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1624-1635页

作者： Saba r.Aliyari Amir Ali Ghaffari Olivier Pernet Kislay Parvatiyar Yao Wang Hoda Gerami Ann-Jay Tong Laurent Vergnes Armin Takallou Adel Zhang Xiaochao Wei Linda D.Chilin Yuntao Wu Clay F.Semenkovich Karen reue Stephen T.Smale Benhur Lee Genhong Cheng Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095USA EnViro International Laboratories Los AngelesCA 90077USA Department of Human Genetics David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Division of Endocrinology Metabolism and Lipid ResearchWashington University School of MedicineSt.LouisMO 63110USA Center for Infectious Disease research School of Systems BiologyGeorge Mason University ManassasVA 20110USA Diabetic Cardiovascular Disease Center WashingtonUniversity School of MedicineSt.LouisMO 63110USA

SArS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the *** part of the innate immune response to viral infection, type Ⅰ interferons(IFN-Ⅰ) trigger a signaling cascade that culminates in the activation of hundreds of genes, known as interferon stimulated genes(ISGs), that collectively foster an antiviral *** report here the identification of a group of type Ⅰ interferon suppressed genes,including fatty acid synthase(FASN), which are involved in lipid *** of FASN or the addition of its downstream product, palmitate, increased viral infection while knockout or knockdown of FASN reduced *** importantly, pharmacological inhibitors of FASN effectively blocked infections with a broad range of viruses, including SArS-CoV-2 and its variants of ***, our studies not only suggest that downregulation of metabolic genes may present an antiviral strategy by type Ⅰ interferon, but they also introduce the potential for FASN inhibitors to have a therapeutic application in combating emerging infectious diseases such as COVID-19.

关键词： Fatty acid synthase FASN IFN-I SArS-CoV-2 COVID-19 C75

重组人类活化蛋白C在严重全身性感染患者重要临床亚组中的应用

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世界医学杂志 2003年第7期7卷 1-7页

作者： E．Wesley MD,MPH MD,DerekC.Angus MD,MPH JeffreyD.Helterbrand,PhD HowardLevy MBBCH,PhD Jean-FrancoisDhainaut,MD,PhD Jean-louis,MD,PhD WillianL.Macias,MD,PhD Gordonr.Bernard,MD Pierre-FrancoisLaterre 不详

目的：评价重组人类活化蛋白C[Drotrecogin alfa(activated)]在严重全身性感染患者中所进行的世界范围的、随机、3期、安慰剂对照研究(PrOWESS)中，对临床亚组的治疗效果。设计：对PrOWESS研究中预先定义的亚组进行单元和多元分析。设... 详细信息

目的：评价重组人类活化蛋白C[Drotrecogin alfa(activated)]在严重全身性感染患者中所进行的世界范围的、随机、3期、安慰剂对照研究(PrOWESS)中，对临床亚组的治疗效果。设计：对PrOWESS研究中预先定义的亚组进行单元和多元分析。设置：共11个国家的164个医疗中心。患者：共1690例严重全身性感染患者。方法和主要结果：我们报告了预先依据人口统计学资料、外科情况、感染的类型和部位，以及代表疾病严重程度的临床和生化指标定义的亚组中，应用Drotrecogin alfa(activated)和安慰剂后观察到的28天死亡率。随后进行了亚组分析，探讨了Drotrecogin alfa(activated)降低整体死亡率是否与降低亚组死亡率一致，并对定量和定性的交互作用进行了检验。我们对Pr0WESS安慰剂组采用逐步逻辑回归法，得到一个预期死亡危险模型，这个模型包括了许多提示死亡危险的临床和生化指标，以检测Drotrecogin alfa(activated)治疗益处的大小和潜在预期死亡危险的范围。因为Drotrecogin alfa(activated)有抗凝血特性，我们也对出血和血栓形成事件进行了分析。在几乎所有预先定义的亚组中，与安慰剂组相比，应用Drotrecogin alfa(activated)的实际死亡率更低。单元和多元回归分析均一致显示了应用Drotrecogin alfa(activated)使28天死亡率的相对危险度降低。当患者有较高的基线预期死亡危险时，发现应用Drotrecogin alfa(activated)使绝对死亡危险度降低更大，而且在所有依据疾病严重程度测量定义的不同亚组中，也发现当安慰剂组死亡率≥20%时，应用Drotrecogin alfa(activated)的实际死亡率更低。虽然因为只观察到很少出血和血栓事件而使鉴别能力有限，但与基线预期死亡危险相比，因治疗导致严重出血事件的绝对危险度似乎并没有增加。结论：对严重全身性感染患者应用Drotrecogin alfa(activated)可以显著提高生存率，而又趋向于可以提高基线死亡可能性较高患者的生存率。现有的资料提示，该药物增加出血的危险性并不随死亡率的增加而改变。

关键词：重组人类活化蛋白C 全身性感染治疗安慰剂对照研究

Effects of therapeutic horseback riding on post-traumatic stress disorder in military veterans

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Military Medical research 2018年第1期5卷 19-32页

作者： rebecca A.Johnson David L.Albright James r.Marzolf Jessica L.Bibbo Hayley D.Yaglom Sandra M.Crowder Gretchen K.Carlisle Amy Willard Cynthia L.russell Karen Grindler Steven Osterlind Marita Wassman Nathan Harms research Center for Human Animal interaction College of Veterinary Medicine University of Missouri Columbia MO 65211 USA. researchService Harry S. Truman Memorial Veterans' Hospital ColumbiaMO 65211 USA. School of Social Work University of AlabamaTuscaloosa AL 35487 USA. Occupational Health Services Harry S. Truman Memorial Veterans' Hospital Columbia MO 65211 USA. Center for the Human-Animal Bond College of Veterinary MedicinePurdue University West Lafayette IN 47907 USA. School of Health Professions University of Missouri Columbia MO 65211 USA. TrEE House of Greater St. louis Wentzville MO 63385 USA. School of Nursing and Health Studies University of Missouri-Kansas CityKansas City MO 64108 USA. Cedar Creek Therapeutic riding Center Columbia MO 65201 USA. College of Education School and Counseling Psychology University of Missouri Columbia MO 65211USA. ride-On St. louis Kimmswick MO 63053 USA.

Background:Large numbers of post-deployment *** are diagnosed with post-traumatic stress disorder(PTSD)and/or traumatic brain injury(TBI),leading to an urgent need for effective interventions to reduce symptoms and increase veterans’*** includes anxiety,flashbacks,and emotional *** symptoms increase health care costs for stress-related illnesses and can make veterans’civilian life ***:We used a randomized wait-list controlled design with repeated measures of *** veterans to address our specific aim to test the efficacy of a 6-week therapeutic horseback riding(THr)program for decreasing PTSD symptoms and increasing coping self-efficacy,emotion regulation,social and emotional *** participants were recruited and 29 enrolled in the randomized *** were randomly assigned to either the horse riding group(n=15)or a wait-list control group(n=14).The wait-list control group experienced a 6-week waiting period,while the horse riding group began *** wait-list control group began riding after 6 weeks of participating in the control *** and health history information was obtained from all the *** symptoms were measured using the standardized PTSD Checklist-Military Version(PCL-M).The PCL-M as well as other instruments including,The Coping Self Efficacy Scale(CSES),The Difficulties in Emotion regulation Scale(DErS)and The Social and Emotional Loneliness Scale for Adults-short version(SELSA)were used to access different aspects of individual well-being and the PTSD ***:Participants had a statistically significant decrease in PTSD scores after 3 weeks of THr(P≤0.01)as well as a statistically and clinically significant decrease after 6 weeks of THr(P≤0.01).Logistic regression showed that participants had a 66.7%likelihood of having lower PTSD scores at 3 weeks and 87.5%likelihood at 6 *** the generalized linear model(GLM),our ANOVA findings for the coping self

关键词： Animal-assisted intervention Coping self-efficacy Emotion regulation Military veterans Post-traumatic stress disorder Social engagement Therapeutic horseback riding Traumatic brain injury

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清凉一“夏”

现代装饰（家居） 2016年第6期 104-115页

作者： Kreoo Sylvain Willenz Jean louis Iratzoki Fogia JSPr Max Voytenko moooi Dan Vakhrameyev UMENODESIGN HAY Sergei Kotsepup Bo reudler Studio & Olav Bruin Kim Markel Eugeni Quitllet Saro Zeville Juno Jeon Bower 李薇范嘉苑

温柔的阳光开始慢慢散去,夏天迈着张扬的步调来临,在满是炙热的空气里,何处觅得一隅清凉?本期我们特别策划了"清凉一‘夏'"家具主题,将分别从"大理石艺术"、"金属·镂空"、"清透质感"三个方面与各位读者分享一些带有清凉特质的家具产品... 详细信息

温柔的阳光开始慢慢散去,夏天迈着张扬的步调来临,在满是炙热的空气里,何处觅得一隅清凉?本期我们特别策划了"清凉一‘夏'"家具主题,将分别从"大理石艺术"、"金属·镂空"、"清透质感"三个方面与各位读者分享一些带有清凉特质的家具产品,希望在这个炎炎夏日可以帮助大家打造一个清凉舒适的家居空间。

关键词：家具产品清透家居空间家居环境天然石材户外家具竹材胶合板家具品牌系列作品木材材质