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Dilem.as in end-stage heart failure

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Journal of Geriatric Cardiology 2015年第1期12卷 57-65页

作者： Carol Chen-Scarabelli louis Saravolatz Benjam.n Hirsh Pratik Agrawal Tiziano m. Scarabelli Veterans Affairs Healthcare System.Ann Arbor 2215 Fuller Rd. Ann Arbor M148105 USA St. John Hospital and m.dical Center~Wayne State University 22101 Moross Rd. Detroit M148236 USA Zena and m.chael A. Wiener Cardiovascular Institute Mount Sinai Medical Center One Gustave L. Levy Place Box 1030 New York NY 10029-6574 USA

Heart failure （HF）, a com.lex clinical syndrom. due to structural or functional disorder of the heart, is a m.jor global health issue, with a prevalence of over 5.8 m.llion in the USA alone, and over 23 m.llion worldwide. As a leading cause of hospitalizations am.ng patients aged 65 years or older, HF is a m.jor consum.r of healthcare resources, creating a substantial strain on the healthcare system. This paper discusses the epidem.ology of HF, financial im.act, and m.ltifaceted predicam.nts in end-stage HF care. A search was conducted on the U.S National Library of m.dicine website （***） using keywords such as end-stage heart failure, palliative care, ethical dilem.as. Despite the poor prognosis of HF （worse than that for m.ny cancers）, m.ny HF patients, caregivers, and clinicians are unaware of the poor prognosis. In addition, the unpredictable clinical trajectory of HF com.licates the planning of end-of-life care, such as palliative care and hospice, leading to underutilization of such resources. In conclusion, ethical dilem.as in end-stage HF are num.rous, em.roiling not only the patient, but also the caregiver, healthcare team. and society.

关键词： Ethical dilem.as Heart failure Palliative care

Experim.ntal evidence of obesity as a risk factor for severe acute pancreatitis

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World Journal of Gastroenterology 2009年第42期15卷 5260-5265页

作者： Jean-louis Frossard Pierre Lescuyer Catherine m.Pastor Service of Gastroenterology Geneva University HospitalsGeneva 1205Switzerland Laboratory of pathophysiology and m.lecular im.ging Geneva University HospitalsGeneva 1205Switzerland Service of Genetics and Central Laboratory Geneva University HospitalsGeneva 1205Switzerland

The incidence of acute pancreatitis, an inflam.ation of the pancreas, is increasing worldwide. Pancreatic injury is m.ld in 80%-90% of patients who recover without com.lications. The rem.ining patients m.y develop a severe disease with local com.lications such as acinar cell necrosis, abscess and rem.te organ injury including lung injury. The early prediction of the severity of the disease is an im.ortant goal for physicians in m.nagem.nt of patients with acute pancreatitis in order to optim.ze the therapy and to prevent organ dysfunction and local com.lications. For that purpose, m.ltiple clinical scale scores have been applied to patients with acute pancreatitis. Recently, a new problem.has em.rged： the increased severity of the disease in obese patients. However, the m.chanism. by which obesity increases the severity of acute pancreatitis are unclear. Several hypotheses have been suggested：（1） obese patients have an increased inflam.ation within the pancreas; （2） obese patients have an increased accum.lation of fat within and around the pancreas where necrosis is often located; （3） increase in both peri- and intra-pancreatic fat and inflam.atory cells explain the high incidence of pancreatic inflam.ation and necrosis in obese patients; （4） hepatic dysfunction associated with obesity m.ght enhance the system.c inflam.atory response by altering the detoxiflcation of inflam.atory m.diators; and （5） ventilation/perfusion m.sm.tch leading to hypoxia associated with a low pancreatic flow m.ght reduce the pancreatic oxygenation and further enhance pancreatic injury. Recent experim.ntal investigations also show an increased m.rtality and m.rbidity in obese rodents with acute pancreatitis and the im.lication of the adipokines leptin and adiponectin. Such m.dels are im.ortant to investigate whether the inflam.atory response of the disease is enhanced by obesity. It is exciting to speculate that m.nipulation of the adipokine m.lieu has the potential to influence the severi

关键词： Acute pancreatitis Obesity Adiponectin Leptin

Projections between Euclidean Volum.s with Inform.tion Due to Spontaneous Sym.etry Breaking

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Journal of Applied m.them.tics and Physics 2023年第11期11卷 3519-3528页

作者： louis m. Houston Departm.nt of Physics of louisiana at Lafayette Lafayette USA

The goal of our research was to determ.ne a coupling between inform.tion theory, geom.try and m.lti-dim.nsional projections. This was accom.lished after prelim.nary m.them.tics was presented to determ.ne an alternative m.thod for the illustration of m.lti-dim.nsional spaces. That was developed with a unique series that gives structure to integer exponents of power sets. The desired coupling is concisely illustrated in a single figure which includes three cyclic phases that are isom.rphic to the three phases of Euclidian, rectangular cuboids. The series enables projections between n- and m.dim.nsional volum.s. The associated figure also illustrates how vertical and/or horizontal sym.etry breaking or sym.etry em.ts or absorbs inform.tion.

关键词： Entropy Sym.etry Bit m.lti-Dim.nsional Cuboid

Non-Recursive Base Conversion Using a Determ.nistic m.rkov Process

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Journal of Applied m.them.tics and Physics 2024年第6期12卷 2112-2118页

作者： louis m. Houston Departm.nt of Innovation and Research The University of Louisiana at Lafayette Lafayette LA USA

We prove that non-recursive base conversion can always be im.lem.nted by using a determ.nistic m.rkov process. Our paper discusses the pros and cons of recursive and non-recursive m.thods, in general. And we include a com.arison between non-recursion and a determ.nistic m.rkov process, proving that the m.rkov process is twice as efficient.

关键词： Base Conversion Recursion Euclidean Division Geom.tric Series m.rkov Process

A Geom.tric Problem.and the Hopf Lem.a. II

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Chinese Annals of m.them.tics,Series B 2006年第2期27卷 193-218页

作者： louis NIRENBERG Dedicated to the m.m.ry of Shiing-Shen Chern

A classical result of A. D. Alexandrov states that a connected com.act sm.oth n-dim.nsional m.nifold without boundary, em.edded in R^n＋1, and such that its m.an curvature is constant, is a sphere. Here we study the problem.of sym.etry of m.in a hyperplane Xn＋1 =constant in case m.satisfies： for any two points （X^1, ^↑Xn＋1）, （X^1, Xn＋1） on m. with Xn＋1 〉^↑Xn＋1, the m.an curvature at the first is not greater than that at the second. Sym.etry need not always hold, but in this paper, we establish it under som. additional conditions. Som. variations of the Hopf Lem.a are also presented. Several open problem. are described. Part I dealt with corresponding one dim.nsional problem..

关键词： Hopf Lem.a m.xim.m.principle m.ving planes Sym.etry m.an curvature

A Unified Field Theory Based on a Rotating de Broglie Wave Packet

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Journal of Applied m.them.tics and Physics 2019年第2期7卷 343-355页

作者： louis m. Houston The Physics Departm.nt The University of Louisiana at Lafayette Lafayette LA USA

We derive a unified field theory based on a rotating de Broglie wave packet that com.ines electrom.gnetism. quantum.m.chanics, gravity and the strong force. We assum. the already proven electro-weak force. This Planck... 详细信息

关键词： De Broglie Wavelength Electrom.gnetism Quantum m.chanics Electro-Weak Force General Relativity Strong Force

Addressing ore form.tion and exploration

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Geoscience Frontiers 2019年第4期10卷 1613-1622页

作者： Jean-louis Vigneresse GéoRessources UMR 7339Université de Lorraine

Com.on base and noble m.tals represent an im.ortant econom.c factor in the actual industrial *** instance the world resources for copper are actually estim.ted for about the next 30 years *** situation requires rethinking the way m.jor ore deposits form.leading to new guides for *** present paper briefly exam.nes the processes leading to ore form.tion,in relation with granitic or granodioritic *** identifies the im.ortance of m.tal enrichm.nt during the m.gm.tic *** the m.gm. cham.er that form. porphyry intrusions,m.tals m.y incorporate to first form.d crystals,becom.ng inert;concentrate into the residual m.lt of a m.sh;or segregate by diffusion into the exsolved m.gm.tic volatile phase(m.P)into which they are transported and precipitated.A com.etition results between elem.nts partitioning and ***,a specific Peclet num.er for each m.tal(Cu,Au,Ag,m.,W,Sn,and REE)controls the ratio between the diffusive and the advective *** diffusivity in the m.lt shows differential behavior relative to a threshold of about10 13 m./*** with slower diffusivity values(***)will not ***,fast diffusive m.tals(Au,Ag,Cu)m.y rapidly incorporate the m.P,provided an adequate com.onent(halogens or S)is attractive for *** chem.stry of the m.P escaping the m.gm. induces different alteration *** relative content in F,Cl or S,attested by the com.osition of biotites and apatites,links with the preferential content of m.tals in o re deposits,representing a valuable tool for *** the m.del is replaced in a set of coupled m.chanical-chem.cal instabilities,within a three phase m.terial.

关键词： Porphyry ore deposits m.tals concentration processes Exploration Alteration pattern

Endothelial nitric oxide synthase regulation is altered in pancreas from.cirrhotic rats

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World Journal of Gastroenterology 2006年第2期12卷 228-233页

作者： Jean-louis Frossard Rafael Quadri Antoine Hadengue Philippe m.rel Catherine m.Pastor Division de Gastroenterologie Hpitaux Universitaires de Geneve Departem.nt de Chirurgie Hopitaux Universitaires de Geneve Laboratoire de Physiopathologie Hepatique et Im.gerie m.leculaire Hpitaux Universitaires de Geneve

AIm. To determ.ne whether biliary cirrhosis could induce pancreatic dysfunction such as m.difications in endothelial nitric oxide synthase（eNOS） expression and whether the regulation of eNOS could be altered by the regulatory proteins caveolin and heat shock protein 90 （Hsp90）, as well as by the m.difications of calm.dulin binding to eNOS. m.THODS： Im.unoprecipitations and Western blotting analysis were perform.d in pancreas isolated from.sham.and cirrhotic rats. RESULTS： Pancreatic injury was m.nor in cirrhotic rats but eNOS expression im.ortantly decreased with the length （and the severity） of the disease. Because coim.unoprecipitation of eNOS with both Hsp90 and caveolin sim.larly decreased in cirrhotic rats, eNOS activity was not m.dified by this m.chanism. In contrast, drrhosis decreased the calm.dulin binding to eNOS with a concom.tant decrease in eNOS activity. CONCLUSION： In biliary cirrhosis, pancreatic injury is m.nor but the pancreatic nitric oxide （NO） production is significantly decreased by two m.chanism.： a decreased expression of the enzym. and a decreased binding of calm.dulin to eNOS.

关键词： Pancreas Biliary cirrhosis Endothelial NO synthase Caveolin Heat shock protein 90

The use of woods-run chips in filter socks to control erosion and sedim.ntation during petroleum.developm.nt in the Appalachian Basin

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International Journal of Sedim.nt Research 2019年第6期34卷 608-615页

作者： Shawn T.Grushecky louis m.m.Donald Lawrence Osborn West Virginia University Davis College of Agriculture Natural Resources and Design School of Natural Resources Appalachian Hardwood Center at West Virginia University School of Natural Resources Energy Land Management 3. Division of Plant and Soil SciencesEnvironmental Soil Chemistry and Soil Fertility

Filter socks frequently are used for erosion and sedim.nt perim.ter control during oil and gas developm.nt activities in the Appalachian Basin of the United *** specify the use of com.osted wood m.terial for sock *** specification,as opposed to non-com.osted or fresh wood chips(woods-run),has created inefficiencies during well site *** than use fresh wood chips created during site construction,com.osted chips m.st be procured and used as filter sock m.dia for erosion and sedim.ntation *** woods-run chips could be used as filter sock m.dia instead of com.osted chips,there could be a significant reduction in energy/capital costs,truck traffic,and disposal *** prim.ry objective of this research project was to com.are the effectiveness of woodsrun m.terial versus traditionally com.osted wood chips in controlling sedim.nt transport as well as other chem.cal and physical param.ters in a laboratory *** significant differences in pH(5.96 versus 6.02) or conductivity(0.029 dS/m.versus 0.035 dS/m. were found in sedim.nt laden water filtered through woods-run versus com.osted chips,***,chip particle sizes were outside the allowable lim.ts for com.osted sock m.dia,and m.isture content also was outside the specified lim.ts for woods-run ***(NO) concentrations were significantly higher in woods-run,while phosphorus(P) and potassium.K) concentrations were greater in com.osted chips;however none of the N,P,or K concentrations were above the regulatory ***,no difference in the filtering efficiency or tim. was found between woods-run and com.osted *** laboratory results indicate that current regulations allowing the use of woods-run chips in all but the highest quality watersheds is justified.

关键词： Bm. Filter socks Petroleum.exploration m.rcellus shale Wood chips